当前位置： SCI文献检索 > European Journal of Internal Medicine期刊下所有文献 > Effect of weight reduction on serum ghrelin and TNFalpha concentrations in obese women.

Effect of weight reduction on serum ghrelin and TNFalpha concentrations in obese women.

Abstract：

:Background: Ghrelin causes weight gain by increasing food intake in rodents. Tumor necrosis factor alpha (TNFalpha) is produced by adipose tissue, modulates its metabolism and stimulates catabolic processes. The aim of our study was to evaluate whether weight loss treatment modulates serum concentrations of TNFalpha and ghrelin in obese women. Methods: The study groups included 46 women: 35 obese patients and 11 controls. Serum concentrations of ghrelin and TNFalpha were measured by ELISA before and after a 3-month weight reduction treatment that consisted of a 1000 kcal/day diet and physical exercises. Body composition was determined by impedance analysis using Bodystat. Results: There were no differences in plasma ghrelin concentrations between obese patients and controls. TNFalpha serum levels were higher in obese patients than in controls (p=0.000). The mean weight loss over the 3-month treatment period was 8.7+/-4.5 kg. Following weight loss, serum ghrelin concentration increased significantly (66.3+/-13.7 vs. 73.7+/-14.8 pg/ml; p=0.002) and TNFalpha concentrations decreased significantly (6.9+/-2.6 vs. 5.2+/-1.5 pg/ml; p=0.002). Ghrelin did not show a correlation with weight or percentage of body fat. There was a positive correlation between the increase in ghrelin and the decrease in body fat percentage during weight loss (p=0.002). Conclusion: The increase in serum ghrelin and the decrease in serum TNFalpha, as observed after weight reduction treatment in obese subjects, may constitute a counter-regulatory mechanism preventing further weight loss.

journal_name

Eur J Intern Med

journal_title

European journal of internal medicine

authors

Zahorska-Markiewicz B,Mizia-Stec K,Olszanecka-Glinianowicz M,Janowska J

doi

10.1016/j.ejim.2004.02.002

subject

Has Abstract

pub_date

2004-06-01 00:00:00

pages

172-175

issue

3

eissn

0953-6205

issn

1879-0828

pii

S0953620504000688

journal_volume

15

pub_type

杂志文章

相关文献

European Journal of Internal Medicine文献大全
  • Typhoid fever in travelers: Time for reassessment.

    abstract：:Enteric fever (EF) is the most common bacteremic disease affecting travelers to the tropics. For more than a decade, fluoroquinolones have been considered the drugs of choice for EF. However, recent reports have raised concern about fluoroquinolone resistance. Treatment with ciprofloxacin failed in a traveler with Sal...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章

    doi：10.1016/j.ejim.2006.09.016

    authors： Paz A,Cohen E,Odeh M,Potasman I

    更新日期：2007-03-01 00:00:00

  • Association between venous and arterial thrombosis: clinical implications.

    abstract：:Venous and arterial thromboses have traditionally been regarded as separate diseases with different causes. However, recent epidemiological studies have documented an association between these vascular complications, probably due to the presence of more overlapping risk factors than previously recognized. This narrati...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章,评审

    doi：10.1016/j.ejim.2012.02.008

    authors： Franchini M,Mannucci PM

    更新日期：2012-06-01 00:00:00

  • Cancer screening in Greece. Guideline awareness and prescription behavior among Hellenic physicians.

    abstract：BACKGROUND:Primary cancer prevention is offered by the Greek health care system to the population on an opportunistic basis. This means that screening depends on advice from primary care providers and on individuals' request for screening, since a centralized invitational register is lacking. In planning preventive ser...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章

    doi：10.1016/j.ejim.2007.10.018

    authors： Kamposioras K,Mauri D,Alevizaki P,Ferentinos G,Karampoiki V,Kouiroukidou P,Zorba E,Proiskos A,Chasioti D,Panou C,Gkinosati A,Chatziioannou I,Aggelinas G,Xilomenos A

    更新日期：2008-10-01 00:00:00

  • Sandfly fever due to Toscana virus: an emerging infection in southern France.

