Abstract：
:The endocannabinoid system is involved in many areas of physiological function and homeostasis. Cannabinoid receptors are expressed in the peripheral and central nervous system and on immune cells, all areas ideally suited to modulation of pain processing. There are a wealth of preclinical data in a number of acute, chronic, neuropathic and cancer pain models that have demonstrated a potent analgesic potential for cannabinoids, especially in patients with cancer. However, although there are some positive results in pain of cancer patients, the clinical evidence for cannabinoids as analgesics has not been convincing and their use can only be weakly recommended. The efficacy of cannabinoids seems to have been 'lost in translation' which may in part be related to using extracts of herbal cannabis rather than targeted selective full agonists at the cannabinoid CB1 and CB2 receptors.
journal_name
Eur J Intern Medjournal_title
European journal of internal medicineauthors
Brown MRD,Farquhar-Smith WPdoi
10.1016/j.ejim.2018.01.020subject
Has Abstractpub_date
2018-03-01 00:00:00pages
30-36eissn
0953-6205issn
1879-0828pii
S0953-6205(18)30020-7journal_volume
49pub_type
杂志文章,评审abstract：:BACKGROUND: Plasma total homocysteine (p-tHcy) is considered to be an independent risk factor for atherosclerotic vascular disease. This cross-sectional study was undertaken to examine p-tHcy levels and their relationship to coronary artery disease (CAD) and alcohol intake. METHODS: We consecutively studied 291 patien...
journal_title：European journal of internal medicine
pub_type： 杂志文章
doi：10.1016/s0953-6205(03)00069-4
更新日期：2003-07-01 00:00:00
abstract：AIM:To describe trends in the incidence and outcomes of community-acquired pneumonia (CAP) hospitalizations in Spain (2004-2013). METHODS:We used national hospital discharge data to select all hospital admissions for CAP as primary diagnosis. We analyzed incidence, Charlson comorbidity index (CCI), diagnostic and ther...
journal_title：European journal of internal medicine
pub_type： 杂志文章,多中心研究
doi：10.1016/j.ejim.2016.12.010
更新日期：2017-05-01 00:00:00
abstract：:Bartonella quintana endocarditis is characterized by sub-acute evolution and severe valvular damage, and is associated with homelessness, alcoholism, and lice infestation. We present a case of B. quintana endocarditis in an Ethiopian immigrant without known risk factors for disease acquisition. This is the first case ...
journal_title：European journal of internal medicine
pub_type： 杂志文章
doi：10.1016/j.ejim.2005.09.004
更新日期：2005-11-01 00:00:00
abstract：OBJECTIVE:The aim of the study was to investigate the patients' characteristics that correlate with greater compliance to CPAP use. METHODS:Patients diagnosed with OSAHS and treated with CPAP, who had at least one follow-up visit in the Sleep Clinic during one year, were included in the study. Demographic data, histor...
journal_title：European journal of internal medicine
pub_type： 杂志文章
doi：10.1016/j.ejim.2009.07.004
更新日期：2009-10-01 00:00:00
abstract：BACKGROUND:Medication reconciliation process has proved to be an effective tool to improve the safety of drug use. The objective of this study was to assess the impact of an intervention aimed to decrease unintended discrepancies between patient's usual treatment and medications prescribed on admission to the Departmen...
journal_title：European journal of internal medicine
pub_type： 临床试验,杂志文章
doi：10.1016/j.ejim.2012.08.013
更新日期：2012-12-01 00:00:00
abstract：BACKGROUND:Percutaneous balloon mitral valvuloplasty (PBMV) has become the procedure of choice for isolated, uncomplicated mitral stenosis (MS) with favorable morphology and may be a useful method for surgical high-risk conditions such as advanced age, the presence of severe tricuspid regurgitation, New York Heart Asso...
journal_title：European journal of internal medicine
pub_type： 杂志文章
doi：10.1016/j.ejim.2005.02.012
更新日期：2005-10-01 00:00:00
abstract：:Most patients above 60 years with acute myeloid leukemia (AML) will die from their disease. Nevertheless, the treatment concepts in elderly patients with myelodysplastic syndromes (MDS) and AML are rapidly evolving. A number of recent reports have identified better survival rates with intensive induction chemotherapy ...
journal_title：European journal of internal medicine
pub_type： 杂志文章,评审
doi：10.1016/j.ejim.2018.05.026
更新日期：2018-12-01 00:00:00
abstract：BACKGROUND:Mallory-Weiss syndrome is defined by upper gastrointestinal bleeding from vomiting-induced mucosal lacerations at the esophago-gastric junction. This study was purposed to investigate the incidence, location, clinical manifestation, diagnosis and effectiveness of treatment (including endoscopic treatment and...
journal_title：European journal of internal medicine
pub_type： 杂志文章
doi：10.1016/j.ejim.2012.02.005
更新日期：2012-06-01 00:00:00
abstract：BACKGROUND:The measurement of femoral intima-media thickness (IMT) is underutilized in the clinical practice, although it is a surrogate marker of cardiovascular disease. MATERIALS AND METHODS:388 Hungarian and Italian twins (121 monozygotic, 73 dizygotic pairs) underwent bilateral B-mode sonography of femoral arterie...
