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Pre-existing diabetes and risks of morbidity and mortality after liver transplantation: A nationwide database study in an Asian population.

Abstract：

BACKGROUND:Whether diabetes mellitus (DM) is associated with a higher risk of perioperative mortality and mortality after liver transplantation (LTx) remains unclear. METHODS:We compared the risk of postoperative mortality and morbidity in DM and non-DM patients undergoing LTx. We enrolled 558 DM patients who underwent LTx from 2000 to 2010. RESULTS:DM was associated with elevated 90-day risk of post-LTx stroke. Otherwise, the DM cohort did not exhibit significantly higher risks of postoperative morbidities, such as septicemia, pneumonia, and wound infection, than the non-DM cohort. Cox proportional hazards regression model showed that patients with DM with coexisting renal manifestations were at a significantly high risk of 30-day and 90-day postoperative mortality. Further comorbidity stratification analysis showed that DM cohort exhibited higher risk of mortality than the non-DM cohort if the patients had liver cancer, or did not have hypertension, ischemic heart disease, and chronic obstructive pulmonary disease. CONCLUSION:DM is associated with elevated risk of 90-day post-LTx. Moreover, DM patients with coexisting renal manifestations exhibited an increased postoperative risk of mortality after LTx.

journal_name

Eur J Intern Med

journal_title

European journal of internal medicine

authors

Tsai MS,Wang YC,Wang HH,Lee PH,Jeng LB,Kao CH

doi

10.1016/j.ejim.2015.05.010

subject

Has Abstract

pub_date

2015-07-01 00:00:00

pages

433-8

issue

6

eissn

0953-6205

issn

1879-0828

pii

S0953-6205(15)00175-2

journal_volume

26

pub_type

杂志文章

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