Abstract：
:Knowledge on the reliability of family history information is essential for every family study. However, systematic analyses of interinformant reliability of family history information on individual relatives have not yet been published. Consequently, family history information on 1306 first-degree relatives and spouses of patients and of control subjects was collected from at least two other family members using questionnaires. Interinformant reliability was acceptable for dementia [Kappa = 0.58, 95% confidence interval (CI) = 0.48-0.68], but less so for alcoholism (Kappa = 0.41, CI = 0.23-0.59), depression (Kappa = 0.26, CI = 0.14-0.38) and anxiety disorders (Kappa = 0.19, CI = 0.05-0.43). Demographic variables of subjects and informants and their familial relationship did not influence diagnostic agreement on the diagnosis of dementia. Diagnostic agreement on depression was significantly reduced when information from siblings of index subjects was compared with information from spouses of index subjects. The interinformant agreement for the diagnosis of depression was higher in younger than in older subjects (relative risk for disagreement 1.08/additional year, CI = 1.02-1.15). Siblings of index subjects seem to provide different, but not necessarily less relevant, family history information in comparison with other relatives. Researchers should be aware of the problem that depression in the elderly can be easily missed by family history. It seems more important for the diagnosis of depression than for a diagnosis of dementia to get information from multiple informants.
journal_name
Eur Arch Psychiatry Clin Neurosciauthors
Heun R,Müller Hdoi
10.1007/s004060050025subject
Has Abstractpub_date
1998-01-01 00:00:00pages
104-9issue
2eissn
0940-1334issn
1433-8491journal_volume
248pub_type
杂志文章abstract：:Proof of efficacy of a psychotropic medicinal product is the key point of clinical psychopharmacology. This especially concerns the licensing of a new compound, but apart from this special case, lots of efficacy questions need to be answered in clinical psychopharmacology, such as, e.g. the question of the efficacy of...
journal_title：European archives of psychiatry and clinical neuroscience
pub_type： 杂志文章
doi：10.1007/s00406-009-0071-8
更新日期：2010-02-01 00:00:00
abstract：:Savoxepine, an atypical neuroleptic compound developed in the 1980s, was believed to act via selective limbic dopamine D(2)-receptor blockade. The results of the presented double-blind, randomised, controlled clinical trial comparing savoxepine (n = 58) with haloperidol (n = 29) did not confirm the preclinical data su...
journal_title：European archives of psychiatry and clinical neuroscience
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s00406-002-0364-7
更新日期：2002-04-01 00:00:00
abstract：:In a single-blind, placebo-controlled crossover trial, the acute efficacy of the dopamine agonist pramipexole was investigated in 11 restless legs syndrome (RLS) patients by sleep laboratory methods, with a clinical follow-up for 4 weeks. In 3 nights (pre-treatment, placebo and drug night), objective sleep quality was...
journal_title：European archives of psychiatry and clinical neuroscience
pub_type： 临床试验,杂志文章
doi：10.1007/s00406-002-0380-7
更新日期：2002-08-01 00:00:00
abstract：:This study investigates the nosological specificity and time stability of reduced facial expressivity in schizophrenia by means of objective measurement. Facial expression in an emotional interview was evaluated using the "Facial Action Coding System" in 33 acute schizophrenia patients and 23 acute depressive patients...
journal_title：European archives of psychiatry and clinical neuroscience
pub_type： 杂志文章
doi：10.1007/s00406-004-0510-5
更新日期：2004-10-01 00:00:00
abstract：:In clinical trials in psychiatry, changes in severity are usually measured with ordinal level scales which are applied repeatedly during the trial, showing a constant decline in psychopathology scores as treatment leads to improvement. Previous non-parametric tests for repeated measures in factorial designs did not te...
journal_title：European archives of psychiatry and clinical neuroscience
pub_type： 临床试验,杂志文章
doi：10.1007/s004060050061
更新日期：1999-01-01 00:00:00
abstract：:The course of obsessive-compulsive disorder (OCD) is variable, ranging from episodic to chronic. We hypothesised that the former course is more likely to be related to bipolar mood disorders. With the use of a specially constructed OCD questionnaire, we studied 135 patients fulfilling DSM-III-R criteria for OCD with a...
journal_title：European archives of psychiatry and clinical neuroscience
pub_type： 杂志文章
doi：10.1007/s004060050044
更新日期：1998-01-01 00:00:00
abstract：:The diagnosis of muscle cramp is based on clinical features. Algorithms are presented for the diagnosis of muscle cramp and cramp syndromes. ...
journal_title：European archives of psychiatry and clinical neuroscience
pub_type： 杂志文章,评审
doi：10.1007/BF02191149
更新日期：1991-01-01 00:00:00
abstract：:Research on emotional expression in adult schizophrenia patients has indicated an impairment of the patients' facial expressions during social interaction. However, it is unclear whether schizophrenia adolescent-onset patients show comparable disturbances in facial expression. Our aim was to analyze facial emotions in...
