当前位置： SCI文献检索 > European Journal of Internal Medicine期刊下所有文献 > The role of tenofovir in preventing and treating hepatitis B virus (HBV) reactivation in immunosuppressed patients. A real life experience from a tertiary center.

The role of tenofovir in preventing and treating hepatitis B virus (HBV) reactivation in immunosuppressed patients. A real life experience from a tertiary center.

Abstract：

INTRODUCTION/AIM:Patients who present HBV reactivation during immunosuppressive treatment are prone to develop life threatening decompensation of the liver function, therefore prophylaxis and treatment are strongly recommended. So far there are no data regarding the role of tenofovir in this context. Therefore, the aim of our study was to describe our "real life" experience with the use of tenofovir (TDF) in patients who underwent immunosuppressive treatment. RESULTS:38 patients with immunosuppression received antiviral treatment with tenofovir (25 patients as prophylaxis and 13 patients as treatment of HBV reactivation). In all 25 patients in whom prophylactic treatment with tenofovir was administered no HBV flare occurred during immunosuppression and the levels of serum HBV-DNA became or remained undetectable during the follow up period (mean follow up 17.2 months, range 6-54). One patient experienced HBsAg seroconversion. In the 13 patients who exhibited HBV reactivation TDF treatment resulted in complete biochemical and virological response within 6 months except two patients with high pretreatment HBV-DNA levels who became HBV-DNA negative at 9 months. No exacerbation of liver disease or liver related death has been observed. One patient who presented with decompensated cirrhosis during HBV reactivation returned into a compensated state after treatment. No side effects of tenofovir have been documented. CONCLUSION:Tenofovir seems to be highly effective and safe in the prophylaxis and rescue treatment of HBV reactivation in patients who receive immunosuppression therapy.

journal_name

Eur J Intern Med

journal_title

European journal of internal medicine

authors

Koskinas JS,Deutsch M,Adamidi S,Skondra M,Tampaki M,Alexopoulou A,Manolakopoulos S,Pectasides D

doi

10.1016/j.ejim.2014.06.028

subject

Has Abstract

pub_date

2014-10-01 00:00:00

pages

768-71

issue

8

eissn

0953-6205

issn

1879-0828

pii

S0953-6205(14)00200-3

journal_volume

25

pub_type

杂志文章

相关文献

European Journal of Internal Medicine文献大全
  • Increased serum uric acid level predicts poor prognosis in mildly severe chronic heart failure with reduced ejection fraction. An analysis from the MECKI score research group.

    abstract：BACKGROUND:Hyperuricemia prognostic impact on clinical outcomes in chronic heart failure (HF) patients has been investigated with inconclusive results. OBJECTIVES:Aim of the study was to evaluate the prognostic impact of serum uric acid (SUA) on long-term clinical outcomes in HF. METHODS:An analysis of MECKI (Metabol...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章

    doi：10.1016/j.ejim.2019.11.003

    authors： Piepoli MF,Salvioni E,Corrà U,Doni F,Bonomi A,La Gioia R,Limongelli G,Paolillo S,Sinagra G,Scardovi AB,Raimondo R,Emdin M,Re F,Cicoira M,Correale M,Badagliacca R,Clemenza F,Lombardi C,Agostoni P

    更新日期：2020-02-01 00:00:00

  • Effectiveness of sulodexide might be associated with inhibition of complement system in hepatitis B virus-associated membranous nephropathy: An inspiration from a pilot trial.

    abstract：BACKGROUND:The activation of complement system is associated with the development of hepatitis B virus-associated membranous nephropathy (HBV-MN) and heparin could inhibit the activation of complement system. METHODS:This was a three-center trial. Seventy-nine patients with HBV-MN participated in the study. The follow...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.ejim.2016.04.017

    authors： Yang Y,Ma L,Wang C,Kong D,Wang Y,Mei C

    更新日期：2016-07-01 00:00:00

  • Predictors of mortality within three months in the patients with malignant pleural effusion.

    abstract：BACKGROUND:Malignant pleural effusion (MPE) has a limited life expectancy (3-12 months). We investigated the predictors of the early mortality (EM) within three months. METHODS:The patients were retrospectively grouped according to the death within three months (Group I) and survival more than three months (Group II)....

