Abstract:
:Various factors contribute to the development and maintenance of delusions in the context of schizophrenic psychoses. Studies with functional and structural MRI were able to detect neurobiological correlates of paranoid symptoms. Consistent with the neurodevelopmental hypothesis of schizophrenic psychosis, which implies an early developmental disorder affecting temporo-limbic areas and resulting in a disinhibition of striatal dopamine release, current imaging studies point towards the involvement of temporo-limbic and frontal dysfunction in delusion formation. In line with this, a specific role of dopamine as a neuromodulator in delusion formation is being discussed. Finally, mechanisms relevant to delusion formation appear to involve cognitive processes such as biases of attribution with regard to emotionally salient events as well as attentional biases during the perception of affective stimuli.
journal_name
Eur Arch Psychiatry Clin Neurosciauthors
Knobel A,Heinz A,Voss Mdoi
10.1007/s00406-008-5008-0subject
Has Abstractpub_date
2008-11-01 00:00:00pages
76-80eissn
0940-1334issn
1433-8491journal_volume
258 Suppl 5pub_type
杂志文章,评审abstract::The present article outlines the different conception of catatonia from its initial description by Kahlbaum to current viewpoints. Originally considered to be an independent disease entity characterized by mental and motor abnormalities, catatonia was later viewed as a subtype of schizophrenia as it is the case in cur...
journal_title:European archives of psychiatry and clinical neuroscience
pub_type: 历史文章,杂志文章
doi:10.1007/pl00014199
更新日期:2001-01-01 00:00:00
abstract::While the impact of mentally ill patients' perceptions of their key relatives' expressed emotion is well examined with regard to relapse, there is a paucity of evidence concerning the impact on their key relatives' burden. The present study aims to evaluate the relative prognostic value of expressed and perceived emot...
journal_title:European archives of psychiatry and clinical neuroscience
pub_type: 杂志文章
doi:10.1007/s00406-010-0178-y
更新日期:2011-08-01 00:00:00
abstract::The Anorexia Nervosa Inventory for Self-Rating (ANIS) was the first instrument covering aspects of the general psychopathology of eating disorders alongside eating attitudes, but its factorial integrity in non-clinical samples has not yet been investigated. Thus, this report is aimed at assessing the factorial structu...
journal_title:European archives of psychiatry and clinical neuroscience
pub_type: 临床试验,杂志文章
doi:10.1007/s004060050035
更新日期:1998-01-01 00:00:00
abstract::We studied 259 female inpatients with bipolar spectrum disorders, of whom 26 (10%) were schizoaffective. Of the remaining 233, 61 (27%) met our conservatively set criteria for index mixed episodes (simultaneous presence of depressive and manic syndromes). These patients with rigorously defined mixed states were, in tu...
journal_title:European archives of psychiatry and clinical neuroscience
pub_type: 杂志文章
doi:10.1007/BF02191568
更新日期:1993-01-01 00:00:00
abstract::Physical activity is a common adjunctive therapy in psychiatric and psychosomatic hospitals. In the present study, we assessed the effects of an exercise program, integrated into routine inpatient treatment, on cognitive performance and subjective severity of depression in a sample of patients suffering from major dep...
journal_title:European archives of psychiatry and clinical neuroscience
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00406-018-0916-0
更新日期:2019-08-01 00:00:00
abstract::Dopamine D(2) blocking typical antipsychotic drugs are known to change the cerebral perfusion patterns of schizophrenic patients, especially in the frontal cortex and basal ganglia. In recent years atypical antipsychotics such as olanzapine, which have high serotonin 5-HT(2A)/dopamine D(2) occupation ratios, have been...
journal_title:European archives of psychiatry and clinical neuroscience
pub_type: 临床试验,杂志文章
doi:10.1007/s00406-003-0401-1
更新日期:2003-02-01 00:00:00
abstract:OBJECTIVE:We tested Kraepelin's dichotomy model by studying the separability of schizophrenia and depression on the basis of symptoms and illness course. MATERIALS AND METHODS:Matched untreated patients with schizophrenia and depression (n = 130 each) and 130 "healthy" controls were assessed from onset to first admiss...
journal_title:European archives of psychiatry and clinical neuroscience
pub_type: 杂志文章
doi:10.1007/s00406-008-2011-4
更新日期:2008-06-01 00:00:00
abstract::Event-related potentials (ERPs) can serve as markers for cognitive processing stages. Identification of those ERPs altered in schizophrenia offer information about cognitive dysfunction. Auditory evoked potentials (AEPs) were elicited within an oddball paradigm in 35 schizophrenic patients and compared with 35 healthy...
journal_title:European archives of psychiatry and clinical neuroscience
pub_type: 临床试验,杂志文章
doi:10.1007/s004060050055
更新日期:1998-01-01 00:00:00
abstract::Decreased availability of serotonin in the central nervous system has been suggested to be a central factor in the pathogenesis of depression. Activation of indoleamine 2-3 dioxygenase following a pro-inflammatory state could reduce the amount of tryptophan converted to serotonin and increase the production of tryptop...
