Abstract：
:This study aims to investigate the relationship between regional connectivity in the brain white matter and the presence of psychotic personality traits, in healthy subjects with psychotic traits. Thirteen healthy controls were administered the MMPI-2, to assess psychotic traits and, according to MMPI results, a dichotomization into a group of "high-psychotic" and "low-psychotic" was performed. Diffusion tensor imaging (DTI) was used as a non-invasive measure, in order to obtain information about the fractional anisotropy (FA), an intravoxel index of local connectivity and, by means of a voxelwise approach, the between-group differences of the FA values were calculated. The "high-psychotic" group showed higher FA in the left arcuate fasciculus. Subjects with low scores for psychotic traits had significantly higher FA in the corpus callosum, right arcuate fasciculus, and fronto-parietal fibers. In line with previous brain imaging studies of schizophrenia spectrum disorders, our results suggest that psychotic personality traits are related to altered connectivity and brain asymmetry.
journal_name
Eur Arch Psychiatry Clin Neurosciauthors
Volpe U,Federspiel A,Mucci A,Dierks T,Frank A,Wahlund LO,Galderisi S,Maj Mdoi
10.1007/s00406-007-0796-1subject
Has Abstractpub_date
2008-08-01 00:00:00pages
292-9issue
5eissn
0940-1334issn
1433-8491journal_volume
258pub_type
杂志文章abstract：:The aim of this study was to estimate the prevalence and incidence of mood disorders, anxiety disorders, and stress and adjustment disorders in primary health care in Sweden and to analyse the relationship between socioeconomic and demographic factors and incidence of these disorders. Prevalence and incidence data on ...
journal_title：European archives of psychiatry and clinical neuroscience
pub_type： 杂志文章
doi：10.1007/s00406-013-0422-3
更新日期：2014-04-01 00:00:00
abstract：:Negative symptoms were examined in 150 primarily first-admission patients diagnosed with schizophrenia, schizoaffective disorder, psychotic depression, psychotic bipolar disorder, and 'other' psychoses. The analysis focused on patients who were rated on the Scale for the Assessment of Negative Symptoms (SANS) within 4...
journal_title：European archives of psychiatry and clinical neuroscience
pub_type： 临床试验,杂志文章
doi：10.1007/BF02274895
更新日期：1996-01-01 00:00:00
abstract：:Dopamine D(2) blocking typical antipsychotic drugs are known to change the cerebral perfusion patterns of schizophrenic patients, especially in the frontal cortex and basal ganglia. In recent years atypical antipsychotics such as olanzapine, which have high serotonin 5-HT(2A)/dopamine D(2) occupation ratios, have been...
journal_title：European archives of psychiatry and clinical neuroscience
pub_type： 临床试验,杂志文章
doi：10.1007/s00406-003-0401-1
更新日期：2003-02-01 00:00:00
abstract：:Protein expression of VGF (nonacronymic) is induced by nerve/brain-derived growth factor, neurotrophin 3, and insulin. VGF is synthesized by neurons in the paraventricular (PVN) and supraoptic (SON) nuclei of the hypothalamus. After enzymatic processing, smaller VGF-derived peptides are secreted into the cerebrospinal...
journal_title：European archives of psychiatry and clinical neuroscience
pub_type： 杂志文章
doi：10.1007/s00406-011-0282-7
更新日期：2012-08-01 00:00:00
abstract：BACKGROUND:While there is ample evidence that the prevalence rates for major depressive disorder (MDD) in the general population are higher in women than in men, there is little data on gender differences as regard to symptoms, causal attribution, help-seeking, coping, or the consequences of depression. METHOD:The lar...
journal_title：European archives of psychiatry and clinical neuroscience
pub_type： 杂志文章
doi：10.1007/s00406-002-0381-6
更新日期：2002-10-01 00:00:00
abstract：:The aim of the study was to examine the psychosis continuum in a Latin-American community setting. Data were from the Brazilian São Paulo Epidemiologic Catchment Area Study, a cross-sectional survey conducted in two boroughs of the city of São Paulo. The Composite International Diagnosis Interview (version 1.1) was ap...
journal_title：European archives of psychiatry and clinical neuroscience
pub_type： 杂志文章
doi：10.1007/s00406-011-0204-8
更新日期：2011-10-01 00:00:00
abstract：:Five cases of acute pandysautonomia and one case of acute autonomic and sensory neuropathy are described with special reference to psychiatric symptoms. They originally presented as psychiatric disorders, such as hysterical neurosis, epilepsy, anorexia nervosa and hypochondriacal neurosis. Psychiatric symptoms arise f...
journal_title：European archives of psychiatry and clinical neuroscience
pub_type： 杂志文章
doi：10.1007/BF02189983
更新日期：1990-01-01 00:00:00
abstract：:In a single-blind, placebo-controlled crossover trial, the acute efficacy of the dopamine agonist pramipexole was investigated in 11 restless legs syndrome (RLS) patients by sleep laboratory methods, with a clinical follow-up for 4 weeks. In 3 nights (pre-treatment, placebo and drug night), objective sleep quality was...
