Abstract:
BACKGROUND:This placebo-controlled study was designed to investigate the influence of two different stimulation procedures of repetitive transcranial magnetic stimulation (rTMS) on depressive symptoms in patients with depressive disorders. Furthermore, effects on cognitive functions and psychomotor functioning were tested. METHODS:Thirty patients with depression (22 females and 8 males; mean age of 56.4 years) were included. They were treated with a stable dosage of antidepressant medication. They received either high frequency rTMS (20 Hz) over the left dorsolateral prefrontal cortex (LDLPFC), low frequency rTMS (1 Hz) over the right dorsolateral prefrontal cortex (RDLPFC) or sham stimulations (10 patients in each group) as add on treatment at 10 days within 2 weeks. Depressive symptoms were registered by means of observer ratings (Hamilton Depression Rating Scale - HDRS) and self reports (Beck Depression Inventory - BDI). Psychomotor retardation was investigated by the Motor Agitation and Retardation Scale and cognitive function by d2 test. RESULTS AND CONCLUSIONS:Differences between the rTMS procedures regarding depressive symptoms could not be found. Motor abnormalities, however, significantly improved exclusively after real stimulation procedures. Patients with less severe deficits in psychomotor speed and concentration responded more intensively than patients with severe deficits.
journal_name
Eur Arch Psychiatry Clin Neurosciauthors
Höppner J,Schulz M,Irmisch G,Mau R,Schläfke D,Richter Jdoi
10.1007/s00406-003-0416-7subject
Has Abstractpub_date
2003-04-01 00:00:00pages
103-9issue
2eissn
0940-1334issn
1433-8491journal_volume
253pub_type
临床试验,杂志文章abstract::Cerebrospinal fluid acetylcholinesterase (CSF AChE) was determined for elderly delirious patients during the acute stage and after a 1- and 4-year follow-up periods, and the AChE levels were compared with age-equivalent controls. The AChE levels measured during the index admission correlated with the length of life af...
journal_title:European archives of psychiatry and clinical neuroscience
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journal_title:European archives of psychiatry and clinical neuroscience
pub_type: 杂志文章,meta分析,评审
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journal_title:European archives of psychiatry and clinical neuroscience
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journal_title:European archives of psychiatry and clinical neuroscience
pub_type: 临床试验,杂志文章,随机对照试验
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abstract::Some studies suggest seasonality of suicide attempts in females, but not in males. The reasons for this gender difference remain unclear. Only few studies addressed the question whether gender differences in seasonality of suicide attempts reflect gender differences in the choice of method for suicide attempts, with i...
journal_title:European archives of psychiatry and clinical neuroscience
pub_type: 杂志文章
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journal_title:European archives of psychiatry and clinical neuroscience
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journal_title:European archives of psychiatry and clinical neuroscience
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journal_title:European archives of psychiatry and clinical neuroscience
pub_type: 杂志文章,多中心研究
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journal_title:European archives of psychiatry and clinical neuroscience
pub_type: 杂志文章,多中心研究
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journal_title:European archives of psychiatry and clinical neuroscience
pub_type: 杂志文章
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journal_title:European archives of psychiatry and clinical neuroscience
pub_type: 临床试验,杂志文章
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journal_title:European archives of psychiatry and clinical neuroscience
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journal_title:European archives of psychiatry and clinical neuroscience
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journal_title:European archives of psychiatry and clinical neuroscience
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journal_title:European archives of psychiatry and clinical neuroscience
pub_type: 临床试验,杂志文章
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journal_title:European archives of psychiatry and clinical neuroscience
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
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journal_title:European archives of psychiatry and clinical neuroscience
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pub_type: 临床试验,杂志文章
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journal_title:European archives of psychiatry and clinical neuroscience
pub_type: 杂志文章
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journal_title:European archives of psychiatry and clinical neuroscience
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journal_title:European archives of psychiatry and clinical neuroscience
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journal_title:European archives of psychiatry and clinical neuroscience
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journal_title:European archives of psychiatry and clinical neuroscience
pub_type: 杂志文章
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journal_title:European archives of psychiatry and clinical neuroscience
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journal_title:European archives of psychiatry and clinical neuroscience
pub_type: 杂志文章
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journal_title:European archives of psychiatry and clinical neuroscience
pub_type: 杂志文章
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更新日期:2016-04-01 00:00:00
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journal_title:European archives of psychiatry and clinical neuroscience
pub_type: 杂志文章
doi:10.1007/s00406-012-0335-6
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