journal_title:European archives of psychiatry and clinical neuroscience
pub_type: 杂志文章
doi:10.1007/s00406-016-0731-4
更新日期:2018-03-01 00:00:00
abstract::Smartphone applications ("apps") may contribute to closing the treatment gap for depression by reaching large populations at relatively low costs. The general public seems open towards the use of apps for mental disorders but less is known about the attitudes of health care professionals. Therefore, the aim of this st...
journal_title:European archives of psychiatry and clinical neuroscience
pub_type: 杂志文章
doi:10.1007/s00406-018-0974-3
更新日期:2020-03-01 00:00:00
abstract::Eating disorders and, in particular, anorexia nervosa (AN) have morbidity and mortality rates that are among the highest of any mental disorders and are associated with significant functional impairment. More than 25 years ago, several researchers hypothesised that the prerequisite for the development of AN was a fami...
journal_title:European archives of psychiatry and clinical neuroscience
pub_type: 杂志文章,评审
doi:10.1007/s00406-011-0246-y
更新日期:2011-11-01 00:00:00
abstract:OBJECTIVE:Risk factors, emergence and accumulation of symptoms in the untreated early course were studied as a basis for understanding the relationship between schizophrenia and depression. MATERIALS AND METHODS:130 representative first admissions for schizophrenia were compared retrospectively with 130 individually m...
journal_title:European archives of psychiatry and clinical neuroscience
pub_type: 杂志文章
doi:10.1007/s00406-005-0584-8
更新日期:2005-06-01 00:00:00
abstract::Schizophrenia is a severe neuropsychiatric disorder with familial loading as heritable risk factor and cannabis abuse as the most relevant environmental risk factor up to date. Cannabis abuse has been related to an earlier onset of the disease and persisting cannabis consumption is associated with reduced symptom impr...
journal_title:European archives of psychiatry and clinical neuroscience
pub_type: 杂志文章
doi:10.1007/s00406-013-0451-y
更新日期:2013-11-01 00:00:00
abstract::DTNBP1 is one of the most established susceptibility genes for schizophrenia, and hippocampal volume reduction is one of the major neuropathological findings in this severe disorder. Consistent with these findings, the encoded protein dysbindin-1 has been shown to be diminished in glutamatergic hippocampal neurons in ...
journal_title:European archives of psychiatry and clinical neuroscience
pub_type: 杂志文章
doi:10.1007/s00406-012-0320-0
更新日期:2013-02-01 00:00:00
abstract:BACKGROUND:Although a number of studies have reported on the association between obsessional personality features as measured by the Munich Personality Test (MPT) "Rigidity" scale and depression, there has been no examination of these relationships in a non-clinical sample. METHODS:The dimensional scores on the MPT we...
journal_title:European archives of psychiatry and clinical neuroscience
pub_type: 杂志文章
doi:10.1007/s004060170043
更新日期:2001-06-01 00:00:00
abstract::Some studies suggest seasonality of suicide attempts in females, but not in males. The reasons for this gender difference remain unclear. Only few studies addressed the question whether gender differences in seasonality of suicide attempts reflect gender differences in the choice of method for suicide attempts, with i...
journal_title:European archives of psychiatry and clinical neuroscience
pub_type: 杂志文章
doi:10.1007/s00406-009-0086-1
更新日期:2010-08-01 00:00:00
abstract::Knowledge on the reliability of family history information is essential for every family study. However, systematic analyses of interinformant reliability of family history information on individual relatives have not yet been published. Consequently, family history information on 1306 first-degree relatives and spous...
journal_title:European archives of psychiatry and clinical neuroscience
pub_type: 杂志文章
doi:10.1007/s004060050025
更新日期:1998-01-01 00:00:00
abstract::In clinical trials in psychiatry, changes in severity are usually measured with ordinal level scales which are applied repeatedly during the trial, showing a constant decline in psychopathology scores as treatment leads to improvement. Previous non-parametric tests for repeated measures in factorial designs did not te...
journal_title:European archives of psychiatry and clinical neuroscience
pub_type: 临床试验,杂志文章
doi:10.1007/s004060050061
更新日期:1999-01-01 00:00:00
abstract::All operationalized diagnostic systems contain a diagnostic category, which corresponds to the concept of major depression. Yet, these corresponding definitions are not identical. Up to now, no comprehensive comparisons of the competing diagnoses have been published. We will therefore present a series of studies, desc...
journal_title:European archives of psychiatry and clinical neuroscience
pub_type: 杂志文章,评审
doi:10.1007/BF02189537
更新日期:1991-01-01 00:00:00
abstract::Thirty inpatients with somatoform disorders were examined with the structured clinical interview SCID for psychiatric lifetime diagnosis. In the present diagnoses, we found a concordance of 63% for somatoform and affective disorders and the lifetime comorbidity of both disorders was 87%. Additionally, patients with so...
