当前位置： SCI文献检索 > European Journal of Internal Medicine期刊下所有文献 > Dual renin-angiotensin system blockade: in patients with single functioning kidney and proteinuria.

Dual renin-angiotensin system blockade: in patients with single functioning kidney and proteinuria.

Abstract：

AIM:Dual blockade of renin-angiotensin system (RAS) has increased antiproteinuric effects and it has been increasingly used on patients with proteinuria, but could have secondary effects when this kind of treatment is administered to patients with single functioning kidney. The aim of this study has been to assess the efficacy and safety of dual blockade of RAS in this group of patients. DESIGN AND METHODS:Sixteen patients with a single functioning kidney have been treated in our unit with dual RAS blockade due to proteinuria higher than 1 g/24 h. Mean age was 54.7+/-12.1 years, they were 12 males and 4 females. Analytical data of six months visit and last follow up visit have been retrospectively registered. Several different angiotensin conversor enzyme (ACE) inhibitors and angiotensin receptor blocking (ARB) drugs were used at the maximal dose tolerated by the patient. RESULTS:A small but not significant reduction of SBP and DBP were was observed throughout the study. Mean K+ increase in the second visit (from 4.65+/-0.67 to 5.01+/-1.02 mmol/l, not significant). There were no changes neither in plasmatic creatinine (baseline 1.86+/-0.67, 6 months 1.96+/-0.85) nor in creatinine clearance (baseline 65.2+/-26.9, 6 months 61.6+/-23.8 ml/min). Proteinuria was not reduced by dual RAS blockade (baseline 4.26+/-0.24, 6 months 4.25+/-0.39). CONCLUSIONS:Dual RAS blockade seems to be safe but unhelpful in renal patients with proteinuria associated to single functioning kidney.

journal_name

Eur J Intern Med

journal_title

European journal of internal medicine

authors

Robles NR,Ruiz Jiménez B,Hernández Gallego R,Ruiz-Calero R,Sánchez Casado E,Cubero JJ

doi

10.1016/j.ejim.2008.06.002

subject

Has Abstract

pub_date

2009-03-01 00:00:00

pages

186-9

issue

2

eissn

0953-6205

issn

1879-0828

pii

S0953-6205(08)00178-7

journal_volume

20

pub_type

杂志文章

相关文献

European Journal of Internal Medicine文献大全
  • COMP serum levels: A new non-invasive biomarker of liver fibrosis in patients with chronic viral hepatitis.

    abstract：BACKGROUND & AIMS:Recently we have shown that cartilage oligomeric matrix protein (COMP), a fibrillar collagen assembly regulator, is strongly associated with cirrhosis and hepatocellular carcinoma progression. Therefore, we assessed whether serum COMP levels can be used as a non-invasive fibrosis marker in patients wi...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章

    doi：10.1016/j.ejim.2017.01.007

    authors： Zachou K,Gabeta S,Shums Z,Gatselis NK,Koukoulis GK,Norman GL,Dalekos GN

    更新日期：2017-03-01 00:00:00

  • Rituximab-induced serum sickness is more frequent in autoimmune diseases as compared to hematological malignancies: A French nationwide study.

    abstract：INTRODUCTION:Rituximab induced serum sickness (RISS) is a rare delayed hypersensitivity reaction. The aim of this study was to describe the epidemiological and clinical characteristics of the RISS cases reported in France. METHOD:Serum sickness cases involving rituximab were identified from the French PharmacoVigilanc...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章

    doi：10.1016/j.ejim.2019.06.009

    authors： Bayer G,Agier MS,Lioger B,Lepelley M,Zenut M,Lanoue MC,Maillot F,Jonville-Bera AP

    更新日期：2019-09-01 00:00:00

  • Renal function and renal disease in the elderly: Part I.

    abstract：:In all industrialized countries, life expectancy has risen in the past 100 years. The incidence of elderly patients reaching end-stage renal disease (ESRD) and requiring renal replacement therapy has also increased. During the past few decades, the pattern of ESRD has changed significantly with the emerging predominan...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章

    doi：10.1016/s0953-6205(01)00121-2

    authors： Mulder WJ,Hillen HF

    更新日期：2001-04-01 00:00:00

  • Porphyrias: A clinically based approach.

