Abstract:
BACKGROUND:Diabetic patients with renal disease have increased mortality, largely from cardiovascular disease. This could be related to insulin resistance or to other inherited factors. The aim of the present study was to investigate whether there is evidence of the familial aggregation of increased mortality, even in the absence of diabetes, by studying the reported parental age of death in type 2 diabetes. METHODS:Patients with type 2 diabetes and nephropathy (group A), patients with type 2 diabetes but without nephropathy (group B) and normal controls (group C) were interviewed and asked to report the age of death of their parents. RESULTS:The mean (+/-standard deviation) parental age of death was 68.2 (+/-13.8) years in group A, 67.3 (+/-16.0) years in group B and 68.1 (+/-14.9) years in group C. There was no statistical difference between any of the groups. CONCLUSION:Our preliminary study has failed to show evidence of reduced life expectancy of parents of patients with type 2 diabetes and nephropathy.
journal_name
Eur J Intern Medjournal_title
European journal of internal medicineauthors
Fava S,Hattersley ATdoi
10.1016/j.ejim.2005.07.005subject
Has Abstractpub_date
2005-11-01 00:00:00pages
482-4issue
7eissn
0953-6205issn
1879-0828pii
S0953-6205(05)00233-5journal_volume
16pub_type
杂志文章abstract::Endothelins are powerful vasoconstrictor peptides that also play numerous other roles. The endothelin (ET) family consists of three peptides produced by a variety of tissues. Endothelin-1 (ET-1) is the principal isoform produced by the endothelium in the human cardiovascular system, and it exerts its actions through b...
journal_title:European journal of internal medicine
pub_type: 杂志文章
doi:10.1016/j.ejim.2007.04.002
更新日期:2007-07-01 00:00:00
abstract::The use of D-dimer in combination with a clinical decision rule has been widely investigated in pulmonary embolism and deep venous thrombosis. Although it has been shown to be safe in excluding venous thromboembolism, the clinician is often faced with specific situations in which the use of D-dimer is controversial. W...
journal_title:European journal of internal medicine
pub_type: 杂志文章,评审
doi:10.1016/j.ejim.2008.12.004
更新日期:2009-09-01 00:00:00
abstract:BACKGROUND:One of the major threats looming over the growing older population is frailty. It is a distinctive health state characterised by increased vulnerability to internal and external stressors. Although the presence of frailty is well acknowledged, its concept and operationalisation are hampered by the extraordin...
journal_title:European journal of internal medicine
pub_type: 杂志文章
doi:10.1016/j.ejim.2018.04.023
更新日期:2018-10-01 00:00:00
abstract:BACKGROUND:To describe the clinical characteristics and evolution of a series of adult patients hospitalized for neuro-Behçet disease (NBD). METHODS:Consecutive patients admitted for NBD in a teaching hospital were retrospectively selected. Disability at discharge and during follow-up was graded with the modified Rank...
journal_title:European journal of internal medicine
pub_type: 杂志文章
doi:10.1016/j.ejim.2010.08.003
更新日期:2010-12-01 00:00:00
abstract::The European School of Internal Medicine (ESIM) is a meeting aimed at young physicians training in internal medicine throughout Europe. Since 1998 the school has been held annually, and in this report we reflect on our experiences during the recent school in Brighton in July 2010. The school combined a broad mix of le...
journal_title:European journal of internal medicine
pub_type: 杂志文章
doi:10.1016/j.ejim.2011.01.006
更新日期:2011-06-01 00:00:00
abstract:BACKGROUND:Renal dysfunction is associated with increased risk of mortality. The novel Full Age Spectrum (FAS) equations estimating the glomerular filtration rate (GFR) based on serum creatinine (FAScrea) and cystatin C (FAScysC) are validated across the entire age spectrum and are superior markers of renal function co...
journal_title:European journal of internal medicine
pub_type: 杂志文章
doi:10.1016/j.ejim.2018.02.005
更新日期:2018-06-01 00:00:00
abstract::The SARS-CoV-2 epidemic, which has spread to many countries around the world, has hit Europe particularly hard. From our point of view, in a rural emergency department (with an annual patient census of around 25,000) in northeastern Italy, it is necessary to preserve the hospital and prevent it from becoming an outbre...
journal_title:European journal of internal medicine
pub_type: 信件
doi:10.1016/j.ejim.2020.06.031
更新日期:2020-10-01 00:00:00
abstract:OBJECTIVES:This study investigated the correlation between Helicobacter pylori (HP) and cancer risk. We compared the age, sex, and comorbidity of cancer patients both infected and not infected by HP. METHODS:In this study, we compared a comparison cohort (N=24,088) and an HP cohort (N=6022), both taken from the NHI da...
