Significant variation of traditional markers of liver injury after a half-marathon run.

Abstract:

BACKGROUND:While the promotion of health-related fitness is thereby widespread, less focus is currently being given on the biological influence that physical activity might exert on results of laboratory testing. As such, this study was undertaken to assess the kinetics of liver injury markers following physical exercise. DESIGN AND METHODS:Total and direct bilirubin as well as the activity of biochemical markers of liver injury including aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), gamma-glutamyl transpeptidase (GGT) and creatine kinase (CK), were measured before and after a half-marathon. RESULTS:Significant increases occurred for GGT, AST, LDH, CK, total and direct bilirubin immediately after the run. AST, LDH, CK, total and direct bilirubin were still increased 24h thereafter, whereas GGT decreased after 6h. None of the athletes exceed the upper reference limit for ALT, ALP and GGT, whereas significant variations were instead observed for LDH, AST, CK, total and direct bilirubin. CONCLUSIONS:Taken together, the results of our prospective investigation clearly attest that an acute bulk of aerobic physical exercise, such as a half-marathon, might produce significant changes in the activity of traditional biomarkers of liver injury, which should be carefully considered when investigating physically active individuals undergoing laboratory testing.

journal_name

Eur J Intern Med

authors

Lippi G,Schena F,Montagnana M,Salvagno GL,Banfi G,Guidi GC

doi

10.1016/j.ejim.2011.02.007

subject

Has Abstract

pub_date

2011-10-01 00:00:00

pages

e36-8

issue

5

eissn

0953-6205

issn

1879-0828

pii

S0953-6205(11)00038-0

journal_volume

22

pub_type

杂志文章
  • Evolving strategies for the use of spironolactone in cardiovascular disease.

    abstract::The evolution of strategies for the use of spironolactone and its analogue, eplerenone, has, over the years, encompassed favourable modification of the natural history of symptomatic heart failure in subjects with subnormal left ventricular ejection fraction (LVEF), and mitigation of the risk of new-onset atrial fibri...

    journal_title:European journal of internal medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.ejim.2012.11.007

    authors: Jolobe OM

    更新日期:2013-06-01 00:00:00

  • Cytotoxic T lymphocyte-associated molecule-4 polymorphisms in Turkish Graves' disease patients and association with probability of remission after antithyroid therapy.

    abstract:BACKGROUND:One of the candidate genes for susceptibility to Graves' disease (GD) is cytotoxic T lymphocyte-associated molecule-4 (CTLA-4), a negative regulator of T-cell activation. In order to elucidate the relationship of GD with the A/G polymorphism in exon 1 and the C/T polymorphism in the promoter region of the CT...

    journal_title:European journal of internal medicine

    pub_type: 杂志文章

    doi:10.1016/j.ejim.2005.06.007

    authors: Sahin M,Erdogan MF,Erdogan G

    更新日期:2005-09-01 00:00:00

  • The quality of oral anticoagulation in general practice in patients with atrial fibrillation.

    abstract:BACKGROUND:The aims of this study were to evaluate the quality of oral anticoagulation (OAC) in AF patients in the practices of general practitioners (GPs) in Germany and to investigate possible causal factors which influence OAC quality. METHODS:We conducted a multi-center, non-interventional, prospective observation...

    journal_title:European journal of internal medicine

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.ejim.2013.12.013

    authors: Mueller S,Pfannkuche M,Breithardt G,Bauersachs R,Maywald U,Kohlmann T,Wilke T

    更新日期:2014-03-01 00:00:00

  • Non-every day statin administration--a literature review.

    abstract:BACKGROUND:Statins are the treatment of choice for lowering LDL-C levels and reducing cardiovascular events. They have a remarkable safety profile, although some patients do not tolerate them. The aim of the study was to summarize the existing data on non-every day statin administration regimens. METHODS:We searched t...

    journal_title:European journal of internal medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.ejim.2012.02.006

    authors: Elis A,Lishner M

    更新日期:2012-07-01 00:00:00

  • The effect of metformin on prolactin levels in patients with drug-induced hyperprolactinemia.

