Abstract：
BACKGROUND:The measurement of femoral intima-media thickness (IMT) is underutilized in the clinical practice, although it is a surrogate marker of cardiovascular disease. MATERIALS AND METHODS:388 Hungarian and Italian twins (121 monozygotic, 73 dizygotic pairs) underwent bilateral B-mode sonography of femoral arteries. IMT was measured by semiautomated software, where available, or by calipers. RESULTS:Within-pair correlation in monozygotic twins was higher than in dizygotics for each parameter. Age-, sex- and country-adjusted genetic effect accounted for 43.9% (95% confidence interval, CI 21.3%-65.2%) and 47.2% (95% CI, 31.4%-62.6%) of the variance of common and superficial femoral artery IMT, respectively, and unshared environmental effect for 56.1% (95% CI 34.6%-78.5%) and 52.8% (95% CI, 37.2%-68.5%). These results did not change significantly after correcting for body mass index or central systolic blood pressure. CONCLUSIONS:Genetic factors have a moderate role in the determination of common and superficial femoral IMT; however, the influence of environmental (lifestyle) factors remains still relevant. Environmental factors may have a role in influencing the genetic predisposition for femoral vascular hypertrophy.
journal_name
Eur J Intern Medjournal_title
European journal of internal medicineauthors
Fejer B,Tarnoki AD,Tarnoki DL,Lucatelli P,Littvay L,Maurovich-Horvat P,Jermendy AL,Kovacs A,Godor E,Fagnani C,Stazi MA,Molnar AA,Fanelli F,Cirelli C,Farina F,Baracchini C,Meneghetti G,Pucci G,Jermendy G,Merkely B,doi
10.1016/j.ejim.2017.02.019subject
Has Abstractpub_date
2017-06-01 00:00:00pages
44-48eissn
0953-6205issn
1879-0828pii
S0953-6205(17)30081-Xjournal_volume
41pub_type
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