    abstract：BACKGROUND:Porphyrias are a group of metabolic diseases, individually rare but with an important combined prevalence. Because of their pathological complexity and clinical heterogeneity, they present a challenging diagnosis. The present review aims to provide a clinically based approach to the recognition and treatment...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章,评审

    doi：10.1016/j.ejim.2019.06.014

    authors： Rigor J,Pinto SA,Martins-Mendes D

    更新日期：2019-09-01 00:00:00

  • The relationship between Helicobacter pylori and cancer risk.

    abstract：OBJECTIVES:This study investigated the correlation between Helicobacter pylori (HP) and cancer risk. We compared the age, sex, and comorbidity of cancer patients both infected and not infected by HP. METHODS:In this study, we compared a comparison cohort (N=24,088) and an HP cohort (N=6022), both taken from the NHI da...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章

    doi：10.1016/j.ejim.2014.01.009

    authors： Hsu WY,Lin CH,Lin CC,Sung FC,Hsu CP,Kao CH

    更新日期：2014-03-01 00:00:00

  • Biological agents and biosimilars: Essential information for the internist.

    abstract：:Biologics embrace a wide range of substances synthesized by cells or living organisms by means of different biological processes, including recombinant DNA technology, controlled gene expression, or antibody technologies. A biosimilar establishes similarity to the reference medicinal product in terms of quality charac...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章

    doi：10.1016/j.ejim.2016.06.005

    authors： Pasina L,Casadei G,Nobili A

    更新日期：2016-09-01 00:00:00

  • Barriers to obesity treatment.

    abstract：:Obesity, one of the most prevalent health problems in the Western world, is a chronic and progressive condition. Therefore, as with other chronic diseases, patients with obesity require lifelong treatment. Long-term efficacy and effectiveness of obesity treatments is notoriously poor. This may in part be attributable ...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章,评审

    doi：10.1016/j.ejim.2007.09.011

    authors： Mauro M,Taylor V,Wharton S,Sharma AM

    更新日期：2008-05-01 00:00:00

  • Pre-existing diabetes and risks of morbidity and mortality after liver transplantation: A nationwide database study in an Asian population.

    abstract：BACKGROUND:Whether diabetes mellitus (DM) is associated with a higher risk of perioperative mortality and mortality after liver transplantation (LTx) remains unclear. METHODS:We compared the risk of postoperative mortality and morbidity in DM and non-DM patients undergoing LTx. We enrolled 558 DM patients who underwen...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章

    doi：10.1016/j.ejim.2015.05.010

    authors： Tsai MS,Wang YC,Wang HH,Lee PH,Jeng LB,Kao CH

    更新日期：2015-07-01 00:00:00

  • Renin-angiotensin system inhibitors reduce the progression of mesangioproliferative glomerulonephritis: 10 year follow-up.

    abstract：BACKGROUND:Proteinuria is a common presentation of mesangioproliferative glomerulonephritis (MsPGN). No studies are available on the long-term effect of treatment by renin-angiotensin system (RAS) inhibitors on renal outcome in MsPGN patients. This study prospectively evaluates the effects of RAS inhibitors on renal ou...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章

    doi：10.1016/j.ejim.2011.08.021

    authors： Presta P,Minutolo R,Iodice C,Comi N,Casoria V,Fuiano L,Caglioti C,Conte G,Fuiano G

    更新日期：2011-12-01 00:00:00

  • Association of statin use and the risk of end-stage renal disease: A nationwide Asian population-based case-control study.

    abstract：BACKGROUND:Although experimental models have shown that statins could alleviate glomerular damage and decrease urinary protein excretion, the renal effects of statins remain unclear. A case-control study was conducted using data from Taiwan's National Health Insurance system. METHODS:An end-stage renal disease (ESRD) ...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章

    doi：10.1016/j.ejim.2016.02.012

    authors： Lin SY,Lin CL,Hsu WH,Lin CC,Chang CT,Kao CH

    更新日期：2016-06-01 00:00:00

  • Association of a DNA polymorphism of the apolipoprotein AI-CIII-AIV gene cluster with myocardial infarction in a Tunisian population.

