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Renal transplant among type 1 and type 2 diabetes patients in Spain: A population-based study from 2002 to 2013.

Abstract：

BACKGROUND:To describe trends in the rates and short-term outcomes of renal transplants (RTx) among patients with or without diabetes in Spain (2002-2013). METHODS:We used national hospital discharge data to select all hospital admissions for RTx. We divided the study period into four three-year periods. Rates were calculated stratified by diabetes status: type 1 diabetes (T1DM), type 2 diabetes (T2DM) and no-diabetes. We analyzed Charlson comorbidity index (CCI), post-transplant infections, in-hospital complications of RTx, rejection, in-hospital mortality and length of hospital stay. FINDINGS:We identified 25,542 RTx. Rates of RTx increased significantly in T2DM patients over time (from 9.3 cases/100,000 in 2002/2004 to 13.3 cases/100,000 in 2011/2013), with higher rates among people with T2DM for all time periods. T2DM patients were older and had higher CCI values than T1DM and non-diabetic patients (CCI≥1, 31.4%, 20.4% and 21.5%, respectively; P<0.05). Time trend analyses showed significant increases in infections, RTx-associated complications and rejection for all groups (all P values<0.05). Infection rates were greater in people with T2DM (20.8%) and T1DM (23.5%) than in non-diabetic people (18.7%; P<0.05). Time trend analyses (2002-2013) showed significant decreases in mortality during admission for RTx (OR 0.75, 95% CI 0.68-0.83). Diabetes was not associated with a higher in-hospital mortality (OR: 1.20, 95% CI 0.92-1.55). INTERPRETATION:RTx rates were higher and increased over time at a higher rate among T2DM patients. Mortality decreased over time in all groups. Diabetes does not predict mortality during admission for RTx. FUNDING:Instituto Salud Carlos III and URJC-Banco Santander.

journal_name

Eur J Intern Med

journal_title

European journal of internal medicine

authors

López-de-Andrés A,de Miguel-Yanes JM,Hernández-Barrera V,Méndez-Bailón M,González-Pascual M,de Miguel-Díez J,Salinero-Fort MA,Pérez-Farinós N,Jiménez-Trujillo I,Jiménez-García R

doi

10.1016/j.ejim.2016.07.031

subject

Has Abstract

pub_date

2017-01-01 00:00:00

pages

64-68

eissn

0953-6205

issn

1879-0828

pii

S0953-6205(16)30239-4

journal_volume

37

pub_type

杂志文章

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