    journal_title：European journal of internal medicine

    pub_type： 杂志文章

    doi：10.1016/j.ejim.2009.09.012

    authors： Ozyurtkan MO,Balci AE,Cakmak M

    更新日期：2010-02-01 00:00:00

  • Factors associated with length of stay following an emergency medical admission.

    abstract：BACKGROUND:Hospitals are under pressure to use resources in the most efficient manner. We have examined the factors predicting Length of Stay (LOS) in one institution, using a database of all episodes of emergency medical admissions prospectively collected over 12 years. AIM:To examine the ability to predict hospital ...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章

    doi：10.1016/j.ejim.2015.02.017

    authors： Cournane S,Byrne D,O'Riordan D,Silke B

    更新日期：2015-05-01 00:00:00

  • Patients' characteristics associated with the decision of "do not attempt cardiopulmonary resuscitation" order in a Swiss hospital.

    abstract：BACKGROUND:According to Swiss legislation, do not attempt cardiopulmonary resuscitation (DNACPR) order can be made at any time by patients only, unless the resuscitation is considered as futile, based on the doctors' evaluation. Little is known about how this decision is made, and which are the factors influencing this...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章

    doi：10.1016/j.ejim.2015.04.003

    authors： Chevaux F,Gagliano M,Waeber G,Marques-Vidal P,Schwab M

    更新日期：2015-06-01 00:00:00

  • Impact of low dose tocilizumab on mortality rate in patients with COVID-19 related pneumonia.

    abstract：BACKGROUND:Pneumonia with respiratory failure represents the main cause of death in COVID-19, where hyper inflammation plays an important role in lung damage. This study aims to evaluate if tocilizumab, an anti-soluble IL-6 receptor monoclonal antibody, reduces patients' mortality. METHODS:85 consecutive patients admi...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章

    doi：10.1016/j.ejim.2020.05.009

    authors： Capra R,De Rossi N,Mattioli F,Romanelli G,Scarpazza C,Sormani MP,Cossi S

    更新日期：2020-06-01 00:00:00

  • Typhoid fever in travelers: Time for reassessment.

    abstract：:Enteric fever (EF) is the most common bacteremic disease affecting travelers to the tropics. For more than a decade, fluoroquinolones have been considered the drugs of choice for EF. However, recent reports have raised concern about fluoroquinolone resistance. Treatment with ciprofloxacin failed in a traveler with Sal...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章

    doi：10.1016/j.ejim.2006.09.016

    authors： Paz A,Cohen E,Odeh M,Potasman I

    更新日期：2007-03-01 00:00:00

  • Quality of care after AKI development in the hospital: Consensus from the 22nd Acute Disease Quality Initiative (ADQI) conference.

    abstract：BACKGROUND:Acute kidney injury (AKI) is independently associated with increased morbidity and mortality. Quality improvement has been identified as an important goal in the care of patients with AKI. Different settings can be targeted to improve AKI care, broadly classified these include the inpatient and outpatient en...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章

    doi：10.1016/j.ejim.2020.04.056

    authors： Macedo E,Bihorac A,Siew ED,Palevsky PM,Kellum JA,Ronco C,Mehta RL,Rosner MH,Haase M,Kashani KB,Barreto EF

    更新日期：2020-10-01 00:00:00

  • A 3-factor epistatic model predicts digital ulcers in Italian scleroderma patients.

    abstract：BACKGROUND:The genetic background may predispose systemic sclerosis (SSc) patients to the development of digital ulcers (DUs). METHODS:Twenty-two functional cytokine single nucleotide polymorphisms (SNPs) and 3 HLA class I and II antigens were typed at the genomic level by polymerase chain reaction in 200 Italian SSc ...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章

    doi：10.1016/j.ejim.2010.05.010

    authors： Beretta L,Santaniello A,Mayo M,Cappiello F,Marchini M,Scorza R

    更新日期：2010-08-01 00:00:00

  • The clinical and hemodynamic results of mitral balloon valvuloplasty for patients with mitral stenosis complicated by severe pulmonary hypertension.

