Abstract:
BACKGROUND:There is a lack of information on long term complications of patients with pulmonary embolism (PE), including chronic complaints of dyspnea. METHODS:Consecutive patients with a prior diagnosis of acute PE and an age and gender matched control group with no medical history of PE were presented with a questionnaire, designed to establish the presence, severity and possible causes of dyspnea in the clinical course of PE. RESULTS:The questionnaire was taken in 48 PE-survivors 40+/-7.4 months after PE; 27 patients (56%) had complaints of dyspnea. Sixteen (35%) were categorized as NYHA class II, 6 (13%) as class III and 5 (10%) as class IV. Overall, 19 patients (70%) had new or worsened complaints after PE. The study included 61 controls. Corrected for gender, age and medical history, the control group was significantly less dyspnoeic compared to the PE survivors (p<0.001). Corrected for gender and age, patients were 4 times more often in NYHA class II (OR 3.6 95%CI 1.4-9.7) and 7-fold more often in NYHA class III or IV (OR 6.5 95%CI 1.7-24), both compared to control subjects. CONCLUSION:A large percentage of patients with prior PE have persistent complaints of dyspnea at long term follow-up. The majority of them developed new or worsened dyspnea after the thrombo-embolic event. In comparison to a control population without a medical history of VTE, PE patients were overall significantly more dyspnoeic. An explanation for this phenomenon needs to be studied in further functional work-up of these patients.
journal_name
Eur J Intern Medjournal_title
European journal of internal medicineauthors
Klok FA,Tijmensen JE,Haeck ML,van Kralingen KW,Huisman MVdoi
10.1016/j.ejim.2008.02.006subject
Has Abstractpub_date
2008-12-01 00:00:00pages
625-9issue
8eissn
0953-6205issn
1879-0828pii
S0953-6205(08)00098-8journal_volume
19pub_type
杂志文章abstract:BACKGROUND:Pneumonia with respiratory failure represents the main cause of death in COVID-19, where hyper inflammation plays an important role in lung damage. This study aims to evaluate if tocilizumab, an anti-soluble IL-6 receptor monoclonal antibody, reduces patients' mortality. METHODS:85 consecutive patients admi...
journal_title:European journal of internal medicine
pub_type: 杂志文章
doi:10.1016/j.ejim.2020.05.009
更新日期:2020-06-01 00:00:00
abstract::Background: We investigated circulating relaxin (RLX) and its potential role in human congestive heart failure (CHF) at rest and after physical exercise. Methods: A total of 10 healthy controls and 35 patients with stable CHF were enrolled in the study. Results: RLX plasma concentrations at rest and after exercise wer...
journal_title:European journal of internal medicine
pub_type: 杂志文章
doi:10.1016/j.ejim.2003.11.009
更新日期:2004-02-01 00:00:00
abstract::Background: Essential mixed cryoglobulinemia (EMC) is a systemic disease frequently associated with chronic viral hepatitis. This study was conducted in order to assess the prevalence of EMC in patients with hepatitis B virus (HBV) or hepatitis C virus (HCV) infections. We also evaluated the possible associations of E...
journal_title:European journal of internal medicine
pub_type: 杂志文章
doi:10.1016/s0953-6205(01)00151-0
更新日期:2001-09-01 00:00:00
abstract:BACKGROUND:inferior vena cava filters (IVCF) are widely used to prevent thromboembolic events in patients not suitable for anticoagulation (AC). Although new generations of filters are optional and therefore retrievable, most of them become permanent. Aim of our study was to evaluate real life IVCF management in a tert...
journal_title:European journal of internal medicine
pub_type: 杂志文章
doi:10.1016/j.ejim.2020.01.025
更新日期:2020-06-01 00:00:00
abstract::There is growing evidence suggesting a causative relationship between adrenal adenomas and metabolic and cardiovascular deteriorations. Although demonstrated frequently in subjects with subclinical Cushing Syndrome, subjects with non-functioning adrenal adenomas feature a variety of metabolic and cardiovascular conseq...
journal_title:European journal of internal medicine
pub_type: 杂志文章,评审
doi:10.1016/j.ejim.2013.02.005
更新日期:2013-09-01 00:00:00
abstract:BACKGROUND:There are ethnic differences in the incidence of venous thromboembolism. This is the first nationwide study to examine whether there is an association between country of birth in first-generation immigrants and first hospitalisation for venous thrombosis (VT) and pulmonary embolism (PE), and to study whether...
journal_title:European journal of internal medicine
pub_type: 杂志文章
doi:10.1016/j.ejim.2011.07.015
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:Prognostic factors of mortality in elderly patients with dementia with aspiration pneumonia (AP) are scarcely known. We determined the mortality rate and prognostic factors in old patients with dementia hospitalized due to AP. METHODS:We prospectively studied 120 consecutive patients aged ≥ 75 years with de...
journal_title:European journal of internal medicine
pub_type: 杂志文章
doi:10.1016/j.ejim.2012.08.006
更新日期:2012-12-01 00:00:00
abstract:BACKGROUND:Hyperuricemia prognostic impact on clinical outcomes in chronic heart failure (HF) patients has been investigated with inconclusive results. OBJECTIVES:Aim of the study was to evaluate the prognostic impact of serum uric acid (SUA) on long-term clinical outcomes in HF. METHODS:An analysis of MECKI (Metabol...
