Abstract:
BACKGROUND:Although experimental models have shown that statins could alleviate glomerular damage and decrease urinary protein excretion, the renal effects of statins remain unclear. A case-control study was conducted using data from Taiwan's National Health Insurance system. METHODS:An end-stage renal disease (ESRD) group comprising 11,486 patients was established. Each patient was frequency-matched by age, sex, and comorbidities with one person without ESRD from the general population. Logistic regression analysis was performed to estimate the influence of statin use on ESRD risk. RESULTS:The overall adjusted odds ratios (ORs) of ESRD among patients who received statins was 1.59 (95% confidence interval=1.50-1.68). The raised ESRD risk of statin remained consolidated regardless of statin type (P<.001), except lovastatin. Further, while stratified by cumulative define daily dose, the risk of ESRD increased with accumulative dosage of statins (P for trend<.001). CONCLUSION:This population-based case-control study showed that statin use might be associated with increased ESRD risks. Large-scale randomized clinical trial encompassing statins of different kinds and populations of different comorbidities would be helpful to clarify the potential ESRD risks of statin users.
journal_name
Eur J Intern Medjournal_title
European journal of internal medicineauthors
Lin SY,Lin CL,Hsu WH,Lin CC,Chang CT,Kao CHdoi
10.1016/j.ejim.2016.02.012subject
Has Abstractpub_date
2016-06-01 00:00:00pages
68-72eissn
0953-6205issn
1879-0828pii
S0953-6205(16)00059-5journal_volume
31pub_type
杂志文章abstract:BACKGROUND:Hepatitis B virus infection has decreased in Italy. The aims of this study were to identify changes, if any, in the epidemiological pattern of HBV infection in a southern Italian town first surveyed in 1996 and to assess the effectiveness of vaccination campaign against hepatitis B. METHODS:In 2010, subject...
journal_title:European journal of internal medicine
pub_type: 杂志文章
doi:10.1016/j.ejim.2012.08.009
更新日期:2012-12-01 00:00:00
abstract::The rising incidence of Clostridium difficile (C. difficile) infection or CDI is now a problem of pandemic proportions. The NAP1 hypervirulent strain of C. difficile is responsible for a majority of recent epidemics and the widespread use of fluoroquinolone antibiotics may have facilitated the selective proliferation ...
journal_title:European journal of internal medicine
pub_type: 杂志文章,评审
doi:10.1016/j.ejim.2011.04.009
更新日期:2011-12-01 00:00:00
abstract:BACKGROUND:Patients with non-transfusion-dependent thalassemia (NTDT) present with a spectrum of disease severities. Since there are multiple pathophysiologies in such patients, tailoring treatment remains essential. Therefore, one simple, reliable tool would be beneficial to assess disease severity and tailor therapy,...
journal_title:European journal of internal medicine
pub_type: 共识发展会议,杂志文章
doi:10.1016/j.ejim.2015.10.003
更新日期:2016-03-01 00:00:00
abstract:BACKGROUND:Mallory-Weiss syndrome is defined by upper gastrointestinal bleeding from vomiting-induced mucosal lacerations at the esophago-gastric junction. This study was purposed to investigate the incidence, location, clinical manifestation, diagnosis and effectiveness of treatment (including endoscopic treatment and...
journal_title:European journal of internal medicine
pub_type: 杂志文章
doi:10.1016/j.ejim.2012.02.005
更新日期:2012-06-01 00:00:00
abstract:BACKGROUND:Arterial stiffness has recently been proposed as a powerful independent predictor of cardiovascular disease. However, the influence of arterial stiffening on the interaction between the heart and large vessels and atherosclerosis is not well defined. The arterial stiffness index (ASI) has recently been deter...
journal_title:European journal of internal medicine
pub_type: 杂志文章
doi:10.1016/j.ejim.2005.06.011
更新日期:2005-12-01 00:00:00
abstract::The morbidity and mortality related to many communicable infectious diseases have significantly decreased in Western countries largely because of the use of antibiotics, and the implementation of well-planned vaccination strategies and national immunisation schedules specifically aimed at infants and children. However...
journal_title:European journal of internal medicine
pub_type: 杂志文章,评审
doi:10.1016/j.ejim.2013.12.004
更新日期:2014-03-01 00:00:00
abstract:BACKGROUND:The association between exacerbation of heart failure (HF) and use of non-steroidal anti-inflammatory drugs (NSAIDs) has long been recognized but the data on this adverse effect are limited. METHODS:To further characterize this possible association, we conducted a systematic review and meta-analysis of obse...
journal_title:European journal of internal medicine
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.ejim.2015.09.012
更新日期:2015-11-01 00:00:00
abstract::This article reports the case of a patient with chronic disseminated intravascular coagulation that led to the diagnosis of an otherwise asymptomatic aorto-bifemoral aneurysm. The bleeding disorder completely resolved with the surgical resection of the aneurysm. Fibrinogen replacement therapy prior to invasive diagnos...
