Abstract：
BACKGROUND:Thalassemia minor (Tm) individuals, are generally considered healthy. However, the prognosis of Tm individuals has not been extensively studied. The aim of this study was to evaluate the prognosis of Tm versus controls without β-thalassemia carrier state. METHODS:A total of 26,006 individuals seeking thalassemia screening at the AOOR Villa Sofia-V. Cervello, Palermo (Italy) were retrospectively studied. Logistic penalised regression model was used to estimate risk of potential complications and survival techniques were used to study mortality. RESULTS:We identified a total of 4943 Tm and 21,063 controls. Tm was associated with significantly higher risks of hospitalisation for cirrhosis (OR 1·94, 95% CI 1·30 to 2·90, p = 0·001), kidney disorders (OR 2·11, 95% CI 1·27 to 3·51, p = 0·004), cholelithiatis (OR 1·39, 95% CI 1·08 to 1·79, p = 0·010), and mood disorders (OR 2·08, 95% CI 1·15 to 3·75, p = 0·015). No statistically difference in life expectancy between thalassemia minor and control group was found (HR 1·090, 95% CI 0·777 to 1·555, p < 0·590; log-rank test p = .426). CONCLUSION:This study shows that Tm affects the prognosis of Tm carriers regarding health expectation. Probably, iron overload and anaemia for several years may be at the basis of these effects.
journal_name
Eur J Intern Medjournal_title
European journal of internal medicineauthors
Graffeo L,Vitrano A,Scondotto S,Dardanoni G,Pollina Addario WS,Giambona A,Sacco M,Di Maggio R,Renda D,Taormina F,Triveri A,Attanasio M,Gluud C,Maggio Adoi
10.1016/j.ejim.2018.06.009subject
Has Abstractpub_date
2018-08-01 00:00:00pages
76-80eissn
0953-6205issn
1879-0828pii
S0953-6205(18)30241-3journal_volume
54pub_type
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