Abstract：
BACKGROUND:Antiphospholipid antibodies, the hallmark of the antiphospholipid syndrome, are associated with both venous and arterial thrombosis. Despite some reports stating that this association may be present in patients with low titres of anticardiolipin antibodies, a clear association has only been established in the presence of a moderate to high concentrations (above 40 GPL or MPL). METHODS:In order to study whether low antibody titres could be associated with thrombosis, we reviewed the files of 196 patients, 94 with and 102 without thrombotic events, for a period of 4.4 and 5.1 years respectively. Files from patients with persistent low titres of antiphospholipid antibodies recorded in the unit database were selected, independently of the associated clinical history or diagnosis. Epidemiology, clinical and treatment information were collected and the serum variability of the antibody titres was analysed in relation to the presence of thrombotic events. RESULTS:Thrombotic events were classified as venous 81.9% and arterial 18.1%. 23/94 (24.5%) patients with thrombosis had miscarriages. There were no significant differences between serum concentrations of antiphospholipid antibodies in the thrombotic and non-thrombotic groups. However, there was a higher consistency of the antibody concentrations in patients with thrombosis, as seen by the significantly lower variability of IgG aCL and abeta2GP1 titres in patients with thrombosis when compared to non-thrombotic controls (p=0.0025 and p<0.0001, respectively). CONCLUSION:Consistency of low titres of antiphospholipid antibody levels may be associated with a higher risk of thrombotic events overall.
journal_name
Eur J Intern Medjournal_title
European journal of internal medicineauthors
Amaral M,Favas C,Delgado Alves Jdoi
10.1016/j.ejim.2009.12.010subject
Has Abstractpub_date
2010-04-01 00:00:00pages
101-3issue
2eissn
0953-6205issn
1879-0828pii
S0953-6205(09)00265-9journal_volume
21pub_type
杂志文章abstract：BACKGROUND:Primary cancer prevention is offered by the Greek health care system to the population on an opportunistic basis. This means that screening depends on advice from primary care providers and on individuals' request for screening, since a centralized invitational register is lacking. In planning preventive ser...
journal_title：European journal of internal medicine
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journal_title：European journal of internal medicine
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journal_title：European journal of internal medicine
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更新日期：2015-01-01 00:00:00
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更新日期：2020-06-01 00:00:00
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journal_title：European journal of internal medicine
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更新日期：2008-05-01 00:00:00
