Abstract：
:The rising number of clinical guidelines poses a new challenge to the internists. The main problems are: 1) available documents suffer from heterogeneous methodological quality, and 2) most of clinical guidelines target an 'ideal' patient affected by a single condition, while in real practice internists must face with comorbid patients typically undergoing a polypharmacy. To help address this challenge, EFIM Clinical Practice Working Group started a project aimed to answer a series of relevant clinical questions, by selecting the best available guidance containing recommendations applicable to complex patients under polypharmacy. The project started with the creation of a research protocol containing details about all the steps needed to write the Clinical Practice Guideline Summary. In particular, this methodological document specifies the rules: 1) to select topics and clinical questions; 2) to build up a panel of experts, carefully managing eventual conflict of interests; 3) to critically appraise clinical guidelines (using a validated tool as AGREE II), selecting the most valid and applicable to the common clinical practice (using ADAPTE; 4) to address and solve potential disagreements among the selected documents.
journal_name
Eur J Intern Medjournal_title
European journal of internal medicineauthors
Leśniak W,Morbidoni L,Dicker D,Marín-León I,EFIM.doi
10.1016/j.ejim.2020.05.016subject
Has Abstractpub_date
2020-07-01 00:00:00pages
1-5eissn
0953-6205issn
1879-0828pii
S0953-6205(20)30202-8journal_volume
77pub_type
杂志文章abstract：BACKGROUND:Diabetic patients with renal disease have increased mortality, largely from cardiovascular disease. This could be related to insulin resistance or to other inherited factors. The aim of the present study was to investigate whether there is evidence of the familial aggregation of increased mortality, even in ...
journal_title：European journal of internal medicine
pub_type： 杂志文章
doi：10.1016/j.ejim.2005.07.005
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abstract：BACKGROUND:In bromocriptine-treated hyperprolactinemic patients with impaired glucose tolerance, metformin was found to reduce plasma levels of prolactin. No previous study has investigated its impact on plasma prolactin in patients with drug-induced hyperprolactinemia. METHODS:The study included 20 women with antipsy...
journal_title：European journal of internal medicine
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abstract：:Inflammatory pseudotumor (IP) is a disorder that constitutes a differential diagnosis of a series of clinical conditions due to a large spectrum of manifestations in presentation since it can involve any organ of the human body. Its basic characteristic is the appearance of inflammatory masses whose symptoms depend on...
journal_title：European journal of internal medicine
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abstract：BACKGROUND:Pneumonia with respiratory failure represents the main cause of death in COVID-19, where hyper inflammation plays an important role in lung damage. This study aims to evaluate if tocilizumab, an anti-soluble IL-6 receptor monoclonal antibody, reduces patients' mortality. METHODS:85 consecutive patients admi...
journal_title：European journal of internal medicine
pub_type： 杂志文章
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abstract：STUDY OBJECTIVE:Early risk stratification of septic patients presenting to the emergency department (ED) is challenging. The aim of the study was to evaluate the prognostic role of plasmatic sodium level (PNa+) derangements at ED presentation in septic patients. METHODS:According to PNa+ at ED presentation patients we...
journal_title：European journal of internal medicine
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更新日期：2021-01-01 00:00:00
abstract：BACKGROUND:The relationship between kidney function and blood pressure (BP) components has been studied in chronic kidney disease patients. Whether cystatin C, a marker of kidney function, is associated in the normal range with systolic BP (SBP), diastolic BP (DBP), and pulse pressure (PP) obtained using ambulatory blo...
journal_title：European journal of internal medicine
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abstract：BACKGROUND:Data on the prevalence of hepatitis C virus (HCV) infection in Italy are outdated and usually derived from studying residents in small towns. METHODS:To assess prevalence of and risk factors for HCV infection among Italian residents in 5 metropolitan areas, subjects ≥20 years of age were randomly selected f...
journal_title：European journal of internal medicine
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doi：10.1016/j.ejim.2018.02.015
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abstract：INTRODUCTION:Patients with chronic hepatitis C (CHC) and end-stage renal disease (ESRD) on dialysis are difficult to treat and show higher dropout rates during treatment. The aim of this study was to analyze the treatment outcomes in patients with CHC and underlying end-stage renal disease on dialysis in Korea. METHOD...
journal_title：European journal of internal medicine
pub_type： 杂志文章,多中心研究
doi：10.1016/j.ejim.2015.03.011
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abstract：:Stroke is the most frequent neurological disease and represents a continuously evolving medical and social problem. Chronic kidney disease (CKD) is also an important worldwide public health problem. Renal dysfunction carries a substantial risk of cardiovascular morbidity and mortality and an independent, graded associ...
journal_title：European journal of internal medicine
pub_type： 杂志文章,评审
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abstract：BACKGROUND:Periodontal disease is prevalent in asthmatics, but it is unclear whether periodontal treatment plays a role in adverse respiratory events in these patients. We evaluated risk of hospitalization for adverse respiratory events (acute exacerbation, pneumonia, and acute respiratory failure) and mortality in ast...
journal_title：European journal of internal medicine
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journal_title：European journal of internal medicine
pub_type： 杂志文章
doi：10.1016/j.ejim.2019.08.001
更新日期：2019-10-01 00:00:00
abstract：:Atypical hemolytic uremic syndrome (aHUS) is a devastating form of renal thrombotic microangiopathy. In the last five years, we have finally witnessed a dramatic improvement in the management of aHUS patients, and three breakthroughs in our understanding of aHUS have led to such an improvement. The first breakthrough ...
