Imaging the deluded brain.

Abstract:

:Various factors contribute to the development and maintenance of delusions in the context of schizophrenic psychoses. Studies with functional and structural MRI were able to detect neurobiological correlates of paranoid symptoms. Consistent with the neurodevelopmental hypothesis of schizophrenic psychosis, which implies an early developmental disorder affecting temporo-limbic areas and resulting in a disinhibition of striatal dopamine release, current imaging studies point towards the involvement of temporo-limbic and frontal dysfunction in delusion formation. In line with this, a specific role of dopamine as a neuromodulator in delusion formation is being discussed. Finally, mechanisms relevant to delusion formation appear to involve cognitive processes such as biases of attribution with regard to emotionally salient events as well as attentional biases during the perception of affective stimuli.

authors

Knobel A,Heinz A,Voss M

doi

10.1007/s00406-008-5008-0

subject

Has Abstract

pub_date

2008-11-01 00:00:00

pages

76-80

eissn

0940-1334

issn

1433-8491

journal_volume

258 Suppl 5

pub_type

杂志文章,评审
  • Risperidone and haloperidol promote survival of stem cells in the rat hippocampus.

    abstract::Altered neuroplasticity contributes to the pathophysiology of schizophrenia. However, the idea that antipsychotics may act, at least in part, by normalizing neurogenesis has not been consistently supported. Our study seeks to determine whether hippocampal cell proliferation is altered in adult rats pretreated with ket...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 杂志文章

    doi:10.1007/s00406-009-0033-1

    authors: Keilhoff G,Grecksch G,Bernstein HG,Roskoden T,Becker A

    更新日期:2010-03-01 00:00:00

  • Perception and evaluation of women's bodies in adolescents and adults with anorexia nervosa.

    abstract::Body image disturbance in anorexia nervosa (AN) has been widely studied with regard to the patient's own body, but little is known about perception of or attitude towards other women's bodies in AN. The aim of the present study was to investigate how 20 girls aged 12-18 years and 19 adult women suffering from AN compa...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 杂志文章

    doi:10.1007/s00406-015-0603-3

    authors: Horndasch S,Heinrich H,Kratz O,Mai S,Graap H,Moll GH

    更新日期:2015-12-01 00:00:00

  • A 10-year matched-pairs study comparing azathioprine and no immunosuppression in multiple sclerosis.

    abstract::In a retrospective matched-pairs study the efficacy of azathioprine treatment was compared with no treatment over a period of at least 10 years. Of 277 patients with clinically definite multiple sclerosis seen during the years 1973 and 1974, 42 pairs were selected by similarity in disability score, sex, age and diseas...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 杂志文章

    doi:10.1007/BF02190090

    authors: Kappos L,Heun R,Mertens HG

    更新日期:1990-01-01 00:00:00

  • Obsessive-compulsive symptoms in psychotic disorders: longitudinal associations of symptom clusters on between- and within-subject levels.

    abstract::Obsessive-compulsive symptoms (OCS) are frequently reported in patients with schizophrenia and have been associated with subjective distress and higher impairment. Recent studies suggest fluctuation in co-occurring OCS and associations with the course of psychotic symptoms. Current evidence is limited by few studies w...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 杂志文章

    doi:10.1007/s00406-018-0884-4

    authors: Schirmbeck F,Konijn M,Hoetjes V,Zink M,de Haan L,For Genetic Risk and Outcome of Psychosis (GROUP).

    更新日期:2019-03-01 00:00:00

  • Cerebral connectivity and psychotic personality traits. A diffusion tensor imaging study.

    abstract::This study aims to investigate the relationship between regional connectivity in the brain white matter and the presence of psychotic personality traits, in healthy subjects with psychotic traits. Thirteen healthy controls were administered the MMPI-2, to assess psychotic traits and, according to MMPI results, a dicho...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 杂志文章

    doi:10.1007/s00406-007-0796-1

    authors: Volpe U,Federspiel A,Mucci A,Dierks T,Frank A,Wahlund LO,Galderisi S,Maj M

    更新日期:2008-08-01 00:00:00

  • Rates and predictors of relapse in first-episode non-affective psychosis: a 3-year longitudinal study in a specialized intervention program (PAFIP).

    abstract::Relapses may represent a critical hazard in schizophrenia spectrum disorders as they are associated with an increased risk of a clinical and functional deterioration. Preventing relapse after recovering from a first psychotic episode has become a major challenge due to its critical impact on lifelong functionality. Th...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 杂志文章

    doi:10.1007/s00406-016-0740-3

    authors: Pelayo-Terán JM,Gajardo Galán VG,de la Ortiz-García de la Foz V,Martínez-García O,Tabarés-Seisdedos R,Crespo-Facorro B,Ayesa-Arriola R

