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Treating high blood pressure: is reaching the target more important than the means? No, the means are important.

Abstract：

:All major antihypertensive drug classes i.e. diuretics, beta-blockers, calcium antagonists and blockers of the renin-angiotensin system have been shown to effectively lower blood pressure and hence to reduce cardiovascular outcomes in hypertensive patients. These drugs decrease cardiovascular complications in hypertension essentially because they reduce systemic blood pressure. Nevertheless, there is growing evidence that the extent of the benefits differed between drug classes suggesting that the various classes of antihypertensive agents are not equivalent in their ability to protect against target organ damages and cardiovascular and renal endpoints. More recently, evidence has also accumulated to demonstrate that even combination therapies are not equally effective in reducing the occurrence of cardiovascular complications in hypertension. These recent observations suggest that the means to lower blood pressure are as important as the achieved target blood pressure in the management of hypertensive patients.

journal_name

Eur J Intern Med

journal_title

European journal of internal medicine

authors

Forni V,Wuerzner G,Pruijm M,Burnier M

doi

10.1016/j.ejim.2010.08.008

subject

Has Abstract

pub_date

2010-12-01 00:00:00

pages

478-83

issue

6

eissn

0953-6205

issn

1879-0828

pii

S0953-6205(10)00181-0

journal_volume

21

pub_type

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