Abstract：
BACKGROUND:Diabetes mellitus can cause a wide variety of vascular complications and it is one of the major risk factors for cardiovascular diseases (CVD). High glucose can induce vascular endothelial cell apoptosis. In this study, we investigated the effect of radix hedysari polysaccharide (HPS) on the depression of apoptosis of human umbilical vein endothelial cells (HUVECs) induced by high glucose. METHODS:HUVECs were treated with media containing 30 mM glucose in the presence or absence of vitamin C or HPS. The level of intracellular reactive oxygen species (ROS) and apoptosis of HUVECs was measured with flow cytometry. Expression of c-Jun NH(2)-terminal kinase (JNK) and caspase-3 were testified by real-time quantitative RT-PCR and immunofluorescence. RESULTS:High glucose was capable of eliciting the overexpression of JNK during the treatment procedure. Moreover, we found that the caspase-3 became overexpressed in apoptosis induced by high glucose; HPS could inhibit apoptosis under high glucose and suppress the generation of ROS and the overexpression of JNK and caspase-3. The effect of HPS on ROS quenching, inhibition of JNK and caspase-3 overexpression at the concentration of 100 μg/ml was similar to that of vitamin C at the concentration of 100 μM. CONCLUSION:The findings of the present study may suggest that HPS play a protection role on HUVECs against apoptosis induced by high glucose.
journal_name
Eur J Intern Medjournal_title
European journal of internal medicineauthors
Liu J,Deng W,Fan L,Tian L,Jin L,Jin Z,Guo Q,Xu Y,Li Ndoi
10.1016/j.ejim.2011.10.006subject
Has Abstractpub_date
2012-04-01 00:00:00pages
287-92issue
3eissn
0953-6205issn
1879-0828pii
S0953-6205(11)00238-Xjournal_volume
23pub_type
杂志文章abstract：:Patients with systemic lupus erythematosus (SLE) are frequently immunodepressed making them more vulnerable to infections. Preventive vaccination is therefore warranted but has often been withheld owing to fears of a link between infection and autoimmunity, and the possibility of inducing or exacerbating lupus after v...
journal_title：European journal of internal medicine
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pub_type： 杂志文章,评审
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