journal_title：European archives of psychiatry and clinical neuroscience
pub_type： 临床试验,杂志文章
doi：10.1007/s00406-002-0380-7
更新日期：2002-08-01 00:00:00
abstract：:This 4-6-year prospective follow-up study compared reactive depressives with (n = 48) and without suicide attempts before index admission (n = 24). Both groups showed a favourable course and outcome concerning psychiatric diagnoses (DSM-III), psychopathology, social integration, and social functioning as well as displ...
journal_title：European archives of psychiatry and clinical neuroscience
pub_type： 杂志文章
doi：10.1007/BF02190337
更新日期：1992-01-01 00:00:00
abstract：:Sustainable observations suggest that suicidal behaviour by itself may have biological correlates, among which those related to the serotonergic synapse hold the key position. Based on the association of suicide and serotonergic dysfunction, it was proposed that genetic mechanisms affecting suicidal behaviour could be...
journal_title：European archives of psychiatry and clinical neuroscience
pub_type： 杂志文章
doi：10.1007/s00406-004-0482-5
更新日期：2004-08-01 00:00:00
abstract：:An involvement of the central serotonergic system has constantly been reported in the pathogenesis of suicide. The dorsal raphe nucleus (DRN) is the main source of serotonergic innervation of forebrain limbic structures disturbed in suicidal behaviour, in which an abnormal microglia reaction seems to play a role. In o...
journal_title：European archives of psychiatry and clinical neuroscience
pub_type： 杂志文章
doi：10.1007/s00406-017-0774-1
更新日期：2017-08-01 00:00:00
abstract：:The alpha 1C subunit of the L-type voltage-gated calcium channel (CACNA1C) gene is one of the best replicated susceptibility loci for bipolar disorder, schizophrenia and major depression. It is involved in learning, memory and brain plasticity. Genetic studies using functional magnetic resonance imaging (fMRI) reporte...
journal_title：European archives of psychiatry and clinical neuroscience
pub_type： 杂志文章
doi：10.1007/s00406-013-0428-x
更新日期：2014-03-01 00:00:00
abstract：:Various factors contribute to the development and maintenance of delusions in the context of schizophrenic psychoses. Studies with functional and structural MRI were able to detect neurobiological correlates of paranoid symptoms. Consistent with the neurodevelopmental hypothesis of schizophrenic psychosis, which impli...
journal_title：European archives of psychiatry and clinical neuroscience
pub_type： 杂志文章,评审
doi：10.1007/s00406-008-5008-0
更新日期：2008-11-01 00:00:00
abstract：OBJECTIVE:Childhood traumatic experiences, rearing styles, familial mental disorders and birth risk factors have been associated with the development of social anxiety disorder. METHOD:Patients with social anxiety disorder (n=50) and healthy controls (n=120) were investigated using a retrospective interview with 203 q...
journal_title：European archives of psychiatry and clinical neuroscience
pub_type： 杂志文章
doi：10.1007/s00406-004-0521-2
更新日期：2004-12-01 00:00:00
abstract：:This report presents the rationale and design of a multi-center clinical trial that examines the efficacy and safety of antipsychotic combination treatment in acutely ill schizophrenia patients compared to antipsychotic monotherapy. Antipsychotic combination treatment is common in clinical practice worldwide, despite ...
journal_title：European archives of psychiatry and clinical neuroscience
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1007/s00406-019-01063-4
更新日期：2020-02-01 00:00:00
abstract：:Posttraumatic stress disorder (PTSD) has been associated with an altered processing of threat-related stimuli. In particular, an attentional bias towards threat cues has been consistently found in behavioral studies. However, it is unclear whether increased attention towards threat cues translates into preferential pr...
journal_title：European archives of psychiatry and clinical neuroscience
pub_type： 杂志文章
doi：10.1007/s00406-009-0006-4
更新日期：2009-09-01 00:00:00
abstract：:Obsessive-compulsive symptoms (OCS) are frequently reported in patients with schizophrenia and have been associated with subjective distress and higher impairment. Recent studies suggest fluctuation in co-occurring OCS and associations with the course of psychotic symptoms. Current evidence is limited by few studies w...
journal_title：European archives of psychiatry and clinical neuroscience
pub_type： 杂志文章
doi：10.1007/s00406-018-0884-4
更新日期：2019-03-01 00:00:00
abstract：:The aim of the study was to explore whether the individual burden of ADHD is the same in the elderly as in younger ages even though the symptomatological impact of ADHD seems to remain stable over the lifespan. To assess ADHD symptoms and ADHD-associated problems in daily life, standardised questionnaires were conduct...
journal_title：European archives of psychiatry and clinical neuroscience
pub_type： 杂志文章
doi：10.1007/s00406-015-0644-7
更新日期：2016-06-01 00:00:00
abstract：OBJECTIVE:Fluoxetine and its active metabolite norfluoxetine have long half-lives. We postulate that, owing to the long elimination half-life and the time to reach steady-state level in plasma is nearly four weeks, patients diagnosed with major depressive disorder might be treated with fluoxetine taken once every third...
