Abstract：
INTRODUCTION:Patients with chronic hepatitis C (CHC) and end-stage renal disease (ESRD) on dialysis are difficult to treat and show higher dropout rates during treatment. The aim of this study was to analyze the treatment outcomes in patients with CHC and underlying end-stage renal disease on dialysis in Korea. METHODS:A retrospective multi-center study of 35 patients with CHC and underlying ESRD on regular dialysis from 13 centers were analyzed. We investigated the tolerability and efficacy of pegylated interferon therapy with or without ribavirin on dialysis patients. RESULTS:Twenty patients (57%) were genotype 1. Sixteen patients (46%) were treated with pegylated interferon monotherapy. Nineteen patients (54%) were treated with pegylated interferon and ribavirin. The overall sustained virological response (SVR) rate was 65.7% in all subjects. Thirteen patients (37%) dropped out before completion of treatment, and six patients (46.2%) showed SVR despite premature termination of treatment. Twenty patients (90.9%) achieved SVR among the 22 patients who completed the scheduled course. The most common side effects were anemia and neutropenia. The patients receiving ribavirin treatment showed a higher dropout rate (52.6% vs. 18.8%, p=0.04) and higher SVR rate (68.4% vs. 62.5%, p=0.07) compared to the pegylated interferon mono-treatment group. CONCLUSIONS:The difficulty in treating HCV patients with ESRD was attributed to higher dropout rate. However, despite the high dropout rate (37%), the SVR rate in genotype 1 was 65% and in genotypes 2 and 3 was 66%. Patients who completed the treatment showed a high SVR rate of 89.5%.
journal_name
Eur J Intern Medjournal_title
European journal of internal medicineauthors
Ahn SB,Jun DW,Kim SG,Lee SH,Shin HP,Choe WH,Kim JK,Jung KS,Kim DY,Shim JJ,Park SY,Seo YS,Kim W,Chung JIdoi
10.1016/j.ejim.2015.03.011subject
Has Abstractpub_date
2015-05-01 00:00:00pages
292-6issue
4eissn
0953-6205issn
1879-0828pii
S0953-6205(15)00094-1journal_volume
26pub_type
杂志文章,多中心研究abstract：BACKGROUND:In Greece, there are few data on the epidemiological characteristics of HBV. Our aim was to study the epidemiological patterns of HBV in Central Greece and identify the possible differences in HBV prevalence (clusters) among areas inside this region using data from the hepatitis registry. METHODS:The study ...
journal_title：European journal of internal medicine
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journal_title：European journal of internal medicine
pub_type： 杂志文章
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abstract：:Enteric fever (EF) is the most common bacteremic disease affecting travelers to the tropics. For more than a decade, fluoroquinolones have been considered the drugs of choice for EF. However, recent reports have raised concern about fluoroquinolone resistance. Treatment with ciprofloxacin failed in a traveler with Sal...
journal_title：European journal of internal medicine
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abstract：:There is growing evidence suggesting a causative relationship between adrenal adenomas and metabolic and cardiovascular deteriorations. Although demonstrated frequently in subjects with subclinical Cushing Syndrome, subjects with non-functioning adrenal adenomas feature a variety of metabolic and cardiovascular conseq...
journal_title：European journal of internal medicine
pub_type： 杂志文章,评审
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abstract：BACKGROUND:Upper gastrointestinal bleeding is the severe complication of stress-related mucosal disease in hospitalized patients. In intensive care units (ICU), risk factors are well defined and only mechanical ventilation and coagulopathy proved to be relevant for significant bleeding. On the contrary, in non-ICU sett...
journal_title：European journal of internal medicine
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journal_title：European journal of internal medicine
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abstract：:Background: Parkinson's disease is a common neurodegenerative disorder that affects an increasing number of older people every year. Dysphagia is not only a common feature, but one that results in poor nutrition and an increased risk of bronchopneumonia. Previous work has suggested that the oral flora is altered in pa...
journal_title：European journal of internal medicine
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abstract：BACKGROUND:Although tramadol and codeine occasionally have been reported to cause hyponatremia the evidence is scarce. The objective of this investigation was to study the association between weak opioids (tramadol and codeine) and hospitalization due to hyponatremia. METHODS:This was a register-based case-control stu...
journal_title：European journal of internal medicine
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journal_title：European journal of internal medicine
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journal_title：European journal of internal medicine
pub_type： 杂志文章,多中心研究
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journal_title：European journal of internal medicine
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journal_title：European journal of internal medicine
pub_type： 杂志文章
doi：10.1016/j.ejim.2005.06.007
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journal_title：European journal of internal medicine
pub_type： 杂志文章
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更新日期：2018-06-01 00:00:00
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journal_title：European journal of internal medicine
pub_type： 杂志文章
doi：10.1016/j.ejim.2013.03.015
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journal_title：European journal of internal medicine
pub_type： 杂志文章
doi：10.1016/j.ejim.2004.10.022
更新日期：2005-06-01 00:00:00
abstract：:Background: Essential mixed cryoglobulinemia (EMC) is a systemic disease frequently associated with chronic viral hepatitis. This study was conducted in order to assess the prevalence of EMC in patients with hepatitis B virus (HBV) or hepatitis C virus (HCV) infections. We also evaluated the possible associations of E...
journal_title：European journal of internal medicine
pub_type： 杂志文章
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更新日期：2001-09-01 00:00:00
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journal_title：European journal of internal medicine
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journal_title：European journal of internal medicine
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journal_title：European journal of internal medicine
pub_type： 杂志文章
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journal_title：European journal of internal medicine
pub_type： 杂志文章
doi：10.1016/j.ejim.2014.10.007
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journal_title：European journal of internal medicine
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journal_title：European journal of internal medicine
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journal_title：European journal of internal medicine
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journal_title：European journal of internal medicine
pub_type： 杂志文章,评审
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journal_title：European journal of internal medicine
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abstract：:Endothelins are powerful vasoconstrictor peptides that also play numerous other roles. The endothelin (ET) family consists of three peptides produced by a variety of tissues. Endothelin-1 (ET-1) is the principal isoform produced by the endothelium in the human cardiovascular system, and it exerts its actions through b...
journal_title：European journal of internal medicine
pub_type： 杂志文章
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abstract：:We report two patients with isolated bone marrow non-Hodgkin's lymphoma and we review the additional 23 cases thus far described. Bicytopenia or pancytopenia and an elevated erythrocyte sedimentation rate were universally present. Some 84% of the patients manifested fever of unknown origin (FUO), 64% constitutional sy...
journal_title：European journal of internal medicine
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journal_title：European journal of internal medicine
pub_type： 杂志文章,评审
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abstract：BACKGROUND:Patients with heart failure with preserved ejection fraction (HFPEF) represent an important group of patients presenting in clinical practice. However, whether it is an earlier stage of heart failure with reduced ejection fraction (HFREF) remains uncertain. We evaluated the potential progression of HFPEF to ...
journal_title：European journal of internal medicine
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abstract：:A 50-year-old man with no medical history was admitted because of progressive respiratory distress, aseptic meningitis, disseminated intravascular coagulation, cholestatic hepatitis, and renal failure. Mycoplasma pneumoniae infection was confirmed serologically. The patient was treated with erythromycin and showed a f...
journal_title：European journal of internal medicine
pub_type： 杂志文章
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更新日期：2003-08-01 00:00:00
