The DTNBP1 (dysbindin-1) gene variant rs2619522 is associated with variation of hippocampal and prefrontal grey matter volumes in humans.

abstract：:Abnormalities of the cerebellum and default-mode network (DMN) in patients with obsessive-compulsive disorder (OCD) have been widely reported. However, alterations of reciprocal functional connections between the cerebellum and DMN at rest in OCD remain unclear. Forty patients with OCD and 38 gender-, age-, and educat...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Lv D,Ou Y,Chen Y,Yang R,Zhong Z,Jia C,Sun L,Wang Y,Zhang G,Sun Z,Wang W,Wang Y,Wang X,Guo W,Li P

更新日期：2020-12-01 00:00:00

abstract：:Affective and non-affective psychoses are severe and frequent psychiatric disorders. Amongst others, they not only have a profound impact on affected individuals through their symptomatology, but also regarding cognition, brain structure and function. Cognitive impairment influences patients' quality of life as well a...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Malchow B,Reich-Erkelenz D,Oertel-Knöchel V,Keller K,Hasan A,Schmitt A,Scheewe TW,Cahn W,Kahn RS,Falkai P

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND:While there is ample evidence that the prevalence rates for major depressive disorder (MDD) in the general population are higher in women than in men, there is little data on gender differences as regard to symptoms, causal attribution, help-seeking, coping, or the consequences of depression. METHOD:The lar...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Angst J,Gamma A,Gastpar M,Lépine JP,Mendlewicz J,Tylee A,Depression Research in European Society Study.

更新日期：2002-10-01 00:00:00

abstract：:The aim of this study was to reexamine and compare the characteristics of the deficit and nondeficit schizophrenic patients. This cross-sectional study consisted of 62 in- and out-patients, 18-65 years of age, diagnosed with schizophrenia according to DSM-IV. The sociodemographic variables, premorbid adjustment, clini...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Tiryaki A,Yazici MK,Anil AE,Kabakçi E,Karaağaoğlu E,Göğüş A

更新日期：2003-10-01 00:00:00

abstract：:Ego-disturbances (passivity phenomena) and formal thought disorder are two hallmark symptoms of schizophrenia. Formal thought disorder has been highlighted already very early by Eugen Bleuler in his concept of basic symptoms (Grundsymptome). In contrast ego-disturbances (Ich-Störungen) or passivity phenomena have been...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Leube D,Whitney C,Kircher T

更新日期：2008-11-01 00:00:00

abstract：:Changes in the surface morphology of the orbitofrontal cortex (OFC), such as a fewer orbital sulci and altered sulcogyral pattern of the 'H-shaped' orbital sulcus, have been reported in schizophrenia, possibly reflecting abnormal neurodevelopment during gestation. However, whether high-risk subjects for developing psy...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Nakamura M,Takahashi T,Takayanagi Y,Sasabayashi D,Katagiri N,Sakuma A,Obara C,Koike S,Yamasue H,Furuichi A,Kido M,Nishikawa Y,Noguchi K,Matsumoto K,Mizuno M,Kasai K,Suzuki M

更新日期：2019-06-01 00:00:00

abstract：:Although classical and atypical antipsychotics may have different neurotoxic effects, their underlying mechanisms remain to be elucidated, especially regarding neuroglial function. In the present study, we compared the atypical antipsychotic risperidone (0.01-10 μM) with the typical antipsychotic haloperidol (0.01-10 ...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Quincozes-Santos A,Bobermin LD,Tonial RP,Bambini-Junior V,Riesgo R,Gottfried C

更新日期：2010-09-01 00:00:00

abstract：BACKGROUND:Increased, decreased, as well as unchanged pituitary volumes have been reported in bipolar disorders (BD). It is unclear, whether abnormal pituitary volumes increase vulnerability for BD (primary vulnerability marker), or are secondary to burden of illness. To address this question, we performed the first hi...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Hajek T,Gunde E,Bernier D,Slaney C,Propper L,Macqueen G,Duffy A,Alda M

更新日期：2008-09-01 00:00:00

abstract：OBJECTIVE:The prevalence and consequences of co-morbid axis-I and axis-II disorders as well as personality traits were examined in a large cohort of adult attention-deficit/hyperactivity disorder (AADHD) at a tertiary referral center. METHODS:In- and outpatients referred for diagnostic assessment of AADHD were screene...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Jacob CP,Romanos J,Dempfle A,Heine M,Windemuth-Kieselbach C,Kruse A,Reif A,Walitza S,Romanos M,Strobel A,Brocke B,Schäfer H,Schmidtke A,Böning J,Lesch KP

