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Drug-related problems identification in general internal medicine: The impact and role of the clinical pharmacist and pharmacologist.

Abstract：

BACKGROUND:Patients admitted to general internal medicine wards might receive a large number of drugs and be at risk for drug-related problems (DRPs) associated with increased morbidity and mortality. This study aimed to detect suboptimal drug use in internal medicine by a pharmacotherapy evaluation, to suggest treatment optimizations and to assess the acceptance and satisfaction of the prescribers. METHODS:This was a 6-month prospective study conducted in two internal medicine wards. Physician rounds were attended by a pharmacist and a pharmacologist. An assessment grid was used to detect the DRPs in electronic prescriptions 24h in advance. One of the following interventions was selected, depending on the relevance and complexity of the DRPs: no intervention, verbal advice of treatment optimization, or written consultation. The acceptance rate and satisfaction of prescribers were measured. RESULTS:In total, 145 patients were included, and 383 DRPs were identified (mean: 2.6 DRPs per patient). The most frequent DRPs were drug interactions (21%), untreated indications (18%), overdosages (16%) and drugs used without a valid indication (10%). The drugs or drug classes most frequently involved were tramadol, antidepressants, acenocoumarol, calcium-vitamin D, statins, aspirin, proton pump inhibitors and paracetamol. The following interventions were selected: no intervention (51%), verbal advice of treatment optimization (42%), and written consultation (7%). The acceptance rate of prescribers was 84% and their satisfaction was high. CONCLUSION:Pharmacotherapy expertise during medical rounds was useful and well accepted by prescribers. Because of the modest allocation of pharmacists and pharmacologists in Swiss hospitals, complementary strategies would be required.

journal_name

Eur J Intern Med

journal_title

European journal of internal medicine

authors

Guignard B,Bonnabry P,Perrier A,Dayer P,Desmeules J,Samer CF

doi

10.1016/j.ejim.2015.05.012

subject

Has Abstract

pub_date

2015-07-01 00:00:00

pages

399-406

issue

eissn

0953-6205

issn

1879-0828

pii

S0953-6205(15)00177-6

journal_volume

pub_type

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Drug-related problems identification in general internal medicine: The impact and role of the clinical pharmacist and pharmacologist.