    abstract:BACKGROUND:In bromocriptine-treated hyperprolactinemic patients with impaired glucose tolerance, metformin was found to reduce plasma levels of prolactin. No previous study has investigated its impact on plasma prolactin in patients with drug-induced hyperprolactinemia. METHODS:The study included 20 women with antipsy...

    journal_title:European journal of internal medicine

    pub_type: 杂志文章

    doi:10.1016/j.ejim.2016.01.015

    authors: Krysiak R,Kowalcze K,Szkrobka W,Okopien B

    更新日期:2016-05-01 00:00:00

  • Anatomy of the ward round.

    abstract::The ward round has been a central activity of hospital life for hundreds of years. It is hardly mentioned in textbooks. The ward round is a parade through the hospital of professionals where most decision making concerning patient care is made. However the traditional format may be intimidating for patients and inadeq...

    journal_title:European journal of internal medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.ejim.2007.09.016

    authors: O'Hare JA

    更新日期:2008-07-01 00:00:00

  • A new direction for medical education in Ireland?

    abstract::In recent years, new concepts of educational theory and practice have stimulated new approaches to medical education in many countries. For various reasons, medical education in Ireland has been slow to change such that there are now increasing concerns about educational standards. In addition, Ireland currently produ...

    journal_title:European journal of internal medicine

    pub_type: 杂志文章

    doi:10.1016/j.ejim.2006.09.001

    authors: Finucane P,Kellett J

    更新日期:2007-03-01 00:00:00

  • Cancer screening in Greece. Guideline awareness and prescription behavior among Hellenic physicians.

    abstract:BACKGROUND:Primary cancer prevention is offered by the Greek health care system to the population on an opportunistic basis. This means that screening depends on advice from primary care providers and on individuals' request for screening, since a centralized invitational register is lacking. In planning preventive ser...

    journal_title:European journal of internal medicine

    pub_type: 杂志文章

    doi:10.1016/j.ejim.2007.10.018

    authors: Kamposioras K,Mauri D,Alevizaki P,Ferentinos G,Karampoiki V,Kouiroukidou P,Zorba E,Proiskos A,Chasioti D,Panou C,Gkinosati A,Chatziioannou I,Aggelinas G,Xilomenos A

    更新日期:2008-10-01 00:00:00

  • Heart rate and cardiovascular protection.

    abstract::Recent large epidemiological studies have confirmed that an elevated resting heart rate is an independent predictor of cardiovascular and overall mortality in the general population as well as in patients with hypertension, coronary heart disease and chronic heart failure. Pathophysiological studies indicate that a hi...

    journal_title:European journal of internal medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.ejim.2015.02.009

    authors: Caetano J,Delgado Alves J

    更新日期:2015-05-01 00:00:00

  • Efficacy and safety of Monascus purpureus Went rice in children and young adults with secondary hyperlipidemia: a preliminary report.

    abstract:BACKGROUNDS/AIMS:Nephrotic dyslipidemia is a risk factor for development of systemic atherosclerosis; also it may aggravate glomerulosclerosis and enhance progression of glomerular disease. We aimed to assess the efficacy and safety of Monascus purpureus Went rice vs. fluvastatin therapy in the management of nephrotic ...

    journal_title:European journal of internal medicine

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.ejim.2008.08.012

    authors: Gheith O,Sheashaa H,Abdelsalam M,Shoeir Z,Sobh M

    更新日期:2009-05-01 00:00:00

  • The impact of resistance to methicillin in Staphylococcus aureus bacteremia on mortality.

    abstract::Background: It is unclear whether methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-sensitive S. aureus (MSSA) differ in virulence. We therefore carried out a prospective study of cases of S. aureus bacteremia over a period of 2 years at our university hospital. We report herein the results of a compa...

    journal_title:European journal of internal medicine

    pub_type: 杂志文章

    doi:10.1016/s0953-6205(01)00189-3

    authors: Talon D,Woronoff-Lemsi MC,Limat S,Bertrand X,Chatillon M,Gil H,Dupond JL

    更新日期:2002-02-01 00:00:00

  • Buerger's disease: What has the last decade taught us?

    abstract::Thrombangiitis obliterans (TAO), or Buerger's disease, is most likely an endarteritis that is introduced by T-cell-mediated cellular immunity and B-cell-mediated humoral immunity associated with the activation of macrophages or dendritic cells in the intima. There is no specific marker of the disease, and the diagnosi...