    更新日期:2017-06-01 00:00:00

  • Human CLOCK gene-associated attention deficit hyperactivity disorder-related features in healthy adults: quantitative association study using Wender Utah Rating Scale.

    abstract::Circadian rhythm disturbance is highly prevalent in attention deficit hyperactivity disorder (ADHD). Recently, the association between the CLOCK gene and ADHD has been demonstrated in clinical samples, and the CLOCK gene's role was thought to be mediated by rhythm dysregulation. Meanwhile, ADHD has been suggested as t...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 杂志文章

    doi:10.1007/s00406-013-0443-y

    authors: Jeong SH,Yu JC,Lee CH,Choi KS,Choi JE,Kim SH,Joo EJ

    更新日期:2014-02-01 00:00:00

  • Myoclonic epileptic seizures during clozapine treatment: a report of three cases.

    abstract::Three adult schizophrenic patients without a previous history of epilepsy are reported who, during clozapine treatment, developed paroxysmal EEG patterns and generalized myoclonic jerks without alteration of consciousness. These seizures were phenomenologically identical to those occurring in juvenile myoclonic epilep...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 杂志文章

    doi:10.1007/BF02279769

    authors: Gouzoulis E,Grunze H,von Bardeleben U

    更新日期:1991-01-01 00:00:00

  • Cerebral networks linked to the event-related potential P300.

    abstract::P300 is an event-related potential that is elicited by an oddball paradigm. In several neuropsychiatric diseases, differences in latencies and amplitude compared to healthy subjects have been reported. Because of its clinical significance, several investigations have tried to elucidate the intracranial origins of the ...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 杂志文章

    doi:10.1007/s00406-003-0419-4

    authors: Horn H,Syed N,Lanfermann H,Maurer K,Dierks T

    更新日期:2003-06-01 00:00:00

  • Cognitive Behavioral Analysis System of Psychotherapy as group psychotherapy for chronically depressed inpatients: a naturalistic multicenter feasibility trial.

    abstract::The Cognitive Behavioral Analysis System of Psychotherapy (CBASP) is a relatively new approach in the treatment of chronic depression (CD). Adapted as group psychotherapy for inpatients, CBASP is attracting increasing attention. In this naturalistic multicenter trial, we investigated its feasibility after 10 sessions ...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s00406-017-0843-5

    authors: Sabaß L,Padberg F,Normann C,Engel V,Konrad C,Helmle K,Jobst A,Worlitz A,Brakemeier EL

    更新日期:2018-12-01 00:00:00

  • The ability of teacher reports to identify child sexual abuse victims.

    abstract::This study concerns the validation of an instrument, the SAB2, designed to measure child behaviour and to help identify emotional problems which arise because the child has been a victim of child sexual abuse. Clinically disturbed children, mainstream school children and sexually abused youngsters were assessed. Relia...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 杂志文章

    doi:10.1007/BF02916247

    authors: Hildreth AJ,Place M

    更新日期:1997-01-01 00:00:00

  • Cannabis use influence on peripheral brain-derived neurotrophic factor levels in antipsychotic-naïve first-episode psychosis.

    abstract::The objective of this study is to determine whether cannabis influences BDNF levels in patients with psychosis (FEP) and healthy volunteers (HV) to help understand the role of BDNF in psychosis. We assessed the association between BDNF and cannabis in a cohort of FEP antipsychotic-naïve patients and HV, whilst control...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 杂志文章

    doi:10.1007/s00406-020-01117-y

    authors: Toll A,Bergé D,Burling K,Scoriels L,Treen D,Monserrat C,Marmol F,Duran X,Jones PB,Pérez-Solà V,Fernandez-Egea E,Mané A

    更新日期:2020-10-01 00:00:00

  • Lifetime cannabis use and cognition in patients with schizophrenia spectrum disorders and their unaffected siblings.

    abstract::The relationship between cannabis and cognitive performance is controversial. While both acute administration and long-term cannabis use impair cognitive performance in healthy subjects, several studies have shown improved cognitive outcomes in patients with schizophrenia spectrum disorders who use cannabis. The aim o...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 杂志文章

    doi:10.1007/s00406-013-0404-5

    authors: Sánchez-Torres AM,Basterra V,Rosa A,Fañanás L,Zarzuela A,Ibáñez B,Peralta V,Cuesta MJ

    更新日期:2013-12-01 00:00:00

  • The association of GABRB2 SNPs with cognitive function in schizophrenia.

    abstract::Cognitive impairment is one of the core symptoms of schizophrenia. Multiple domains of cognition are affected in patients with schizophrenia, which has a major effect on the functional outcome. Recent studies indicate that SNPs in the gamma-aminobutyric acid type A receptor beta 2 subunit (GABRB2) gene are associated ...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 杂志文章

    doi:10.1007/s00406-019-00985-3

    authors: Zhang Q,Zhang X,Song S,Wang S,Wang X,Yu H,Han H,Zhou X,Li G,Wu Y

    更新日期:2020-06-01 00:00:00

  • Psychopathology in dual diagnosis and non-addicted schizophrenics--are there differences?

