Abstract:
OBJECTIVE:The use of commercially available noninvasive markers for chronic hepatitis B (CHB) related fibrosis is not widely available in developing countries so clinicians in those countries frequently use free alternatives. We aimed to create an optimized algorithm for selection of patients with the highest probability for presence/absence of significant liver fibrosis and cirrhosis based on the use of multiple free scores. METHODS:We evaluated six free noninvasive markers for CHB related fibrosis against liver biopsy and selected the best thresholds for prediction/exclusion of significant fibrosis and cirrhosis in CHB patients. Algorithm based on four scores and their corresponding thresholds was created. RESULTS:The calculator based on developed algorithm can be found at http://www.chb-lfc.com. We evaluated 211 patients in main group and 65 patients in external validation group. We selected four scores for creation of combination algorithm. The algorithm was able to classify 123/211 (58.3%) patients with a 93.5% accuracy of correct classification for prediction of presence/absence of significant fibrosis in main group. In validation group, the algorithm was able to classify 48/65 (73.8%) of patients with 93.8% (45/48) overall accuracy. When used to predict presence/absence of cirrhosis, the algorithm was able to correctly classify 181/211 (85.8%) and 59/65 (90.8%) of patients in main and validation group, respectively, with an overall accuracy of 97.8% and 98.3%, respectively. CONCLUSION:Developed algorithm based on routine laboratory tests is a usable, applicable and accurate tool for diagnosis of CHB related fibrosis and cirrhosis, suitable for resource-limited settings where more expensive modalities are unavailable.
journal_name
Eur J Intern Medjournal_title
European journal of internal medicineauthors
Salkic NN,Cickusic E,Jovanovic P,Denjagic MB,Iljazovic-Topcic S,Bevanda M,Ahmetagic Sdoi
10.1016/j.ejim.2015.07.005subject
Has Abstractpub_date
2015-10-01 00:00:00pages
628-34issue
8eissn
0953-6205issn
1879-0828pii
S0953-6205(15)00231-9journal_volume
26pub_type
杂志文章abstract:BACKGROUND:Few data on patterns of care and outcomes are available for elderly patients with diffuse large B-cell lymphoma (DLBCL) outside of clinical trials. METHODS:We identified patients with DLBCL older than 60 years from a regional cancer registry between 2000 and 2010. Based on registry data and chart review, 12...
journal_title:European journal of internal medicine
pub_type: 杂志文章
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abstract:BACKGROUND:Nephropathia epidemica (NE), caused by Puumala virus (PUUV), is characterized by acute kidney injury (AKI) and thrombocytopenia. Cardiac involvement with electrocardiographic (ECG) abnormalities has been previously reported in NE; however, its prognostic value is unknown. Relative bradycardia is an important...
journal_title:European journal of internal medicine
pub_type: 杂志文章
doi:10.1016/j.ejim.2016.06.001
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abstract::Background: It is unclear whether methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-sensitive S. aureus (MSSA) differ in virulence. We therefore carried out a prospective study of cases of S. aureus bacteremia over a period of 2 years at our university hospital. We report herein the results of a compa...
journal_title:European journal of internal medicine
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abstract:BACKGROUND:We tested our hypothesis that serum BNP levels rise in sepsis and septic shock patients as a result of an inflammatory state and not only because of left ventricular dysfunction. METHODS:Twenty-one patients with sepsis or septic shock were enrolled in the study. Echocardiography was performed in every patie...
journal_title:European journal of internal medicine
pub_type: 杂志文章
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abstract::Background: We recently observed that a short course of trimethoprim 300 mg b.i.d. in healthy volunteers can cause a substantial increase in fasting plasma homocysteine levels, up to concentrations reportedly associated with atherothrombotic complications. The purpose of this study was to determine whether primary Pne...
journal_title:European journal of internal medicine
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journal_title:European journal of internal medicine
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abstract:OBJECTIVE OF THE STUDY:To report on the results of two projects on chronic hepatitis B in Western Balkans lead by Ioannina, Northwest Greece and Tirana, Albania. METHODS:In two prospective projects, HEPAGA I and HEPAGA II which lasted 4 years. In HEPAGA I, serum samples from 410 Albanians were tested for HBV. In HEPAG...