    journal_title:European journal of internal medicine

    pub_type: 杂志文章

    doi:10.1016/j.ejim.2005.11.020

    authors: Kröger K

    更新日期:2006-07-01 00:00:00

  • Bed-side inferior vena cava diameter and mean arterial pressure predict long-term mortality in hospitalized patients with heart failure: 36 months of follow-up.

    abstract:BACKGROUND:In discharged patients with heart failure (HF), diverse conditions can intervene to worsen outcome. We would investigate whether such factors present on hospital admission can affect long-term mortality in subjects hospitalized for acute HF. METHODS:One hundred twenty-three consecutive patients hospitalized...

    journal_title:European journal of internal medicine

    pub_type: 杂志文章

    doi:10.1016/j.ejim.2015.11.029

    authors: Torres D,Cuttitta F,Paterna S,Garofano A,Conti G,Pinto A,Parrinello G

    更新日期:2016-03-01 00:00:00

  • A quarter of admitted poisoned patients have a mild poisoning and require no treatment: An observational study.

    abstract:BACKGROUND:Poisoned patients are frequently admitted following Emergency Department (ED) presentation, while the necessity of such admissions is hardly investigated. We determined the proportion and characteristics of poisoned patients who were admitted, but in retrospect had an uneventful admission. METHODS:For this ...

    journal_title:European journal of internal medicine

    pub_type: 杂志文章

    doi:10.1016/j.ejim.2019.05.012

    authors: Hondebrink L,Rietjens SJ,Donker DW,Hunault CC,van den Hengel-Koot I,Verputten PM,de Vries I,Kaasjager KAH,Dekker D,de Lange DW

    更新日期:2019-08-01 00:00:00

  • Clinical findings of bacteremic septic arthritis according to the site of acquisition: The overlap between health care-related and community- and nosocomial-acquired cases.

    abstract:BACKGROUND:The site of acquisition of infection may have a major impact on outcome. The health care-related (HCR) environment has recently come under scrutiny. In a group of patients with bacteremic septic arthritis (SA), we compared their characteristics, type of SA, microbiology and prognosis according to the site of...

    journal_title:European journal of internal medicine

    pub_type: 杂志文章

    doi:10.1016/j.ejim.2015.11.013

    authors: Murillo O,Gomez-Junyent J,Grau I,Ribera A,Cabrera C,Pedrero S,Tubau F,Nolla JM,Ariza J,Pallares R

    更新日期:2016-03-01 00:00:00

  • Venous thromboembolism prophylaxis of acutely ill hospitalized medical patients. Are we under-treating our patients?

    abstract::Venous thromboembolism (VTE) is frequent in patients hospitalized in Internal Medicine wards. It carries a considerable morbidity and mortality. Recommendations for use of anticoagulation are graded 1A in leading evidence-based consensus guidelines. Implementation of these guidelines is suboptimal. Lack of awareness s...

    journal_title:European journal of internal medicine

    pub_type: 杂志文章

    doi:10.1016/j.ejim.2011.11.005

    authors: Roth-Yelinek B

    更新日期:2012-04-01 00:00:00

  • The prognostic effect of left ventricular thrombus formation after acute myocardial infarction in the contemporary era of primary percutaneous coronary intervention: A meta-analysis.

    abstract:BACKGROUNDS:The prognosis and management of left ventricular thrombus (LVT) following acute myocardial infarction (AMI) have not been well evaluated since the advent of primary percutaneous coronary intervention (PCI). We therefore conducted a meta-analysis to assess the prognostic effect of LVT after AMI in primary PC...

    journal_title:European journal of internal medicine

    pub_type: 杂志文章

    doi:10.1016/j.ejim.2019.10.029

    authors: Chen PF,Tang L,Yi JL,Pei JY,Hu XQ

    更新日期:2020-03-01 00:00:00

  • Obesity and fat distribution as predictors of aortoiliac peripheral arterial disease in middle-aged men.

    abstract:BACKGROUND:Peripheral arterial disease (PAD) in the aortoiliac segment is found in nearly a half of patients with PAD. The aim of this study was to estimate the influence of obesity and fat distribution on the occurrence of aortoiliac PAD in middle-aged men. METHODS:This case-control study included 204 middle-aged men...

