Abstract：
:Background: It is unclear whether methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-sensitive S. aureus (MSSA) differ in virulence. We therefore carried out a prospective study of cases of S. aureus bacteremia over a period of 2 years at our university hospital. We report herein the results of a comparative analysis of the clinical characteristics and mortality rates associated with cases of bacteremia caused by MRSA and MSSA. Methods: Over a 2-year period, we reviewed the medical records of hospitalized patients with blood cultures positive for S. aureus. Demographic characteristics, underlying diseases, diagnosis, clinical features, severity, laboratory findings, antimicrobial treatment, and resistance to methicillin were analyzed as possible risk factors for death attributed to bacteremia. Results: The rate of mortality attributed to bacteremia was 27.3% (27 patients): 13 (43.3%) deaths were recorded for patients infected with MRSA and 14 (20.3%) for patients infected with MSSA (P=0.0339, OR=3.00 (1.08--8.46)). Two variables were significantly associated with death within 14 days of the onset of bacteremia in univariate and multivariate analyses after adjusting for antimicrobial treatment: malignant hematologic disease (protective factor; OR=0.184 (0.038--0.882)) and resistance to methicillin (risk factor; OR=2.97 (1.12--7.88)). Conclusion: This study shows that S. aureus bacteremia has a high mortality rate, especially if the strain involved is methicillin-resistant, regardless of patient age and the efficacy of antimicrobial treatment.
journal_name
Eur J Intern Medjournal_title
European journal of internal medicineauthors
Talon D,Woronoff-Lemsi MC,Limat S,Bertrand X,Chatillon M,Gil H,Dupond JLdoi
10.1016/s0953-6205(01)00189-3subject
Has Abstractpub_date
2002-02-01 00:00:00pages
31-36issue
1eissn
0953-6205issn
1879-0828pii
S0953620501001893journal_volume
13pub_type
杂志文章abstract：:Thrombangiitis obliterans (TAO), or Buerger's disease, is most likely an endarteritis that is introduced by T-cell-mediated cellular immunity and B-cell-mediated humoral immunity associated with the activation of macrophages or dendritic cells in the intima. There is no specific marker of the disease, and the diagnosi...
journal_title：European journal of internal medicine
pub_type： 杂志文章
doi：10.1016/j.ejim.2005.11.020
更新日期：2006-07-01 00:00:00
abstract：BACKGROUNDS/AIMS:Nephrotic dyslipidemia is a risk factor for development of systemic atherosclerosis; also it may aggravate glomerulosclerosis and enhance progression of glomerular disease. We aimed to assess the efficacy and safety of Monascus purpureus Went rice vs. fluvastatin therapy in the management of nephrotic ...
journal_title：European journal of internal medicine
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.ejim.2008.08.012
更新日期：2009-05-01 00:00:00
abstract：:Mycobacterium fortuitum is a rapidly growing, nontuberculous mycobacteria that has rarely been associated with central nervous system impairment. We describe the case of a patient who developed multiple cerebral abscesses revealing Mycobacterium fortuitum infection. Brain biopsy specimens showed suppurative, noncaseat...
journal_title：European journal of internal medicine
pub_type： 杂志文章
doi：10.1016/s0953-6205(03)90008-2
更新日期：2003-10-01 00:00:00
abstract：:We describe an 80-year-old patient who developed Staphylococcus aureus septicemia several days after the implantation of a double stent in the proximal and mid-left anterior descending artery. The infection was complicated by multiple abscesses in the lungs and liver, as well as by bilateral bacterial endophthalmitis ...
journal_title：European journal of internal medicine
pub_type： 杂志文章
doi：10.1016/j.ejim.2004.10.010
更新日期：2005-04-01 00:00:00
abstract：:A 59 year old lady had just completed renal dialysis via a central venous catheter when she developed severe chest pain. She subsequently has severe haematemesis and emergency endoscopy showed a lesion in her esophagus consistent with the tip of her venous catheter, and extensive bleeding from the lesion. A chest X-ra...
