Abstract：
BACKGROUND:Infliximab (IFX) and adalimumab (ADA) are the key treatments for Crohn's Disease (CD), unresponsive to standard treatments. Our aim was to compare the efficacy and safety of IFX and ADA in treating CD in clinical practice. METHODS:One hundred and twenty-six patients (61 M, 65 F, mean age 36.2 years, range 19-67 years), affected by CD, were treated with infliximab (IFX, 59 patients) or adalimumab (ADA, 66 patients). Clinical efficacy, mucosal healing (MH), histological healing (HH), and safety were assessed. MH was defined complicated if healing of ulcers occurred with deformation of bowel profile and/or complete colonoscopy was impossible because of scars. RESULTS:Patients were followed-up for 36 months. No difference was found between IFX and ADA in maintaining long-term clinical remission, MH and HH. Complicated MH was present in 17 (28.8%) patients in IFX group and in 7 (10.6%) patients in ADA group (p=0.012). In 9 (15.2%) patients in IFX group and 2 (3.0%) patients in ADA group colonoscopy was incomplete without cecal intubation or terminal ileum exploration (p=0.024). Side effects were similar in both groups. CONCLUSIONS:Both IFX and ADA seem to be effective and safe in long-term outpatient treatment of CD in clinical practice.
journal_name
Eur J Intern Medjournal_title
European journal of internal medicineauthors
Tursi A,Elisei W,Picchio M,Penna A,Lecca PG,Forti G,Giorgetti G,Faggiani R,Zampaletta C,Pelecca G,Brandimarte Gdoi
10.1016/j.ejim.2014.02.010subject
Has Abstractpub_date
2014-06-01 00:00:00pages
485-90issue
5eissn
0953-6205issn
1879-0828pii
S0953-6205(14)00074-0journal_volume
25pub_type
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