当前位置： SCI文献检索 > European Journal of Internal Medicine期刊下所有文献 > Comparison of the effects of three angiotensin II receptor type 1 blockers on metabolic parameters in hypertensive patients with type 2 diabetes mellitus.

Comparison of the effects of three angiotensin II receptor type 1 blockers on metabolic parameters in hypertensive patients with type 2 diabetes mellitus.

Abstract：

OBJECTIVE:In a previous study involving 18 hypertensive patients with type 2 diabetes mellitus, we found that replacement of valsartan and candesartan by telmisartan significantly improved insulin sensitivity and significantly increased serum adiponectin levels in the patients. We investigated the effects of 3 angiotensin II type 1 receptor blockers (ARBs)-telmisartan, candesartan, and valsartan-on metabolic parameters in hypertensive patients with type 2 diabetes. METHODS:A total of 308 hypertensive patients with diabetes were enrolled in our multicentre, randomized, open-label study. The patients received 40 mg telmisartan, 8 mg candesartan, or 80 mg valsartan for 3 months, and the data of 227 patients (telmisartan: n=74, candesartan: n=79, and valsartan: n=74) were analysed. RESULTS:The systolic and diastolic blood pressures significantly decreased in all the groups at the end of the study; the decrease was comparable among the 3 groups. The changes in fasting plasma glucose, fasting insulin, glycated haemoglobin (HbA1c), total cholesterol, triglyceride, high-density lipoprotein (HDL) cholesterol, adiponectin, free fatty acids, high-sensitivity C-reactive protein (hs-CRP), and plasminogen activator inhibitor-1 (PAI-1) were comparable between the 3 groups. Telmisartan and candesartan administration tended to lower urinary albumin excretion. CONCLUSIONS:Low dose telmisartan had a neutral effect on metabolic dysfunction in hypertensive patients with type 2 diabetes; the effect produced by 40 mg telmisartan was comparable with that of 8 mg candesartan and 80 mg valsartan. Failure to detect metabolic differences among the various ARB treatments could have been due to the low statistical power of the study design.

journal_name

Eur J Intern Med

journal_title

European journal of internal medicine

authors

Ozaki N,Nomura Y,Sobajima H,Kondo K,Oiso Y

doi

10.1016/j.ejim.2010.01.014

subject

Has Abstract

pub_date

2010-06-01 00:00:00

pages

236-9

issue

3

eissn

0953-6205

issn

1879-0828

pii

S0953-6205(10)00017-8

journal_volume

21

pub_type

杂志文章,多中心研究,随机对照试验

相关文献

European Journal of Internal Medicine文献大全
  • Antineutrophil cytoplasmic antibody-associated neutropenia.

    abstract：:BACKGROUND: Antineutrophil cytoplasmic antibodies (ANCA) can be associated with various disorders. However, their association with neutropenia has never been reported. METHODS: Nine patients with chronic unexplained neutropenia and ANCA were studied. Clinical charts were extensively analyzed and all patients underwent...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章

    doi：10.1016/j.ejim.2004.08.009

    authors： Coppo P,Ghez D,Fuentes V,Bengoufa D,Oksenhendler E,Tribout B,Clauvel JP,Lassoued K

    更新日期：2004-11-01 00:00:00

  • Long-term outcome of patients with macroprolactinomas initially treated with dopamine agonists.

    abstract：OBJECTIVE:Dopamine agonists are the first line therapy for the treatment of prolactinomas. The aim of this study was to assess the outcome of macroprolactinomas during long-term follow-up after initial treatment with dopamine agonists. DESIGN:Retrospective follow-up study. PATIENTS:We included 72 consecutive patients...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章

    doi：10.1016/j.ejim.2008.11.012

    authors： Kars M,Pereira AM,Smit JW,Romijn JA

    更新日期：2009-07-01 00:00:00

  • Off-label use of tocilizumab for the treatment of SARS-CoV-2 pneumonia in Milan, Italy.

    abstract：BACKGROUND:Tocilizumab, a humanized monoclonal antibody, targets IL-6 receptors blocking downstream pro-inflammatory effects of IL-6. In preliminary reports it was suggested to be beneficial in patients with severe COVID-19. METHODS:In this open-label prospective study we describe clinical characteristics and outcome ...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章

    doi：10.1016/j.ejim.2020.05.011

    authors： Morena V,Milazzo L,Oreni L,Bestetti G,Fossali T,Bassoli C,Torre A,Cossu MV,Minari C,Ballone E,Perotti A,Mileto D,Niero F,Merli S,Foschi A,Vimercati S,Rizzardini G,Sollima S,Bradanini L,Galimberti L,Colombo R,Mic

