Abstract:
SUMMARY:The aims of this study were to determine the incidence of fungal infections in hospital intensive care units and to evaluate a molecular method to detect these infections. MATERIAL AND METHODS:The participants in this study were patients admitted to any of the 10 intensive care units at Nemazi Hospital (Shiraz, southern Iran) between March 2009 and January 2010. Oral and rectal swabs, urine, and sputum samples from patients were checked for fungal colonization. If a nosocomial fungal infection was suspected, clinical samples were examined for fungal infection by culture, direct microscopic examination and real-time PCR. Blood samples were cultured by bedside inoculation onto BACTEC medium. Susceptibility of the isolates to antifungal agents was also determined. RESULTS:Of 870 patients, 550 (63.2%) had Candida colonization in different body sites and 17 (1.9%) had fungal infections. The mortality rate in patients with fungal infections was 58.8% (10 cases). The etiologic agents were Candida albicans, Candida glabrata, Aspergillus flavus, Aspergillus fumigatus and Aspergillus spp. Three C. albicans were found to be resistant to amphotericin B and itraconazole, and one A. fumigatus and two A. flavus were resistant to amphotericin B, ketoconazole and itraconazole. One A. fumigatus was additionally resistant to caspofungin. CONCLUSIONS:Considering the incidence of fungal infections and their high mortality rate, early detection, prompt diagnosis and treatment are critical. Molecular assays can serve as a diagnostic tool to manage patients admitted to the intensive care unit. Antifungal susceptibility testing in different geographical regions can support the choice of prophylaxis and treatment for these patients.
journal_name
Eur J Intern Medjournal_title
European journal of internal medicineauthors
Badiee P,Alborzi A,Joukar Mdoi
10.1016/j.ejim.2011.08.025subject
Has Abstractpub_date
2011-12-01 00:00:00pages
611-5issue
6eissn
0953-6205issn
1879-0828pii
S0953-6205(11)00198-1journal_volume
22pub_type
杂志文章,多中心研究abstract:BACKGROUND:Vascular endothelium activation is a key pathogenic step in systemic inflammatory response syndrome (SIRS) that can be triggered by both microbial and sterile proinflammatory stimuli. The relevance of soluble adhesion molecules as clinical biomarkers to discriminate between infectious and non-infectious SIRS...
journal_title:European journal of internal medicine
pub_type: 杂志文章
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abstract:BACKGROUND AND PURPOSE:Sex related differences in cardiovascular disease and stroke are issues of increasing interest. The aim of this study was to evaluate for sex differences in clinical presentation, severity of stroke and outcome in a population of patients admitted to 4 public and 1 private hospitals in three diff...
journal_title:European journal of internal medicine
pub_type: 杂志文章,多中心研究
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journal_title:European journal of internal medicine
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pub_type: 临床试验,杂志文章
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journal_title:European journal of internal medicine
pub_type: 杂志文章,评审
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journal_title:European journal of internal medicine
pub_type: 杂志文章,随机对照试验
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更新日期:2009-05-01 00:00:00
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journal_title:European journal of internal medicine
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journal_title:European journal of internal medicine
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journal_title:European journal of internal medicine
pub_type: 杂志文章
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更新日期:2014-11-01 00:00:00
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更新日期:2012-10-01 00:00:00