更新日期：2007-09-01 00:00:00

abstract：:Thirty inpatients with somatoform disorders were examined with the structured clinical interview SCID for psychiatric lifetime diagnosis. In the present diagnoses, we found a concordance of 63% for somatoform and affective disorders and the lifetime comorbidity of both disorders was 87%. Additionally, patients with so...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Rief W,Schaefer S,Hiller W,Fichter MM

更新日期：1992-01-01 00:00:00

abstract：:Emil Kraepelin is well known due to his development of the psychiatric classification. The ICD-10 and DSM-IV classification is based on the dichotomy of endogenous psychoses into affective psychoses and schizophrenia as early as 1899. Moreover, beside his classification system he put enormous impact on the development...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Hippius H,Müller N

更新日期：2008-06-01 00:00:00

abstract：:The alpha 1C subunit of the L-type voltage-gated calcium channel (CACNA1C) gene is one of the best replicated susceptibility loci for bipolar disorder, schizophrenia and major depression. It is involved in learning, memory and brain plasticity. Genetic studies using functional magnetic resonance imaging (fMRI) reporte...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Krug A,Witt SH,Backes H,Dietsche B,Nieratschker V,Shah NJ,Nöthen MM,Rietschel M,Kircher T

更新日期：2014-03-01 00:00:00

abstract：:Overactive performance monitoring has been consistently reported in obsessive-compulsive disorder (OCD). OCD is a clinically heterogeneous disorder and is characterized by several symptom dimensions that may have partially distinct neural correlates. We examined whether performance-monitoring alterations are related t...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Riesel A,Kathmann N,Endrass T

更新日期：2014-12-01 00:00:00

abstract：:Cognitive models suggest that top-down and emotional processes increase false perceptions in schizophrenia spectrum disorders (SSD). However, little is still known about the interaction of these processes in false auditory perceptions. The present study aimed at investigating the specific as well as joint impacts of e...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Gawęda Ł,Moritz S

更新日期：2019-09-06 00:00:00

abstract：:Previous research on neuropsychological disturbances in first-episode and chronic schizophrenic patients has provided mixed results which can be partially attributed to methodological inconsistencies. For the present study, 70 schizophrenic patients (40 with chronic and 30 with first-episode schizophrenia) were compar...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Moritz S,Andresen B,Perro C,Schickel M,Krausz M,Naber D,PERSIST Study Group.

更新日期：2002-02-01 00:00:00

abstract：:For the functional psychoses of late life, epidemiological information comes from two sources: studies of persons who have reached psychiatric services; and surveys of elderly persons sampled from the general population. A conspectus of published data from both sources leads to the following conclusions: States phenom...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Henderson AS,Kay DW

更新日期：1997-01-01 00:00:00

abstract：:Various factors contribute to the development and maintenance of delusions in the context of schizophrenic psychoses. Studies with functional and structural MRI were able to detect neurobiological correlates of paranoid symptoms. Consistent with the neurodevelopmental hypothesis of schizophrenic psychosis, which impli...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Knobel A,Heinz A,Voss M

更新日期：2008-11-01 00:00:00

abstract：:We performed an updated meta-analysis of randomized double-blind placebo-controlled trials (RCTs) on the effects of varenicline adjuvant therapy for smoking cessation in people with schizophrenia, on the basis of a previous meta-analysis (Tsoi in Cochrane Database Syst Rev 2:CD007253, 2013). We searched PubMed, the Co...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Kishi T,Iwata N

更新日期：2015-04-01 00:00:00

abstract：:The conceptualization of rapidly cycling bipolar disorder remains controversial. The DSM-IV definition of rapid cycling, although very reliable, may be not sufficiently inclusive (i.e., it may exclude patients with very short episodes of very high frequency, who are very typical in terms of external validators, and ar...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Maj M

更新日期：2001-01-01 00:00:00

abstract：:Schizophrenia is a severe neuropsychiatric disorder with familial loading as heritable risk factor and cannabis abuse as the most relevant environmental risk factor up to date. Cannabis abuse has been related to an earlier onset of the disease and persisting cannabis consumption is associated with reduced symptom impr...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Malchow B,Hasan A,Schneider-Axmann T,Jatzko A,Gruber O,Schmitt A,Falkai P,Wobrock T