    更新日期：2020-06-01 00:00:00

  • The syndrome of rhabdomyolysis: complications and treatment.

    abstract：:Rhabdomyolysis is a syndrome of skeletal muscle cell damage that leads to the release of toxic intracellular material into the systemic circulation. The pathogenesis of rhabdomyolysis is based on an increase in free ionized calcium in the cytoplasm. Its main complications include (a) acute renal failure, which is trig...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章,评审

    doi：10.1016/j.ejim.2007.06.037

    authors： Chatzizisis YS,Misirli G,Hatzitolios AI,Giannoglou GD

    更新日期：2008-12-01 00:00:00

  • Non-alcoholic fatty liver disease, metabolic syndrome and patatin-like phospholipase domain-containing protein3 gene variants.

    abstract：BACKGROUND & AIMS:Non-alcoholic fatty liver disease was traditionally interpreted as a condition which may progress to liver-related complications. However, the increased mortality is primarily a result of cardiovascular diseases. It has been suggested that fatty liver can be considered as the hepatic consequence of th...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章

    doi：10.1016/j.ejim.2014.05.012

    authors： Del Ben M,Polimeni L,Brancorsini M,Di Costanzo A,D'Erasmo L,Baratta F,Loffredo L,Pastori D,Pignatelli P,Violi F,Arca M,Angelico F

    更新日期：2014-07-01 00:00:00

  • Feasibility and safety of multiple daily insulin injections in general medicine wards.

    abstract：AIM:Intravenous insulin improves clinical outcome in patients hospitalized in intensive care units. Whether glucose control with multiple daily subcutaneous insulin injections (MDI) is beneficial in patients hospitalized in general medical wards is unknown. We tested the feasibility, safety and efficacy of glucose cont...

    journal_title：European journal of internal medicine

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.ejim.2008.12.010

    authors： Buchs AE,Bloemers R,Shiloah E,Horowitz M,Aminov S,Ramot Y,Rapoport MJ

    更新日期：2009-07-01 00:00:00

  • Cannabinoids and cancer pain: A new hope or a false dawn?

    abstract：:The endocannabinoid system is involved in many areas of physiological function and homeostasis. Cannabinoid receptors are expressed in the peripheral and central nervous system and on immune cells, all areas ideally suited to modulation of pain processing. There are a wealth of preclinical data in a number of acute, c...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章,评审

    doi：10.1016/j.ejim.2018.01.020

    authors： Brown MRD,Farquhar-Smith WP

    更新日期：2018-03-01 00:00:00

  • Acute respiratory failure due to diaphragmatic weakness revealing a polymyositis.

    abstract：:Of the different respiratory disorders that complicate the course of polymyositis, diaphragmatic weakness is one that is seldom described and most often suspected rather than confirmed. We report a case of severe diaphragmatic weakness as a cause of acute respiratory failure revealing a polymyositis. The diaphragmatic...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章

    doi：10.1016/s0953-6205(02)00015-8

    authors： Dauriat G,Stern JB,Similowski T,Herson S,Belmatoug N,Marceau A,Fantin B,Fournier M,Mal H

    更新日期：2002-05-01 00:00:00

  • Limited prognostic accuracy of the CRB-65 and qSOFA in patients presenting with pneumonia and immunosuppression.

    abstract：BACKGROUND:Scores for risk prediction used in immunocompetent patients with sepsis or pneumonia are poorly evaluated in immunocompromised patients. Therefore, we evaluated the prognostic value of the qSOFA- and CRB-65-criteria in immunocompromised patients presenting with pneumonia. METHODS:Retrospective cohort study ...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章

    doi：10.1016/j.ejim.2020.08.006

    authors： Frantz S,Schulte-Hubbert B,Halank M,Koschel D,Kolditz M

    更新日期：2020-11-01 00:00:00

  • Association of a DNA polymorphism of the apolipoprotein AI-CIII-AIV gene cluster with myocardial infarction in a Tunisian population.

    abstract：BACKGROUND:Apolipoproteins AI-CIII-AIV play important roles in the metabolism of triglycerides and high-density lipoprotein cholesterol. However, whether genetic variations in the ApoAI-CIII-AIV gene cluster are associated with the risk of myocardial infarction (MI) remains uncertain. In the present study, we examined ...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章

    doi：10.1016/j.ejim.2011.03.002

    authors： Sediri Y,Kallel A,Feki M,Mourali S,Elasmi M,Abdessalem S,Mechmeche R,Jemaa R,Kaabachi N