    abstract：BACKGROUND:Apolipoproteins AI-CIII-AIV play important roles in the metabolism of triglycerides and high-density lipoprotein cholesterol. However, whether genetic variations in the ApoAI-CIII-AIV gene cluster are associated with the risk of myocardial infarction (MI) remains uncertain. In the present study, we examined ...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章

    doi：10.1016/j.ejim.2011.03.002

    authors： Sediri Y,Kallel A,Feki M,Mourali S,Elasmi M,Abdessalem S,Mechmeche R,Jemaa R,Kaabachi N

    更新日期：2011-08-01 00:00:00

  • Circulating vascular endothelial growth factor is unaffected by acute hyperglycemia and hyperinsulinemia in type 1 diabetes mellitus.

    abstract：BACKGROUND:Circulating levels of vascular endothelial growth factor (VEGF) may predict microvascular complications in type 1 diabetes mellitus and are elevated when metabolic control is poor. We tested whether serum VEGF is influenced by prevailing glucose and insulin levels. METHODS:In 15 type 1 diabetic patients, se...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章

    doi：10.1016/j.ejim.2006.11.006

    authors： Dullaart RP,Oomen PH,Sluiter WJ

    更新日期：2007-05-01 00:00:00

  • Antineutrophil cytoplasmic antibody-associated neutropenia.

    abstract：:BACKGROUND: Antineutrophil cytoplasmic antibodies (ANCA) can be associated with various disorders. However, their association with neutropenia has never been reported. METHODS: Nine patients with chronic unexplained neutropenia and ANCA were studied. Clinical charts were extensively analyzed and all patients underwent...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章

    doi：10.1016/j.ejim.2004.08.009

    authors： Coppo P,Ghez D,Fuentes V,Bengoufa D,Oksenhendler E,Tribout B,Clauvel JP,Lassoued K

    更新日期：2004-11-01 00:00:00

  • The annual yield of diagnostic endoscopy of the lower digestive tract.

    abstract：:BACKGROUND: Endoscopy of the colon and rectum has become a standard diagnostic procedure. No data are presented in the literature on the annual yield or on morbidity patterns. A large, cross-sectional, single-center study was done in order to detect the annual yield of endoscopy of the colon and rectum. METHODS: All c...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章

    doi：10.1016/j.ejim.2004.07.015

    authors： Loffeld RJ,van der Putten AB

    更新日期：2005-02-01 00:00:00

  • Different impact of aspirin on renal progression in patients with predialysis advanced chronic kidney disease with or without previous stroke.

    abstract：BACKGROUND:The benefit of reducing the risk of stroke against increasing the risk of renal progression associated with antiplatelet therapy in patients with advanced chronic kidney disease (CKD) is controversial. METHODS:We enrolled 1301 adult patients with advanced CKD treated with erythropoiesis stimulating agents f...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章

    doi：10.1016/j.ejim.2016.11.009

    authors： Hsiao KC,Huang JY,Lee CT,Hung TW,Liaw YP,Chang HR

    更新日期：2017-04-01 00:00:00

  • Hypernatremia and moderate-to-severe hyponatremia are independent predictors of mortality in septic patients at emergency department presentation: A sub-group analysis of the need-speed trial.

    abstract：STUDY OBJECTIVE:Early risk stratification of septic patients presenting to the emergency department (ED) is challenging. The aim of the study was to evaluate the prognostic role of plasmatic sodium level (PNa+) derangements at ED presentation in septic patients. METHODS:According to PNa+ at ED presentation patients we...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章

    doi：10.1016/j.ejim.2020.10.003

    authors： Castello LM,Gavelli F,Baldrighi M,Salmi L,Mearelli F,Fiotti N,Patrucco F,Bellan M,Sainaghi PP,Ronzoni G,Di Somma S,Lupia E,Muiesan ML,Biolo G,Avanzi GC

    更新日期：2021-01-01 00:00:00

  • Prevalence of gastrointestinal malignancy in iron deficiency without anaemia: A systematic review and meta-analysis.