    abstract：:Infections due to Toscana virus (TOSV) have been described in the Mediterranean area, mainly in Italy. We describe two cases of acute TOSV infection in southern France, one aseptic meningitis and one influenza-like illness. To our knowledge, only one other case of TOSV infection has been reported in this area. ...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章

    doi：10.1016/j.ejim.2004.05.006

    authors： Hemmersbach-Miller M,Parola P,Charrel RN,Paul Durand J,Brouqui P

    更新日期：2004-08-01 00:00:00

  • Evolving strategies for the use of spironolactone in cardiovascular disease.

    abstract：:The evolution of strategies for the use of spironolactone and its analogue, eplerenone, has, over the years, encompassed favourable modification of the natural history of symptomatic heart failure in subjects with subnormal left ventricular ejection fraction (LVEF), and mitigation of the risk of new-onset atrial fibri...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章,评审

    doi：10.1016/j.ejim.2012.11.007

    authors： Jolobe OM

    更新日期：2013-06-01 00:00:00

  • BNP in septic patients without systolic myocardial dysfunction.

    abstract：BACKGROUND:We tested our hypothesis that serum BNP levels rise in sepsis and septic shock patients as a result of an inflammatory state and not only because of left ventricular dysfunction. METHODS:Twenty-one patients with sepsis or septic shock were enrolled in the study. Echocardiography was performed in every patie...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章

    doi：10.1016/j.ejim.2006.07.013

    authors： Shor R,Rozenman Y,Bolshinsky A,Harpaz D,Tilis Y,Matas Z,Fux A,Boaz M,Halabe A

    更新日期：2006-12-01 00:00:00

  • Increased serum uric acid level predicts poor prognosis in mildly severe chronic heart failure with reduced ejection fraction. An analysis from the MECKI score research group.

    abstract：BACKGROUND:Hyperuricemia prognostic impact on clinical outcomes in chronic heart failure (HF) patients has been investigated with inconclusive results. OBJECTIVES:Aim of the study was to evaluate the prognostic impact of serum uric acid (SUA) on long-term clinical outcomes in HF. METHODS:An analysis of MECKI (Metabol...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章

    doi：10.1016/j.ejim.2019.11.003

    authors： Piepoli MF,Salvioni E,Corrà U,Doni F,Bonomi A,La Gioia R,Limongelli G,Paolillo S,Sinagra G,Scardovi AB,Raimondo R,Emdin M,Re F,Cicoira M,Correale M,Badagliacca R,Clemenza F,Lombardi C,Agostoni P

    更新日期：2020-02-01 00:00:00

  • The relationship between plasma homocysteine levels and bone mineral density in post-menopausal women.

    abstract：BACKGROUND:Whether or not mild hyperhomocysteinemia and low serum levels of folates or vitamin B12 are risk factors for osteoporosis in the elderly is controversial. AIMS AND METHODS:To investigate whether or not plasma levels of total homocysteine (tHcy) and serum levels of folates and vitamin B12 are associated with...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章

    doi：10.1016/j.ejim.2010.03.017

    authors： Bucciarelli P,Martini G,Martinelli I,Ceccarelli E,Gennari L,Bader R,Valenti R,Franci B,Nuti R,Mannucci PM

    更新日期：2010-08-01 00:00:00

  • Treating high blood pressure: is reaching the target more important than the means? No, the means are important.

    abstract：:All major antihypertensive drug classes i.e. diuretics, beta-blockers, calcium antagonists and blockers of the renin-angiotensin system have been shown to effectively lower blood pressure and hence to reduce cardiovascular outcomes in hypertensive patients. These drugs decrease cardiovascular complications in hyperten...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章

    doi：10.1016/j.ejim.2010.08.008

    authors： Forni V,Wuerzner G,Pruijm M,Burnier M

    更新日期：2010-12-01 00:00:00

  • Peripheral bone density in patients with rheumatoid arthritis and factors which influence it.

    abstract：:INTRODUCTION: Patients with rheumatoid arthritis (RA) frequently possess a number of risk factors for osteoporosis. Additionally, oral steroids are often used to control active rheumatoid disease and may further potentiate bone loss. We wished to establish the degree of peripheral bone loss in RA and to assess the inf...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章

    doi：10.1016/s0953-6205(02)00129-2

    authors： Kelly C,Bartholomew P,Lapworth A,Basu A,Hamilton J,Heycock C

    更新日期：2002-10-01 00:00:00

  • Bacterial endocarditis with dual presentation as endophthalmitis and glomerulonephritis.