    abstract：BACKGROUND:Percutaneous balloon mitral valvuloplasty (PBMV) has become the procedure of choice for isolated, uncomplicated mitral stenosis (MS) with favorable morphology and may be a useful method for surgical high-risk conditions such as advanced age, the presence of severe tricuspid regurgitation, New York Heart Asso...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章

    doi：10.1016/j.ejim.2005.02.012

    authors： Maoqin S,Guoxiang H,Zhiyuan S,Luxiang C,Houyuan H,Liangyi S,Ling Z,Guoqiang Z

    更新日期：2005-10-01 00:00:00

  • Erdheim-Chester disease.

    abstract：:Erdheim-Chester disease (ECD) is rare form of non-Langerhans cells histiocytosis with multiorgan involvement. Individuals are more frequently affected in their fifth decade and there is a slight male prevalence. Recent studies have demonstrated that ECD patients bare mutations in the proto-oncogene BRAF (and more rare...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章,评审

    doi：10.1016/j.ejim.2015.03.004

    authors： Campochiaro C,Tomelleri A,Cavalli G,Berti A,Dagna L

    更新日期：2015-05-01 00:00:00

  • Limited prognostic accuracy of the CRB-65 and qSOFA in patients presenting with pneumonia and immunosuppression.

    abstract：BACKGROUND:Scores for risk prediction used in immunocompetent patients with sepsis or pneumonia are poorly evaluated in immunocompromised patients. Therefore, we evaluated the prognostic value of the qSOFA- and CRB-65-criteria in immunocompromised patients presenting with pneumonia. METHODS:Retrospective cohort study ...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章

    doi：10.1016/j.ejim.2020.08.006

    authors： Frantz S,Schulte-Hubbert B,Halank M,Koschel D,Kolditz M

    更新日期：2020-11-01 00:00:00

  • Blessings of the grape.

    abstract：:Numerous epidemiological studies have shown an inverse correlation between moderate consumption of alcoholic drinks and the risk of coronary heart disease. Wine, especially red wine, may be more favorable in this respect than beer or spirits because of its high content of flavonoids. These polyphenols originate from t...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章

    doi：10.1016/s0953-6205(01)00170-4

    authors： van de Wiel A,van Golde PH,Hart HC

    更新日期：2001-12-01 00:00:00

  • Do PubMed and Google searches help medical students and young doctors reach the correct diagnosis? A pilot study.

    abstract：BACKGROUND:In the era of the World Wide Web we sought to examine whether the use of PubMed and Google can help physicians to improve their diagnostic skills. METHODS:Twenty-six diagnostic cases presented in the case records of the New England Journal of Medicine during 2005 were used for our analysis. Three investigat...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章

    doi：10.1016/j.ejim.2009.07.014

    authors： Falagas ME,Ntziora F,Makris GC,Malietzis GA,Rafailidis PI

    更新日期：2009-12-01 00:00:00

  • Determinants of continuous positive airway pressure compliance in a group of Greek patients with obstructive sleep apnea.

    abstract：OBJECTIVE:The aim of the study was to investigate the patients' characteristics that correlate with greater compliance to CPAP use. METHODS:Patients diagnosed with OSAHS and treated with CPAP, who had at least one follow-up visit in the Sleep Clinic during one year, were included in the study. Demographic data, histor...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章

    doi：10.1016/j.ejim.2009.07.004

    authors： Amfilochiou A,Tsara V,Kolilekas L,Gizopoulou E,Maniou C,Bouros D,Polychronopoulos V

    更新日期：2009-10-01 00:00:00

  • Higher prevalence of risk factors for type 2 diabetes mellitus and subsequent higher incidence in men.

    abstract：BACKGROUND:This study investigates risk factors and the incidence of type 2 diabetes mellitus (type 2 DM) in both sexes of a northern European population. METHODS:A total of 14,223 randomly selected men and women were studied from 1976 to 1978. Patients with diabetes (self-reported type 2 DM or non-fasting plasma gluc...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章

    doi：10.1016/j.ejim.2007.05.011

    authors： Almdal T,Scharling H,Jensen JS,Vestergaard H

    更新日期：2008-01-01 00:00:00

  • Clinical characteristics and one-year survival in heart failure patients more than 85 years of age compared with younger.

