Abstract:
BACKGROUND:In Greece, there are few data on the epidemiological characteristics of HBV. Our aim was to study the epidemiological patterns of HBV in Central Greece and identify the possible differences in HBV prevalence (clusters) among areas inside this region using data from the hepatitis registry. METHODS:The study was performed in Thessaly, one out of the thirteen regions of Greece and covers most of the part of Central Greece. A total of 921 HBV patients were registered in the hepatitis registry during the period 1999-2004 while 303 were randomly selected to be studied further using a detailed questionnaire on several epidemiological factors. RESULTS:187/303 patients (61.7%) classified as chronic inactive HBV carriers, 78/303 (25.7%) had chronic hepatitis B, 29/303 (9.6%) had HBV-related cirrhosis and 9/303 (3%) HBV-related hepatocellular carcinoma (HCC). The route of HBV transmission was vertical in 103 (34%), sexual in 46 (15.1%) and intrafamilial in 98 (32.4%). Folk remedies were identified as the predisposing risk factor for contracting HBV infection in 38 (12.5%), previous transfusion in 9 (3%) and unknown mode of transmission in 9 patients (3%). Alcohol abuse was the only independent factor (OR: 2.5; p=0.01) associated with the progression to cirrhosis-HCC. There were specific areas (clusters) inside Thessaly region with increased ratio of HBV infection; Vertical and sexual modes of transmission were more prominent in some of these areas. CONCLUSIONS:Vertical, intrafamilial and sexual modes of HBV transmission identified as the major routes of HBV infection in our study. We also identified cluster areas of HBV infection in Central Greece. Alcohol abuse is frequent among HBV patients and is acting as an effect modificator risk factor for the development of HBV-related cirrhosis and HCC. Extended population studies in Greece are needed to assess in detail the epidemiological patterns of HBV and evaluate control programmes.
journal_name
Eur J Intern Medjournal_title
European journal of internal medicineauthors
Stefos A,Gatselis N,Zachou K,Rigopoulou E,Hadjichristodoulou C,Dalekos GNdoi
10.1016/j.ejim.2008.04.023subject
Has Abstractpub_date
2009-01-01 00:00:00pages
35-43issue
1eissn
0953-6205issn
1879-0828pii
S0953-6205(08)00140-4journal_volume
20pub_type
杂志文章abstract:BACKGROUND:Anticholinergic drugs may increase the risk of delirium in non-critically ill patients, but it is unclear whether exposure to these drugs is also a risk factor for Intensive Care Unit (ICU) delirium. In this study the hypothesis was tested that anticholinergic drug exposure at ICU admission increases the ris...
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abstract::Most patients above 60 years with acute myeloid leukemia (AML) will die from their disease. Nevertheless, the treatment concepts in elderly patients with myelodysplastic syndromes (MDS) and AML are rapidly evolving. A number of recent reports have identified better survival rates with intensive induction chemotherapy ...
journal_title:European journal of internal medicine
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abstract:BACKGROUND:Penicillamine (PA) treatment may be associated with a wide spectrum of adverse effects. There are many case reports and small series of PA-induced nephrotic syndrome (NS). In addition to our patient, in this study, we review all the cases of NS due to PA treatment in the English literature. METHODS:A retros...
journal_title:European journal of internal medicine
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doi:10.1016/j.ejim.2006.03.001
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abstract::Microchimerism is defined by the presence within an individual of a low level of cells derived from another individual. Systemic sclerosis is clinically similar to chronic graft-versus-host disease, a known condition of chimerism, which has led some authors to explore the hypothesis that microchimerism may contribute ...
journal_title:European journal of internal medicine
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abstract::Stroke is a leading cause of death worldwide and the first cause of disability in the Western world. Over the last 20 years, antiplatelet agents have reduced overall stroke rates in primary and secondary prevention in men. However, this has not been the case for women. In this narrative review, the most widely used an...
journal_title:European journal of internal medicine
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journal_title:European journal of internal medicine
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abstract::Coronary heart disease (CHD) and specifically acute myocardial infarction (AMI) are the most common causes of death among both men and women throughout the world. Although CHD mortality rates have been halved in many developed countries in recent decades, some studies have pointed out significant differences regarding...
journal_title:European journal of internal medicine
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journal_title:European journal of internal medicine
pub_type: 杂志文章
doi:10.1016/j.ejim.2016.06.031
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journal_title:European journal of internal medicine
pub_type: 杂志文章,多中心研究
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journal_title:European journal of internal medicine
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abstract::In all industrialized countries, life expectancy has risen in the past 100 years. The incidence of elderly patients reaching end-stage renal disease (ESRD) and requiring renal replacement therapy has also increased. During the past few decades, the pattern of ESRD has changed significantly with the emerging predominan...
journal_title:European journal of internal medicine
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doi:10.1016/s0953-6205(01)00121-2
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journal_title:European journal of internal medicine
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doi:10.1016/j.ejim.2018.09.019
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abstract::BACKGROUND: Plasma total homocysteine (p-tHcy) is considered to be an independent risk factor for atherosclerotic vascular disease. This cross-sectional study was undertaken to examine p-tHcy levels and their relationship to coronary artery disease (CAD) and alcohol intake. METHODS: We consecutively studied 291 patien...
journal_title:European journal of internal medicine
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journal_title:European journal of internal medicine
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doi:10.1016/j.ejim.2006.04.009
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journal_title:European journal of internal medicine
pub_type: 杂志文章
doi:10.1016/j.ejim.2018.02.005
更新日期:2018-06-01 00:00:00
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journal_title:European journal of internal medicine
pub_type: 杂志文章
doi:10.1016/j.ejim.2015.11.013
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journal_title:European journal of internal medicine
pub_type: 杂志文章
doi:10.1016/j.ejim.2014.05.012
更新日期:2014-07-01 00:00:00
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journal_title:European journal of internal medicine
pub_type: 杂志文章,评审
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journal_title:European journal of internal medicine
pub_type: 杂志文章,评审
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更新日期:2010-04-01 00:00:00
abstract:BACKGROUND:Heart failure (HF) with reduced ejection fraction remains a major therapeutic challenge. The aim of this study was to investigate the role of novel cardiovascular biomarkers, i.e. soluble suppression of tumorigenicity (sST2), growth-differentiation factor-15 (GDF-15), soluble urokinase plasminogen activator ...
journal_title:European journal of internal medicine
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更新日期:2017-10-01 00:00:00
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journal_title:European journal of internal medicine
pub_type: 杂志文章
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更新日期:2013-07-01 00:00:00
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journal_title:European journal of internal medicine
pub_type: 杂志文章
doi:10.1016/j.ejim.2017.12.008
更新日期:2018-05-01 00:00:00
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journal_title:European journal of internal medicine
pub_type: 杂志文章
doi:10.1016/j.ejim.2015.10.006
更新日期:2016-03-01 00:00:00
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journal_title:European journal of internal medicine
pub_type: 杂志文章,多中心研究,随机对照试验
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pub_type: 杂志文章
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更新日期:2012-09-01 00:00:00
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journal_title:European journal of internal medicine
pub_type: 杂志文章,评审
doi:10.1016/j.ejim.2015.02.020
更新日期:2015-04-01 00:00:00
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pub_type: 杂志文章
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更新日期:2006-11-01 00:00:00