当前位置： SCI文献检索 > EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE期刊下所有文献 > Microglia in the dorsal raphe nucleus plays a potential role in both suicide facilitation and prevention in affective disorders.

Microglia in the dorsal raphe nucleus plays a potential role in both suicide facilitation and prevention in affective disorders.

Abstract：

:An involvement of the central serotonergic system has constantly been reported in the pathogenesis of suicide. The dorsal raphe nucleus (DRN) is the main source of serotonergic innervation of forebrain limbic structures disturbed in suicidal behaviour, in which an abnormal microglia reaction seems to play a role. In our present study, the density of microglia immunostained for the HLA-DR antigen was evaluated in the DRN. These analyses were carried out on paraffin-embedded brains from 24 suicidal and 21 non-suicidal patients; among them, 27 depressed (15 major depressive disorder and 12 bipolar disorder) and 18 schizophrenia (9 residual and 9 paranoid) patients and 22 matched controls without mental disorders. Only the non-suicidal depressed subgroup revealed significantly lower microglial reaction, i.e., a decreased density of HLA-DR positive microglia versus both depressed suicide victims and controls. The effect was not related to antidepressant or antipsychotic medication, as the former correlated positively with microglial density in non-suicidal depressed patients, and the latter had no effect. Moreover, the comparison of these results with previously published data from our workgroup in the same cohort (Krzyżanowska et al. in Psychiatry Res 241:43-46, 4) suggested a positive impact of microglia on ribosomal DNA transcription in DRN neurons in the non-suicidal depressed subgroup, but not in depressed suicidal cases. Therefore, the interaction between microglia and neurons in the DRN may be potentially involved in opposite ways regarding suicide facilitation and prevention in the tested subgroups of depressed patients.

journal_name

Eur Arch Psychiatry Clin Neurosci

journal_title

European archives of psychiatry and clinical neuroscience

authors

Brisch R,Steiner J,Mawrin C,Krzyżanowska M,Jankowski Z,Gos T

doi

10.1007/s00406-017-0774-1

subject

Has Abstract

pub_date

2017-08-01 00:00:00

pages

403-415

issue

5

eissn

0940-1334

issn

1433-8491

pii

10.1007/s00406-017-0774-1

journal_volume

267

pub_type

杂志文章

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