    abstract：BACKGROUND:Heart failure (HF) is frequent in elderly patients, but few studies have focused on patients older than 84 years. The aim of this study was to evaluate major comorbidities and 1-year survival in HF patients aged ≥85 years compared with younger age groups. METHODS:Patients included in a prospective national ...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.ejim.2013.01.005

    authors： Conde-Martel A,Formiga F,Pérez-Bocanegra C,Armengou-Arxé A,Muela-Molinero A,Sánchez-Sánchez C,Diez-Manglano J,Montero-Pérez-Barquero M

    更新日期：2013-06-01 00:00:00

  • Atypical hemolytic uremic syndrome: from the rediscovery of complement to targeted therapy.

    abstract：:Atypical hemolytic uremic syndrome (aHUS) is a devastating form of renal thrombotic microangiopathy. In the last five years, we have finally witnessed a dramatic improvement in the management of aHUS patients, and three breakthroughs in our understanding of aHUS have led to such an improvement. The first breakthrough ...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章,评审

    doi：10.1016/j.ejim.2013.05.008

    authors： Fakhouri F,Frémeaux-Bacchi V,Loirat C

    更新日期：2013-09-01 00:00:00

  • Bilateral fractured neck of the femur in an adult patient with cystic fibrosis.

    abstract：:A 34-year-old man with cystic fibrosis (CF) sustained a bilateral fractured neck of the femur during the course of six grand mal seizures. The fractures were successfully treated with bipolar hemi-arthroplasties. Several risk factors for osteoporosis were present. Bone pathology showed reduced femoral head bone densit...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章

    doi：10.1016/s0953-6205(03)00036-0

    authors： Lim AY,Isopescu S,Thickett KM,Gumery LB,Darby AJ,Honeybourne D,Stableforth DE

    更新日期：2003-05-01 00:00:00

  • Lessons from acute pancreatitis-induced thrombotic thrombocytopenic purpura.

    abstract：:Acute pancreatitis is an inflammatory disease characterized by local tissue injury which can trigger a systemic inflammatory response. There is increasing evidence that endothelial dysfunction is one of the critical pathophysiologic manifestations in patients with severe form of acute pancreatitis. In keeping with thi...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章,评审

    doi：10.1016/j.ejim.2009.09.008

    authors： Thachil J

    更新日期：2009-12-01 00:00:00

  • Monoclonal gammopathies of unknown significance and smoldering myeloma: Assessment and management of the elderly patients.

    abstract：:Monoclonal gammopathy of unknown significance (MGUS) is the most frequent plasma cell disorder that commonly affects elderly patients. Although it is an asymptomatic condition, as well as smoldering myeloma (SMM), the risk of progression to multiple myeloma requiring therapy or other B-cell disorders varies greatly fo...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章,评审

    doi：10.1016/j.ejim.2018.05.029

    authors： González-Calle V,Mateos MV

    更新日期：2018-12-01 00:00:00

  • Drug-related problems identification in general internal medicine: The impact and role of the clinical pharmacist and pharmacologist.

    abstract：BACKGROUND:Patients admitted to general internal medicine wards might receive a large number of drugs and be at risk for drug-related problems (DRPs) associated with increased morbidity and mortality. This study aimed to detect suboptimal drug use in internal medicine by a pharmacotherapy evaluation, to suggest treatme...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章

    doi：10.1016/j.ejim.2015.05.012

    authors： Guignard B,Bonnabry P,Perrier A,Dayer P,Desmeules J,Samer CF

    更新日期：2015-07-01 00:00:00

  • Cytotoxic T lymphocyte-associated molecule-4 polymorphisms in Turkish Graves' disease patients and association with probability of remission after antithyroid therapy.

    abstract：BACKGROUND:One of the candidate genes for susceptibility to Graves' disease (GD) is cytotoxic T lymphocyte-associated molecule-4 (CTLA-4), a negative regulator of T-cell activation. In order to elucidate the relationship of GD with the A/G polymorphism in exon 1 and the C/T polymorphism in the promoter region of the CT...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章

    doi：10.1016/j.ejim.2005.06.007

    authors： Sahin M,Erdogan MF,Erdogan G

    更新日期：2005-09-01 00:00:00

  • Gallbladder and gastric emptying: relationship to cholecystokininemia in diabetics.