journal_title：European journal of internal medicine
pub_type： 杂志文章,多中心研究
doi：10.1016/j.ejim.2017.02.019
更新日期：2017-06-01 00:00:00
abstract：BACKGROUND:Porphyrias are a group of metabolic diseases, individually rare but with an important combined prevalence. Because of their pathological complexity and clinical heterogeneity, they present a challenging diagnosis. The present review aims to provide a clinically based approach to the recognition and treatment...
journal_title：European journal of internal medicine
pub_type： 杂志文章,评审
doi：10.1016/j.ejim.2019.06.014
更新日期：2019-09-01 00:00:00
abstract：:Venous thromboembolism (VTE) is frequent in patients hospitalized in Internal Medicine wards. It carries a considerable morbidity and mortality. Recommendations for use of anticoagulation are graded 1A in leading evidence-based consensus guidelines. Implementation of these guidelines is suboptimal. Lack of awareness s...
journal_title：European journal of internal medicine
pub_type： 杂志文章
doi：10.1016/j.ejim.2011.11.005
更新日期：2012-04-01 00:00:00
abstract：:Background: Impaired gastrointestinal and gallbladder motility, as a complication of long-lasting diabetes mellitus, has been ascribed to the possible development of autonomic neuropathy, although the intervention of hormonal factors may not completely be excluded. In this regard, cholecystokinin (CCK), a gut hormone ...
journal_title：European journal of internal medicine
pub_type： 杂志文章
doi：10.1016/s0953-6205(02)00003-1
更新日期：2002-03-01 00:00:00
abstract：:BACKGROUND: The aims of this study were to investigate the frequency of halitosis before and after eradication therapy and to determine whether halitosis is a valid indication for eradication therapy in patients with Helicobacter pylori (H. pylori)-positive non-ulcer dyspepsia. METHODS: Dyspepsia, related symptoms, an...
journal_title：European journal of internal medicine
pub_type： 杂志文章
doi：10.1016/s0953-6205(02)00206-6
更新日期：2003-02-01 00:00:00
abstract：BACKGROUND:The Charlson's is the most used comorbidity index. It comprises 19 comorbidities, some of which are infrequent in elderly patients with acute coronary syndrome (ACS), while some others are manifestations of cardiac disease rather than comorbidities. Our goal was to simplify comorbidity assessment in elderly ...
journal_title：European journal of internal medicine
pub_type： 杂志文章
doi：10.1016/j.ejim.2019.01.018
更新日期：2019-04-01 00:00:00
abstract：BACKGROUND:Iron deficiency anaemia is associated with gastrointestinal (GI) malignancy and is an indication for GI investigations. However, the relevance of iron deficiency without anaemia (IDWA) and the underlying risks of GI malignancy are uncertain. Therefore, the aim of this study was to estimate the prevalence of ...
journal_title：European journal of internal medicine
pub_type： 杂志文章,评审
doi：10.1016/j.ejim.2019.12.015
更新日期：2020-02-01 00:00:00
abstract：:In all industrialized countries, life expectancy has risen in the past 100 years. The incidence of elderly patients reaching end-stage renal disease (ESRD) and requiring renal replacement therapy has also increased. During the past few decades, the pattern of ESRD has changed significantly with the emerging predominan...
journal_title：European journal of internal medicine
pub_type： 杂志文章
doi：10.1016/s0953-6205(01)00121-2
更新日期：2001-04-01 00:00:00
abstract：INTRODUCTION:Hospital readmission within a short time of discharge is a common phenomenon in internal medicine. Although there are a few reports of intensive care and surgical readmission rates there is almost no information available on the readmission rates of internal medicine patients. AIMS:To explore the medical ...
journal_title：European journal of internal medicine
pub_type： 杂志文章
doi：10.1016/j.ejim.2005.10.004
更新日期：2006-01-01 00:00:00
abstract：:We report a case of hypocomplementemic urticarial vasculitis heralding a relapsing polychondritis in a 63-year-old woman. The patient, who had suffered in the past from polymyalgia rheumatica, suddenly experienced a generalized urticarial eruption with a dramatic decrease in C4 complement fraction and the presence of ...
journal_title：European journal of internal medicine
pub_type： 杂志文章
doi：10.1016/j.ejim.2004.10.022
更新日期：2005-06-01 00:00:00
abstract：BACKGROUND:Antithrombotic/anticoagulation effects of direct oral anticoagulants (DOACs) are dose-dependent. However, recent observations suggest that administering lower dose DOACs may better protect against all-cause mortality. We investigated whether, in patients with established atherosclerosis, DOAC dose selection ...
