Abstract：
BACKGROUND:The epidemiological pattern of hepatitis B virus infection in Italy has greatly changed over the past decades. The aim of the study was to evaluate during time the epidemiological features of acute hepatitis B cases referred to an Infectious Disease Unit in North-East of Italy between 1978 and 1995. PATIENTS AND METHODS:Stored sera of 183 cases were tested for HBV markers, HBV genotypes, anti-Delta and anti-HCV. RESULTS:Anti-HBcIgM was positive in all cases. Mean age increased from 30.2 years in 1978 to 37.5 in 1995 (P<0.01). Significant increase was observed in proportion of cases reporting intravenous drug use from 11.5% to 29.6% (P<0.03). Chronicity rate was as low as 1.1%. Mean days of hospitalization significantly decreased. HBV genotype determination showed that majority of cases was infected by genotype D, but its prevalence decreased from 88.2% in 1978 to 75.0% in 1995. Delta coinfection was present in 8.2%. The prevalence of HCV in patients with acute HBV was 35.0%; it fluctuated from 26.2% to 44.2%, mostly related (53.1%) to intravenous drug use. Dual infection did not lead to a more severe course of disease. CONCLUSIONS:From this retrospective study, remarkable fluctuations in the prevalence of dual HBV-HCV infection before the implementation of HBV vaccination were observed. Presence of anti-HCV did not affect the course of acute HBV.
journal_name
Eur J Intern Medjournal_title
European journal of internal medicineauthors
Stroffolini T,Rapicetta M,Lombardo F,Chionne P,Madonna E,Candido A,Taffon S,Rinaldi R,Ermg E,Bortolotti Fdoi
10.1016/j.ejim.2012.03.007subject
Has Abstractpub_date
2012-09-01 00:00:00pages
e146-9issue
6eissn
0953-6205issn
1879-0828pii
S0953-6205(12)00076-3journal_volume
23pub_type
杂志文章abstract：OBJECTIVE:The use of commercially available noninvasive markers for chronic hepatitis B (CHB) related fibrosis is not widely available in developing countries so clinicians in those countries frequently use free alternatives. We aimed to create an optimized algorithm for selection of patients with the highest probabili...
journal_title：European journal of internal medicine
pub_type： 杂志文章
doi：10.1016/j.ejim.2015.07.005
更新日期：2015-10-01 00:00:00
abstract：:Human serum albumin (HSA) is the most abundant circulating protein and accounts for about 70% of the plasma colloid osmotic pressure. Beside the well known capacity to act as plasma-expander, HSA is provided of many other properties which are unrelated to the regulation of fluid compartmentalization, including binding...
journal_title：European journal of internal medicine
pub_type： 杂志文章,评审
doi：10.1016/j.ejim.2013.05.015
更新日期：2013-12-01 00:00:00
abstract：BACKGROUND:Cranial nerve involvement is commonly observed in patients with tuberculous meningitis. The present study evaluated the incidence, predictors and prognostic significance of cranial nerve involvement in tuberculous meningitis. MATERIALS AND METHOD:One hundred-fifty-eight adult patients with tuberculous menin...
journal_title：European journal of internal medicine
pub_type： 杂志文章
doi：10.1016/j.ejim.2011.01.007
更新日期：2011-06-01 00:00:00
abstract：INTRODUCTION:Patients with chronic hepatitis C (CHC) and end-stage renal disease (ESRD) on dialysis are difficult to treat and show higher dropout rates during treatment. The aim of this study was to analyze the treatment outcomes in patients with CHC and underlying end-stage renal disease on dialysis in Korea. METHOD...
journal_title：European journal of internal medicine
pub_type： 杂志文章,多中心研究
doi：10.1016/j.ejim.2015.03.011
更新日期：2015-05-01 00:00:00
abstract：:Background: We investigated circulating relaxin (RLX) and its potential role in human congestive heart failure (CHF) at rest and after physical exercise. Methods: A total of 10 healthy controls and 35 patients with stable CHF were enrolled in the study. Results: RLX plasma concentrations at rest and after exercise wer...