    abstract：BACKGROUND:Iron deficiency anaemia is associated with gastrointestinal (GI) malignancy and is an indication for GI investigations. However, the relevance of iron deficiency without anaemia (IDWA) and the underlying risks of GI malignancy are uncertain. Therefore, the aim of this study was to estimate the prevalence of ...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章,评审

    doi：10.1016/j.ejim.2019.12.015

    authors： Alexandre L,Manning C,Chan SSM

    更新日期：2020-02-01 00:00:00

  • Association between the polymorphism of estrogen receptor α and coronary artery disease in a Chinese population.

    abstract：BACKGROUND:The role of estrogen receptor α (ERα) polymorphism in coronary artery disease (CAD) was investigated previously in several populations. There are few data on relation between ERa polymorphism and CAD in Chinese population. Our study was to investigate the possible association between ERα polymorphism and CAD...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章

    doi：10.1016/j.ejim.2011.05.006

    authors： Shen C,Chen J,Fan S,Li Z,Hu Y,Zhong Q

    更新日期：2012-03-01 00:00:00

  • Persistency of low levels of anticardiolipin and anti-beta2 glycoprotein1 in thrombosis.

    abstract：BACKGROUND:Antiphospholipid antibodies, the hallmark of the antiphospholipid syndrome, are associated with both venous and arterial thrombosis. Despite some reports stating that this association may be present in patients with low titres of anticardiolipin antibodies, a clear association has only been established in th...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章

    doi：10.1016/j.ejim.2009.12.010

    authors： Amaral M,Favas C,Delgado Alves J

    更新日期：2010-04-01 00:00:00

  • Severe acute kidney injury and multiple myeloma: evaluation of kidney and patient prognostic factors.

    abstract：BACKGROUND:Patients with multiple myeloma (MM) manifesting acute kidney injury (AKI) and who later recover renal function and independence from renal replacement therapy (RRT) are considered to have a better outcome. The aim of this work was to study the factors associated with renal function recovery (independence of ...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章

    doi：10.1016/j.ejim.2014.06.023

    authors： Rodrigues L,Neves M,Sá H,Gomes H,Pratas J,Campos M

    更新日期：2014-09-01 00:00:00

  • Atherogen lipid profile in HIV-1-infected patients with lipodystrophy syndrome.

    abstract：:Background: Cases of lipodystrophy syndrome and metabolic disorders have been described since the onset of highly active antiretroviral therapy in HIV-infected patients. The aim of our study was to estimate the prevalence of lipodystrophy (LD) and to define the associated lipid profile of these patients. Methods: The ...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章

    doi：10.1016/s0953-6205(00)00103-5

    authors： Mercié P,Tchamgoué S,Thiébaut R,Viallard J,Faure I I,Dancourt V V,Marimoutou C,Dabis F,Rispal P,Darmon Y,Leng B,Pellegrin J

    更新日期：2000-10-01 00:00:00

  • Non-alcoholic fatty liver disease, metabolic syndrome and patatin-like phospholipase domain-containing protein3 gene variants.

    abstract：BACKGROUND & AIMS:Non-alcoholic fatty liver disease was traditionally interpreted as a condition which may progress to liver-related complications. However, the increased mortality is primarily a result of cardiovascular diseases. It has been suggested that fatty liver can be considered as the hepatic consequence of th...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章

    doi：10.1016/j.ejim.2014.05.012

    authors： Del Ben M,Polimeni L,Brancorsini M,Di Costanzo A,D'Erasmo L,Baratta F,Loffredo L,Pastori D,Pignatelli P,Violi F,Arca M,Angelico F

    更新日期：2014-07-01 00:00:00

  • Association between venous and arterial thrombosis: clinical implications.

    abstract：:Venous and arterial thromboses have traditionally been regarded as separate diseases with different causes. However, recent epidemiological studies have documented an association between these vascular complications, probably due to the presence of more overlapping risk factors than previously recognized. This narrati...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章,评审

    doi：10.1016/j.ejim.2012.02.008

    authors： Franchini M,Mannucci PM

    更新日期：2012-06-01 00:00:00

  • Development of a new disease severity scoring system for patients with non-transfusion-dependent thalassemia.

