Lessons from acute pancreatitis-induced thrombotic thrombocytopenic purpura.

Abstract:

:Acute pancreatitis is an inflammatory disease characterized by local tissue injury which can trigger a systemic inflammatory response. There is increasing evidence that endothelial dysfunction is one of the critical pathophysiologic manifestations in patients with severe form of acute pancreatitis. In keeping with this, there have been recent reports of a haematological disorder, thrombotic thrombocytopenic purpura (TTP), as being precipitated by acute pancreatitis. However, the patients who develop TTP, secondary to acute pancreatitis, do not always have the characteristic low levels of VonWillebrand multimer cleaving enzyme, ADAMTS-13 suggesting the involvement of other pathophysiological factors. On the contrary, the occurrence of acute pancreatitis in haemolytic diseases may suggest TTP as being a precipitating factor for the pancreatic inflammatory state. This review focuses on the association of these two conditions which have given insights into the role players and the pathogenic mechanisms leading to the development of either of these conditions.

journal_name

Eur J Intern Med

authors

Thachil J

doi

10.1016/j.ejim.2009.09.008

subject

Has Abstract

pub_date

2009-12-01 00:00:00

pages

739-43

issue

8

eissn

0953-6205

issn

1879-0828

pii

S0953-6205(09)00185-X

journal_volume

20

pub_type

杂志文章,评审
  • Descriptive epidemiology of chronic hepatitis B by using data from a hepatitis registry in Central Greece.

    abstract:BACKGROUND:In Greece, there are few data on the epidemiological characteristics of HBV. Our aim was to study the epidemiological patterns of HBV in Central Greece and identify the possible differences in HBV prevalence (clusters) among areas inside this region using data from the hepatitis registry. METHODS:The study ...

    journal_title:European journal of internal medicine

    pub_type: 杂志文章

    doi:10.1016/j.ejim.2008.04.023

    authors: Stefos A,Gatselis N,Zachou K,Rigopoulou E,Hadjichristodoulou C,Dalekos GN

    更新日期:2009-01-01 00:00:00

  • Quality of care after AKI development in the hospital: Consensus from the 22nd Acute Disease Quality Initiative (ADQI) conference.

    abstract:BACKGROUND:Acute kidney injury (AKI) is independently associated with increased morbidity and mortality. Quality improvement has been identified as an important goal in the care of patients with AKI. Different settings can be targeted to improve AKI care, broadly classified these include the inpatient and outpatient en...

    journal_title:European journal of internal medicine

    pub_type: 杂志文章

    doi:10.1016/j.ejim.2020.04.056

    authors: Macedo E,Bihorac A,Siew ED,Palevsky PM,Kellum JA,Ronco C,Mehta RL,Rosner MH,Haase M,Kashani KB,Barreto EF

    更新日期:2020-10-01 00:00:00

  • Aspiration pneumonia in old patients with dementia. Prognostic factors of mortality.

    abstract:BACKGROUND:Prognostic factors of mortality in elderly patients with dementia with aspiration pneumonia (AP) are scarcely known. We determined the mortality rate and prognostic factors in old patients with dementia hospitalized due to AP. METHODS:We prospectively studied 120 consecutive patients aged ≥ 75 years with de...

    journal_title:European journal of internal medicine

    pub_type: 杂志文章

    doi:10.1016/j.ejim.2012.08.006

    authors: Bosch X,Formiga F,Cuerpo S,Torres B,Rosón B,López-Soto A

    更新日期:2012-12-01 00:00:00

  • The use of D-dimer in specific clinical conditions: a narrative review.

    abstract::The use of D-dimer in combination with a clinical decision rule has been widely investigated in pulmonary embolism and deep venous thrombosis. Although it has been shown to be safe in excluding venous thromboembolism, the clinician is often faced with specific situations in which the use of D-dimer is controversial. W...

    journal_title:European journal of internal medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.ejim.2008.12.004

    authors: Bruinstroop E,van de Ree MA,Huisman MV

    更新日期:2009-09-01 00:00:00

  • Efficacy and safety of Monascus purpureus Went rice in children and young adults with secondary hyperlipidemia: a preliminary report.

    abstract:BACKGROUNDS/AIMS:Nephrotic dyslipidemia is a risk factor for development of systemic atherosclerosis; also it may aggravate glomerulosclerosis and enhance progression of glomerular disease. We aimed to assess the efficacy and safety of Monascus purpureus Went rice vs. fluvastatin therapy in the management of nephrotic ...