journal_title：European journal of internal medicine
pub_type： 杂志文章
doi：10.1016/j.ejim.2003.11.009
更新日期：2004-02-01 00:00:00
abstract：:The rising number of clinical guidelines poses a new challenge to the internists. The main problems are: 1) available documents suffer from heterogeneous methodological quality, and 2) most of clinical guidelines target an 'ideal' patient affected by a single condition, while in real practice internists must face with...
journal_title：European journal of internal medicine
pub_type： 杂志文章
doi：10.1016/j.ejim.2020.05.016
更新日期：2020-07-01 00:00:00
abstract：:Background: Thrombomodulin (TM) is a membrane glycoprotein in the vascular endothelium. It may be cleaved from endothelial cells and released into the circulation. The plasma TM level depends on the integrity of the endothelium and the clearance of the molecule. The physiological role of soluble TM forms is still uncl...
journal_title：European journal of internal medicine
pub_type： 杂志文章
doi：10.1016/s0953-6205(00)00066-2
更新日期：2000-04-01 00:00:00
abstract：BACKGROUND:Whether or not mild hyperhomocysteinemia and low serum levels of folates or vitamin B12 are risk factors for osteoporosis in the elderly is controversial. AIMS AND METHODS:To investigate whether or not plasma levels of total homocysteine (tHcy) and serum levels of folates and vitamin B12 are associated with...
journal_title：European journal of internal medicine
pub_type： 杂志文章
doi：10.1016/j.ejim.2010.03.017
更新日期：2010-08-01 00:00:00
abstract：:The Medical Emergency Team (MET) has enhanced the recognition and response to clinical deterioration in acute healthcare. However, patients reviewed by the MET are at increased risk of in-hospital death. Identifying patients at risk of deterioration may improve patient outcomes. AIM: To identify patient demographic, m...
journal_title：European journal of internal medicine
pub_type： 杂志文章
doi：10.1016/j.ejim.2019.05.021
更新日期：2019-08-01 00:00:00
abstract：:Pattern recognition of the long-term disease course before, during, and after pregnancy can provide us with data about the influence of pregnancy on IBD, and vice versa. Determinants that predict an indolent versus an aggressive disease course are currently being sought. Our intention is to analyze the disease course ...
journal_title：European journal of internal medicine
pub_type： 杂志文章
doi：10.1016/s0953-6205(00)00088-1
更新日期：2000-08-01 00:00:00
abstract：:Background: Impaired gastrointestinal and gallbladder motility, as a complication of long-lasting diabetes mellitus, has been ascribed to the possible development of autonomic neuropathy, although the intervention of hormonal factors may not completely be excluded. In this regard, cholecystokinin (CCK), a gut hormone ...
journal_title：European journal of internal medicine
pub_type： 杂志文章
doi：10.1016/s0953-6205(02)00003-1
更新日期：2002-03-01 00:00:00
abstract：BACKGROUND:chronic viral infections by both HCV and HIV may lead to polyclonal activation of B cells resulting in hypergammaglobulinemia. This study retrospectively analyzed the effect of HCV eradication with interferon-free direct-acting antiviral agents (DAAs) on the gamma globulin levels in HCV-infected patients wit...
journal_title：European journal of internal medicine
pub_type： 杂志文章
doi：10.1016/j.ejim.2020.01.006
更新日期：2020-05-01 00:00:00
abstract：:The management of arterial hypertension is very challenging in everyday clinical practice. Blood pressure control rates remain disappointingly low, despite intense efforts. Poor adherence to antihypertensive treatment is among the main causes of inadequate blood pressure control. Among the various parameters leading t...
