Abstract：
:In all industrialized countries, life expectancy has risen in the past 100 years. The incidence of elderly patients reaching end-stage renal disease (ESRD) and requiring renal replacement therapy has also increased. During the past few decades, the pattern of ESRD has changed significantly with the emerging predominance of elderly patients. The causes of this phenomenon are manifold and include an increasing number of chronic diseases typical of the 'third age', such as type 2 diabetes mellitus and vascular disease. In many species, a consequence of aging includes deterioration of renal function, partly due to structural alterations, and partly as the result of a diminishing blood flow. In humans, the aging kidney is characterized by modifications resulting from organic and functional disturbances. In particular, type 2 diabetes mellitus has emerged as an important condition, the microvascular and macrovascular complications of which are a common cause of morbidity and mortality in older patients. In part I of this review, the morphological and functional changes of the aging kidney will be reviewed, as well as the pathological conditions leading to the loss of renal function in the elderly.
journal_name
Eur J Intern Medjournal_title
European journal of internal medicineauthors
Mulder WJ,Hillen HFdoi
10.1016/s0953-6205(01)00121-2subject
Has Abstractpub_date
2001-04-01 00:00:00pages
86-97issue
2eissn
0953-6205issn
1879-0828pii
S0953620501001212journal_volume
12pub_type
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journal_title：European journal of internal medicine
pub_type： 杂志文章,多中心研究
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更新日期：2012-03-01 00:00:00
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