当前位置： SCI文献检索 > European Journal of Internal Medicine期刊下所有文献 > The effect of fatty pancreas on serum glucose parameters in patients with nonalcoholic steatohepatitis.

The effect of fatty pancreas on serum glucose parameters in patients with nonalcoholic steatohepatitis.

Abstract：

OBJECTIVE:Fatty pancreas (FP) is related to obesity, and may have some clinical implications on glucose metabolism. The frequency and importance of FP in patients with nonalcoholic steatohepatitis (NASH) are not clear. This study aimed to investigate: the frequency of FP in patients with NASH, and its effects on serum glucose parameters. METHODS:FP was detected and graded by transabdominal ultrasonography (USG) in patients with biopsy-proven NASH and healthy controls. Body Mass Index and waist circumference were recorded, and serum lipids, fasting serum glucose, HbA1c, OGTT 2-h, insulin level, insulin resistance, type 2 diabetes mellitus (DM) and prediabetes rates were detected. RESULTS:Eighty-four subjects with NASH and 35 healthy controls were enrolled in the study. There was no FP in 41 (48.8%) of the NASH patients according to the study criteria. Forty-three of the NASH patients and 5 of the controls had different grades of fat in their pancreas (51.2% vs. 14%, p=0.001). The HbA1c and OGTT 2-h results were significantly higher in NASH patients with FP compared to those without FP (p=0.003 and p=0.018). The rates of both prediabetes and DM were also found to be significantly increased in NASH patients with FP (p=0.004). The mean waist circumference was higher in patients with FP (p=0.027). Grade of FP by USG showed no effect on study parameters in subgroup analysis. CONCLUSION:FP is common in patients with NASH and increases the rate of prediabetes and DM. The coexistence of both NASH and FP has a further impact on glucose metabolism and DM frequency.

journal_name

Eur J Intern Med

journal_title

European journal of internal medicine

authors

Uygun A,Kadayifci A,Demirci H,Saglam M,Sakin YS,Ozturk K,Polat Z,Karslioglu Y,Bolu E

doi

10.1016/j.ejim.2014.11.007

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

37-41

issue

1

eissn

0953-6205

issn

1879-0828

pii

S0953-6205(14)00352-5

journal_volume

26

pub_type

杂志文章

相关文献

European Journal of Internal Medicine文献大全
  • Drug-related problems identification in general internal medicine: The impact and role of the clinical pharmacist and pharmacologist.

    abstract：BACKGROUND:Patients admitted to general internal medicine wards might receive a large number of drugs and be at risk for drug-related problems (DRPs) associated with increased morbidity and mortality. This study aimed to detect suboptimal drug use in internal medicine by a pharmacotherapy evaluation, to suggest treatme...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章

    doi：10.1016/j.ejim.2015.05.012

    authors： Guignard B,Bonnabry P,Perrier A,Dayer P,Desmeules J,Samer CF

    更新日期：2015-07-01 00:00:00

  • A case of intravascular lymphomatosis (IVL) presenting as polyneuropathy.

    abstract：:Intravascular lymphomatosis (IVL) is a rare, yet important, cause of a variety of unexplained neurological syndromes. In this clinical context, the only clue to the diagnosis may be a significantly raised plasma lactate dehydrogenase (LDH) on a background of clinical features of a systemic illness. ...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章

    doi：10.1016/j.ejim.2005.06.001

    authors： Wong P,Moonie A,Dennett X,Anpalahan M

    更新日期：2006-01-01 00:00:00

  • Bacterial endocarditis with dual presentation as endophthalmitis and glomerulonephritis.

    abstract：:We report a case of Streptococcus sanguis endocarditis in a 45-year-old male who presented with bilateral endophthalmitis and glomerulonephritis. The patient responded favorably to appropriate antimicrobial chemotherapy with resolution of endophthalmitis and nephritis. Some striking features of this case and a compari...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章

    doi：10.1016/j.ejim.2005.09.019

    authors： Maliaga A,Mintzias D,Zigouris N,Kappou-Rigatou I,Skoutelis A

    更新日期：2006-03-01 00:00:00

  • Anemia in new-onset congestive heart failure inpatients admitted for acute decompensation.