    更新日期：2011-08-01 00:00:00

  • Venous thromboembolism prophylaxis of acutely ill hospitalized medical patients. Are we under-treating our patients?

    abstract：:Venous thromboembolism (VTE) is frequent in patients hospitalized in Internal Medicine wards. It carries a considerable morbidity and mortality. Recommendations for use of anticoagulation are graded 1A in leading evidence-based consensus guidelines. Implementation of these guidelines is suboptimal. Lack of awareness s...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章

    doi：10.1016/j.ejim.2011.11.005

    authors： Roth-Yelinek B

    更新日期：2012-04-01 00:00:00

  • Interference in free thyroxine immunoassay.

    abstract：:We report two patients who presented with non-specific symptoms of tiredness that prompted their clinician to order a thyroid function test. In both cases, free thyroxine (T4) was reported to be high, with a normal thyroid-stimulating hormone (TSH). Repeated blood tests from the same laboratory using the same assay me...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章

    doi：10.1016/j.ejim.2007.05.009

    authors： Ghosh S,Howlett M,Boag D,Malik I,Collier A

    更新日期：2008-05-01 00:00:00

  • Time trends in incidence and outcomes of hospitalizations for aspiration pneumonia among elderly people in Spain (2003-2013).

    abstract：BACKGROUND:Aspiration pneumonia (AP) is an infectious process causing high rates of mortality. The purpose of this study was: 1, to describe the incidence from 2003 to 2013 of AP hospitalizations; 2, to assess time trends in hospital outcomes variables, and; 3, to identify the factors independently associated with in-h...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章

    doi：10.1016/j.ejim.2016.12.022

    authors： Palacios-Ceña D,Hernández-Barrera V,López-de-Andrés A,Fernández-de-Las-Peñas C,Palacios-Ceña M,de Miguel-Díez J,Carrasco-Garrido P,Jiménez-García R

    更新日期：2017-03-01 00:00:00

  • Pre-existing diabetes and risks of morbidity and mortality after liver transplantation: A nationwide database study in an Asian population.

    abstract：BACKGROUND:Whether diabetes mellitus (DM) is associated with a higher risk of perioperative mortality and mortality after liver transplantation (LTx) remains unclear. METHODS:We compared the risk of postoperative mortality and morbidity in DM and non-DM patients undergoing LTx. We enrolled 558 DM patients who underwen...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章

    doi：10.1016/j.ejim.2015.05.010

    authors： Tsai MS,Wang YC,Wang HH,Lee PH,Jeng LB,Kao CH

    更新日期：2015-07-01 00:00:00

  • Non-steroidal anti-inflammatory drugs and risk of heart failure exacerbation: A systematic review and meta-analysis.

    abstract：BACKGROUND:The association between exacerbation of heart failure (HF) and use of non-steroidal anti-inflammatory drugs (NSAIDs) has long been recognized but the data on this adverse effect are limited. METHODS:To further characterize this possible association, we conducted a systematic review and meta-analysis of obse...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章,meta分析,评审

    doi：10.1016/j.ejim.2015.09.012

    authors： Ungprasert P,Srivali N,Kittanamongkolchai W

    更新日期：2015-11-01 00:00:00

  • Circulating sICAM-1 and sE-Selectin as biomarker of infection and prognosis in patients with systemic inflammatory response syndrome.

    abstract：BACKGROUND:Vascular endothelium activation is a key pathogenic step in systemic inflammatory response syndrome (SIRS) that can be triggered by both microbial and sterile proinflammatory stimuli. The relevance of soluble adhesion molecules as clinical biomarkers to discriminate between infectious and non-infectious SIRS...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章

    doi：10.1016/j.ejim.2012.10.009

    authors： de Pablo R,Monserrat J,Reyes E,Díaz D,Rodríguez-Zapata M,de la Hera A,Prieto A,Álvarez-Mon M

    更新日期：2013-03-01 00:00:00

  • Clinical, biochemical and genetic spectrum of low alkaline phosphatase levels in adults.