    journal_title:European journal of internal medicine

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.ejim.2008.08.012

    authors: Gheith O,Sheashaa H,Abdelsalam M,Shoeir Z,Sobh M

    更新日期:2009-05-01 00:00:00

  • Hypersersensitivity and Kounis syndrome due to a viper bite.

    abstract::A 60-year-old male was bitten by a venomous snake (Vipera ammodytes) and gradually developed signs of an allergic reaction including generalized itching, generalized rash, and chest discomfort. This was followed by severe retrosternal pain with electrocardiographic evidence of an inferior myocardial ischemia progressi...

    journal_title:European journal of internal medicine

    pub_type: 杂志文章

    doi:10.1016/j.ejim.2005.11.016

    authors: Frangides C,Kouni S,Niarchos C,Koutsojannis C

    更新日期:2006-05-01 00:00:00

  • Sex differences in clinical presentation, severity and outcome of stroke: results from a hospital-based registry.

    abstract:BACKGROUND AND PURPOSE:Sex related differences in cardiovascular disease and stroke are issues of increasing interest. The aim of this study was to evaluate for sex differences in clinical presentation, severity of stroke and outcome in a population of patients admitted to 4 public and 1 private hospitals in three diff...

    journal_title:European journal of internal medicine

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.ejim.2012.10.004

    authors: Santalucia P,Pezzella FR,Sessa M,Monaco S,Torgano G,Anticoli S,Zanoli E,Maimone Baronello M,Paciaroni M,Caso V,Women Stroke Association (WSA).

    更新日期:2013-03-01 00:00:00

  • Clinical characteristics and one-year survival in heart failure patients more than 85 years of age compared with younger.

    abstract:BACKGROUND:Heart failure (HF) is frequent in elderly patients, but few studies have focused on patients older than 84 years. The aim of this study was to evaluate major comorbidities and 1-year survival in HF patients aged ≥85 years compared with younger age groups. METHODS:Patients included in a prospective national ...

    journal_title:European journal of internal medicine

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.ejim.2013.01.005

    authors: Conde-Martel A,Formiga F,Pérez-Bocanegra C,Armengou-Arxé A,Muela-Molinero A,Sánchez-Sánchez C,Diez-Manglano J,Montero-Pérez-Barquero M

    更新日期:2013-06-01 00:00:00

  • Hyperhomocysteinemia in bodybuilders taking anabolic steroids.

    abstract::Background: Hyperhomocysteinemia has been accepted as an independent risk factor for atherosclerosis and atherothrombosis. In recent years, several reports have appeared in the literature linking the use of anabolic steroids with acute vascular events in bodybuilders. In this study, we investigated whether hyperhomocy...

    journal_title:European journal of internal medicine

    pub_type: 杂志文章

    doi:10.1016/s0953-6205(00)00131-x

    authors: Ebenbichler CF,Kaser S,Bodner J,Gander R,Lechleitner M,Herold M,Patsch JR

    更新日期:2001-02-01 00:00:00

  • Clinical indications for the albumin use: still a controversial issue.

    abstract::Human serum albumin (HSA) is the most abundant circulating protein and accounts for about 70% of the plasma colloid osmotic pressure. Beside the well known capacity to act as plasma-expander, HSA is provided of many other properties which are unrelated to the regulation of fluid compartmentalization, including binding...

    journal_title:European journal of internal medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.ejim.2013.05.015

    authors: Caraceni P,Domenicali M,Tovoli A,Napoli L,Ricci CS,Tufoni M,Bernardi M

    更新日期:2013-12-01 00:00:00

  • Echocardiographic estimation of pulmonary arterial systolic pressure in acute heart failure. Prognostic implications.

    abstract:BACKGROUND:Prognostic implications of echocardiographic assessment of pulmonary hypertension (PH) in non-selected patients hospitalized for acute heart failure (AHF) are not clearly defined. The aim of this study was to evaluate the association between echocardiography-derived PH in AHF and 1-year all-cause mortality. ...

    journal_title:European journal of internal medicine

    pub_type: 杂志文章

    doi:10.1016/j.ejim.2013.04.009

    authors: Merlos P,Núñez J,Sanchis J,Miñana G,Palau P,Bodí V,Husser O,Santas E,Bondanza L,Chorro FJ