journal_title：European journal of internal medicine
pub_type： 杂志文章
doi：10.1016/j.ejim.2020.09.007
更新日期：2021-01-01 00:00:00
abstract：BACKGROUND:Multimorbidity is a huge burden to individuals and societies and more attention should be paid on its risk factors and prevention possibilities. The aim of this study was to investigate which clinical and lifestyle characteristics predict the development of multimorbidity both among initially disease-free pe...
journal_title：European journal of internal medicine
pub_type： 杂志文章
doi：10.1016/j.ejim.2015.02.012
更新日期：2015-04-01 00:00:00
abstract：:The rising incidence of Clostridium difficile (C. difficile) infection or CDI is now a problem of pandemic proportions. The NAP1 hypervirulent strain of C. difficile is responsible for a majority of recent epidemics and the widespread use of fluoroquinolone antibiotics may have facilitated the selective proliferation ...
journal_title：European journal of internal medicine
pub_type： 杂志文章,评审
doi：10.1016/j.ejim.2011.04.009
更新日期：2011-12-01 00:00:00
abstract：BACKGROUND & AIMS:Recently we have shown that cartilage oligomeric matrix protein (COMP), a fibrillar collagen assembly regulator, is strongly associated with cirrhosis and hepatocellular carcinoma progression. Therefore, we assessed whether serum COMP levels can be used as a non-invasive fibrosis marker in patients wi...
journal_title：European journal of internal medicine
pub_type： 杂志文章
doi：10.1016/j.ejim.2017.01.007
更新日期：2017-03-01 00:00:00
abstract：:The need for anticoagulation in patients with atrial fibrillation (AF), and the inherent limitations of warfarin have fostered the search for direct oral anticoagulant drugs (DOACs). In recent years, inhibitors of thrombin (Dabigatran etexilate) and of activated factor X (Rivaroxaban, Apixaban) have become clinically ...
journal_title：European journal of internal medicine
pub_type： 杂志文章,评审
doi：10.1016/j.ejim.2013.01.021
更新日期：2013-06-01 00:00:00
abstract：:Human serum albumin (HSA) is the most abundant circulating protein and accounts for about 70% of the plasma colloid osmotic pressure. Beside the well known capacity to act as plasma-expander, HSA is provided of many other properties which are unrelated to the regulation of fluid compartmentalization, including binding...
journal_title：European journal of internal medicine
pub_type： 杂志文章,评审
doi：10.1016/j.ejim.2013.05.015
更新日期：2013-12-01 00:00:00
abstract：BACKGROUND:Hepatitis B virus infection has decreased in Italy. The aims of this study were to identify changes, if any, in the epidemiological pattern of HBV infection in a southern Italian town first surveyed in 1996 and to assess the effectiveness of vaccination campaign against hepatitis B. METHODS:In 2010, subject...
journal_title：European journal of internal medicine
pub_type： 杂志文章
doi：10.1016/j.ejim.2012.08.009
更新日期：2012-12-01 00:00:00
abstract：BACKGROUND:An abnormal ankle-brachial pressure index (ABI) is a marker of the risk for increased total and cardiovascular (CV) mortality. However, it is not clear whether it is associated with an even worse prognosis in patients with previous CV events or with cancer mortality. MATERIALS AND METHODS:Consecutive subjec...
journal_title：European journal of internal medicine
pub_type： 杂志文章
doi：10.1016/j.ejim.2020.02.033
更新日期：2020-07-01 00:00:00
abstract：BACKGROUND:The prognostic significance of red cell distribution width (RDW) during hospitalization in internal medicine wards was not sufficiently investigated. METHODS:Demographic, clinical and laboratory characteristics were collected from 586 internal medicine inpatients. Following discharge, all-cause mortality wa...
journal_title：European journal of internal medicine
pub_type： 杂志文章
doi：10.1016/j.ejim.2015.07.018
更新日期：2015-10-01 00:00:00
abstract：:INTRODUCTION: Patients with rheumatoid arthritis (RA) frequently possess a number of risk factors for osteoporosis. Additionally, oral steroids are often used to control active rheumatoid disease and may further potentiate bone loss. We wished to establish the degree of peripheral bone loss in RA and to assess the inf...
journal_title：European journal of internal medicine
pub_type： 杂志文章
doi：10.1016/s0953-6205(02)00129-2
更新日期：2002-10-01 00:00:00
abstract：:Numerous epidemiological studies have shown an inverse correlation between moderate consumption of alcoholic drinks and the risk of coronary heart disease. Wine, especially red wine, may be more favorable in this respect than beer or spirits because of its high content of flavonoids. These polyphenols originate from t...
journal_title：European journal of internal medicine
pub_type： 杂志文章
doi：10.1016/s0953-6205(01)00170-4
更新日期：2001-12-01 00:00:00
abstract：:The morbidity and mortality related to many communicable infectious diseases have significantly decreased in Western countries largely because of the use of antibiotics, and the implementation of well-planned vaccination strategies and national immunisation schedules specifically aimed at infants and children. However...
journal_title：European journal of internal medicine
pub_type： 杂志文章,评审
doi：10.1016/j.ejim.2013.12.004
更新日期：2014-03-01 00:00:00
