Abstract:
BACKGROUND:Patients with heart failure with preserved ejection fraction (HFPEF) represent an important group of patients presenting in clinical practice. However, whether it is an earlier stage of heart failure with reduced ejection fraction (HFREF) remains uncertain. We evaluated the potential progression of HFPEF to HFREF. METHODS AND RESULTS:We evaluated retrospectively 178 patients (mean age 80.5±5.8 years; 75.3% females) with heart failure with preserved ejection fraction from a specialized Internal Medicine unit, offering an integrated usual care. Diagnosis of heart failure with preserved ejection fraction was made according to European guidelines. The main objective was to evaluate the progression to systolic dysfunction, defined by left ventricular ejection fraction less than 45%. Mean baseline left ventricular ejection fraction was 64.6±7.2. After a mean follow-up of 24-months, mean baseline ejection fraction was 67.1±9.3%. Only five patients (2.8%) progressed to HFREF. Brain natriuretic peptide values were significantly higher in those patients who progressed. CONCLUSIONS:These results strongly suggest that heart failure with preserved and reduced ejection fraction could be distinct pathophysiological entities, at least in elderly patients.
journal_name
Eur J Intern Medjournal_title
European journal of internal medicineauthors
Páez-Rubio MI,Carrasco-Sánchez FJ,Escobar-Cervantes C,Sánchez-Gómez N,Santiago-Ruiz JL,Yebra-Yebra M,Manzano Ldoi
10.1016/j.ejim.2013.01.018subject
Has Abstractpub_date
2013-06-01 00:00:00pages
346-8issue
4eissn
0953-6205issn
1879-0828pii
S0953-6205(13)00038-1journal_volume
24pub_type
杂志文章abstract:BACKGROUND:Primary cancer prevention is offered by the Greek health care system to the population on an opportunistic basis. This means that screening depends on advice from primary care providers and on individuals' request for screening, since a centralized invitational register is lacking. In planning preventive ser...
journal_title:European journal of internal medicine
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