    abstract：:We report a case of Streptococcus sanguis endocarditis in a 45-year-old male who presented with bilateral endophthalmitis and glomerulonephritis. The patient responded favorably to appropriate antimicrobial chemotherapy with resolution of endophthalmitis and nephritis. Some striking features of this case and a compari...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章

    doi：10.1016/j.ejim.2005.09.019

    authors： Maliaga A,Mintzias D,Zigouris N,Kappou-Rigatou I,Skoutelis A

    更新日期：2006-03-01 00:00:00

  • Gender differences in the management and survival of patients with acute myocardial infarction.

    abstract：:Coronary heart disease (CHD) and specifically acute myocardial infarction (AMI) are the most common causes of death among both men and women throughout the world. Although CHD mortality rates have been halved in many developed countries in recent decades, some studies have pointed out significant differences regarding...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章

    doi：10.1016/s0953-6205(02)00156-5

    authors： Karciogcaron;lu O,Unal Aslan B,Aslan O

    更新日期：2002-12-01 00:00:00

  • Exaggerated exercise blood pressure response and risk of stroke in patients referred for stress testing.

    abstract：BACKGROUND/OBJECTIVES:There is some evidence to suggest that exercise systolic blood pressure (SBP) may be associated with future risk of stroke in subjects without a history of coronary artery disease (CAD). However, the value of an exaggerated exercise SBP response (EESBPR) for predicting stroke in patients referred ...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章

    doi：10.1016/j.ejim.2014.05.013

    authors： Bouzas-Mosquera Mdel C,Bouzas-Mosquera A,Peteiro J,Broullón FJ,Alvarez-García N,Castro-Beiras A

    更新日期：2014-07-01 00:00:00

  • Historical study of acute hepatitis B in subjects with or without hepatitis C infection.

    abstract：BACKGROUND:The epidemiological pattern of hepatitis B virus infection in Italy has greatly changed over the past decades. The aim of the study was to evaluate during time the epidemiological features of acute hepatitis B cases referred to an Infectious Disease Unit in North-East of Italy between 1978 and 1995. PATIENT...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章

    doi：10.1016/j.ejim.2012.03.007

    authors： Stroffolini T,Rapicetta M,Lombardo F,Chionne P,Madonna E,Candido A,Taffon S,Rinaldi R,Ermg E,Bortolotti F

    更新日期：2012-09-01 00:00:00

  • Atherogen lipid profile in HIV-1-infected patients with lipodystrophy syndrome.

    abstract：:Background: Cases of lipodystrophy syndrome and metabolic disorders have been described since the onset of highly active antiretroviral therapy in HIV-infected patients. The aim of our study was to estimate the prevalence of lipodystrophy (LD) and to define the associated lipid profile of these patients. Methods: The ...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章

    doi：10.1016/s0953-6205(00)00103-5

    authors： Mercié P,Tchamgoué S,Thiébaut R,Viallard J,Faure I I,Dancourt V V,Marimoutou C,Dabis F,Rispal P,Darmon Y,Leng B,Pellegrin J

    更新日期：2000-10-01 00:00:00

  • Risk of venous thromboembolism in first- and second-generation immigrants in Sweden.

    abstract：BACKGROUND:There are ethnic differences in the incidence of venous thromboembolism. This is the first nationwide study to examine whether there is an association between country of birth in first-generation immigrants and first hospitalisation for venous thrombosis (VT) and pulmonary embolism (PE), and to study whether...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章

    doi：10.1016/j.ejim.2011.07.015

    authors： Zöller B,Li X,Sundquist J,Sundquist K

    更新日期：2012-01-01 00:00:00

  • The discriminatory power of bleeding assessment tools in adult patients with a mild to moderate bleeding tendency.