    更新日期:2013-09-01 00:00:00

  • Barriers to obesity treatment.

    abstract::Obesity, one of the most prevalent health problems in the Western world, is a chronic and progressive condition. Therefore, as with other chronic diseases, patients with obesity require lifelong treatment. Long-term efficacy and effectiveness of obesity treatments is notoriously poor. This may in part be attributable ...

    journal_title:European journal of internal medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.ejim.2007.09.011

    authors: Mauro M,Taylor V,Wharton S,Sharma AM

    更新日期:2008-05-01 00:00:00

  • Thromboembolic renal infarction due to a renal artery aneurysm in a patient with Ehlers-Danlos syndrome type IV.

    abstract::Type IV Ehlers-Danlos syndrome (EDS) is the only lethal form of EDS, mostly due to vascular complications. We describe a patient suffering from EDS type IV who presented with right thromboembolic renal infarctions due to a right renal artery aneurysm. We preferred observation to anticoagulation therapy because the thr...

    journal_title:European journal of internal medicine

    pub_type: 杂志文章

    doi:10.1016/j.ejim.2006.02.008

    authors: Yigal A,Tal H,Nurit H,Tova CS,Hershcovici T

    更新日期:2006-08-01 00:00:00

  • Extrapulmonary tuberculosis: 7 year-experience of a tertiary center in Istanbul.

    abstract:BACKGROUND:Although a decreasing trend of tuberculosis (TB) was reported in Turkey, higher proportion of extrapulmonary tuberculosis (EPT) was revealed. MATERIAL AND METHODS:In this retrospective study, clinical and laboratory data of 141 EPT patients were evaluated for a seven-year period by using descriptive statist...

    journal_title:European journal of internal medicine

    pub_type: 杂志文章

    doi:10.1016/j.ejim.2013.08.704

    authors: Sevgi DY,Derin O,Alpay AS,Gündüz A,Konuklar AS,Bayraktar B,Bulut E,Uzun N,Sonmez E

    更新日期:2013-12-01 00:00:00

  • Erectile dysfunction as the presenting symptom of a pheochromocytoma.

    abstract::We report the case of a 59-year-old man with a pheochromocytoma in which erectile dysfunction was the main symptom. Erectile function was related to the amount of noradrenaline secreted by the tumor, as was determined when recurrence of the malignancy was diagnosed twice. Erectile function could be restored by lowerin...

    journal_title:European journal of internal medicine

    pub_type: 杂志文章

    doi:10.1016/j.ejim.2007.02.027

    authors: van den Berge K,van Guldener C,van Wijngaarden P

    更新日期:2007-12-01 00:00:00

  • A case of pseudomembranous colitis presenting with massive ascites.

    abstract::Clostridium difficile-associated disease seems to be increasing worldwide. A wide spectrum of clinical manifestations, ranging from asymptomatic to life-threatening disease, has been described. A case of pseudomembranous colitis with massive ascites as the main presenting manifestation is described in order to illustr...

    journal_title:European journal of internal medicine

    pub_type: 杂志文章

    doi:10.1016/j.ejim.2006.09.034

    authors: Tsourous GI,Raftopoulos LG,Kafe EE,Manoleris EK,Makaritsis KP,Pinis SG

    更新日期:2007-07-01 00:00:00

  • Antineutrophil cytoplasmic antibody-associated neutropenia.

    abstract::BACKGROUND: Antineutrophil cytoplasmic antibodies (ANCA) can be associated with various disorders. However, their association with neutropenia has never been reported. METHODS: Nine patients with chronic unexplained neutropenia and ANCA were studied. Clinical charts were extensively analyzed and all patients underwent...

    journal_title:European journal of internal medicine

    pub_type: 杂志文章

    doi:10.1016/j.ejim.2004.08.009

    authors: Coppo P,Ghez D,Fuentes V,Bengoufa D,Oksenhendler E,Tribout B,Clauvel JP,Lassoued K

    更新日期:2004-11-01 00:00:00

  • European School of Internal Medicine (ESIM) in Brighton: experiences and reflections.

    abstract::The European School of Internal Medicine (ESIM) is a meeting aimed at young physicians training in internal medicine throughout Europe. Since 1998 the school has been held annually, and in this report we reflect on our experiences during the recent school in Brighton in July 2010. The school combined a broad mix of le...

