Abstract：
:Early repolarization syndrome (ERS) is characterized by the presence, in most cases in mid-to-lateral precordial leads, of a J wave on the downsloping portion of the QRS complex, followed by an elevation of the ST-segment with upward concavity. ERS is considered a benign electrocardiographic pattern of ventricular repolarization and, thus far, clinical interest in this syndrome has been confined to its differential diagnosis from myocardial infarction and pericarditis. Brugada syndrome (BS), an inherited cardiac disease first described in 1992, exhibits a characteristic electrocardiographic pattern consisting of a J wave mimicking a right bundle branch block with typical ST-segment elevation in the right precordial leads. Believed to be a normal repolarization variant for more than three decades, the syndrome is now known instead to be associated with a high incidence of life-threatening ventricular tachyarrhythmias and is responsible for a number of sudden deaths in young adults worldwide. Although clinical findings seem to differentiate the two syndromes, similarities between BS and ERS in terms of response to heart rate, pharmacologic agents, and neuromodulation could suggest a linkage in their pathophysiological mechanism. The authors review the clinical and experimental data in order to test this hypothesis.
journal_name
Eur J Intern Medjournal_title
European journal of internal medicineauthors
Di Grande A,Tabita V,Lizzio MM,Giuffrida C,Bellanuova I,Lisi M,Le Moli C,Amico Sdoi
10.1016/j.ejim.2007.06.013subject
Has Abstractpub_date
2008-06-01 00:00:00pages
236-40issue
4eissn
0953-6205issn
1879-0828pii
S0953-6205(07)00349-4journal_volume
19pub_type
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journal_title：European journal of internal medicine
pub_type： 杂志文章
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pub_type： 杂志文章,评审
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