    abstract：BACKGROUND:Anemia may have important deleterious effects on patients with heart failure. We investigated the presence and causes of anemia among patients admitted because of new-onset congestive heart failure. The prognostic value of anemia was also evaluated. METHODS:We evaluated the presence of anemia, which was def...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章

    doi：10.1016/j.ejim.2005.11.015

    authors： Formiga F,Chivite D,Castañer O,Manito N,Ramón JM,Pujol R

    更新日期：2006-05-01 00:00:00

  • Non-every day statin administration--a literature review.

    abstract：BACKGROUND:Statins are the treatment of choice for lowering LDL-C levels and reducing cardiovascular events. They have a remarkable safety profile, although some patients do not tolerate them. The aim of the study was to summarize the existing data on non-every day statin administration regimens. METHODS:We searched t...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章,评审

    doi：10.1016/j.ejim.2012.02.006

    authors： Elis A,Lishner M

    更新日期：2012-07-01 00:00:00

  • Circulating sICAM-1 and sE-Selectin as biomarker of infection and prognosis in patients with systemic inflammatory response syndrome.

    abstract：BACKGROUND:Vascular endothelium activation is a key pathogenic step in systemic inflammatory response syndrome (SIRS) that can be triggered by both microbial and sterile proinflammatory stimuli. The relevance of soluble adhesion molecules as clinical biomarkers to discriminate between infectious and non-infectious SIRS...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章

    doi：10.1016/j.ejim.2012.10.009

    authors： de Pablo R,Monserrat J,Reyes E,Díaz D,Rodríguez-Zapata M,de la Hera A,Prieto A,Álvarez-Mon M

    更新日期：2013-03-01 00:00:00

  • Prevalence of gastrointestinal malignancy in iron deficiency without anaemia: A systematic review and meta-analysis.

    abstract：BACKGROUND:Iron deficiency anaemia is associated with gastrointestinal (GI) malignancy and is an indication for GI investigations. However, the relevance of iron deficiency without anaemia (IDWA) and the underlying risks of GI malignancy are uncertain. Therefore, the aim of this study was to estimate the prevalence of ...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章,评审

    doi：10.1016/j.ejim.2019.12.015

    authors： Alexandre L,Manning C,Chan SSM

    更新日期：2020-02-01 00:00:00

  • What diagnoses may make patients more seriously ill than they first appear? Mortality according to the Simple Clinical Score Risk Class at the time of admission compared to the observed mortality of different ICD9 codes identified on death or discharge.

    abstract：BACKGROUND:The Simple Clinical Score (SCS) determined at the time of admission places acutely ill general medical patients into one of five risk classes associated with an increasing risk of death within 30 days. The cohort of acute medical patient that the SCS was derived from had, on average, four combinations of 74 ...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章

    doi：10.1016/j.ejim.2008.04.012

    authors： Kellett J,Deane B

    更新日期：2009-01-01 00:00:00

  • Hypersersensitivity and Kounis syndrome due to a viper bite.

    abstract：:A 60-year-old male was bitten by a venomous snake (Vipera ammodytes) and gradually developed signs of an allergic reaction including generalized itching, generalized rash, and chest discomfort. This was followed by severe retrosternal pain with electrocardiographic evidence of an inferior myocardial ischemia progressi...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章

    doi：10.1016/j.ejim.2005.11.016

    authors： Frangides C,Kouni S,Niarchos C,Koutsojannis C

    更新日期：2006-05-01 00:00:00

  • Atherogen lipid profile in HIV-1-infected patients with lipodystrophy syndrome.

    abstract：:Background: Cases of lipodystrophy syndrome and metabolic disorders have been described since the onset of highly active antiretroviral therapy in HIV-infected patients. The aim of our study was to estimate the prevalence of lipodystrophy (LD) and to define the associated lipid profile of these patients. Methods: The ...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章

    doi：10.1016/s0953-6205(00)00103-5

    authors： Mercié P,Tchamgoué S,Thiébaut R,Viallard J,Faure I I,Dancourt V V,Marimoutou C,Dabis F,Rispal P,Darmon Y,Leng B,Pellegrin J