journal_title:European journal of internal medicine
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abstract:BACKGROUND:Patients with multiple myeloma (MM) manifesting acute kidney injury (AKI) and who later recover renal function and independence from renal replacement therapy (RRT) are considered to have a better outcome. The aim of this work was to study the factors associated with renal function recovery (independence of ...
journal_title:European journal of internal medicine
pub_type: 杂志文章
doi:10.1016/j.ejim.2014.06.023
更新日期:2014-09-01 00:00:00
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journal_title:European journal of internal medicine
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journal_title:European journal of internal medicine
pub_type: 杂志文章
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更新日期:2007-10-01 00:00:00
abstract:INTRODUCTION:Patients with chronic hepatitis C (CHC) and end-stage renal disease (ESRD) on dialysis are difficult to treat and show higher dropout rates during treatment. The aim of this study was to analyze the treatment outcomes in patients with CHC and underlying end-stage renal disease on dialysis in Korea. METHOD...
journal_title:European journal of internal medicine
pub_type: 杂志文章,多中心研究
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abstract::We report the case of a 59-year-old man with a pheochromocytoma in which erectile dysfunction was the main symptom. Erectile function was related to the amount of noradrenaline secreted by the tumor, as was determined when recurrence of the malignancy was diagnosed twice. Erectile function could be restored by lowerin...
journal_title:European journal of internal medicine
pub_type: 杂志文章
doi:10.1016/j.ejim.2007.02.027
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journal_title:European journal of internal medicine
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更新日期:2006-12-01 00:00:00
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journal_title:European journal of internal medicine
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更新日期:2009-09-01 00:00:00
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journal_title:European journal of internal medicine
pub_type: 杂志文章,评审
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journal_title:European journal of internal medicine
pub_type: 杂志文章
doi:10.1016/j.ejim.2013.03.015
更新日期:2013-10-01 00:00:00
abstract::The endocannabinoid system is involved in many areas of physiological function and homeostasis. Cannabinoid receptors are expressed in the peripheral and central nervous system and on immune cells, all areas ideally suited to modulation of pain processing. There are a wealth of preclinical data in a number of acute, c...
journal_title:European journal of internal medicine
pub_type: 杂志文章,评审
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更新日期:2018-03-01 00:00:00
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journal_title:European journal of internal medicine
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doi:10.1016/j.ejim.2004.11.012
更新日期:2005-08-01 00:00:00
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journal_title:European journal of internal medicine
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journal_title:European journal of internal medicine
pub_type: 杂志文章
doi:10.1016/j.ejim.2011.10.006
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journal_title:European journal of internal medicine
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更新日期:2006-11-01 00:00:00
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journal_title:European journal of internal medicine
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更新日期:2015-07-01 00:00:00
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journal_title:European journal of internal medicine
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更新日期:2013-04-01 00:00:00
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journal_title:European journal of internal medicine
pub_type: 杂志文章
doi:10.1016/j.ejim.2008.09.001
更新日期:2009-05-01 00:00:00
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journal_title:European journal of internal medicine
pub_type: 杂志文章
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更新日期:2015-10-01 00:00:00
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journal_title:European journal of internal medicine
pub_type: 杂志文章
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更新日期:2020-04-01 00:00:00
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journal_title:European journal of internal medicine
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更新日期:2016-03-01 00:00:00
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journal_title:European journal of internal medicine
pub_type: 杂志文章
doi:10.1016/s0953-6205(03)00102-x
更新日期:2003-08-01 00:00:00
abstract:BACKGROUNDS/AIMS:Nephrotic dyslipidemia is a risk factor for development of systemic atherosclerosis; also it may aggravate glomerulosclerosis and enhance progression of glomerular disease. We aimed to assess the efficacy and safety of Monascus purpureus Went rice vs. fluvastatin therapy in the management of nephrotic ...
journal_title:European journal of internal medicine
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.ejim.2008.08.012
更新日期:2009-05-01 00:00:00