    abstract：:Background: Impaired gastrointestinal and gallbladder motility, as a complication of long-lasting diabetes mellitus, has been ascribed to the possible development of autonomic neuropathy, although the intervention of hormonal factors may not completely be excluded. In this regard, cholecystokinin (CCK), a gut hormone ...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章

    doi：10.1016/s0953-6205(02)00003-1

    authors： Bucceri AM,Calogero AE,Brogna A

    更新日期：2002-03-01 00:00:00

  • Urticarial vasculitis revealing relapsing polychondritis.

    abstract：:We report a case of hypocomplementemic urticarial vasculitis heralding a relapsing polychondritis in a 63-year-old woman. The patient, who had suffered in the past from polymyalgia rheumatica, suddenly experienced a generalized urticarial eruption with a dramatic decrease in C4 complement fraction and the presence of ...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章

    doi：10.1016/j.ejim.2004.10.022

    authors： Serratrice J,de Roux-Serratrice C,Ené N,Granel B,Disdier P,Weiller PJ

    更新日期：2005-06-01 00:00:00

  • Feasibility and safety of multiple daily insulin injections in general medicine wards.

    abstract：AIM:Intravenous insulin improves clinical outcome in patients hospitalized in intensive care units. Whether glucose control with multiple daily subcutaneous insulin injections (MDI) is beneficial in patients hospitalized in general medical wards is unknown. We tested the feasibility, safety and efficacy of glucose cont...

    journal_title：European journal of internal medicine

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.ejim.2008.12.010

    authors： Buchs AE,Bloemers R,Shiloah E,Horowitz M,Aminov S,Ramot Y,Rapoport MJ

    更新日期：2009-07-01 00:00:00

  • Early repolarization syndrome and Brugada syndrome: is there any linkage?

    abstract：:Early repolarization syndrome (ERS) is characterized by the presence, in most cases in mid-to-lateral precordial leads, of a J wave on the downsloping portion of the QRS complex, followed by an elevation of the ST-segment with upward concavity. ERS is considered a benign electrocardiographic pattern of ventricular rep...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章,评审

    doi：10.1016/j.ejim.2007.06.013

    authors： Di Grande A,Tabita V,Lizzio MM,Giuffrida C,Bellanuova I,Lisi M,Le Moli C,Amico S

    更新日期：2008-06-01 00:00:00

  • Peripheral bone density in patients with rheumatoid arthritis and factors which influence it.

    abstract：:INTRODUCTION: Patients with rheumatoid arthritis (RA) frequently possess a number of risk factors for osteoporosis. Additionally, oral steroids are often used to control active rheumatoid disease and may further potentiate bone loss. We wished to establish the degree of peripheral bone loss in RA and to assess the inf...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章

    doi：10.1016/s0953-6205(02)00129-2

    authors： Kelly C,Bartholomew P,Lapworth A,Basu A,Hamilton J,Heycock C

    更新日期：2002-10-01 00:00:00

  • Sodium levels on admission are associated with mortality risk in hospitalized patients.

    abstract：AIMS:Abnormal sodium values are common among hospitalized patients. We aimed to investigate the association of admission sodium values and mortality. METHODS:Historical prospectively data of adult patients hospitalized to medical wards between January 2011 and December 2013. Admission sodium values were classified to ...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章

    doi：10.1016/j.ejim.2017.07.017

    authors： Akirov A,Diker-Cohen T,Steinmetz T,Amitai O,Shimon I

    更新日期：2017-12-01 00:00:00

  • Extrapulmonary tuberculosis: 7 year-experience of a tertiary center in Istanbul.

    abstract：BACKGROUND:Although a decreasing trend of tuberculosis (TB) was reported in Turkey, higher proportion of extrapulmonary tuberculosis (EPT) was revealed. MATERIAL AND METHODS:In this retrospective study, clinical and laboratory data of 141 EPT patients were evaluated for a seven-year period by using descriptive statist...

    journal_title：European journal of internal medicine

    pub_type： 杂志文章

    doi：10.1016/j.ejim.2013.08.704

    authors： Sevgi DY,Derin O,Alpay AS,Gündüz A,Konuklar AS,Bayraktar B,Bulut E,Uzun N,Sonmez E

    更新日期：2013-12-01 00:00:00