journal_title:European journal of internal medicine
pub_type: 杂志文章
doi:10.1016/j.ejim.2004.11.012
更新日期:2005-08-01 00:00:00
abstract::Background: It is unclear whether methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-sensitive S. aureus (MSSA) differ in virulence. We therefore carried out a prospective study of cases of S. aureus bacteremia over a period of 2 years at our university hospital. We report herein the results of a compa...
journal_title:European journal of internal medicine
pub_type: 杂志文章
doi:10.1016/s0953-6205(01)00189-3
更新日期:2002-02-01 00:00:00
abstract:OBJECTIVE:To assess security of "blind" percutaneous liver biopsy as an ambulatory procedure. MATERIAL AND METHODS:Defining inclusion criteria, surveillance protocol, data from ultrasonography done 6 h after procedure and complications. RESULTS:We analysed 192 percutaneous liver biopsies done between 2000-2007. There...
journal_title:European journal of internal medicine
pub_type: 杂志文章
doi:10.1016/j.ejim.2009.02.002
更新日期:2009-09-01 00:00:00
abstract::The rising number of clinical guidelines poses a new challenge to the internists. The main problems are: 1) available documents suffer from heterogeneous methodological quality, and 2) most of clinical guidelines target an 'ideal' patient affected by a single condition, while in real practice internists must face with...
journal_title:European journal of internal medicine
pub_type: 杂志文章
doi:10.1016/j.ejim.2020.05.016
更新日期:2020-07-01 00:00:00
abstract:BACKGROUND:Pneumonia with respiratory failure represents the main cause of death in COVID-19, where hyper inflammation plays an important role in lung damage. This study aims to evaluate if tocilizumab, an anti-soluble IL-6 receptor monoclonal antibody, reduces patients' mortality. METHODS:85 consecutive patients admi...
journal_title:European journal of internal medicine
pub_type: 杂志文章
doi:10.1016/j.ejim.2020.05.009
更新日期:2020-06-01 00:00:00
abstract::Clostridium difficile-associated disease seems to be increasing worldwide. A wide spectrum of clinical manifestations, ranging from asymptomatic to life-threatening disease, has been described. A case of pseudomembranous colitis with massive ascites as the main presenting manifestation is described in order to illustr...
journal_title:European journal of internal medicine
pub_type: 杂志文章
doi:10.1016/j.ejim.2006.09.034
更新日期:2007-07-01 00:00:00
abstract:INTRODUCTION:Rituximab induced serum sickness (RISS) is a rare delayed hypersensitivity reaction. The aim of this study was to describe the epidemiological and clinical characteristics of the RISS cases reported in France. METHOD:Serum sickness cases involving rituximab were identified from the French PharmacoVigilanc...
journal_title:European journal of internal medicine
pub_type: 杂志文章
doi:10.1016/j.ejim.2019.06.009
更新日期:2019-09-01 00:00:00
abstract:BACKGROUND:One of the candidate genes for susceptibility to Graves' disease (GD) is cytotoxic T lymphocyte-associated molecule-4 (CTLA-4), a negative regulator of T-cell activation. In order to elucidate the relationship of GD with the A/G polymorphism in exon 1 and the C/T polymorphism in the promoter region of the CT...
journal_title:European journal of internal medicine
pub_type: 杂志文章
doi:10.1016/j.ejim.2005.06.007
更新日期:2005-09-01 00:00:00
abstract:BACKGROUND:The prognostic significance of hypoalbuminemia and the dynamic changes in serum albumin during hospitalization in internal medicine wards has not been sufficiently investigated. METHODS:Demographic, clinical and laboratory data were collected from 276 patients admitted to our internal medicine ward for a va...
journal_title:European journal of internal medicine
pub_type: 杂志文章
doi:10.1016/j.ejim.2013.08.004
更新日期:2013-12-01 00:00:00
abstract::Background: Hyperhomocysteinemia has been accepted as an independent risk factor for atherosclerosis and atherothrombosis. In recent years, several reports have appeared in the literature linking the use of anabolic steroids with acute vascular events in bodybuilders. In this study, we investigated whether hyperhomocy...
journal_title:European journal of internal medicine
pub_type: 杂志文章
doi:10.1016/s0953-6205(00)00131-x
更新日期:2001-02-01 00:00:00
abstract:BACKGROUND:Nephropathia epidemica (NE), caused by Puumala virus (PUUV), is characterized by acute kidney injury (AKI) and thrombocytopenia. Cardiac involvement with electrocardiographic (ECG) abnormalities has been previously reported in NE; however, its prognostic value is unknown. Relative bradycardia is an important...
journal_title:European journal of internal medicine
pub_type: 杂志文章
doi:10.1016/j.ejim.2016.06.001
更新日期:2016-09-01 00:00:00
abstract:BACKGROUND:We aimed to evaluate the presence of nocturnal hypotension (NHP) in ischemic stroke (IS) survivors using ambulatory blood pressure (BP) monitoring (ABPM). METHODS:We included fifty consecutive patients presenting at our outpatient clinic for review and who had been discharged for IS in the previous six mont...