journal_title:European journal of internal medicine
pub_type: 杂志文章
doi:10.1016/j.ejim.2019.11.003
更新日期:2020-02-01 00:00:00
abstract:OBJECTIVE:Left ventricular (LV) dysfunction is a predictor of mortality in patients with sepsis. However, whether the adverse impact of LV dysfunction depends on fluid balance remains unclear. We retrospectively investigated the impact of LV dysfunction and fluid balance on various outcomes of patients with sepsis. ME...
journal_title:European journal of internal medicine
pub_type: 杂志文章
doi:10.1016/j.ejim.2019.11.019
更新日期:2020-04-01 00:00:00
abstract::We report two patients with isolated bone marrow non-Hodgkin's lymphoma and we review the additional 23 cases thus far described. Bicytopenia or pancytopenia and an elevated erythrocyte sedimentation rate were universally present. Some 84% of the patients manifested fever of unknown origin (FUO), 64% constitutional sy...
journal_title:European journal of internal medicine
pub_type: 杂志文章
doi:10.1016/s0953-6205(02)00216-9
更新日期:2003-03-01 00:00:00
abstract:BACKGROUND:The association between exacerbation of heart failure (HF) and use of non-steroidal anti-inflammatory drugs (NSAIDs) has long been recognized but the data on this adverse effect are limited. METHODS:To further characterize this possible association, we conducted a systematic review and meta-analysis of obse...
journal_title:European journal of internal medicine
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.ejim.2015.09.012
更新日期:2015-11-01 00:00:00
abstract:BACKGROUND:The aims of this study were to evaluate the quality of oral anticoagulation (OAC) in AF patients in the practices of general practitioners (GPs) in Germany and to investigate possible causal factors which influence OAC quality. METHODS:We conducted a multi-center, non-interventional, prospective observation...
journal_title:European journal of internal medicine
pub_type: 杂志文章,多中心研究
doi:10.1016/j.ejim.2013.12.013
更新日期:2014-03-01 00:00:00
abstract:BACKGROUND:To assess the prevalence of decreased iron stores and anemia in pregnant women. To determine whether the risk factors: socio-demographic background, age, BMI, and parity are associated with abnormal hemoglobin concentrations and/or abnormal iron status. METHODS:A longitudinal study was carried out at the De...
journal_title:European journal of internal medicine
pub_type: 杂志文章
doi:10.1016/j.ejim.2012.04.008
更新日期:2012-09-01 00:00:00
abstract::Fasciitis-panniculitis syndrome (FPS) is a condition characterized by inflammation of the subcutaneous cellular tissue, the aponeurosis and, eventually, the muscles. A 49-year-old female who was previously diagnosed as having retroperitoneal fibrosis presented recurrent episodes of intermittent inflammation of her lim...
journal_title:European journal of internal medicine
pub_type: 杂志文章
doi:10.1016/j.ejim.2006.09.025
更新日期:2007-05-01 00:00:00
abstract:BACKGROUND:Anemia may have important deleterious effects on patients with heart failure. We investigated the presence and causes of anemia among patients admitted because of new-onset congestive heart failure. The prognostic value of anemia was also evaluated. METHODS:We evaluated the presence of anemia, which was def...
journal_title:European journal of internal medicine
pub_type: 杂志文章
doi:10.1016/j.ejim.2005.11.015
更新日期:2006-05-01 00:00:00
abstract::The management of arterial hypertension is very challenging in everyday clinical practice. Blood pressure control rates remain disappointingly low, despite intense efforts. Poor adherence to antihypertensive treatment is among the main causes of inadequate blood pressure control. Among the various parameters leading t...
journal_title:European journal of internal medicine
pub_type: 杂志文章,评审
doi:10.1016/j.ejim.2020.07.009
更新日期:2020-11-01 00:00:00
abstract:OBJECTIVE:The use of commercially available noninvasive markers for chronic hepatitis B (CHB) related fibrosis is not widely available in developing countries so clinicians in those countries frequently use free alternatives. We aimed to create an optimized algorithm for selection of patients with the highest probabili...
journal_title:European journal of internal medicine
pub_type: 杂志文章
doi:10.1016/j.ejim.2015.07.005
更新日期:2015-10-01 00:00:00
abstract::Kingella kingae is an aerobic gram-negative coccobacillus that has been associated predominantly with bone and joint infection but also with septicemia and endocarditis. Until now, only four cases of proven K. kingae meningitis have been reported. We describe a case of a K. kingae meningitis in a male adolescent who p...
journal_title:European journal of internal medicine
pub_type: 杂志文章
doi:10.1016/s0953-6205(00)00115-1
更新日期:2000-12-20 00:00:00
abstract:OBJECTIVE:This work aims to evaluate the Minimum Basic Data Set (MBDS) as a data source in the detection of malignant tumors and explore its usefulness as a tool for epidemiological surveillance of cancer. MATERIALS AND METHODS:MBDS hospital data discharge from Prince of Asturias University Hospital (HUPA, Alcalá de H...