    更新日期：2000-10-01 00:00:00

  • Acute chest syndrome in sickle-cell trait; Two case reports in persons of Mediterranean origin and review of the literature.

    abstract：:Sickle-cell trait has been characterized as a benign condition. However, life-threatening complications sometimes develop. Acute chest syndrome (ACS) is usually described in homozygous sickle cell disease, but it rarely develops in individuals with sickle-cell trait. Two cases of ACS in patients with sickle-cell trait...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章

    doi：10.1016/j.ejim.2004.03.010

    authors： Dourakis SP,Alexopoulou A,Papageorgiou C,Kaloterakis A,Hadziyannis SJ

    更新日期：2004-07-01 00:00:00

  • Microchimerism and autoimmune diseases.

    abstract：:Microchimerism is defined by the presence within an individual of a low level of cells derived from another individual. Systemic sclerosis is clinically similar to chronic graft-versus-host disease, a known condition of chimerism, which has led some authors to explore the hypothesis that microchimerism may contribute ...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章

    doi：10.1016/s0953-6205(02)00098-5

    authors： Régnier S,Aractingi S

    更新日期：2002-09-01 00:00:00

  • Aspiration pneumonia in old patients with dementia. Prognostic factors of mortality.

    abstract：BACKGROUND:Prognostic factors of mortality in elderly patients with dementia with aspiration pneumonia (AP) are scarcely known. We determined the mortality rate and prognostic factors in old patients with dementia hospitalized due to AP. METHODS:We prospectively studied 120 consecutive patients aged ≥ 75 years with de...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章

    doi：10.1016/j.ejim.2012.08.006

    authors： Bosch X,Formiga F,Cuerpo S,Torres B,Rosón B,López-Soto A

    更新日期：2012-12-01 00:00:00

  • Repetitive 18F-FDG-PET/CT in patients with large-vessel giant-cell arteritis and controlled disease.

    abstract：OBJECTIVE:18F-FDG PET/CT can detect large-vessel involvement in giant-cell arteritis (GCA) with a good sensitivity. In patients with clinically and biologically controlled disease, we aimed to assess how vascular uptakes evolve on repetitive FDG-PET/CT. PATIENTS AND METHODS:All included patients had to satisfy the 4 f...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.ejim.2017.08.013

    authors： de Boysson H,Aide N,Liozon E,Lambert M,Parienti JJ,Monteil J,Huglo D,Bienvenu B,Manrique A,Aouba A

    更新日期：2017-12-01 00:00:00

  • Prognostic significance of changes in red cell distribution width in an internal medicine ward.

    abstract：BACKGROUND:The prognostic significance of red cell distribution width (RDW) during hospitalization in internal medicine wards was not sufficiently investigated. METHODS:Demographic, clinical and laboratory characteristics were collected from 586 internal medicine inpatients. Following discharge, all-cause mortality wa...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章

    doi：10.1016/j.ejim.2015.07.018

    authors： Shteinshnaider M,Barchel D,Almoznino-Sarafian D,Tzur I,Tsatsanashvili N,Swarka M,Cohen N,Gorelik O

    更新日期：2015-10-01 00:00:00

  • Unconscious defensive medicine: The case of erythrocyte sedimentation rate.

    abstract：BACKGROUND:We investigated physician rationale for and against performing routine erythrocyte sedimentation rate (ESR) tests during hospital admissions. METHODS:A comparative, descriptive, prospective study among 82 physicians in 15 departments of internal medicine from two University Medical Centers - A and B - in Is...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章

    doi：10.1016/j.ejim.2006.07.021

    authors： Asher E,Parag Y,Zeller L,Yerushalmi R,Reuveni H

    更新日期：2007-01-01 00:00:00

  • Comparison of demographic and clinical characteristics of patients with early vs. adult vs. late onset ulcerative colitis.