    journal_title:European journal of internal medicine

    pub_type: 杂志文章

    doi:10.1016/j.ejim.2011.01.006

    authors: Hewitt S,Weidanz F,Westgeest H,Ruza I,Ciferska H,Pasquet F,Salomäki S,Olsen E

    更新日期:2011-06-01 00:00:00

  • Acute chest syndrome in sickle-cell trait; Two case reports in persons of Mediterranean origin and review of the literature.

    abstract::Sickle-cell trait has been characterized as a benign condition. However, life-threatening complications sometimes develop. Acute chest syndrome (ACS) is usually described in homozygous sickle cell disease, but it rarely develops in individuals with sickle-cell trait. Two cases of ACS in patients with sickle-cell trait...

    journal_title:European journal of internal medicine

    pub_type: 杂志文章

    doi:10.1016/j.ejim.2004.03.010

    authors: Dourakis SP,Alexopoulou A,Papageorgiou C,Kaloterakis A,Hadziyannis SJ

    更新日期:2004-07-01 00:00:00

  • Determinants of continuous positive airway pressure compliance in a group of Greek patients with obstructive sleep apnea.

    abstract:OBJECTIVE:The aim of the study was to investigate the patients' characteristics that correlate with greater compliance to CPAP use. METHODS:Patients diagnosed with OSAHS and treated with CPAP, who had at least one follow-up visit in the Sleep Clinic during one year, were included in the study. Demographic data, histor...

    journal_title:European journal of internal medicine

    pub_type: 杂志文章

    doi:10.1016/j.ejim.2009.07.004

    authors: Amfilochiou A,Tsara V,Kolilekas L,Gizopoulou E,Maniou C,Bouros D,Polychronopoulos V

    更新日期:2009-10-01 00:00:00

  • The Diagnosis of Acute Myocarditis in Emergency (DAME) score: improving diagnostics within the emergency department.

    abstract:PURPOSE:. The final diagnosis of myocarditis is challenging. The aim of our study was to provide the D.A.M.E. (Diagnosis of Acute Myocarditis in Emergency) Score for the fast identification of patients suffering from myocarditis at Emergency Department (ED). METHODS:. This was a multicenter, retrospective study involv...

    journal_title:European journal of internal medicine

    pub_type: 杂志文章

    doi:10.1016/j.ejim.2021.01.011

    authors: Scicchitano P,Grazioli Gauthier L,D'Agostino C,Caldarola P,Solarino B,Massari F,Chiarella F,Sinagra G,Manca F,Ciccone MM

    更新日期:2021-01-24 00:00:00

  • Outpatient percutaneous liver biopsy: still a good option.

    abstract:OBJECTIVE:To assess security of "blind" percutaneous liver biopsy as an ambulatory procedure. MATERIAL AND METHODS:Defining inclusion criteria, surveillance protocol, data from ultrasonography done 6 h after procedure and complications. RESULTS:We analysed 192 percutaneous liver biopsies done between 2000-2007. There...

    journal_title:European journal of internal medicine

    pub_type: 杂志文章

    doi:10.1016/j.ejim.2009.02.002

    authors: Pinelo E,Presa J

    更新日期:2009-09-01 00:00:00

  • A quarter of admitted poisoned patients have a mild poisoning and require no treatment: An observational study.

    abstract:BACKGROUND:Poisoned patients are frequently admitted following Emergency Department (ED) presentation, while the necessity of such admissions is hardly investigated. We determined the proportion and characteristics of poisoned patients who were admitted, but in retrospect had an uneventful admission. METHODS:For this ...

    journal_title:European journal of internal medicine

    pub_type: 杂志文章

    doi:10.1016/j.ejim.2019.05.012

    authors: Hondebrink L,Rietjens SJ,Donker DW,Hunault CC,van den Hengel-Koot I,Verputten PM,de Vries I,Kaasjager KAH,Dekker D,de Lange DW

    更新日期:2019-08-01 00:00:00

  • Impact of low dose tocilizumab on mortality rate in patients with COVID-19 related pneumonia.

    abstract:BACKGROUND:Pneumonia with respiratory failure represents the main cause of death in COVID-19, where hyper inflammation plays an important role in lung damage. This study aims to evaluate if tocilizumab, an anti-soluble IL-6 receptor monoclonal antibody, reduces patients' mortality. METHODS:85 consecutive patients admi...