journal_title:European archives of psychiatry and clinical neuroscience
pub_type: 杂志文章
doi:10.1007/BF02190259
更新日期:1992-01-01 00:00:00
abstract::The aim of this study was to estimate the prevalence and incidence of mood disorders, anxiety disorders, and stress and adjustment disorders in primary health care in Sweden and to analyse the relationship between socioeconomic and demographic factors and incidence of these disorders. Prevalence and incidence data on ...
journal_title:European archives of psychiatry and clinical neuroscience
pub_type: 杂志文章
doi:10.1007/s00406-013-0422-3
更新日期:2014-04-01 00:00:00
abstract::To assess the course of neuropsychological (NP) impairment in schizophrenia, 71 patients with first episode (FE) schizophrenia and 71 healthy controls were given a comprehensive battery of NP tests at index assessment, after a 2-year and after a 5-year follow-up period. By means of the z-score standardization, summary...
journal_title:European archives of psychiatry and clinical neuroscience
pub_type: 杂志文章
doi:10.1007/s00406-006-0667-1
更新日期:2006-10-01 00:00:00
abstract::Clinical and neurobiological findings have reported the involvement of endocannabinoid signaling in the pathophysiology of schizophrenia. This system modulates dopaminergic and glutamatergic neurotransmission that is associated with positive, negative, and cognitive symptoms of schizophrenia. Despite neurotransmitter ...
journal_title:European archives of psychiatry and clinical neuroscience
pub_type: 杂志文章,评审
doi:10.1007/s00406-018-0874-6
更新日期:2018-10-01 00:00:00
abstract::While impairments in executive functions have been well established in major depressive disorder (MDD), specific deficits in proactive control have scarcely been studied so far. Proactive control refers to cognitive processes during anticipation of a behaviorally relevant event that facilitate readiness to react. In t...
journal_title:European archives of psychiatry and clinical neuroscience
pub_type: 杂志文章
doi:10.1007/s00406-018-0956-5
更新日期:2019-10-01 00:00:00
abstract::The deficit syndrome is thought to be specific to and a subtype of schizophrenia; however, there are scarce or no data on the prevalence and characteristics of this syndrome in non-schizophrenic psychoses. The aim of this study was to explore the prevalence and correlates of different types of negative symptoms (NegS)...
journal_title:European archives of psychiatry and clinical neuroscience
pub_type: 杂志文章
doi:10.1007/s00406-004-0464-7
更新日期:2004-06-01 00:00:00
abstract::Our previous study has found that a long duration of untreated prodromal symptoms (DUPrS) does not increase the conversion risk to psychosis in individuals with attenuated psychosis syndrome (APS). However, whether a long DUPrS will lead to other poor outcomes remains unknown. The purpose of this study was to analyse ...
journal_title:European archives of psychiatry and clinical neuroscience
pub_type: 杂志文章
doi:10.1007/s00406-018-0917-z
更新日期:2019-12-01 00:00:00
abstract::Previous research suggests disturbed emotional learning and memory in borderline personality disorder (BPD). Studies investigating the neural correlates of aversive differential delay conditioning in BPD are currently lacking. We aimed to investigate acquisition, within-session extinction, between-session extinction r...
journal_title:European archives of psychiatry and clinical neuroscience
pub_type: 杂志文章
doi:10.1007/s00406-015-0593-1
更新日期:2016-06-01 00:00:00
abstract::Emotional dysregulation (ED) is being increasingly recognized as a core feature of attention-deficit/hyperactivity disorder (ADHD), but the pathophysiological underpinnings remain unclear. In this study, we provide meaningful electrophysiological evidence of ED in adult patients with ADHD (n = 39) compared to healthy ...
journal_title:European archives of psychiatry and clinical neuroscience
pub_type: 杂志文章
doi:10.1007/s00406-017-0826-6
更新日期:2018-06-01 00:00:00
abstract::Depressive disorders are influenced by a complex interplay between genetic and environmental factors. Multiple studies support a role of serotonergic pathways in the pathophysiology of depressive disorders. As a rate-limiting enzyme of serotonin synthesis in the brain, tryptophan hydroxylase 2 (TPH2) represents a plau...
journal_title:European archives of psychiatry and clinical neuroscience
pub_type: 杂志文章,多中心研究
doi:10.1007/s00406-014-0536-2
更新日期:2014-11-01 00:00:00
abstract::Circadian rhythm disturbance is highly prevalent in attention deficit hyperactivity disorder (ADHD). Recently, the association between the CLOCK gene and ADHD has been demonstrated in clinical samples, and the CLOCK gene's role was thought to be mediated by rhythm dysregulation. Meanwhile, ADHD has been suggested as t...
journal_title:European archives of psychiatry and clinical neuroscience
pub_type: 杂志文章
doi:10.1007/s00406-013-0443-y
更新日期:2014-02-01 00:00:00