    abstract：BACKGROUND & AIMS:There is limited data comparing influence of age on the presentation, clinical course, and therapeutic response of patients with ulcerative colitis. We aimed to compare the demographic and clinical characteristics of patients diagnosed with UC in older age vs. adulthood vs. early age. METHODS:Five-hu...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章

    doi：10.1016/j.ejim.2012.12.014

    authors： Kalkan IH,Dağli U,Oztaş E,Tunç B,Ulker A

    更新日期：2013-04-01 00:00:00

  • Autoimmune manifestations in acquired idiopathic splenic atrophy: A puzzling association.

    abstract：:Splenic atrophy is an uncommon diagnosis associated with celiac sprue or other well-characterized connective tissue diseases, drepanocytosis, or amyloidosis. We report two patients with splenic atrophy revealed by thrombocytosis. Both patients had anti-nuclear antibodies. Patient 1 also had a grade III Chisholm lympho...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章

    doi：10.1016/j.ejim.2006.07.008

    authors： Coppo P,Saadoun D,Varet B

    更新日期：2006-12-01 00:00:00

  • Circulating vascular endothelial growth factor is unaffected by acute hyperglycemia and hyperinsulinemia in type 1 diabetes mellitus.

    abstract：BACKGROUND:Circulating levels of vascular endothelial growth factor (VEGF) may predict microvascular complications in type 1 diabetes mellitus and are elevated when metabolic control is poor. We tested whether serum VEGF is influenced by prevailing glucose and insulin levels. METHODS:In 15 type 1 diabetic patients, se...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章

    doi：10.1016/j.ejim.2006.11.006

    authors： Dullaart RP,Oomen PH,Sluiter WJ

    更新日期：2007-05-01 00:00:00

  • Clinical indications for the albumin use: still a controversial issue.

    abstract：:Human serum albumin (HSA) is the most abundant circulating protein and accounts for about 70% of the plasma colloid osmotic pressure. Beside the well known capacity to act as plasma-expander, HSA is provided of many other properties which are unrelated to the regulation of fluid compartmentalization, including binding...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章,评审

    doi：10.1016/j.ejim.2013.05.015

    authors： Caraceni P,Domenicali M,Tovoli A,Napoli L,Ricci CS,Tufoni M,Bernardi M

    更新日期：2013-12-01 00:00:00

  • Mallory-Weiss syndrome: clinical and endoscopic characteristics.

    abstract：BACKGROUND:Mallory-Weiss syndrome is defined by upper gastrointestinal bleeding from vomiting-induced mucosal lacerations at the esophago-gastric junction. This study was purposed to investigate the incidence, location, clinical manifestation, diagnosis and effectiveness of treatment (including endoscopic treatment and...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章

    doi：10.1016/j.ejim.2012.02.005

    authors： Yin A,Li Y,Jiang Y,Liu J,Luo H

    更新日期：2012-06-01 00:00:00

  • Quality of care after AKI development in the hospital: Consensus from the 22nd Acute Disease Quality Initiative (ADQI) conference.

    abstract：BACKGROUND:Acute kidney injury (AKI) is independently associated with increased morbidity and mortality. Quality improvement has been identified as an important goal in the care of patients with AKI. Different settings can be targeted to improve AKI care, broadly classified these include the inpatient and outpatient en...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章

    doi：10.1016/j.ejim.2020.04.056

    authors： Macedo E,Bihorac A,Siew ED,Palevsky PM,Kellum JA,Ronco C,Mehta RL,Rosner MH,Haase M,Kashani KB,Barreto EF

    更新日期：2020-10-01 00:00:00

  • Efficacy and safety of Monascus purpureus Went rice in children and young adults with secondary hyperlipidemia: a preliminary report.

    abstract：BACKGROUNDS/AIMS:Nephrotic dyslipidemia is a risk factor for development of systemic atherosclerosis; also it may aggravate glomerulosclerosis and enhance progression of glomerular disease. We aimed to assess the efficacy and safety of Monascus purpureus Went rice vs. fluvastatin therapy in the management of nephrotic ...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.ejim.2008.08.012

    authors： Gheith O,Sheashaa H,Abdelsalam M,Shoeir Z,Sobh M

    更新日期：2009-05-01 00:00:00

  • Atypical hemolytic uremic syndrome: from the rediscovery of complement to targeted therapy.