journal_title：European journal of internal medicine
pub_type： 杂志文章
doi：10.1016/j.ejim.2007.07.004
更新日期：2008-07-01 00:00:00
abstract：BACKGROUND AND PURPOSE:Sex related differences in cardiovascular disease and stroke are issues of increasing interest. The aim of this study was to evaluate for sex differences in clinical presentation, severity of stroke and outcome in a population of patients admitted to 4 public and 1 private hospitals in three diff...
journal_title：European journal of internal medicine
pub_type： 杂志文章,多中心研究
doi：10.1016/j.ejim.2012.10.004
更新日期：2013-03-01 00:00:00
abstract：:Bartonella quintana endocarditis is characterized by sub-acute evolution and severe valvular damage, and is associated with homelessness, alcoholism, and lice infestation. We present a case of B. quintana endocarditis in an Ethiopian immigrant without known risk factors for disease acquisition. This is the first case ...
journal_title：European journal of internal medicine
pub_type： 杂志文章
doi：10.1016/j.ejim.2005.09.004
更新日期：2005-11-01 00:00:00
abstract：BACKGROUND:The association between exacerbation of heart failure (HF) and use of non-steroidal anti-inflammatory drugs (NSAIDs) has long been recognized but the data on this adverse effect are limited. METHODS:To further characterize this possible association, we conducted a systematic review and meta-analysis of obse...
journal_title：European journal of internal medicine
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.ejim.2015.09.012
更新日期：2015-11-01 00:00:00
abstract：AIM:We investigated the association among long-term proton-pump inhibitors (PPIs) use with serum magnesium (Mg) levels in chronic hemodialysis (HD) patients, as well as possible association among PPI use and increased risk of cardiovascular (CVD) morbidity in HD patients. METHODS:Of 418 HD patients that were screened ...
journal_title：European journal of internal medicine
pub_type： 杂志文章
doi：10.1016/j.ejim.2016.01.026
更新日期：2016-05-01 00:00:00
abstract：BACKGROUND:Prognostic factors of mortality in elderly patients with dementia with aspiration pneumonia (AP) are scarcely known. We determined the mortality rate and prognostic factors in old patients with dementia hospitalized due to AP. METHODS:We prospectively studied 120 consecutive patients aged ≥ 75 years with de...
journal_title：European journal of internal medicine
pub_type： 杂志文章
doi：10.1016/j.ejim.2012.08.006
更新日期：2012-12-01 00:00:00
abstract：:We report the case of a 59-year-old man with a pheochromocytoma in which erectile dysfunction was the main symptom. Erectile function was related to the amount of noradrenaline secreted by the tumor, as was determined when recurrence of the malignancy was diagnosed twice. Erectile function could be restored by lowerin...
journal_title：European journal of internal medicine
pub_type： 杂志文章
doi：10.1016/j.ejim.2007.02.027
更新日期：2007-12-01 00:00:00
abstract：BACKGROUND:Although a decreasing trend of tuberculosis (TB) was reported in Turkey, higher proportion of extrapulmonary tuberculosis (EPT) was revealed. MATERIAL AND METHODS:In this retrospective study, clinical and laboratory data of 141 EPT patients were evaluated for a seven-year period by using descriptive statist...
journal_title：European journal of internal medicine
pub_type： 杂志文章
doi：10.1016/j.ejim.2013.08.704
更新日期：2013-12-01 00:00:00
abstract：:A 34-year-old immunocompetent man with varicella zoster (VZ) infection developed deep vein thrombosis and pulmonary embolism after suffering severe pneumonitis. He recovered after treatment with acyclovir, high-dose steroids, and ventilatory support. The endothelial damage could be a direct link between VZ pneumonitis...