更新日期：2013-11-01 00:00:00

abstract：:Compounds targeting serotonin (5-HT) are widely used as antidepressants. However, the role of 5-HT in mediating the effects of electroconvulsive seizure (ECS) therapy remains undefined. Using Tph2-/- mice depleted of brain 5-HT, we studied the effects of ECS on behavior and neurobiology. ECS significantly prolonged th...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Kronenberg G,Petermann M,Dormann C,Bader M,Gass P,Hellweg R,Klempin F

更新日期：2018-12-01 00:00:00

abstract：:Low social integration is commonly described in acutely suicidal individuals. Neural mechanisms underlying low social integration are poorly understood in depressed and suicidal patients. We sought to characterize the neural response to low social integration in acutely suicidal patients. Adult depressed patients with...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Cáceda R,James GA,Stowe ZN,Delgado PL,Kordsmeier N,Kilts CD

更新日期：2020-08-01 00:00:00

abstract：:Schizophrenia is a severe neuropsychiatric disease that is associated with neurobiological alterations in multiple brain regions and peripheral organs. Negative symptoms and cognitive deficits are present in about half of patients and are difficult to treat, leading to an unfavorable functional outcome. To investigate...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Maurus I,Hasan A,Röh A,Takahashi S,Rauchmann B,Keeser D,Malchow B,Schmitt A,Falkai P

更新日期：2019-08-01 00:00:00

abstract：:The anxiogenic effects of yohimbine, a specific alpha-2-receptor antagonist were examined by administering 20 mg yohimbine orally to 8 panic patients on placebo treatment, 7 panic patients on alprazolam treatment and 12 controls using a double-blind randomized design, instructions that minimized the expectancy of expe...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Albus M,Zahn TP,Breier A

更新日期：1992-01-01 00:00:00

abstract：:Gamma oscillations are key in coordinating brain activity and seem to be altered in schizophrenia. In previous work, we studied the spatial distribution of a noise power measure (scalp-recorded electroencephalographic activity unlocked to stimuli) and found higher magnitudes in the gamma band related to symptoms and c...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Suazo V,Lubeiro A,Jurado-Barba R,Moreno-Ortega M,Dompablo M,Morales-Muñoz I,Rodriguez-Jimenez R,Palomo T,Molina V

更新日期：2016-12-01 00:00:00

abstract：:The main goal of the present study was to explore whether regional cerebral blood flow (rCBF) differs between obsessive-compulsive disorder (OCD) patients without chronic motor tic disorder and those OCD patients with a comorbid chronic tic disorder. Twenty-seven patients suffering from OCD (DSM-IV criteria), includin...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Crespo-Facorro B,Cabranes JA,López-Ibor Alcocer MI,Payá B,Fernández Pérez C,Encinas M,Ayuso Mateos JL,López-Ibor JJ Jr

更新日期：1999-01-01 00:00:00

abstract：OBJECTIVE:We tested Kraepelin's dichotomy model by studying the separability of schizophrenia and depression on the basis of symptoms and illness course. MATERIALS AND METHODS:Matched untreated patients with schizophrenia and depression (n = 130 each) and 130 "healthy" controls were assessed from onset to first admiss...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Häfner H,an der Heiden W,Maurer K

更新日期：2008-06-01 00:00:00

abstract：:P300 is an event-related potential that is elicited by an oddball paradigm. In several neuropsychiatric diseases, differences in latencies and amplitude compared to healthy subjects have been reported. Because of its clinical significance, several investigations have tried to elucidate the intracranial origins of the ...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Horn H,Syed N,Lanfermann H,Maurer K,Dierks T

更新日期：2003-06-01 00:00:00

abstract：:The course of obsessive-compulsive disorder (OCD) is variable, ranging from episodic to chronic. We hypothesised that the former course is more likely to be related to bipolar mood disorders. With the use of a specially constructed OCD questionnaire, we studied 135 patients fulfilling DSM-III-R criteria for OCD with a...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Perugi G,Akiskal HS,Gemignani A,Pfanner C,Presta S,Milanfranchi A,Lensi P,Ravagli S,Maremmani I,Cassano GB

更新日期：1998-01-01 00:00:00

abstract：:In a single-blind, placebo-controlled crossover trial, the acute efficacy of the dopamine agonist pramipexole was investigated in 11 restless legs syndrome (RLS) patients by sleep laboratory methods, with a clinical follow-up for 4 weeks. In 3 nights (pre-treatment, placebo and drug night), objective sleep quality was...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Saletu M,Anderer P,Saletu-Zyhlarz G,Hauer C,Saletu B

更新日期：2002-08-01 00:00:00