journal_title:European journal of internal medicine
pub_type: 杂志文章
doi:10.1016/j.ejim.2014.01.009
更新日期:2014-03-01 00:00:00
abstract:BACKGROUND:The optimal revascularization strategy for non-ST elevation acute coronary syndromes (NSTE-ACS) remains controversial, especially in a real world context. The objective of this work was to assess differences at 1 year in all-cause mortality and the composite endpoint of mortality or acute myocardial infarcti...
journal_title:European journal of internal medicine
pub_type: 杂志文章
doi:10.1016/j.ejim.2006.12.011
更新日期:2007-09-01 00:00:00
abstract:BACKGROUND AND AIM:Chronic kidney disease (CKD) and cardiovascular disease are closely interrelated and the presence of one condition synergistically affects the prognosis of the other, in a negative manner. There are surprisingly very few data on the relationship between baseline coronary artery disease (CAD) severity...
journal_title:European journal of internal medicine
pub_type: 杂志文章
doi:10.1016/j.ejim.2016.06.031
更新日期:2016-09-01 00:00:00
abstract:BACKGROUND:chronic viral infections by both HCV and HIV may lead to polyclonal activation of B cells resulting in hypergammaglobulinemia. This study retrospectively analyzed the effect of HCV eradication with interferon-free direct-acting antiviral agents (DAAs) on the gamma globulin levels in HCV-infected patients wit...
journal_title:European journal of internal medicine
pub_type: 杂志文章
doi:10.1016/j.ejim.2020.01.006
更新日期:2020-05-01 00:00:00
abstract:PURPOSE:. The final diagnosis of myocarditis is challenging. The aim of our study was to provide the D.A.M.E. (Diagnosis of Acute Myocarditis in Emergency) Score for the fast identification of patients suffering from myocarditis at Emergency Department (ED). METHODS:. This was a multicenter, retrospective study involv...
journal_title:European journal of internal medicine
pub_type: 杂志文章
doi:10.1016/j.ejim.2021.01.011
更新日期:2021-01-24 00:00:00
abstract::We report a case of Strongyloides stercoralis hyperinfection in a Spanish patient who had never traveled to an endemic area and in whom HIV infection and long-term immunosuppressive treatment most likely contributed to the dissemination of strongyloidiasis. ...
journal_title:European journal of internal medicine
pub_type: 杂志文章
doi:10.1016/j.ejim.2004.10.002
更新日期:2004-12-01 00:00:00
abstract:AIM:We investigated the association among long-term proton-pump inhibitors (PPIs) use with serum magnesium (Mg) levels in chronic hemodialysis (HD) patients, as well as possible association among PPI use and increased risk of cardiovascular (CVD) morbidity in HD patients. METHODS:Of 418 HD patients that were screened ...
journal_title:European journal of internal medicine
pub_type: 杂志文章
doi:10.1016/j.ejim.2016.01.026
更新日期:2016-05-01 00:00:00
abstract::BACKGROUND: Tests able to help in the diagnostic work-up of pleural exudates are needed. C-reactive protein (CRP) may be useful for distinguishing between benign and malignant exudates. METHODS: A total of 123 consecutive patients diagnosed as having exudative pleural effusion (60 associated with malignancy and 63 ben...
journal_title:European journal of internal medicine
pub_type: 杂志文章
doi:10.1016/s0953-6205(02)00036-5
更新日期:2002-06-01 00:00:00
abstract:BACKGROUND:Antithrombotic/anticoagulation effects of direct oral anticoagulants (DOACs) are dose-dependent. However, recent observations suggest that administering lower dose DOACs may better protect against all-cause mortality. We investigated whether, in patients with established atherosclerosis, DOAC dose selection ...
journal_title:European journal of internal medicine
pub_type: 杂志文章
doi:10.1016/j.ejim.2020.09.007
更新日期:2021-01-01 00:00:00
abstract:BACKGROUND:Medication reconciliation process has proved to be an effective tool to improve the safety of drug use. The objective of this study was to assess the impact of an intervention aimed to decrease unintended discrepancies between patient's usual treatment and medications prescribed on admission to the Departmen...
journal_title:European journal of internal medicine
pub_type: 临床试验,杂志文章
doi:10.1016/j.ejim.2012.08.013
更新日期:2012-12-01 00:00:00
abstract::The purpose of this study is to determine the relationship between heat stroke and ischemic heart disease (IHD), in a nationwide population using a longitudinal approach. We retrospectively examined the data from the National Health Insurance Research Database (NHIRD) in Taiwan, for patients examined between 2000 and ...
journal_title:European journal of internal medicine
pub_type: 杂志文章
doi:10.1016/j.ejim.2018.09.019
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Pneumonia with respiratory failure represents the main cause of death in COVID-19, where hyper inflammation plays an important role in lung damage. This study aims to evaluate if tocilizumab, an anti-soluble IL-6 receptor monoclonal antibody, reduces patients' mortality. METHODS:85 consecutive patients admi...