    abstract：BACKGROUND:Low serum levels of alkaline phosphatase (ALP) are a hallmark of hypophosphatasia. However, the clinical significance and the underlying genetics of low ALP in unselected populations are unclear. METHODS:In order to clarify this issue, we performed a clinical, biochemical and genetic study of 42 individuals...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章

    doi：10.1016/j.ejim.2015.12.019

    authors： Riancho-Zarrabeitia L,García-Unzueta M,Tenorio JA,Gómez-Gerique JA,Ruiz Pérez VL,Heath KE,Lapunzina P,Riancho JA

    更新日期：2016-04-01 00:00:00

  • Early repolarization syndrome and Brugada syndrome: is there any linkage?

    abstract：:Early repolarization syndrome (ERS) is characterized by the presence, in most cases in mid-to-lateral precordial leads, of a J wave on the downsloping portion of the QRS complex, followed by an elevation of the ST-segment with upward concavity. ERS is considered a benign electrocardiographic pattern of ventricular rep...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章,评审

    doi：10.1016/j.ejim.2007.06.013

    authors： Di Grande A,Tabita V,Lizzio MM,Giuffrida C,Bellanuova I,Lisi M,Le Moli C,Amico S

    更新日期：2008-06-01 00:00:00

  • Impact of left ventricular dysfunction and fluid balance on the outcomes of patients with sepsis.

    abstract：OBJECTIVE:Left ventricular (LV) dysfunction is a predictor of mortality in patients with sepsis. However, whether the adverse impact of LV dysfunction depends on fluid balance remains unclear. We retrospectively investigated the impact of LV dysfunction and fluid balance on various outcomes of patients with sepsis. ME...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章

    doi：10.1016/j.ejim.2019.11.019

    authors： Hong JY,Shin J,Kim WY

    更新日期：2020-04-01 00:00:00

  • Dramatic effect of sirolimus on renal angiomyolipomas in a patient with tuberous sclerosis complex.

    abstract：:Angiomyolipomas are very common in patients with tuberous sclerosis complex (TSC) and cause substantial morbidity. Until now, arterial embolization has been the recommended treatment for symptomatic patients. We report the case of a woman with TSC and giant angiolipomas in whom sirolimus induced a dramatic reduction i...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章

    doi：10.1016/j.ejim.2006.07.017

    authors： Herry I,Neukirch C,Debray MP,Mignon F,Crestani B

    更新日期：2007-01-01 00:00:00

  • Heart failure with preserved and reduced ejection fraction: different phenotypes in old-elderly patients?

    abstract：BACKGROUND:Patients with heart failure with preserved ejection fraction (HFPEF) represent an important group of patients presenting in clinical practice. However, whether it is an earlier stage of heart failure with reduced ejection fraction (HFREF) remains uncertain. We evaluated the potential progression of HFPEF to ...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章

    doi：10.1016/j.ejim.2013.01.018

    authors： Páez-Rubio MI,Carrasco-Sánchez FJ,Escobar-Cervantes C,Sánchez-Gómez N,Santiago-Ruiz JL,Yebra-Yebra M,Manzano L

    更新日期：2013-06-01 00:00:00

  • Aspiration pneumonia in old patients with dementia. Prognostic factors of mortality.

    abstract：BACKGROUND:Prognostic factors of mortality in elderly patients with dementia with aspiration pneumonia (AP) are scarcely known. We determined the mortality rate and prognostic factors in old patients with dementia hospitalized due to AP. METHODS:We prospectively studied 120 consecutive patients aged ≥ 75 years with de...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章

    doi：10.1016/j.ejim.2012.08.006

    authors： Bosch X,Formiga F,Cuerpo S,Torres B,Rosón B,López-Soto A

    更新日期：2012-12-01 00:00:00

  • Efficacy and safety of incretin-based therapies in patients with type 2 diabetes mellitus.

    abstract：:This article aims to provide an overview of efficacy and safety data on glucagon-like peptide-1 (GLP-1) receptor agonists and dipeptidyl peptidase-4 (DPP-4) inhibitors in the treatment of type 2 diabetes mellitus. Our goal is to differentiate the clinical profiles of GLP-1 receptor agonists and DPP-4 inhibitors, as we...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章,评审

    doi：10.1016/j.ejim.2009.05.011

    authors： Gilbert MP,Pratley RE

    更新日期：2009-07-01 00:00:00

  • The discriminatory power of bleeding assessment tools in adult patients with a mild to moderate bleeding tendency.