    abstract：BACKGROUND:Patients with non-transfusion-dependent thalassemia (NTDT) present with a spectrum of disease severities. Since there are multiple pathophysiologies in such patients, tailoring treatment remains essential. Therefore, one simple, reliable tool would be beneficial to assess disease severity and tailor therapy,...

    journal_title：European journal of internal medicine

    pub_type： 共识发展会议,杂志文章

    doi：10.1016/j.ejim.2015.10.003

    authors： Cappellini MD,Porter JB,Musallam KM,Kattamis A,Viprakasit V,Galanello R,Taher AT

    更新日期：2016-03-01 00:00:00

  • Exaggerated exercise blood pressure response and risk of stroke in patients referred for stress testing.

    abstract：BACKGROUND/OBJECTIVES:There is some evidence to suggest that exercise systolic blood pressure (SBP) may be associated with future risk of stroke in subjects without a history of coronary artery disease (CAD). However, the value of an exaggerated exercise SBP response (EESBPR) for predicting stroke in patients referred ...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章

    doi：10.1016/j.ejim.2014.05.013

    authors： Bouzas-Mosquera Mdel C,Bouzas-Mosquera A,Peteiro J,Broullón FJ,Alvarez-García N,Castro-Beiras A

    更新日期：2014-07-01 00:00:00

  • Blessings of the grape.

    abstract：:Numerous epidemiological studies have shown an inverse correlation between moderate consumption of alcoholic drinks and the risk of coronary heart disease. Wine, especially red wine, may be more favorable in this respect than beer or spirits because of its high content of flavonoids. These polyphenols originate from t...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章

    doi：10.1016/s0953-6205(01)00170-4

    authors： van de Wiel A,van Golde PH,Hart HC

    更新日期：2001-12-01 00:00:00

  • Deep vein thrombosis: Current diagnostic strategy.

    abstract：:Over the last 15 years, diagnostic strategies to diagnose deep vein thrombosis (DVT) and pulmonary embolism (PE) have changed significantly. The gold standard for detecting DVT is still venography, but invasivity, radiation, contrast media, and the painful injection in pedal veins are limiting factors for initial and ...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章

    doi：10.1016/j.ejim.2005.04.001

    authors： Beyer J,Schellong S

    更新日期：2005-08-01 00:00:00

  • The role of tenofovir in preventing and treating hepatitis B virus (HBV) reactivation in immunosuppressed patients. A real life experience from a tertiary center.

    abstract：INTRODUCTION/AIM:Patients who present HBV reactivation during immunosuppressive treatment are prone to develop life threatening decompensation of the liver function, therefore prophylaxis and treatment are strongly recommended. So far there are no data regarding the role of tenofovir in this context. Therefore, the aim...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章

    doi：10.1016/j.ejim.2014.06.028

    authors： Koskinas JS,Deutsch M,Adamidi S,Skondra M,Tampaki M,Alexopoulou A,Manolakopoulos S,Pectasides D

    更新日期：2014-10-01 00:00:00

  • A case of intravascular lymphomatosis (IVL) presenting as polyneuropathy.

    abstract：:Intravascular lymphomatosis (IVL) is a rare, yet important, cause of a variety of unexplained neurological syndromes. In this clinical context, the only clue to the diagnosis may be a significantly raised plasma lactate dehydrogenase (LDH) on a background of clinical features of a systemic illness. ...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章

    doi：10.1016/j.ejim.2005.06.001

    authors： Wong P,Moonie A,Dennett X,Anpalahan M

    更新日期：2006-01-01 00:00:00

  • Online combination algorithm for non-invasive assessment of chronic hepatitis B related liver fibrosis and cirrhosis in resource-limited settings.

    abstract：OBJECTIVE:The use of commercially available noninvasive markers for chronic hepatitis B (CHB) related fibrosis is not widely available in developing countries so clinicians in those countries frequently use free alternatives. We aimed to create an optimized algorithm for selection of patients with the highest probabili...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章

    doi：10.1016/j.ejim.2015.07.005

    authors： Salkic NN,Cickusic E,Jovanovic P,Denjagic MB,Iljazovic-Topcic S,Bevanda M,Ahmetagic S

    更新日期：2015-10-01 00:00:00