    journal_title:European journal of internal medicine

    pub_type: 杂志文章

    doi:10.1016/j.ejim.2010.07.019

    authors: Jakovljević B,Stojanov V,Lović D,Paunović K,Radosavljević V,Tutić I

    更新日期:2011-02-01 00:00:00

  • Interference in free thyroxine immunoassay.

    abstract::We report two patients who presented with non-specific symptoms of tiredness that prompted their clinician to order a thyroid function test. In both cases, free thyroxine (T4) was reported to be high, with a normal thyroid-stimulating hormone (TSH). Repeated blood tests from the same laboratory using the same assay me...

    journal_title:European journal of internal medicine

    pub_type: 杂志文章

    doi:10.1016/j.ejim.2007.05.009

    authors: Ghosh S,Howlett M,Boag D,Malik I,Collier A

    更新日期:2008-05-01 00:00:00

  • Nocturnal hypotension in patients after ischemic stroke: does it really matter?

    abstract:BACKGROUND:We aimed to evaluate the presence of nocturnal hypotension (NHP) in ischemic stroke (IS) survivors using ambulatory blood pressure (BP) monitoring (ABPM). METHODS:We included fifty consecutive patients presenting at our outpatient clinic for review and who had been discharged for IS in the previous six mont...

    journal_title:European journal of internal medicine

    pub_type: 杂志文章

    doi:10.1016/j.ejim.2011.03.004

    authors: Castilla-Guerra L,Fernández-Moreno Mdel C,Espino-Montoro A,López-Chozas JM

    更新日期:2011-10-01 00:00:00

  • Effectiveness of sulodexide might be associated with inhibition of complement system in hepatitis B virus-associated membranous nephropathy: An inspiration from a pilot trial.

    abstract:BACKGROUND:The activation of complement system is associated with the development of hepatitis B virus-associated membranous nephropathy (HBV-MN) and heparin could inhibit the activation of complement system. METHODS:This was a three-center trial. Seventy-nine patients with HBV-MN participated in the study. The follow...

    journal_title:European journal of internal medicine

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1016/j.ejim.2016.04.017

    authors: Yang Y,Ma L,Wang C,Kong D,Wang Y,Mei C

    更新日期:2016-07-01 00:00:00

  • Changes in lipid and carbohydrate metabolism under mTOR- and calcineurin-based immunosuppressive regimen in adult patients after liver transplantation.

    abstract:BACKGROUND:Cardiovascular disease is a leading cause of long-term mortality after liver transplantation (LT). Life long immunosuppression harbors the risk of metabolic alterations. We aimed to analyze the impact of calcineurin (CNI)-only containing regimen (group A) compared to mTOR-containing regimen (group B) on lipi...

    journal_title:European journal of internal medicine

    pub_type: 杂志文章

    doi:10.1016/j.ejim.2015.12.022

    authors: Zimmermann A,Zobeley C,Weber MM,Lang H,Galle PR,Zimmermann T

    更新日期:2016-04-01 00:00:00

  • Thromboembolic renal infarction due to a renal artery aneurysm in a patient with Ehlers-Danlos syndrome type IV.

    abstract::Type IV Ehlers-Danlos syndrome (EDS) is the only lethal form of EDS, mostly due to vascular complications. We describe a patient suffering from EDS type IV who presented with right thromboembolic renal infarctions due to a right renal artery aneurysm. We preferred observation to anticoagulation therapy because the thr...

    journal_title:European journal of internal medicine

    pub_type: 杂志文章

    doi:10.1016/j.ejim.2006.02.008

    authors: Yigal A,Tal H,Nurit H,Tova CS,Hershcovici T

    更新日期:2006-08-01 00:00:00

  • A training course for the Israeli phase I written board examination in internal medicine increases the success rate of foreign graduate physicians.

    abstract::BACKGROUND: Foreign graduate residents in internal medicine perform poorly on the Israeli phase I written board examination as compared to local graduates from Israeli medical schools. The aim of this study was to determine the effect of a preparatory course, aimed at foreign graduates, on their success rate in the Is...