    journal_title:European journal of internal medicine

    pub_type: 杂志文章

    doi:10.1016/j.ejim.2020.05.009

    authors: Capra R,De Rossi N,Mattioli F,Romanelli G,Scarpazza C,Sormani MP,Cossi S

    更新日期:2020-06-01 00:00:00

  • Chronic cough in adults.

    abstract::Cough, a defense mechanism for clearing the airways of secretions, exudate, or foreign bodies, may become a troublesome symptom. Chronic cough, one of the most frequent symptoms requiring medical attention, is often not due to identifiable causes in adults. Chronic productive cough defines chronic bronchitis, and thus...

    journal_title:European journal of internal medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.ejim.2020.03.018

    authors: Spanevello A,Beghé B,Visca D,Fabbri LM,Papi A

    更新日期:2020-08-01 00:00:00

  • Sandfly fever due to Toscana virus: an emerging infection in southern France.

    abstract::Infections due to Toscana virus (TOSV) have been described in the Mediterranean area, mainly in Italy. We describe two cases of acute TOSV infection in southern France, one aseptic meningitis and one influenza-like illness. To our knowledge, only one other case of TOSV infection has been reported in this area. ...

    journal_title:European journal of internal medicine

    pub_type: 杂志文章

    doi:10.1016/j.ejim.2004.05.006

    authors: Hemmersbach-Miller M,Parola P,Charrel RN,Paul Durand J,Brouqui P

    更新日期:2004-08-01 00:00:00

  • Circulating vascular endothelial growth factor is unaffected by acute hyperglycemia and hyperinsulinemia in type 1 diabetes mellitus.

    abstract:BACKGROUND:Circulating levels of vascular endothelial growth factor (VEGF) may predict microvascular complications in type 1 diabetes mellitus and are elevated when metabolic control is poor. We tested whether serum VEGF is influenced by prevailing glucose and insulin levels. METHODS:In 15 type 1 diabetic patients, se...

    journal_title:European journal of internal medicine

    pub_type: 杂志文章

    doi:10.1016/j.ejim.2006.11.006

    authors: Dullaart RP,Oomen PH,Sluiter WJ

    更新日期:2007-05-01 00:00:00

  • Rituximab-induced serum sickness is more frequent in autoimmune diseases as compared to hematological malignancies: A French nationwide study.

    abstract:INTRODUCTION:Rituximab induced serum sickness (RISS) is a rare delayed hypersensitivity reaction. The aim of this study was to describe the epidemiological and clinical characteristics of the RISS cases reported in France. METHOD:Serum sickness cases involving rituximab were identified from the French PharmacoVigilanc...

    journal_title:European journal of internal medicine

    pub_type: 杂志文章

    doi:10.1016/j.ejim.2019.06.009

    authors: Bayer G,Agier MS,Lioger B,Lepelley M,Zenut M,Lanoue MC,Maillot F,Jonville-Bera AP

    更新日期:2019-09-01 00:00:00

  • Thrombophilic and cardiovascular risk factors for retinal vein occlusion.

    abstract:BACKGROUND:The role of thrombophilic and cardiovascular risk factors in different manifestations of retinal vein occlusion (RVO), i.e., central or branch RVO, and at different ages is still debated. AIMS:To evaluate the association between thrombophilic and cardiovascular risk factors and the risk of RVO (overall, sep...

    journal_title:European journal of internal medicine

    pub_type: 杂志文章

    doi:10.1016/j.ejim.2017.06.022

    authors: Bucciarelli P,Passamonti SM,Gianniello F,Artoni A,Martinelli I

    更新日期:2017-10-01 00:00:00

  • The annual yield of diagnostic endoscopy of the lower digestive tract.

    abstract::BACKGROUND: Endoscopy of the colon and rectum has become a standard diagnostic procedure. No data are presented in the literature on the annual yield or on morbidity patterns. A large, cross-sectional, single-center study was done in order to detect the annual yield of endoscopy of the colon and rectum. METHODS: All c...

    journal_title:European journal of internal medicine

    pub_type: 杂志文章

    doi:10.1016/j.ejim.2004.07.015

    authors: Loffeld RJ,van der Putten AB

    更新日期:2005-02-01 00:00:00