journal_title：European archives of psychiatry and clinical neuroscience
pub_type： 杂志文章
doi：10.1007/s00406-012-0386-8
更新日期：2013-09-01 00:00:00
abstract：:Two sisters with muscular dystrophy of Becker-like clinical features presented. Muscle weakness was most prominent in the pelvic girdle, but in the elder sister the distal muscles of the lower extremities were also affected. The progression was different in the siblings: The older sister showed a more pronounced deter...
journal_title：European archives of psychiatry and clinical neuroscience
pub_type： 杂志文章
doi：10.1007/BF02191875
更新日期：1995-01-01 00:00:00
abstract：:The novel coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The escalating number of SARS-CoV-2-infected individuals has conferred the viral spread with the status of global pandemic. However, there are no prophylactic or therapeutic drugs available on the m...
journal_title：European archives of psychiatry and clinical neuroscience
pub_type： 杂志文章,评审
doi：10.1007/s00406-020-01231-x
更新日期：2021-01-05 00:00:00
abstract：:Schizophrenia is a severe neuropsychiatric disorder with familial loading as heritable risk factor and cannabis abuse as the most relevant environmental risk factor up to date. Cannabis abuse has been related to an earlier onset of the disease and persisting cannabis consumption is associated with reduced symptom impr...
journal_title：European archives of psychiatry and clinical neuroscience
pub_type： 杂志文章
doi：10.1007/s00406-013-0451-y
更新日期：2013-11-01 00:00:00
abstract：:Oral cenesthopathy is a somatic delusion or hallucination involving the oral area and is categorized as a delusional disorder, somatic type. The pathophysiology of this intractable condition remains obscure. In this study, we clarified the pathophysiology of oral cenesthopathy by evaluating regional brain perfusion. W...
journal_title：European archives of psychiatry and clinical neuroscience
pub_type： 杂志文章
doi：10.1007/s00406-013-0390-7
更新日期：2013-06-01 00:00:00
abstract：:Childhood maltreatment and low socioeconomic status (SES) are considered stressful environmental events with lasting detrimental effects on adult mental health and associated cognitive performance, such as memory. However, the association between childhood maltreatment and low SES remains unclear, probably due to desi...
journal_title：European archives of psychiatry and clinical neuroscience
pub_type： 杂志文章
doi：10.1007/s00406-012-0382-z
更新日期：2013-08-01 00:00:00
abstract：:Impaired perceptual inference has been suggested to be at the core of positive symptoms in schizophrenia. Apparent motion (AM) is a visual illusion in which perceptual inference gives rise to the experience of a single object moving back and forth when two spatially separated objects are flashed in alternation. Here, ...
journal_title：European archives of psychiatry and clinical neuroscience
pub_type： 杂志文章
doi：10.1007/s00406-012-0344-5
更新日期：2013-04-01 00:00:00
abstract：:The purpose of this article is to encourage research investigating the role of measured gene-environment interaction (G x E) in the etiology of posttraumatic stress disorder (PTSD). PTSD is uniquely suited to the study of G x E as the diagnosis requires exposure to a potentially-traumatic life event. PTSD is also mode...
journal_title：European archives of psychiatry and clinical neuroscience
pub_type： 杂志文章,评审
doi：10.1007/s00406-007-0787-2
更新日期：2008-03-01 00:00:00
abstract：:The conceptualization of rapidly cycling bipolar disorder remains controversial. The DSM-IV definition of rapid cycling, although very reliable, may be not sufficiently inclusive (i.e., it may exclude patients with very short episodes of very high frequency, who are very typical in terms of external validators, and ar...
journal_title：European archives of psychiatry and clinical neuroscience
pub_type： 杂志文章
doi：10.1007/BF03035130
更新日期：2001-01-01 00:00:00
abstract：:Cerebrospinal fluid acetylcholinesterase (CSF AChE) was determined for elderly delirious patients during the acute stage and after a 1- and 4-year follow-up periods, and the AChE levels were compared with age-equivalent controls. The AChE levels measured during the index admission correlated with the length of life af...
journal_title：European archives of psychiatry and clinical neuroscience
pub_type： 杂志文章
doi：10.1007/BF02195729
更新日期：1994-01-01 00:00:00
abstract：:This paper reports on psychiatric case identification by the application of the Structured Clinical Interview for DSM-III-R (SCID) in a sample of 198 Greek migrants repatriated from western europe in a northwestern province of Greece. The current (1 month) prevalence of psychiatric morbidity, based on the total number...
journal_title：European archives of psychiatry and clinical neuroscience
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF02191542
更新日期：1995-01-01 00:00:00
abstract：:P300 is an event-related potential that is elicited by an oddball paradigm. In several neuropsychiatric diseases, differences in latencies and amplitude compared to healthy subjects have been reported. Because of its clinical significance, several investigations have tried to elucidate the intracranial origins of the ...
journal_title：European archives of psychiatry and clinical neuroscience
pub_type： 杂志文章
doi：10.1007/s00406-003-0419-4
更新日期：2003-06-01 00:00:00
abstract：:The National Institute on Aging-Alzheimer's Association (NIA-AA) clinical research criteria for mild cognitive impairment (MCI) due to Alzheimer's disease (AD) incorporate the use of biomarkers to classify patients according to the likelihood of the presence of AD pathology. The aim of the study was to compare the ris...