journal_title:European journal of internal medicine
pub_type: 杂志文章
doi:10.1016/j.ejim.2011.03.004
更新日期:2011-10-01 00:00:00
abstract::Cardiac resynchronization therapy (CRT) is an established treatment for refractory chronic heart failure (CHF) patients with ventricular dyssynchrony. The patient selection for this therapy remains the basis for response improvement. Various parameters, methods and technology for identification of appropriate patient ...
journal_title:European journal of internal medicine
pub_type: 杂志文章,评审
doi:10.1016/j.ejim.2010.11.002
更新日期:2011-02-01 00:00:00
abstract::Anthracosis is a form of pneumoconiosis caused by coal dust or by a smoky and polluted environment. Anthracosis often presents in pulmonary form; only rarely are extrathoracic, esophageal, and mediastinal anthracoses documented. We report a rare case of anthracosis with multiple mediastinal lymphadenopathy. ...
journal_title:European journal of internal medicine
pub_type: 杂志文章
doi:10.1016/j.ejim.2003.09.001
更新日期:2003-11-01 00:00:00
abstract:OBJECTIVE:Left ventricular (LV) dysfunction is a predictor of mortality in patients with sepsis. However, whether the adverse impact of LV dysfunction depends on fluid balance remains unclear. We retrospectively investigated the impact of LV dysfunction and fluid balance on various outcomes of patients with sepsis. ME...
journal_title:European journal of internal medicine
pub_type: 杂志文章
doi:10.1016/j.ejim.2019.11.019
更新日期:2020-04-01 00:00:00
abstract:BACKGROUND/AIM:The spontaneous preterm birth (SPB) rates in a group of HBeAg-negative chronic HBV infected pregnant women without several known risk factors for preterm delivery as well as the mother to infant HBV transmission rates was evaluated. Moreover the role of maternal data during perinatal period as well as th...
journal_title:European journal of internal medicine
pub_type: 杂志文章
doi:10.1016/j.ejim.2010.12.005
更新日期:2011-04-01 00:00:00
abstract::The International Society of Hypertension (ISH) has recently developed practice guidelines for the management of hypertension in adults aged ≥18 years. Conceptually, the 2020 ISH Guidelines are closer to the 2018 ESC/ESH Guidelines rather than to the 2017 ACC/AHA Guidelines. The ISH Guidelines have two distinctive fea...
journal_title:European journal of internal medicine
pub_type: 杂志文章,评审
doi:10.1016/j.ejim.2020.09.001
更新日期:2020-12-01 00:00:00
abstract:BACKGROUND:The activation of complement system is associated with the development of hepatitis B virus-associated membranous nephropathy (HBV-MN) and heparin could inhibit the activation of complement system. METHODS:This was a three-center trial. Seventy-nine patients with HBV-MN participated in the study. The follow...
journal_title:European journal of internal medicine
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.ejim.2016.04.017
更新日期:2016-07-01 00:00:00
abstract:BACKGROUND:Penicillamine (PA) treatment may be associated with a wide spectrum of adverse effects. There are many case reports and small series of PA-induced nephrotic syndrome (NS). In addition to our patient, in this study, we review all the cases of NS due to PA treatment in the English literature. METHODS:A retros...
journal_title:European journal of internal medicine
pub_type: 杂志文章
doi:10.1016/j.ejim.2006.03.001
更新日期:2006-08-01 00:00:00
abstract:BACKGROUND:Acute kidney injury (AKI) is a serious complication in patients hospitalized for decompensated heart failure (HF). Currently, AKI definitions consider creatinine levels at admission as reference of baseline renal function (RF). However, renal impairment may already be present at admission. We aimed to study ...
journal_title:European journal of internal medicine
pub_type: 杂志文章
doi:10.1016/j.ejim.2020.02.028
更新日期:2020-07-01 00:00:00
abstract::Biologics embrace a wide range of substances synthesized by cells or living organisms by means of different biological processes, including recombinant DNA technology, controlled gene expression, or antibody technologies. A biosimilar establishes similarity to the reference medicinal product in terms of quality charac...
journal_title:European journal of internal medicine
pub_type: 杂志文章
doi:10.1016/j.ejim.2016.06.005
更新日期:2016-09-01 00:00:00
abstract::BACKGROUND: Tests able to help in the diagnostic work-up of pleural exudates are needed. C-reactive protein (CRP) may be useful for distinguishing between benign and malignant exudates. METHODS: A total of 123 consecutive patients diagnosed as having exudative pleural effusion (60 associated with malignancy and 63 ben...
journal_title:European journal of internal medicine
pub_type: 杂志文章
doi:10.1016/s0953-6205(02)00036-5
更新日期:2002-06-01 00:00:00
abstract:AIM:To describe trends in the incidence and outcomes of community-acquired pneumonia (CAP) hospitalizations in Spain (2004-2013). METHODS:We used national hospital discharge data to select all hospital admissions for CAP as primary diagnosis. We analyzed incidence, Charlson comorbidity index (CCI), diagnostic and ther...
journal_title:European journal of internal medicine
pub_type: 杂志文章,多中心研究
doi:10.1016/j.ejim.2016.12.010
更新日期:2017-05-01 00:00:00