    abstract::In a previous publication we reported lifetime and 3-month prevalence estimates for substance use in two large samples of schizophrenic inpatients (Soyka et al. 1993). A subsequent analysis of psychopathological findings assessed by means of the AMDP Manual (Guy and Ban 1982) in schizophrenic in-patients of the Haar M...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 杂志文章

    doi:10.1007/s004060170032

    authors: Soyka M,Albus M,Immler B,Kathmann N,Hippius H

    更新日期:2001-10-01 00:00:00

  • Quantitative EEG analysis at rest and during photic stimulation in drug-naive patients with first-episode paranoid schizophrenia.

    abstract::In the present study, quantitative EEG analysis was performed at rest and during 10 Hz photic stimulation in 14 drug-naive patients with first-episode paranoid schizophrenia and 20 sex- and age-matched control subjects. Compared with the normal controls, the patients had significantly lower alpha-2 band amplitude in t...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 杂志文章

    doi:10.1007/BF02190377

    authors: Wada Y,Takizawa Y,Kitazawa S,Jiang ZY,Yamaguchi N

    更新日期:1994-01-01 00:00:00

  • Would the use of dimensions instead of categories remove problems related to subthreshold disorders?

    abstract::Scientific progress fostered in DSM and ICD over the past quarter of century has significantly increased awareness of the limitation of categorical definitions of mental illness. Disorders highly merge into another with no natural boundary in between. The addition of continuous, "dimensional" measures into the various...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 杂志文章,评审

    doi:10.1007/s00406-009-0052-y

    authors: Okasha A

    更新日期:2009-11-01 00:00:00

  • Substance P-like immunoreactivity and somatostatin-like immunoreactivity in the ventricular fluid of patients with chronic pain syndromes.

    abstract::Substance P-like and somatostatin-like immunoreactivities (SPLI and SLI) were determined in ventricular fluid of patients with chronic pain syndromes and in a comparison group with multiple sclerosis, essential tremor, epilepsy and postanoxic myoclonus. Concentrations of SPLI and SLI were non-significantly decreased b...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 杂志文章

    doi:10.1007/BF02191152

    authors: Jost S,Reuner C,Geiger J,Mohadjer M,Milios E,Cramer H

    更新日期:1991-01-01 00:00:00

  • Evidence for separate diseases?: Stages of one disease or different combinations of symptom dimensions?

    abstract:OBJECTIVE:We tested Kraepelin's dichotomy model by studying the separability of schizophrenia and depression on the basis of symptoms and illness course. MATERIALS AND METHODS:Matched untreated patients with schizophrenia and depression (n = 130 each) and 130 "healthy" controls were assessed from onset to first admiss...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 杂志文章

    doi:10.1007/s00406-008-2011-4

    authors: Häfner H,an der Heiden W,Maurer K

    更新日期:2008-06-01 00:00:00

  • Working memory associated with anti-suicidal ideation effect of repeated-dose intravenous ketamine in depressed patients.

    abstract::Suicide is a tremendous threat to global public health, and a large number of people who committed suicide suffered the pain of mental diseases, especially major depressive disorder (MDD). Previous study showed that ketamine could reduce suicidal ideation (SI), potentially by improving the impaired working memory (WM)...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 杂志文章

    doi:10.1007/s00406-020-01221-z

    authors: Chen X,Wang M,Hu Y,Zhan Y,Zhou Y,Zheng W,Liu W,Wang C,Zhong X,Li H,Lan X,Ning Y,Zhang B

    更新日期:2021-01-01 00:00:00

  • Gonadal hormones in schizophrenia and mood disorders.

    abstract::There are gender-related differences in the prevalence, course and treatment response characteristics of schizophrenia and mood disorders. Gonadal steroids exert potent effects on mood, cognition and behavior, and there is little doubt that androgens are crucial for differentiating to each gender. Serum level of total...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 杂志文章

    doi:10.1007/s00406-003-0424-7

    authors: Ozcan ME,Banoglu R

    更新日期:2003-08-01 00:00:00

  • Becker-like muscular dystrophy in sisters.

    abstract::Two sisters with muscular dystrophy of Becker-like clinical features presented. Muscle weakness was most prominent in the pelvic girdle, but in the elder sister the distal muscles of the lower extremities were also affected. The progression was different in the siblings: The older sister showed a more pronounced deter...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 杂志文章

    doi:10.1007/BF02191875

    authors: Diószeghy P,Molnár M,Mechler F

    更新日期:1995-01-01 00:00:00

  • 5HT-2C receptor polymorphism in suicide victims. Association studies in German and Slavic populations.