journal_title：European journal of internal medicine
pub_type： 杂志文章,评审
doi：10.1016/j.ejim.2020.07.009
更新日期：2020-11-01 00:00:00
abstract：SUMMARY:Diabetes mellitus (DM) has been declared as a global public health threat to society. However, the burden of the disease in elderly Asian patients has not been described. The aim of the study is to assess the disease burden of DM and its associated adverse outcomes in elderly patients from an Asian hospital usi...
journal_title：European journal of internal medicine
pub_type： 杂志文章
doi：10.1016/j.ejim.2011.10.017
更新日期：2012-01-01 00:00:00
abstract：OBJECTIVE:To present our experience regarding the use of a rapid diagnostic test for seasonal influenza A and B. METHODS:We systematically collected and analyzed our data regarding the use of a rapid diagnostic test for seasonal influenza A and B in patients with specific respiratory symptoms that sought medical servi...
journal_title：European journal of internal medicine
pub_type： 临床试验,杂志文章
doi：10.1016/j.ejim.2010.06.013
更新日期：2010-10-01 00:00:00
abstract：BACKGROUND:Bleeding assessment tools (BATs) have been developed to quantify bleeding severity. Their ability to predict for the diagnosis of a bleeding disorder has not been thoroughly investigated. OBJECTIVES:To evaluate the ability of the Vicenza BAT and the ISTH BAT to distinguish patients with an established bleed...
journal_title：European journal of internal medicine
pub_type： 杂志文章
doi：10.1016/j.ejim.2020.04.023
更新日期：2020-08-01 00:00:00
abstract：BACKGROUND:To describe trends in the rates and short-term outcomes of renal transplants (RTx) among patients with or without diabetes in Spain (2002-2013). METHODS:We used national hospital discharge data to select all hospital admissions for RTx. We divided the study period into four three-year periods. Rates were ca...
journal_title：European journal of internal medicine
pub_type： 杂志文章
doi：10.1016/j.ejim.2016.07.031
更新日期：2017-01-01 00:00:00
abstract：:The use of D-dimer in combination with a clinical decision rule has been widely investigated in pulmonary embolism and deep venous thrombosis. Although it has been shown to be safe in excluding venous thromboembolism, the clinician is often faced with specific situations in which the use of D-dimer is controversial. W...
journal_title：European journal of internal medicine
pub_type： 杂志文章,评审
doi：10.1016/j.ejim.2008.12.004
更新日期：2009-09-01 00:00:00
abstract：BACKGROUND:There is a lack of information on long term complications of patients with pulmonary embolism (PE), including chronic complaints of dyspnea. METHODS:Consecutive patients with a prior diagnosis of acute PE and an age and gender matched control group with no medical history of PE were presented with a questio...
journal_title：European journal of internal medicine
pub_type： 杂志文章
doi：10.1016/j.ejim.2008.02.006
更新日期：2008-12-01 00:00:00
abstract：BACKGROUND:In Greece, there are few data on the epidemiological characteristics of HBV. Our aim was to study the epidemiological patterns of HBV in Central Greece and identify the possible differences in HBV prevalence (clusters) among areas inside this region using data from the hepatitis registry. METHODS:The study ...
journal_title：European journal of internal medicine
pub_type： 杂志文章
doi：10.1016/j.ejim.2008.04.023
更新日期：2009-01-01 00:00:00
abstract：BACKGROUND:Diabetes mellitus can cause a wide variety of vascular complications and it is one of the major risk factors for cardiovascular diseases (CVD). High glucose can induce vascular endothelial cell apoptosis. In this study, we investigated the effect of radix hedysari polysaccharide (HPS) on the depression of ap...
journal_title：European journal of internal medicine
pub_type： 杂志文章
doi：10.1016/j.ejim.2011.10.006
更新日期：2012-04-01 00:00:00
abstract：BACKGROUND:Diagnostic algorithms for pulmonary embolism (PE) have been validated in patients attending hospital emergency departments. However, general practitioners (GPs) are often the professionals of first resort for the majority of non-critical cases of PE. AIM:To evaluate the knowledge of the diagnostic algorithm...