journal_title：European journal of internal medicine
pub_type： 杂志文章
doi：10.1016/j.ejim.2005.02.011
更新日期：2005-10-01 00:00:00
abstract：BACKGROUND:Prognostic implications of echocardiographic assessment of pulmonary hypertension (PH) in non-selected patients hospitalized for acute heart failure (AHF) are not clearly defined. The aim of this study was to evaluate the association between echocardiography-derived PH in AHF and 1-year all-cause mortality. ...
journal_title：European journal of internal medicine
pub_type： 杂志文章
doi：10.1016/j.ejim.2013.04.009
更新日期：2013-09-01 00:00:00
abstract：BACKGROUND:Venous and arterial thrombosis share a number of pathogenic mechanisms, but the burden of pulmonary embolism (PE) has not been consistently compared with that in other arterial diseases. METHODS:We used the Spanish National Discharge Database to compare the frequency, clinical characteristics and mortality ...
journal_title：European journal of internal medicine
pub_type： 杂志文章
doi：10.1016/j.ejim.2015.10.006
更新日期：2016-03-01 00:00:00
abstract：:Venous thromboembolism (VTE) is frequent in patients hospitalized in Internal Medicine wards. It carries a considerable morbidity and mortality. Recommendations for use of anticoagulation are graded 1A in leading evidence-based consensus guidelines. Implementation of these guidelines is suboptimal. Lack of awareness s...
journal_title：European journal of internal medicine
pub_type： 杂志文章
doi：10.1016/j.ejim.2011.11.005
更新日期：2012-04-01 00:00:00
abstract：:The introduction of substrate reduction therapy (SRT) using miglustat (Zavesca(R)) gives physicians and patients a choice of treatment options for type 1 Gaucher's disease. Enzyme replacement therapy (ERT) has proven a successful approach to treating the haematologic abnormalities and organomegaly. However, long-term ...
journal_title：European journal of internal medicine
pub_type： 杂志文章
doi：10.1016/j.ejim.2006.07.003
更新日期：2006-11-01 00:00:00
abstract：BACKGROUND:Hospitals are under pressure to use resources in the most efficient manner. We have examined the factors predicting Length of Stay (LOS) in one institution, using a database of all episodes of emergency medical admissions prospectively collected over 12 years. AIM:To examine the ability to predict hospital ...
journal_title：European journal of internal medicine
pub_type： 杂志文章
doi：10.1016/j.ejim.2015.02.017
更新日期：2015-05-01 00:00:00
abstract：:Enteric fever (EF) is the most common bacteremic disease affecting travelers to the tropics. For more than a decade, fluoroquinolones have been considered the drugs of choice for EF. However, recent reports have raised concern about fluoroquinolone resistance. Treatment with ciprofloxacin failed in a traveler with Sal...
journal_title：European journal of internal medicine
pub_type： 杂志文章
doi：10.1016/j.ejim.2006.09.016
更新日期：2007-03-01 00:00:00
abstract：:The SARS-CoV-2 epidemic, which has spread to many countries around the world, has hit Europe particularly hard. From our point of view, in a rural emergency department (with an annual patient census of around 25,000) in northeastern Italy, it is necessary to preserve the hospital and prevent it from becoming an outbre...
journal_title：European journal of internal medicine
pub_type： 信件
doi：10.1016/j.ejim.2020.06.031
更新日期：2020-10-01 00:00:00
abstract：BACKGROUND:Patients with chronic diseases often receive multiple medications and are associated with increased vulnerability to medication errors. Identifying high-alert medications for them would help to prioritize the interventions with greatest impact for improving medication safety. The aim of this study was to dev...
journal_title：European journal of internal medicine
pub_type： 杂志文章
doi：10.1016/j.ejim.2014.10.021
更新日期：2014-12-01 00:00:00
abstract：BACKGROUND:Peripheral arterial disease (PAD) in the aortoiliac segment is found in nearly a half of patients with PAD. The aim of this study was to estimate the influence of obesity and fat distribution on the occurrence of aortoiliac PAD in middle-aged men. METHODS:This case-control study included 204 middle-aged men...
