Abstract：
AIM:Intravenous insulin improves clinical outcome in patients hospitalized in intensive care units. Whether glucose control with multiple daily subcutaneous insulin injections (MDI) is beneficial in patients hospitalized in general medical wards is unknown. We tested the feasibility, safety and efficacy of glucose control with MDI in diabetic patients hospitalized in a general medicine ward. METHODS:Eighty-eight adults with diabetes mellitus were studied in an internal medicine department. All patients were treated with subcutaneous pre-meal insulin analogue and Glargin insulin. A conservative and an intensified protocol was tested. RESULTS:Mean daily glucose levels decreased in the conservatively treated patients from 275+/-71 mg/dl at day 1 to 197.0+/-60 mg/dl at day 4 of hospitalization p=0.0001 and in the intensified protocol to 191+/-38 mg/dl already on day 1 remaining stable throughout the hospitalization. A mean daily glucose <180 mg% was reached by day 2 in 48% of patients in the intensified and in 32% in the conservative groups. Only one serious event of hypoglycemia was noted in the intensified group. CONCLUSION:Intensive insulin treatment with MDI is feasible, safe and efficacious in general medicine wards.
journal_name
Eur J Intern Medjournal_title
European journal of internal medicineauthors
Buchs AE,Bloemers R,Shiloah E,Horowitz M,Aminov S,Ramot Y,Rapoport MJdoi
10.1016/j.ejim.2008.12.010subject
Has Abstractpub_date
2009-07-01 00:00:00pages
435-9issue
4eissn
0953-6205issn
1879-0828pii
S0953-6205(08)00332-4journal_volume
20pub_type
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