Interference in free thyroxine immunoassay.

Abstract:

:We report two patients who presented with non-specific symptoms of tiredness that prompted their clinician to order a thyroid function test. In both cases, free thyroxine (T4) was reported to be high, with a normal thyroid-stimulating hormone (TSH). Repeated blood tests from the same laboratory using the same assay method yielded similar results. Due to discrepancies between the clinical and laboratory findings, we decided to repeat the blood tests at another laboratory using a different assay method. This revealed normal free T4 and TSH levels, suggesting that heterophile antibodies were interfering with the free T4 assay, leading to clinical confusion.

journal_name

Eur J Intern Med

authors

Ghosh S,Howlett M,Boag D,Malik I,Collier A

doi

10.1016/j.ejim.2007.05.009

subject

Has Abstract

pub_date

2008-05-01 00:00:00

pages

221-2

issue

3

eissn

0953-6205

issn

1879-0828

pii

S0953-6205(07)00244-0

journal_volume

19

pub_type

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