journal_title：European journal of internal medicine
pub_type： 杂志文章
doi：10.1016/j.ejim.2014.11.005
更新日期：2015-01-01 00:00:00
abstract：BACKGROUND:Cardiovascular disease is a leading cause of long-term mortality after liver transplantation (LT). Life long immunosuppression harbors the risk of metabolic alterations. We aimed to analyze the impact of calcineurin (CNI)-only containing regimen (group A) compared to mTOR-containing regimen (group B) on lipi...
journal_title：European journal of internal medicine
pub_type： 杂志文章
doi：10.1016/j.ejim.2015.12.022
更新日期：2016-04-01 00:00:00
abstract：:The use of non-invasive ventilation in patients with community-acquired pneumonia is controversial since this is associated with high rates of treatment failure, compared with other causes of severe acute respiratory failure. The populations of patients with community-acquired pneumonia who have demonstrated better re...
journal_title：European journal of internal medicine
pub_type： 杂志文章,评审
doi：10.1016/j.ejim.2012.02.011
更新日期：2012-07-01 00:00:00
abstract：BACKGROUND:Hepatitis B virus infection has decreased in Italy. The aims of this study were to identify changes, if any, in the epidemiological pattern of HBV infection in a southern Italian town first surveyed in 1996 and to assess the effectiveness of vaccination campaign against hepatitis B. METHODS:In 2010, subject...
journal_title：European journal of internal medicine
pub_type： 杂志文章
doi：10.1016/j.ejim.2012.08.009
更新日期：2012-12-01 00:00:00
abstract：BACKGROUND:For nonneoplastic neurological diseases, no recommendation exists regarding the place or appropriate timing of brain biopsy. The aim of this study was to evaluate the diagnostic yield and safety of brain biopsies from patients with neurological diseases of unknown etiology. METHODS:We performed a retrospect...
journal_title：European journal of internal medicine
pub_type： 杂志文章
doi：10.1016/j.ejim.2020.05.029
更新日期：2020-10-01 00:00:00
abstract：BACKGROUND:Circulating levels of vascular endothelial growth factor (VEGF) may predict microvascular complications in type 1 diabetes mellitus and are elevated when metabolic control is poor. We tested whether serum VEGF is influenced by prevailing glucose and insulin levels. METHODS:In 15 type 1 diabetic patients, se...
journal_title：European journal of internal medicine
pub_type： 杂志文章
doi：10.1016/j.ejim.2006.11.006
更新日期：2007-05-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Non-Invasive Ventilation (NIV) represents a standard of care to treat some acute respiratory failure (ARF). Data on its use in pneumonia are lacking, especially in a setting outside the Intensive Care Unit (ICU). The aims of this study were to evaluate the use of NIV in ARF due to pneumonia out...
journal_title：European journal of internal medicine
pub_type： 杂志文章,多中心研究
doi：10.1016/j.ejim.2018.09.025
更新日期：2019-01-01 00:00:00
abstract：:Background: Parkinson's disease is a common neurodegenerative disorder that affects an increasing number of older people every year. Dysphagia is not only a common feature, but one that results in poor nutrition and an increased risk of bronchopneumonia. Previous work has suggested that the oral flora is altered in pa...
journal_title：European journal of internal medicine
pub_type： 杂志文章
doi：10.1016/j.ejim.2003.09.009
更新日期：2003-12-01 00:00:00
abstract：BACKGROUND:The measurement of femoral intima-media thickness (IMT) is underutilized in the clinical practice, although it is a surrogate marker of cardiovascular disease. MATERIALS AND METHODS:388 Hungarian and Italian twins (121 monozygotic, 73 dizygotic pairs) underwent bilateral B-mode sonography of femoral arterie...
journal_title：European journal of internal medicine
pub_type： 杂志文章,多中心研究
doi：10.1016/j.ejim.2017.02.019
更新日期：2017-06-01 00:00:00
