Abstract：
:Fungal dimorphism is the capacity of certain species of fungi to grow in the form of budding yeasts or mycelium depending on the environmental conditions. This characteristic is a complex phenomenon that involves modifications of the molecular machinery in response to different environmental signals. Through the use of microarrays, in this work we identified genes involved in the early stages of the yeast-to-mycelium transition of Yarrowia lipolytica induced by a shift in pH of the medium. As controls, yeast and mycelium monomorphic mutants were used, identifying by this mean a total of 61 upregulated and 165 downregulated genes specifically involved in dimorphism. Determination of the putative function of these genes was accomplished by means of BLAST analyses which showed that they were involved mainly in processes such as remodeling and biogenesis of the cell wall, membrane trafficking and N- or O-glycosylation. Some of these genes were identified by homology with Saccharomyces cerevisiae genes, and found to play a role during the dimorphic transition in both systems.
journal_name
Res Microbioljournal_title
Research in microbiologyauthors
Morales-Vargas AT,Domínguez A,Ruiz-Herrera Jdoi
10.1016/j.resmic.2012.03.002subject
Has Abstractpub_date
2012-06-01 00:00:00pages
378-87issue
5eissn
0923-2508issn
1769-7123pii
S0923-2508(12)00042-3journal_volume
163pub_type
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