journal_title：European journal of internal medicine
pub_type： 杂志文章
doi：10.1016/j.ejim.2010.07.019
更新日期：2011-02-01 00:00:00
abstract：BACKGROUND:Circulating levels of vascular endothelial growth factor (VEGF) may predict microvascular complications in type 1 diabetes mellitus and are elevated when metabolic control is poor. We tested whether serum VEGF is influenced by prevailing glucose and insulin levels. METHODS:In 15 type 1 diabetic patients, se...
journal_title：European journal of internal medicine
pub_type： 杂志文章
doi：10.1016/j.ejim.2006.11.006
更新日期：2007-05-01 00:00:00
abstract：INTRODUCTION:Patients with chronic hepatitis C (CHC) and end-stage renal disease (ESRD) on dialysis are difficult to treat and show higher dropout rates during treatment. The aim of this study was to analyze the treatment outcomes in patients with CHC and underlying end-stage renal disease on dialysis in Korea. METHOD...
journal_title：European journal of internal medicine
pub_type： 杂志文章,多中心研究
doi：10.1016/j.ejim.2015.03.011
更新日期：2015-05-01 00:00:00
abstract：:Background: Ghrelin causes weight gain by increasing food intake in rodents. Tumor necrosis factor alpha (TNFalpha) is produced by adipose tissue, modulates its metabolism and stimulates catabolic processes. The aim of our study was to evaluate whether weight loss treatment modulates serum concentrations of TNFalpha a...
journal_title：European journal of internal medicine
pub_type： 杂志文章
doi：10.1016/j.ejim.2004.02.002
更新日期：2004-06-01 00:00:00
abstract：OBJECTIVE:To identify analytical and clinical variables that may improve the effectiveness of temporal artery biopsy (TAB) for the diagnosis of giant cell arteritis (GCA). MATERIALS AND METHODS:A retrospective study of TABs conducted between 1989 and 2007 at the 450-bed Hospital Parc Taulí, Sabadell. Demographic data,...
journal_title：European journal of internal medicine
pub_type： 杂志文章
doi：10.1016/j.ejim.2009.05.002
更新日期：2009-09-01 00:00:00
abstract：BACKGROUND:Thalassemia minor (Tm) individuals, are generally considered healthy. However, the prognosis of Tm individuals has not been extensively studied. The aim of this study was to evaluate the prognosis of Tm versus controls without β-thalassemia carrier state. METHODS:A total of 26,006 individuals seeking thalas...
journal_title：European journal of internal medicine
pub_type： 杂志文章,评审
doi：10.1016/j.ejim.2018.06.009
更新日期：2018-08-01 00:00:00
abstract：:The management of arterial hypertension is very challenging in everyday clinical practice. Blood pressure control rates remain disappointingly low, despite intense efforts. Poor adherence to antihypertensive treatment is among the main causes of inadequate blood pressure control. Among the various parameters leading t...
journal_title：European journal of internal medicine
pub_type： 杂志文章,评审
doi：10.1016/j.ejim.2020.07.009
更新日期：2020-11-01 00:00:00
abstract：:Splenic atrophy is an uncommon diagnosis associated with celiac sprue or other well-characterized connective tissue diseases, drepanocytosis, or amyloidosis. We report two patients with splenic atrophy revealed by thrombocytosis. Both patients had anti-nuclear antibodies. Patient 1 also had a grade III Chisholm lympho...
journal_title：European journal of internal medicine
pub_type： 杂志文章
doi：10.1016/j.ejim.2006.07.008
更新日期：2006-12-01 00:00:00
abstract：:BACKGROUND: Foreign graduate residents in internal medicine perform poorly on the Israeli phase I written board examination as compared to local graduates from Israeli medical schools. The aim of this study was to determine the effect of a preparatory course, aimed at foreign graduates, on their success rate in the Is...
journal_title：European journal of internal medicine
pub_type： 杂志文章
doi：10.1016/j.ejim.2004.12.002
更新日期：2005-06-01 00:00:00