journal_title:European journal of internal medicine
pub_type: 杂志文章
doi:10.1016/j.ejim.2016.06.038
更新日期:2016-10-01 00:00:00
abstract:BACKGROUND:To describe the clinical characteristics and evolution of a series of adult patients hospitalized for neuro-Behçet disease (NBD). METHODS:Consecutive patients admitted for NBD in a teaching hospital were retrospectively selected. Disability at discharge and during follow-up was graded with the modified Rank...
journal_title:European journal of internal medicine
pub_type: 杂志文章
doi:10.1016/j.ejim.2010.08.003
更新日期:2010-12-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:There is some evidence to suggest that exercise systolic blood pressure (SBP) may be associated with future risk of stroke in subjects without a history of coronary artery disease (CAD). However, the value of an exaggerated exercise SBP response (EESBPR) for predicting stroke in patients referred ...
journal_title:European journal of internal medicine
pub_type: 杂志文章
doi:10.1016/j.ejim.2014.05.013
更新日期:2014-07-01 00:00:00
abstract:BACKGROUND:Tachycardia is a reliable predictor of adverse outcomes in normotensive patients with acute pulmonary embolism (PE). However, different prognostic relevant heart rate thresholds have been proposed. The aim of the study was to investigate the prognostic performance of different thresholds used for defining ta...
journal_title:European journal of internal medicine
pub_type: 杂志文章
doi:10.1016/j.ejim.2020.08.009
更新日期:2020-12-01 00:00:00
abstract::BACKGROUND: Plasma total homocysteine (p-tHcy) is considered to be an independent risk factor for atherosclerotic vascular disease. This cross-sectional study was undertaken to examine p-tHcy levels and their relationship to coronary artery disease (CAD) and alcohol intake. METHODS: We consecutively studied 291 patien...
journal_title:European journal of internal medicine
pub_type: 杂志文章
doi:10.1016/s0953-6205(03)00069-4
更新日期:2003-07-01 00:00:00
abstract::The atherothrombotic conditions, coronary artery disease, cerebrovascular disease and peripheral arterial disease (PAD), together account for almost one-half of all deaths in Europe each year; however, perception of the specific risks associated with PAD is generally poor compared with its related conditions. PAD is n...
journal_title:European journal of internal medicine
pub_type: 杂志文章,评审
doi:10.1016/j.ejim.2008.09.013
更新日期:2009-03-01 00:00:00
abstract:BACKGROUND:Iron deficiency anaemia is associated with gastrointestinal (GI) malignancy and is an indication for GI investigations. However, the relevance of iron deficiency without anaemia (IDWA) and the underlying risks of GI malignancy are uncertain. Therefore, the aim of this study was to estimate the prevalence of ...
journal_title:European journal of internal medicine
pub_type: 杂志文章,评审
doi:10.1016/j.ejim.2019.12.015
更新日期:2020-02-01 00:00:00
abstract:BACKGROUND:Bleeding assessment tools (BATs) have been developed to quantify bleeding severity. Their ability to predict for the diagnosis of a bleeding disorder has not been thoroughly investigated. OBJECTIVES:To evaluate the ability of the Vicenza BAT and the ISTH BAT to distinguish patients with an established bleed...
journal_title:European journal of internal medicine
pub_type: 杂志文章
doi:10.1016/j.ejim.2020.04.023
更新日期:2020-08-01 00:00:00
abstract::BACKGROUND: Foreign graduate residents in internal medicine perform poorly on the Israeli phase I written board examination as compared to local graduates from Israeli medical schools. The aim of this study was to determine the effect of a preparatory course, aimed at foreign graduates, on their success rate in the Is...
journal_title:European journal of internal medicine
pub_type: 杂志文章
doi:10.1016/j.ejim.2004.12.002
更新日期:2005-06-01 00:00:00
abstract:BACKGROUND:While the promotion of health-related fitness is thereby widespread, less focus is currently being given on the biological influence that physical activity might exert on results of laboratory testing. As such, this study was undertaken to assess the kinetics of liver injury markers following physical exerci...
journal_title:European journal of internal medicine
pub_type: 杂志文章
doi:10.1016/j.ejim.2011.02.007
更新日期:2011-10-01 00:00:00
abstract::The use of D-dimer in combination with a clinical decision rule has been widely investigated in pulmonary embolism and deep venous thrombosis. Although it has been shown to be safe in excluding venous thromboembolism, the clinician is often faced with specific situations in which the use of D-dimer is controversial. W...
journal_title:European journal of internal medicine
pub_type: 杂志文章,评审
doi:10.1016/j.ejim.2008.12.004
更新日期:2009-09-01 00:00:00
abstract:AIM:To assess whether in individuals aged 80years or older adherence to statins is accompanied by a reduced risk of all-cause mortality and major cardiovascular events. METHODS:A nested case-control study was carried out on a cohort of patients aged 80years or older (very elderly individuals), who were under treatment...
journal_title:European journal of internal medicine
pub_type: 杂志文章
doi:10.1016/j.ejim.2017.09.023
更新日期:2018-01-01 00:00:00