journal_title：European journal of internal medicine
pub_type： 杂志文章,评审
doi：10.1016/j.ejim.2013.05.008
更新日期：2013-09-01 00:00:00
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journal_title：European journal of internal medicine
pub_type： 杂志文章
doi：10.1016/s0953-6205(01)00134-0
更新日期：2001-07-01 00:00:00
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journal_title：European journal of internal medicine
pub_type： 杂志文章
doi：10.1016/j.ejim.2014.10.021
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journal_title：European journal of internal medicine
pub_type： 杂志文章
doi：10.1016/j.ejim.2006.11.006
更新日期：2007-05-01 00:00:00
abstract：BACKGROUND:There is a lack of information on long term complications of patients with pulmonary embolism (PE), including chronic complaints of dyspnea. METHODS:Consecutive patients with a prior diagnosis of acute PE and an age and gender matched control group with no medical history of PE were presented with a questio...
journal_title：European journal of internal medicine
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doi：10.1016/j.ejim.2008.02.006
更新日期：2008-12-01 00:00:00
abstract：:A 50-year-old man with no medical history was admitted because of progressive respiratory distress, aseptic meningitis, disseminated intravascular coagulation, cholestatic hepatitis, and renal failure. Mycoplasma pneumoniae infection was confirmed serologically. The patient was treated with erythromycin and showed a f...
journal_title：European journal of internal medicine
pub_type： 杂志文章
doi：10.1016/s0953-6205(03)00102-x
更新日期：2003-08-01 00:00:00
abstract：BACKGROUND AND AIM:Chronic kidney disease (CKD) and cardiovascular disease are closely interrelated and the presence of one condition synergistically affects the prognosis of the other, in a negative manner. There are surprisingly very few data on the relationship between baseline coronary artery disease (CAD) severity...
journal_title：European journal of internal medicine
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abstract：BACKGROUND:The health status of patients with sarcoidosis has rarely been studied, despite the increasing numbers of health-related quality of life publications on other respiratory diseases. The aim of this cross-sectional study was to investigate whether sarcoidosis affects quality of life (QoL), using specifically d...
journal_title：European journal of internal medicine
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doi：10.1016/j.ejim.2006.02.024
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abstract：BACKGROUND/AIM:The spontaneous preterm birth (SPB) rates in a group of HBeAg-negative chronic HBV infected pregnant women without several known risk factors for preterm delivery as well as the mother to infant HBV transmission rates was evaluated. Moreover the role of maternal data during perinatal period as well as th...
journal_title：European journal of internal medicine
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journal_title：European journal of internal medicine
pub_type： 杂志文章
doi：10.1016/j.ejim.2003.09.001
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journal_title：European journal of internal medicine
pub_type： 杂志文章,评审
doi：10.1016/j.ejim.2013.02.005
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abstract：:Approximately 30% of patients with chronic HCV infection show persistently normal ALT levels. Although formerly referred to as 'healthy' or 'asymptomatic' HCV carriers, and thus historically excluded from antiviral treatment, it has now become clear that the majority of these patients have some degree of histological ...
journal_title：European journal of internal medicine
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更新日期：2010-04-01 00:00:00
abstract：BACKGROUND:Cardiovascular disease is a leading cause of long-term mortality after liver transplantation (LT). Life long immunosuppression harbors the risk of metabolic alterations. We aimed to analyze the impact of calcineurin (CNI)-only containing regimen (group A) compared to mTOR-containing regimen (group B) on lipi...
journal_title：European journal of internal medicine
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更新日期：2016-04-01 00:00:00
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journal_title：European journal of internal medicine
pub_type： 杂志文章
doi：10.1016/s0953-6205(01)00189-3
更新日期：2002-02-01 00:00:00
abstract：BACKGROUND:One of the candidate genes for susceptibility to Graves' disease (GD) is cytotoxic T lymphocyte-associated molecule-4 (CTLA-4), a negative regulator of T-cell activation. In order to elucidate the relationship of GD with the A/G polymorphism in exon 1 and the C/T polymorphism in the promoter region of the CT...
journal_title：European journal of internal medicine
pub_type： 杂志文章
doi：10.1016/j.ejim.2005.06.007
更新日期：2005-09-01 00:00:00
abstract：BACKGROUND:Few data on patterns of care and outcomes are available for elderly patients with diffuse large B-cell lymphoma (DLBCL) outside of clinical trials. METHODS:We identified patients with DLBCL older than 60 years from a regional cancer registry between 2000 and 2010. Based on registry data and chart review, 12...
journal_title：European journal of internal medicine
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journal_title：European journal of internal medicine
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journal_title：European journal of internal medicine
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更新日期：2015-09-01 00:00:00
abstract：BACKGROUND AND PURPOSE:Sex related differences in cardiovascular disease and stroke are issues of increasing interest. The aim of this study was to evaluate for sex differences in clinical presentation, severity of stroke and outcome in a population of patients admitted to 4 public and 1 private hospitals in three diff...
journal_title：European journal of internal medicine
pub_type： 杂志文章,多中心研究
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更新日期：2013-03-01 00:00:00