journal_title:European journal of internal medicine
pub_type: 杂志文章
doi:10.1016/j.ejim.2020.05.009
更新日期:2020-06-01 00:00:00
abstract:BACKGROUND:The measurement of femoral intima-media thickness (IMT) is underutilized in the clinical practice, although it is a surrogate marker of cardiovascular disease. MATERIALS AND METHODS:388 Hungarian and Italian twins (121 monozygotic, 73 dizygotic pairs) underwent bilateral B-mode sonography of femoral arterie...
journal_title:European journal of internal medicine
pub_type: 杂志文章,多中心研究
doi:10.1016/j.ejim.2017.02.019
更新日期:2017-06-01 00:00:00
abstract:BACKGROUND:Scores for risk prediction used in immunocompetent patients with sepsis or pneumonia are poorly evaluated in immunocompromised patients. Therefore, we evaluated the prognostic value of the qSOFA- and CRB-65-criteria in immunocompromised patients presenting with pneumonia. METHODS:Retrospective cohort study ...
journal_title:European journal of internal medicine
pub_type: 杂志文章
doi:10.1016/j.ejim.2020.08.006
更新日期:2020-11-01 00:00:00
abstract::Monoclonal gammopathy of unknown significance (MGUS) is the most frequent plasma cell disorder that commonly affects elderly patients. Although it is an asymptomatic condition, as well as smoldering myeloma (SMM), the risk of progression to multiple myeloma requiring therapy or other B-cell disorders varies greatly fo...
journal_title:European journal of internal medicine
pub_type: 杂志文章,评审
doi:10.1016/j.ejim.2018.05.029
更新日期:2018-12-01 00:00:00
abstract:AIM:To assess whether in individuals aged 80years or older adherence to statins is accompanied by a reduced risk of all-cause mortality and major cardiovascular events. METHODS:A nested case-control study was carried out on a cohort of patients aged 80years or older (very elderly individuals), who were under treatment...
journal_title:European journal of internal medicine
pub_type: 杂志文章
doi:10.1016/j.ejim.2017.09.023
更新日期:2018-01-01 00:00:00
abstract::BACKGROUND: Plasma total homocysteine (p-tHcy) is considered to be an independent risk factor for atherosclerotic vascular disease. This cross-sectional study was undertaken to examine p-tHcy levels and their relationship to coronary artery disease (CAD) and alcohol intake. METHODS: We consecutively studied 291 patien...
journal_title:European journal of internal medicine
pub_type: 杂志文章
doi:10.1016/s0953-6205(03)00069-4
更新日期:2003-07-01 00:00:00
abstract:BACKGROUND:Tachycardia is a reliable predictor of adverse outcomes in normotensive patients with acute pulmonary embolism (PE). However, different prognostic relevant heart rate thresholds have been proposed. The aim of the study was to investigate the prognostic performance of different thresholds used for defining ta...
journal_title:European journal of internal medicine
pub_type: 杂志文章
doi:10.1016/j.ejim.2020.08.009
更新日期:2020-12-01 00:00:00
abstract::Mycobacterium fortuitum is a rapidly growing, nontuberculous mycobacteria that has rarely been associated with central nervous system impairment. We describe the case of a patient who developed multiple cerebral abscesses revealing Mycobacterium fortuitum infection. Brain biopsy specimens showed suppurative, noncaseat...
journal_title:European journal of internal medicine
pub_type: 杂志文章
doi:10.1016/s0953-6205(03)90008-2
更新日期:2003-10-01 00:00:00
abstract:BACKGROUND:We aimed to evaluate the presence of nocturnal hypotension (NHP) in ischemic stroke (IS) survivors using ambulatory blood pressure (BP) monitoring (ABPM). METHODS:We included fifty consecutive patients presenting at our outpatient clinic for review and who had been discharged for IS in the previous six mont...
journal_title:European journal of internal medicine
pub_type: 杂志文章
doi:10.1016/j.ejim.2011.03.004
更新日期:2011-10-01 00:00:00
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journal_title:European journal of internal medicine
pub_type: 杂志文章
doi:10.1016/j.ejim.2006.07.017
更新日期:2007-01-01 00:00:00
abstract:OBJECTIVE:In a previous study involving 18 hypertensive patients with type 2 diabetes mellitus, we found that replacement of valsartan and candesartan by telmisartan significantly improved insulin sensitivity and significantly increased serum adiponectin levels in the patients. We investigated the effects of 3 angioten...
journal_title:European journal of internal medicine
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.ejim.2010.01.014
更新日期:2010-06-01 00:00:00
abstract:INTRODUCTION:Early warning scores (EWS) have been developed to identify the degree of illness severity among acutely ill patients. One system, The Laboratory Decision Tree Early Warning Score (LDT-EWS) is wholly laboratory data based. Laboratory data was used in the development of a rare computerized method, developing...
journal_title:European journal of internal medicine
pub_type: 杂志文章
doi:10.1016/j.ejim.2017.12.008
更新日期:2018-05-01 00:00:00