journal_title：European archives of psychiatry and clinical neuroscience
pub_type： 杂志文章
doi：10.1007/s00406-012-0349-0
更新日期：2013-06-01 00:00:00
abstract：BACKGROUND:This placebo-controlled study was designed to investigate the influence of two different stimulation procedures of repetitive transcranial magnetic stimulation (rTMS) on depressive symptoms in patients with depressive disorders. Furthermore, effects on cognitive functions and psychomotor functioning were tes...
journal_title：European archives of psychiatry and clinical neuroscience
pub_type： 临床试验,杂志文章
doi：10.1007/s00406-003-0416-7
更新日期：2003-04-01 00:00:00
abstract：OBJECTIVE:We tested Kraepelin's dichotomy model by studying the separability of schizophrenia and depression on the basis of symptoms and illness course. MATERIALS AND METHODS:Matched untreated patients with schizophrenia and depression (n = 130 each) and 130 "healthy" controls were assessed from onset to first admiss...
journal_title：European archives of psychiatry and clinical neuroscience
pub_type： 杂志文章
doi：10.1007/s00406-008-2011-4
更新日期：2008-06-01 00:00:00
abstract：:As a result of the multifactorial etiopathology of schizophrenia, a treatment strategy combining drug therapy with psychosocial measures is indicated. Depending on the stage of the disease and on the individual condition of the patient, the accent is set alternatively more on one approach or on the other. However, und...
journal_title：European archives of psychiatry and clinical neuroscience
pub_type： 杂志文章,评审
doi：10.1007/BF02190273
更新日期：1996-01-01 00:00:00
abstract：:This study aims to investigate the relationship between regional connectivity in the brain white matter and the presence of psychotic personality traits, in healthy subjects with psychotic traits. Thirteen healthy controls were administered the MMPI-2, to assess psychotic traits and, according to MMPI results, a dicho...
journal_title：European archives of psychiatry and clinical neuroscience
pub_type： 杂志文章
doi：10.1007/s00406-007-0796-1
更新日期：2008-08-01 00:00:00
abstract：:Bipolar disorder (BD) has been associated with a proinflammatory state in which TNF-α seems to play a relevant role. The aim of the present study was to evaluate the plasma levels of TNF-α and its soluble receptors (sTNFR1 and sTNFR2) in BD patients in mania and euthymia in comparison with control subjects. We evaluat...
journal_title：European archives of psychiatry and clinical neuroscience
pub_type： 杂志文章
doi：10.1007/s00406-010-0116-z
更新日期：2011-03-01 00:00:00
abstract：:The Neuregulin (NRG1) gene has been associated with schizophrenia, but its functional implications are largely unknown. Our aim was to assess differential brain activation between patients carrying an at-risk allele on the Neuregulin 1 gene and patients without this genetic risk. Neural signal changes between 14 first...
journal_title：European archives of psychiatry and clinical neuroscience
pub_type： 杂志文章
doi：10.1007/s00406-008-0837-4
更新日期：2009-03-01 00:00:00
abstract：:Severe psychiatric disorders such as schizophrenia are related to cognitive and negative symptoms, which often are resistant to current treatment approaches. The glutamatergic system has been implicated in the pathophysiology of schizophrenia and affective disorders. A key component is the dysfunction of the glutamate...
journal_title：European archives of psychiatry and clinical neuroscience
pub_type： 杂志文章,评审
doi：10.1007/s00406-013-0399-y
更新日期：2013-08-01 00:00:00
abstract：:The Anorexia Nervosa Inventory for Self-Rating (ANIS) was the first instrument covering aspects of the general psychopathology of eating disorders alongside eating attitudes, but its factorial integrity in non-clinical samples has not yet been investigated. Thus, this report is aimed at assessing the factorial structu...
journal_title：European archives of psychiatry and clinical neuroscience
pub_type： 临床试验,杂志文章
doi：10.1007/s004060050035
更新日期：1998-01-01 00:00:00
abstract：:Eating disorders and, in particular, anorexia nervosa (AN) have morbidity and mortality rates that are among the highest of any mental disorders and are associated with significant functional impairment. More than 25 years ago, several researchers hypothesised that the prerequisite for the development of AN was a fami...
journal_title：European archives of psychiatry and clinical neuroscience
pub_type： 杂志文章,评审
doi：10.1007/s00406-011-0246-y
更新日期：2011-11-01 00:00:00
abstract：:In a recent randomized, double-blind, placebo-controlled trial, we established a robust efficacy (Cohen's d = 2.17) of osmotic release oral system-methylphenidate (OROS-methylphenidate) delivered 72 mg daily for 5 weeks versus placebo on attention deficit hyperactivity disorder (ADHD) symptoms, global severity and glo...
journal_title：European archives of psychiatry and clinical neuroscience
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00406-012-0317-8
更新日期：2012-12-01 00:00:00
