Abstract:
BACKGROUND:One of the candidate genes for susceptibility to Graves' disease (GD) is cytotoxic T lymphocyte-associated molecule-4 (CTLA-4), a negative regulator of T-cell activation. In order to elucidate the relationship of GD with the A/G polymorphism in exon 1 and the C/T polymorphism in the promoter region of the CTLA-4 gene, the frequency of these two polymorphisms was identified in 98 healthy individuals and 77 patients with GD. METHODS:Polymorphisms were analyzed using a PCR-RFLP method. We also examined the relationship between the A/G polymorphism and various clinical and laboratory variables among patients with GD. All patients were treated with an initial dose of propranolol (40-60 mg /day) and PTU (300-400 mg/day). Subjects remained on this treatment for a minimum of 6 months and were followed in our clinic for 1 year after cessation of treatment. RESULTS:The frequency of the GG genotype was significantly higher among patients with GD than among controls of both sexes (P<0.05; odds ratio=3.145, 95% CI=1.212-8.161). There was no difference between patients and controls with regard to the C/T polymorphism. There was no statistical difference in age, sex, cigarette smoking, initial serum thyroid hormone levels, initial goiter size, initial TSH-receptor antibodies, or NOSPECS classification for orbitopathy among the patients with the three different genotypes (GG, AG, and AA). Of the patients with the AA genotype, 17 of 29 (58.6%) were in remission 1 year after PTU withdrawal, while 18 of 33 patients (54.4%) with the AG genotype were in remission 1 year later. However, only 3 of 15 patients (20%) with the GG genotype were in remission 1 year after withdrawal of antithyroid drug therapy (P=0.016 GG/AA, P=0.025 GG/AG). Using 1 year after discontinuation of antithyroid drug therapy as the cut-off point for multivariate logistic regression analysis, we found that the GG genotype, TSH at the end of therapy, and age were independent risk factors for recurrence. CONCLUSION:We conclude that the occurrence of GD is linked to the A/G polymorphism of the CTLA molecule in the Turkish population and is associated with a lower chance of remission after discontinuation of PTU treatment.
journal_name
Eur J Intern Medjournal_title
European journal of internal medicineauthors
Sahin M,Erdogan MF,Erdogan Gdoi
10.1016/j.ejim.2005.06.007subject
Has Abstractpub_date
2005-09-01 00:00:00pages
352-5issue
5eissn
0953-6205issn
1879-0828pii
S0953-6205(05)00176-7journal_volume
16pub_type
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journal_title:European journal of internal medicine
pub_type: 杂志文章
doi:10.1016/s0953-6205(00)00103-5
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journal_title:European journal of internal medicine
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journal_title:European journal of internal medicine
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journal_title:European journal of internal medicine
pub_type: 杂志文章
doi:10.1016/j.ejim.2006.12.011
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abstract:BACKGROUND:Aspiration pneumonia (AP) is an infectious process causing high rates of mortality. The purpose of this study was: 1, to describe the incidence from 2003 to 2013 of AP hospitalizations; 2, to assess time trends in hospital outcomes variables, and; 3, to identify the factors independently associated with in-h...
journal_title:European journal of internal medicine
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更新日期:2017-03-01 00:00:00
abstract::BACKGROUND: The aim of this retrospective study was to determine the clinical, laboratory, and radiological features of all adult patients with varicella-zoster virus pneumonia (VZVP) treated in our departments during the last 5 years. Important therapeutic and evolutionary features are also reported. METHODS: Fourtee...
