The neural correlates of ego-disturbances (passivity phenomena) and formal thought disorder in schizophrenia.

Abstract:

:Ego-disturbances (passivity phenomena) and formal thought disorder are two hallmark symptoms of schizophrenia. Formal thought disorder has been highlighted already very early by Eugen Bleuler in his concept of basic symptoms (Grundsymptome). In contrast ego-disturbances (Ich-Störungen) or passivity phenomena have been declared as core symptoms of schizophrenia by Kurt Schneider in his concept of first-rank symptoms (Erstrangsymptome) that influenced the whole concept of schizophrenia until today (ICD10; DSM IV). We present new neuroimaging and cognitive neuropsychological results that help to explain what brain and cognitive functions may be involved in the emergence of these symptoms. Questions on cognitive and neural correlates of notions such as self-awareness, self-consciousness, introspective perspective or subjective experiences have re-emerged as topics of great interest in the scientific community. Employing new neuroscientific methods such as functional brain imaging, advances into thus far unexplored territory of mind-brain relationships have been made. These findings give new impulses for the search on the neural basis of psychopathological symptoms. We will review neuroscientific data and models on the pathogenesis of two of the core symptoms of schizophrenia, i.e. passivity phenomena and formal thought disorder.

authors

Leube D,Whitney C,Kircher T

doi

10.1007/s00406-008-5017-z

subject

Has Abstract

pub_date

2008-11-01 00:00:00

pages

22-7

eissn

0940-1334

issn

1433-8491

journal_volume

258 Suppl 5

pub_type

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