    abstract：BACKGROUND:Bleeding assessment tools (BATs) have been developed to quantify bleeding severity. Their ability to predict for the diagnosis of a bleeding disorder has not been thoroughly investigated. OBJECTIVES:To evaluate the ability of the Vicenza BAT and the ISTH BAT to distinguish patients with an established bleed...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章

    doi：10.1016/j.ejim.2020.04.023

    authors： Gebhart J,Hofer S,Kaider A,Rejtö J,Ay C,Pabinger I

    更新日期：2020-08-01 00:00:00

  • Clinical manifestations and outcome of anti-PL7 positive patients with antisynthetase syndrome.

    abstract：BACKGROUND:The aims of the present study were to determine both clinical manifestations and outcome of anti-PL7 patients with antisynthetase syndrome (ASS). METHODS:The medical records of 15 consecutive anti-PL7 patients with biopsy proven ASS were retrospectively analyzed without prior selection. RESULTS:Anti-PL7 pa...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章

    doi：10.1016/j.ejim.2013.01.002

    authors： Marie I,Josse S,Decaux O,Diot E,Landron C,Roblot P,Jouneau S,Hatron PY,Hachulla E,Vittecoq O,Menard JF,Jouen F,Dominique S

    更新日期：2013-07-01 00:00:00

  • Gallbladder and gastric emptying: relationship to cholecystokininemia in diabetics.

    abstract：:Background: Impaired gastrointestinal and gallbladder motility, as a complication of long-lasting diabetes mellitus, has been ascribed to the possible development of autonomic neuropathy, although the intervention of hormonal factors may not completely be excluded. In this regard, cholecystokinin (CCK), a gut hormone ...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章

    doi：10.1016/s0953-6205(02)00003-1

    authors： Bucceri AM,Calogero AE,Brogna A

    更新日期：2002-03-01 00:00:00

  • Prevalence, risk factors and proteomic bioprofiles associated with heart failure in rheumatoid arthritis: The RA-HF study.

    abstract：BACKGROUND:Rheumatoid arthritis (RA) patients have high risk of heart failure (HF). AIMS:Identifying the risk factors and mechanistic pathways associated with HF in patients with RA. METHODS:Cohort study enrolling 355 RA patients. HF was defined according to the ESC criteria. 93 circulating protein-biomarkers (91CVDI...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章

    doi：10.1016/j.ejim.2020.11.002

    authors： Ferreira MB,Fonseca T,Costa R,Marinhoc A,Carvalho HC,Oliveira JC,Zannad F,Rossignol P,Gottenberg JE,Saraiva FA,Rodrigues P,Barros AS,Ferreira JP

    更新日期：2020-11-06 00:00:00

  • Bed-side inferior vena cava diameter and mean arterial pressure predict long-term mortality in hospitalized patients with heart failure: 36 months of follow-up.

    abstract：BACKGROUND:In discharged patients with heart failure (HF), diverse conditions can intervene to worsen outcome. We would investigate whether such factors present on hospital admission can affect long-term mortality in subjects hospitalized for acute HF. METHODS:One hundred twenty-three consecutive patients hospitalized...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章

    doi：10.1016/j.ejim.2015.11.029

    authors： Torres D,Cuttitta F,Paterna S,Garofano A,Conti G,Pinto A,Parrinello G

    更新日期：2016-03-01 00:00:00

  • HCV carriers with normal alanine aminotransferase levels: healthy persons or severely ill patients? Dealing with an everyday clinical problem.

    abstract：:Approximately 30% of patients with chronic HCV infection show persistently normal ALT levels. Although formerly referred to as 'healthy' or 'asymptomatic' HCV carriers, and thus historically excluded from antiviral treatment, it has now become clear that the majority of these patients have some degree of histological ...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章,评审

    doi：10.1016/j.ejim.2009.12.006

    authors： Puoti C,Bellis L,Guarisco R,Dell' Unto O,Spilabotti L,Costanza OM

    更新日期：2010-04-01 00:00:00

  • Prognostic differences between routine invasive and conservative strategies for the management of high-risk, non-ST segment acute coronary syndromes: Experience from two consecutive periods in a single center.

    abstract：BACKGROUND:The optimal revascularization strategy for non-ST elevation acute coronary syndromes (NSTE-ACS) remains controversial, especially in a real world context. The objective of this work was to assess differences at 1 year in all-cause mortality and the composite endpoint of mortality or acute myocardial infarcti...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章

    doi：10.1016/j.ejim.2006.12.011

    authors： Núñez J,Sanchis J,Núñez E,Bodi V,Bertomeu-González V,Bosch MJ,Santas E,Fácila L,Chorro FJ,Gómez C,Consuegra L,Llàcer A

    更新日期：2007-09-01 00:00:00