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journal_title:European journal of internal medicine
pub_type: 杂志文章
doi:10.1016/j.ejim.2015.07.018
更新日期:2015-10-01 00:00:00
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journal_title:European journal of internal medicine
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journal_title:European journal of internal medicine
pub_type: 杂志文章
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更新日期:2010-04-01 00:00:00
abstract:INTRODUCTION:Rituximab induced serum sickness (RISS) is a rare delayed hypersensitivity reaction. The aim of this study was to describe the epidemiological and clinical characteristics of the RISS cases reported in France. METHOD:Serum sickness cases involving rituximab were identified from the French PharmacoVigilanc...
journal_title:European journal of internal medicine
pub_type: 杂志文章
doi:10.1016/j.ejim.2019.06.009
更新日期:2019-09-01 00:00:00
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journal_title:European journal of internal medicine
pub_type: 杂志文章
doi:10.1016/j.ejim.2008.01.011
更新日期:2008-11-01 00:00:00
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journal_title:European journal of internal medicine
pub_type: 杂志文章
doi:10.1016/j.ejim.2004.11.012
更新日期:2005-08-01 00:00:00
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journal_title:European journal of internal medicine
pub_type: 杂志文章
doi:10.1016/j.ejim.2009.05.002
更新日期:2009-09-01 00:00:00
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journal_title:European journal of internal medicine
pub_type: 杂志文章
doi:10.1016/j.ejim.2019.05.021
更新日期:2019-08-01 00:00:00
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journal_title:European journal of internal medicine
pub_type: 杂志文章
doi:10.1016/j.ejim.2020.02.028
更新日期:2020-07-01 00:00:00
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journal_title:European journal of internal medicine
pub_type: 杂志文章,评审
doi:10.1016/j.ejim.2013.05.015
更新日期:2013-12-01 00:00:00
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journal_title:European journal of internal medicine
pub_type: 杂志文章
doi:10.1016/j.ejim.2014.11.005
更新日期:2015-01-01 00:00:00
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journal_title:European journal of internal medicine
pub_type: 杂志文章,评审
doi:10.1016/j.ejim.2012.02.008
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journal_title:European journal of internal medicine
pub_type: 杂志文章
doi:10.1016/j.ejim.2005.11.016
更新日期:2006-05-01 00:00:00
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journal_title:European journal of internal medicine
pub_type: 杂志文章,评审
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更新日期:2020-08-01 00:00:00
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journal_title:European journal of internal medicine
pub_type: 杂志文章,评审
doi:10.1016/j.ejim.2015.02.009
更新日期:2015-05-01 00:00:00
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journal_title:European journal of internal medicine
pub_type: 杂志文章
doi:10.1016/j.ejim.2013.05.004
更新日期:2013-09-01 00:00:00
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journal_title:European journal of internal medicine
pub_type: 杂志文章
doi:10.1016/j.ejim.2020.12.025
更新日期:2021-01-12 00:00:00
abstract::BACKGROUND: Foreign graduate residents in internal medicine perform poorly on the Israeli phase I written board examination as compared to local graduates from Israeli medical schools. The aim of this study was to determine the effect of a preparatory course, aimed at foreign graduates, on their success rate in the Is...
journal_title:European journal of internal medicine
pub_type: 杂志文章
doi:10.1016/j.ejim.2004.12.002
更新日期:2005-06-01 00:00:00
abstract:BACKGROUND:Data on the prevalence of hepatitis C virus (HCV) infection in Italy are outdated and usually derived from studying residents in small towns. METHODS:To assess prevalence of and risk factors for HCV infection among Italian residents in 5 metropolitan areas, subjects ≥20 years of age were randomly selected f...
journal_title:European journal of internal medicine
pub_type: 杂志文章
doi:10.1016/j.ejim.2018.02.015
更新日期:2018-07-01 00:00:00
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journal_title:European journal of internal medicine
pub_type: 杂志文章
doi:10.1016/j.ejim.2005.04.001
更新日期:2005-08-01 00:00:00
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journal_title:European journal of internal medicine
pub_type: 杂志文章
doi:10.1016/j.ejim.2005.10.004
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND:This study investigates risk factors and the incidence of type 2 diabetes mellitus (type 2 DM) in both sexes of a northern European population. METHODS:A total of 14,223 randomly selected men and women were studied from 1976 to 1978. Patients with diabetes (self-reported type 2 DM or non-fasting plasma gluc...
journal_title:European journal of internal medicine
pub_type: 杂志文章
doi:10.1016/j.ejim.2007.05.011
更新日期:2008-01-01 00:00:00