    abstract：BACKGROUND:Bleeding assessment tools (BATs) have been developed to quantify bleeding severity. Their ability to predict for the diagnosis of a bleeding disorder has not been thoroughly investigated. OBJECTIVES:To evaluate the ability of the Vicenza BAT and the ISTH BAT to distinguish patients with an established bleed...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章

    doi：10.1016/j.ejim.2020.04.023

    authors： Gebhart J,Hofer S,Kaider A,Rejtö J,Ay C,Pabinger I

    更新日期：2020-08-01 00:00:00

  • The burden of diabetes mellitus in elderly patients from an Asian tertiary hospital.

    abstract：SUMMARY:Diabetes mellitus (DM) has been declared as a global public health threat to society. However, the burden of the disease in elderly Asian patients has not been described. The aim of the study is to assess the disease burden of DM and its associated adverse outcomes in elderly patients from an Asian hospital usi...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章

    doi：10.1016/j.ejim.2011.10.017

    authors： Yang Y,Goh SY,Tan SB,Ho HJ,Emmanuel S,Wang P,Ng HS

    更新日期：2012-01-01 00:00:00

  • Relaxin kinetics during dynamic exercise in patients with chronic heart failure.

    abstract：:Background: We investigated circulating relaxin (RLX) and its potential role in human congestive heart failure (CHF) at rest and after physical exercise. Methods: A total of 10 healthy controls and 35 patients with stable CHF were enrolled in the study. Results: RLX plasma concentrations at rest and after exercise wer...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章

    doi：10.1016/j.ejim.2003.11.009

    authors： Krüger S,Graf J,Merx MW,Stickel T,Kunz D,Hanrath P,Janssens U

    更新日期：2004-02-01 00:00:00

  • Repetitive 18F-FDG-PET/CT in patients with large-vessel giant-cell arteritis and controlled disease.

    abstract：OBJECTIVE:18F-FDG PET/CT can detect large-vessel involvement in giant-cell arteritis (GCA) with a good sensitivity. In patients with clinically and biologically controlled disease, we aimed to assess how vascular uptakes evolve on repetitive FDG-PET/CT. PATIENTS AND METHODS:All included patients had to satisfy the 4 f...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.ejim.2017.08.013

    authors： de Boysson H,Aide N,Liozon E,Lambert M,Parienti JJ,Monteil J,Huglo D,Bienvenu B,Manrique A,Aouba A

    更新日期：2017-12-01 00:00:00

  • Cystatin C and blood pressure: results of 24 h ambulatory blood pressure monitoring.

    abstract：BACKGROUND:The relationship between kidney function and blood pressure (BP) components has been studied in chronic kidney disease patients. Whether cystatin C, a marker of kidney function, is associated in the normal range with systolic BP (SBP), diastolic BP (DBP), and pulse pressure (PP) obtained using ambulatory blo...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章

    doi：10.1016/j.ejim.2010.01.016

    authors： Mena C,Robles NR,de Prado JM,Gallego FG,Cidoncha A

    更新日期：2010-06-01 00:00:00

  • Thrombomodulin as a marker of endothelium damage in some clinical conditions.

    abstract：:Background: Thrombomodulin (TM) is a membrane glycoprotein in the vascular endothelium. It may be cleaved from endothelial cells and released into the circulation. The plasma TM level depends on the integrity of the endothelium and the clearance of the molecule. The physiological role of soluble TM forms is still uncl...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章

    doi：10.1016/s0953-6205(00)00066-2

    authors： Remková A,Kovácová E,Príkazská M,Kratochvíl'ová H

    更新日期：2000-04-01 00:00:00

  • Renin-angiotensin system inhibitors reduce the progression of mesangioproliferative glomerulonephritis: 10 year follow-up.

    abstract：BACKGROUND:Proteinuria is a common presentation of mesangioproliferative glomerulonephritis (MsPGN). No studies are available on the long-term effect of treatment by renin-angiotensin system (RAS) inhibitors on renal outcome in MsPGN patients. This study prospectively evaluates the effects of RAS inhibitors on renal ou...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章

    doi：10.1016/j.ejim.2011.08.021

    authors： Presta P,Minutolo R,Iodice C,Comi N,Casoria V,Fuiano L,Caglioti C,Conte G,Fuiano G

    更新日期：2011-12-01 00:00:00

  • Clinical and lifestyle-related risk factors for incident multimorbidity: 10-year follow-up of Finnish population-based cohorts 1982-2012.