    abstract::Sustainable observations suggest that suicidal behaviour by itself may have biological correlates, among which those related to the serotonergic synapse hold the key position. Based on the association of suicide and serotonergic dysfunction, it was proposed that genetic mechanisms affecting suicidal behaviour could be...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 杂志文章

    doi:10.1007/s00406-004-0482-5

    authors: Stefulj J,Büttner A,Kubat M,Zill P,Balija M,Eisenmenger W,Bondy B,Jernej B

    更新日期:2004-08-01 00:00:00

  • High prevalence of restless legs syndrome in somatoform pain disorder.

    abstract:UNLABELLED:Patients with somatoform pain often complain of sleep disorders, but sleep disorders are not an integrated part of the diagnosis of this disorder. Restless legs syndrome is associated with painful symptoms and sleep disturbances. The aim of our study was to evaluate the prevalence of restless legs syndrome (...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 杂志文章

    doi:10.1007/s00406-006-0684-0

    authors: Aigner M,Prause W,Freidl M,Weiss M,Izadi S,Bach M,Saletu B

    更新日期:2007-02-01 00:00:00

  • Glutamate modulators as potential therapeutic drugs in schizophrenia and affective disorders.

    abstract::Severe psychiatric disorders such as schizophrenia are related to cognitive and negative symptoms, which often are resistant to current treatment approaches. The glutamatergic system has been implicated in the pathophysiology of schizophrenia and affective disorders. A key component is the dysfunction of the glutamate...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 杂志文章,评审

    doi:10.1007/s00406-013-0399-y

    authors: Hashimoto K,Malchow B,Falkai P,Schmitt A

    更新日期:2013-08-01 00:00:00

  • Varenicline for smoking cessation in people with schizophrenia: systematic review and meta-analysis.

    abstract::We performed an updated meta-analysis of randomized double-blind placebo-controlled trials (RCTs) on the effects of varenicline adjuvant therapy for smoking cessation in people with schizophrenia, on the basis of a previous meta-analysis (Tsoi in Cochrane Database Syst Rev 2:CD007253, 2013). We searched PubMed, the Co...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 杂志文章,meta分析,评审

    doi:10.1007/s00406-014-0551-3

    authors: Kishi T,Iwata N

    更新日期:2015-04-01 00:00:00

  • A pilot investigation of accelerated deep transcranial magnetic stimulation protocols in treatment-resistant depression.

    abstract::Accelerated repetitive transcranial magnetic stimulation (rTMS) protocols are being increasingly studied because of their potential to provide quicker and enhanced treatment efficacy. However, there is a lack of accelerated deep TMS with H1-coil (adTMS) treatment research. This randomized pilot study investigated the ...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 杂志文章

    doi:10.1007/s00406-020-01141-y

    authors: Filipčić I,Šimunović Filipčić I,Sučić S,Milovac Ž,Gereš N,Matić K,Čelić-Ružić M,Zečević Penić S,Orgulan I,Požgaj V,Bajić Ž

    更新日期:2020-05-24 00:00:00

  • Effects of physical activity on cognitive performance: a controlled clinical study in depressive patients.

    abstract::Physical activity is a common adjunctive therapy in psychiatric and psychosomatic hospitals. In the present study, we assessed the effects of an exercise program, integrated into routine inpatient treatment, on cognitive performance and subjective severity of depression in a sample of patients suffering from major dep...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00406-018-0916-0

    authors: Buschert V,Prochazka D,Bartl H,Diemer J,Malchow B,Zwanzger P,Brunnauer A

    更新日期:2019-08-01 00:00:00

  • Anxiogenic properties of yohimbine. I. Behavioral, physiological and biochemical measures.

    abstract::The anxiogenic effects of yohimbine, a specific alpha-2-receptor antagonist were examined by administering 20 mg yohimbine orally to 8 panic patients on placebo treatment, 7 panic patients on alprazolam treatment and 12 controls using a double-blind randomized design, instructions that minimized the expectancy of expe...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1007/BF02191958

    authors: Albus M,Zahn TP,Breier A

    更新日期:1992-01-01 00:00:00

  • Non-neuroleptic approaches to treating negative symptoms in schizophrenia.

    abstract::The novel/atypical neuroleptics have proven to be effective in treating negative symptoms but although clinical experience appears to show that they have advantages over the traditional neuroleptics in treating negative symptoms, superiority has not always been statistically confirmed and the treatment results in indi...

    journal_title:European archives of psychiatry and clinical neuroscience

    pub_type: 杂志文章,评审

    doi:10.1007/s00406-004-0503-4

    authors: Möller HJ

    更新日期:2004-04-01 00:00:00