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The relationship between Helicobacter pylori and cancer risk.

Abstract：

OBJECTIVES:This study investigated the correlation between Helicobacter pylori (HP) and cancer risk. We compared the age, sex, and comorbidity of cancer patients both infected and not infected by HP. METHODS:In this study, we compared a comparison cohort (N=24,088) and an HP cohort (N=6022), both taken from the NHI database. We performed a statistical analysis with the multivariable Cox proportional model to estimate the risk of developing cancer for a comparison and the HP cohort. RESULTS:Our results showed that the proportion of peptic ulcers in the HP cohort was nearly 4 times higher than that in the comparison cohort. The HP cohort was significantly associated with increased colorectal (HR=1.73, 95% CI=1.08-2.77), stomach (HR=5.21, 95% CI=2.46-11.05) and pancreatic (HR=2.77, 95% CI=1.04-7.39) cancer risks compared to the comparison cohort. In addition, the cancer risk in the HP cohort was considerably higher than that in the comparison cohort when hypertension was absent in both cohorts. CONCLUSIONS:In this study, we proposed a method to investigate the correlation between HP infection and cancer risk. We found that HP infection is associated with the development of colorectal, stomach, and pancreatic cancers, and could thus be an independent carcinogenic risk factor.

journal_name

Eur J Intern Med

journal_title

European journal of internal medicine

authors

Hsu WY,Lin CH,Lin CC,Sung FC,Hsu CP,Kao CH

doi

10.1016/j.ejim.2014.01.009

subject

Has Abstract

pub_date

2014-03-01 00:00:00

pages

235-40

issue

3

eissn

0953-6205

issn

1879-0828

pii

S0953-6205(14)00010-7

journal_volume

25

pub_type

杂志文章

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