    abstract：:Atypical hemolytic uremic syndrome (aHUS) is a devastating form of renal thrombotic microangiopathy. In the last five years, we have finally witnessed a dramatic improvement in the management of aHUS patients, and three breakthroughs in our understanding of aHUS have led to such an improvement. The first breakthrough ...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章,评审

    doi：10.1016/j.ejim.2013.05.008

    authors： Fakhouri F,Frémeaux-Bacchi V,Loirat C

    更新日期：2013-09-01 00:00:00

  • Factors associated with length of stay following an emergency medical admission.

    abstract：BACKGROUND:Hospitals are under pressure to use resources in the most efficient manner. We have examined the factors predicting Length of Stay (LOS) in one institution, using a database of all episodes of emergency medical admissions prospectively collected over 12 years. AIM:To examine the ability to predict hospital ...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章

    doi：10.1016/j.ejim.2015.02.017

    authors： Cournane S,Byrne D,O'Riordan D,Silke B

    更新日期：2015-05-01 00:00:00

  • Persistency of low levels of anticardiolipin and anti-beta2 glycoprotein1 in thrombosis.

    abstract：BACKGROUND:Antiphospholipid antibodies, the hallmark of the antiphospholipid syndrome, are associated with both venous and arterial thrombosis. Despite some reports stating that this association may be present in patients with low titres of anticardiolipin antibodies, a clear association has only been established in th...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章

    doi：10.1016/j.ejim.2009.12.010

    authors： Amaral M,Favas C,Delgado Alves J

    更新日期：2010-04-01 00:00:00

  • Multiple cerebral abscesses as a complication of Mycobacterium fortuitum infection.

    abstract：:Mycobacterium fortuitum is a rapidly growing, nontuberculous mycobacteria that has rarely been associated with central nervous system impairment. We describe the case of a patient who developed multiple cerebral abscesses revealing Mycobacterium fortuitum infection. Brain biopsy specimens showed suppurative, noncaseat...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章

    doi：10.1016/s0953-6205(03)90008-2

    authors： Marie I,Héron F,Lecomte F,Jarlier V,Truffot-Pernot C,Laquerriere A,Huerre M,Levesque H,Courtois H

    更新日期：2003-10-01 00:00:00

  • Obesity and fat distribution as predictors of aortoiliac peripheral arterial disease in middle-aged men.

    abstract：BACKGROUND:Peripheral arterial disease (PAD) in the aortoiliac segment is found in nearly a half of patients with PAD. The aim of this study was to estimate the influence of obesity and fat distribution on the occurrence of aortoiliac PAD in middle-aged men. METHODS:This case-control study included 204 middle-aged men...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章

    doi：10.1016/j.ejim.2010.07.019

    authors： Jakovljević B,Stojanov V,Lović D,Paunović K,Radosavljević V,Tutić I

    更新日期：2011-02-01 00:00:00

  • Varicella zoster infection and pulmonary complications.

    abstract：:A 34-year-old immunocompetent man with varicella zoster (VZ) infection developed deep vein thrombosis and pulmonary embolism after suffering severe pneumonitis. He recovered after treatment with acyclovir, high-dose steroids, and ventilatory support. The endothelial damage could be a direct link between VZ pneumonitis...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章

    doi：10.1016/j.ejim.2005.02.011

    authors： Dahan E,Simsolo C,Merei M,Vigder F,Tatoor I,Blum A

    更新日期：2005-10-01 00:00:00

  • Diagnostic value of C-reactive protein in exudative pleural effusions.

    abstract：:BACKGROUND: Tests able to help in the diagnostic work-up of pleural exudates are needed. C-reactive protein (CRP) may be useful for distinguishing between benign and malignant exudates. METHODS: A total of 123 consecutive patients diagnosed as having exudative pleural effusion (60 associated with malignancy and 63 ben...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章

    doi：10.1016/s0953-6205(02)00036-5

    authors： Garcia-Pachon E,Llorca I

    更新日期：2002-06-01 00:00:00