journal_title：European archives of psychiatry and clinical neuroscience
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s00406-003-0445-2
更新日期：2003-12-01 00:00:00
abstract：:The conceptualization of rapidly cycling bipolar disorder remains controversial. The DSM-IV definition of rapid cycling, although very reliable, may be not sufficiently inclusive (i.e., it may exclude patients with very short episodes of very high frequency, who are very typical in terms of external validators, and ar...
journal_title：European archives of psychiatry and clinical neuroscience
pub_type： 杂志文章
doi：10.1007/BF03035130
更新日期：2001-01-01 00:00:00
abstract：:Research on emotional expression in adult schizophrenia patients has indicated an impairment of the patients' facial expressions during social interaction. However, it is unclear whether schizophrenia adolescent-onset patients show comparable disturbances in facial expression. Our aim was to analyze facial emotions in...
journal_title：European archives of psychiatry and clinical neuroscience
pub_type： 杂志文章
doi：10.1007/s00406-012-0386-8
更新日期：2013-09-01 00:00:00
abstract：:Cognitive models suggest that top-down and emotional processes increase false perceptions in schizophrenia spectrum disorders (SSD). However, little is still known about the interaction of these processes in false auditory perceptions. The present study aimed at investigating the specific as well as joint impacts of e...
journal_title：European archives of psychiatry and clinical neuroscience
pub_type： 杂志文章
doi：10.1007/s00406-019-01065-2
更新日期：2019-09-06 00:00:00
abstract：:Comorbid disorders are common in psychiatric diseases and understanding the risk of secondary diseases can aid successful clinical treatment. The objective of this study was to compare the frequency of comorbid dementia, affective disorders, and inflammatory polyarthropathies. Healthcare data obtained via the German H...
journal_title：European archives of psychiatry and clinical neuroscience
pub_type： 杂志文章
doi：10.1007/s00406-019-01015-y
更新日期：2020-03-01 00:00:00
abstract：:To improve recognition and treatment of depression in primary care it would be advantageous to have criteria for identification of later depression. Only a few studies were performed on primary care samples to examine risk factors for new depressive episodes. These were mostly cross-sectional and did not include psych...
journal_title：European archives of psychiatry and clinical neuroscience
pub_type： 杂志文章
doi：10.1007/BF03035122
更新日期：2001-01-01 00:00:00
abstract：OBJECTIVE:Interpersonal psychotherapy (IPT) is a time-limited psychotherapy for major depression. The aim of this study is to summarize findings from controlled trials of the efficacy of IPT in the treatment of depressive spectrum disorders (DSD) using a meta-analytic approach. METHODS:Studies of randomized clinical t...
journal_title：European archives of psychiatry and clinical neuroscience
pub_type： 杂志文章,评审
doi：10.1007/s00406-004-0542-x
更新日期：2005-04-01 00:00:00
abstract：:Mental health problems do significantly impact on a person's functioning. In the past, problems with psychosocial functioning were mainly associated with the diagnoses of schizophrenia. However, nowadays it is clear that impaired psychosocial functioning is also a common phenomenon in people suffering from affective d...
journal_title：European archives of psychiatry and clinical neuroscience
pub_type： 杂志文章
doi：10.1007/s00406-012-0335-6
更新日期：2013-03-01 00:00:00
abstract：:The objective of this study is to determine whether cannabis influences BDNF levels in patients with psychosis (FEP) and healthy volunteers (HV) to help understand the role of BDNF in psychosis. We assessed the association between BDNF and cannabis in a cohort of FEP antipsychotic-naïve patients and HV, whilst control...
journal_title：European archives of psychiatry and clinical neuroscience
pub_type： 杂志文章
doi：10.1007/s00406-020-01117-y
更新日期：2020-10-01 00:00:00
abstract：:In the present study, quantitative EEG analysis was performed at rest and during 10 Hz photic stimulation in 14 drug-naive patients with first-episode paranoid schizophrenia and 20 sex- and age-matched control subjects. Compared with the normal controls, the patients had significantly lower alpha-2 band amplitude in t...
journal_title：European archives of psychiatry and clinical neuroscience
pub_type： 杂志文章
doi：10.1007/BF02190377
更新日期：1994-01-01 00:00:00
abstract：:The novel/atypical neuroleptics have proven to be effective in treating negative symptoms but although clinical experience appears to show that they have advantages over the traditional neuroleptics in treating negative symptoms, superiority has not always been statistically confirmed and the treatment results in indi...
journal_title：European archives of psychiatry and clinical neuroscience
pub_type： 杂志文章,评审
doi：10.1007/s00406-004-0503-4
更新日期：2004-04-01 00:00:00
abstract：:Mutations in the presenilin-1 gene (PS-1 gene) on chromosome 14 have recently been identified as a cause of familial early-onset Alzheimer's disease (EOAD). To our knowledge, only two German EOAD patients with mutations in the PS-1 gene have been identified thus far. Herein we report the case of a German EOAD patient ...
journal_title：European archives of psychiatry and clinical neuroscience
pub_type： 杂志文章
doi：10.1007/s004060050028
更新日期：1998-01-01 00:00:00
