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Heart rate and cardiovascular protection.

Abstract：

:Recent large epidemiological studies have confirmed that an elevated resting heart rate is an independent predictor of cardiovascular and overall mortality in the general population as well as in patients with hypertension, coronary heart disease and chronic heart failure. Pathophysiological studies indicate that a higher heart rate has detrimental effects that favor myocardial ischemia, ventricular arrhythmias, as well as an increase in vascular oxidative stress, endothelial dysfunction and atherosclerosis progression. Benefits of heart rate lowering drugs, such as beta-blockers and ivabradine, in reducing overall and cardiovascular-related mortality, have been demonstrated particularly in patients with coronary heart disease and heart failure. However, despite these evidences, resting heart rate is still an overlooked cardiovascular risk factor.

journal_name

Eur J Intern Med

journal_title

European journal of internal medicine

authors

Caetano J,Delgado Alves J

doi

10.1016/j.ejim.2015.02.009

subject

Has Abstract

pub_date

2015-05-01 00:00:00

pages

217-22

issue

4

eissn

0953-6205

issn

1879-0828

pii

S0953-6205(15)00044-8

journal_volume

26

pub_type

杂志文章,评审

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