    abstract：BACKGROUND:Multimorbidity is a huge burden to individuals and societies and more attention should be paid on its risk factors and prevention possibilities. The aim of this study was to investigate which clinical and lifestyle characteristics predict the development of multimorbidity both among initially disease-free pe...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章

    doi：10.1016/j.ejim.2015.02.012

    authors： Wikström K,Lindström J,Harald K,Peltonen M,Laatikainen T

    更新日期：2015-04-01 00:00:00

  • Clinicopathologic features and outcomes of neuro-Behçet disease in Spain: a study of 20 patients.

    abstract：BACKGROUND:To describe the clinical characteristics and evolution of a series of adult patients hospitalized for neuro-Behçet disease (NBD). METHODS:Consecutive patients admitted for NBD in a teaching hospital were retrospectively selected. Disability at discharge and during follow-up was graded with the modified Rank...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章

    doi：10.1016/j.ejim.2010.08.003

    authors： Riera-Mestre A,Martínez-Yelamos S,Martínez-Yelamos A,Ferrer I,Pujol R,Vidaller A

    更新日期：2010-12-01 00:00:00

  • Determinants of continuous positive airway pressure compliance in a group of Greek patients with obstructive sleep apnea.

    abstract：OBJECTIVE:The aim of the study was to investigate the patients' characteristics that correlate with greater compliance to CPAP use. METHODS:Patients diagnosed with OSAHS and treated with CPAP, who had at least one follow-up visit in the Sleep Clinic during one year, were included in the study. Demographic data, histor...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章

    doi：10.1016/j.ejim.2009.07.004

    authors： Amfilochiou A,Tsara V,Kolilekas L,Gizopoulou E,Maniou C,Bouros D,Polychronopoulos V

    更新日期：2009-10-01 00:00:00

  • Tramadol- and codeine-induced severe hyponatremia: A Swedish population-based case-control study.

    abstract：BACKGROUND:Although tramadol and codeine occasionally have been reported to cause hyponatremia the evidence is scarce. The objective of this investigation was to study the association between weak opioids (tramadol and codeine) and hospitalization due to hyponatremia. METHODS:This was a register-based case-control stu...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章

    doi：10.1016/j.ejim.2019.08.006

    authors： Falhammar H,Calissendorff J,Skov J,Nathanson D,Lindh JD,Mannheimer B

    更新日期：2019-11-01 00:00:00

  • Patients' characteristics associated with the decision of "do not attempt cardiopulmonary resuscitation" order in a Swiss hospital.

    abstract：BACKGROUND:According to Swiss legislation, do not attempt cardiopulmonary resuscitation (DNACPR) order can be made at any time by patients only, unless the resuscitation is considered as futile, based on the doctors' evaluation. Little is known about how this decision is made, and which are the factors influencing this...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章

    doi：10.1016/j.ejim.2015.04.003

    authors： Chevaux F,Gagliano M,Waeber G,Marques-Vidal P,Schwab M

    更新日期：2015-06-01 00:00:00

  • Occult nasal sinus tumours causing oncogenic osteomalacia.

    abstract：:Oncogenic osteomalacia (OOM) is a rare but curable cause of metabolic bone disease. We report 9 patients with OOM, including 2 patients with occult nasal sinus tumours and 1 in whom a progressive increase in the post-operative FGF23 level heralded the development of metastatic pulmonary disease. The median duration of...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章

    doi：10.1016/j.ejim.2008.01.011

    authors： Kenealy H,Holdaway I,Grey A

    更新日期：2008-11-01 00:00:00

  • The role of radix hedysari polysaccharide on the human umbilical vein endothelial cells (HUVECs) induced by high glucose.

    abstract：BACKGROUND:Diabetes mellitus can cause a wide variety of vascular complications and it is one of the major risk factors for cardiovascular diseases (CVD). High glucose can induce vascular endothelial cell apoptosis. In this study, we investigated the effect of radix hedysari polysaccharide (HPS) on the depression of ap...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章

    doi：10.1016/j.ejim.2011.10.006

    authors： Liu J,Deng W,Fan L,Tian L,Jin L,Jin Z,Guo Q,Xu Y,Li N

    更新日期：2012-04-01 00:00:00