    journal_title:European journal of internal medicine

    pub_type: 杂志文章

    doi:10.1016/j.ejim.2004.12.002

    authors: Elis A,Notzer N,Lewinski U,Rapoport MJ

    更新日期:2005-06-01 00:00:00

  • Readmissions to hospital within 30 days of discharge from the internal medicine wards in southern Israel.

    abstract:INTRODUCTION:Hospital readmission within a short time of discharge is a common phenomenon in internal medicine. Although there are a few reports of intensive care and surgical readmission rates there is almost no information available on the readmission rates of internal medicine patients. AIMS:To explore the medical ...

    journal_title:European journal of internal medicine

    pub_type: 杂志文章

    doi:10.1016/j.ejim.2005.10.004

    authors: Zamir D,Zamir M,Reitblat T,Zeev W,Polishchuk I

    更新日期:2006-01-01 00:00:00

  • Predictors of mortality within three months in the patients with malignant pleural effusion.

    abstract:BACKGROUND:Malignant pleural effusion (MPE) has a limited life expectancy (3-12 months). We investigated the predictors of the early mortality (EM) within three months. METHODS:The patients were retrospectively grouped according to the death within three months (Group I) and survival more than three months (Group II)....

    journal_title:European journal of internal medicine

    pub_type: 杂志文章

    doi:10.1016/j.ejim.2009.09.012

    authors: Ozyurtkan MO,Balci AE,Cakmak M

    更新日期:2010-02-01 00:00:00

  • Influence of BMI and geographical region on prescription of oral anticoagulants in newly diagnosed atrial fibrillation: The GLORIA-AF Registry Program.

    abstract:OBJECTIVE:To investigate the association between body mass index (BMI) and oral anticoagulant (OAC) prescription in atrial fibrillation (AF). METHODS:Patients with newly diagnosed non-valvular AF (<3 months) with ≥1 stroke risk factors enrolled in the Global Registry on Long-Term Oral Antithrombotic Treatment in Patie...

    journal_title:European journal of internal medicine

    pub_type: 杂志文章

    doi:10.1016/j.ejim.2020.04.032

    authors: Boriani G,Huisman MV,Teutsch C,Marler S,França LR,Lu S,Lip GYH,GLORIA-AF Investigators.

    更新日期:2020-10-01 00:00:00

  • Aspiration pneumonia in old patients with dementia. Prognostic factors of mortality.

    abstract:BACKGROUND:Prognostic factors of mortality in elderly patients with dementia with aspiration pneumonia (AP) are scarcely known. We determined the mortality rate and prognostic factors in old patients with dementia hospitalized due to AP. METHODS:We prospectively studied 120 consecutive patients aged ≥ 75 years with de...

    journal_title:European journal of internal medicine

    pub_type: 杂志文章

    doi:10.1016/j.ejim.2012.08.006

    authors: Bosch X,Formiga F,Cuerpo S,Torres B,Rosón B,López-Soto A

    更新日期:2012-12-01 00:00:00

  • Endothelins in health and disease.

    abstract::Endothelins are powerful vasoconstrictor peptides that also play numerous other roles. The endothelin (ET) family consists of three peptides produced by a variety of tissues. Endothelin-1 (ET-1) is the principal isoform produced by the endothelium in the human cardiovascular system, and it exerts its actions through b...

    journal_title:European journal of internal medicine

    pub_type: 杂志文章

    doi:10.1016/j.ejim.2007.04.002

    authors: Shah R

    更新日期:2007-07-01 00:00:00

  • The discriminatory power of bleeding assessment tools in adult patients with a mild to moderate bleeding tendency.

    abstract:BACKGROUND:Bleeding assessment tools (BATs) have been developed to quantify bleeding severity. Their ability to predict for the diagnosis of a bleeding disorder has not been thoroughly investigated. OBJECTIVES:To evaluate the ability of the Vicenza BAT and the ISTH BAT to distinguish patients with an established bleed...

    journal_title:European journal of internal medicine

    pub_type: 杂志文章

    doi:10.1016/j.ejim.2020.04.023

    authors: Gebhart J,Hofer S,Kaider A,Rejtö J,Ay C,Pabinger I

    更新日期:2020-08-01 00:00:00