当前位置： SCI文献检索 > RESTORATIVE NEUROLOGY AND NEUROSCIENCE期刊下所有文献 > rTMS with motor training modulates cortico-basal ganglia-thalamocortical circuits in stroke patients.

rTMS with motor training modulates cortico-basal ganglia-thalamocortical circuits in stroke patients.

Abstract：

BACKGROUND AND PURPOSE:Repetitive transcranial magnetic stimulation (rTMS) may enhance plastic changes in the human cortex and modulation of behavior. However, the underlying neural mechanisms have not been sufficiently investigated. We examined the clinical effects and neural correlates of high-frequency rTMS coupled with motor training in patients with hemiparesis after stroke. METHODS:Twenty-one patients were randomly divided into two groups, and received either real or sham rTMS. Ten daily sessions of 1,000 pulses of real or sham rTMS were applied at 10 Hz over the primary motor cortex of the affected hemisphere, coupled with sequential finger motor training of the paretic hand. Functional MRIs were obtained before and after training using sequential finger motor tasks, and performances were assessed. RESULTS:Following rTMS intervention, movement accuracy of sequential finger motor tasks showed significantly greater improvement in the real group than in the sham group (p < 0.05). Real rTMS modulated areas of brain activation during performance of motor tasks with a significant interaction effect in the sensorimotor cortex, thalamus, and caudate nucleus. Patients in the real rTMS group also showed significantly enhanced activation in the affected hemisphere compared to the sham rTMS group. CONCLUSION:According to these results, a 10 day course of high-frequency rTMS coupled with motor training improved motor performance through modulation of activities in the cortico-basal ganglia-thalamocortical circuits.

journal_name

Restor Neurol Neurosci

journal_title

Restorative neurology and neuroscience

authors

Chang WH,Kim YH,Yoo WK,Goo KH,Park CH,Kim ST,Pascual-Leone A

doi

10.3233/RNN-2012-110162

subject

Has Abstract

pub_date

2012-01-01 00:00:00

pages

179-89

issue

3

eissn

0922-6028

issn

1878-3627

pii

VK3J42P62L7183UP

journal_volume

30

pub_type

杂志文章,随机对照试验

相关文献

RESTORATIVE NEUROLOGY AND NEUROSCIENCE文献大全
  • Vascular insufficiency, not inflammation, contributes to chronic gliosis in a rat CNS transplantation model.

    abstract：PURPOSE:There is considerable variability in the extent and nature of the glial response to injury and neurodegeneration. Transplantation of fetal cortical tissue onto the brain of neonatal host rats or mice results in region-specific changes dependent on where the fetal tissue is placed. These changes include chronic ...

    journal_title：Restorative neurology and neuroscience

    pub_type： 杂志文章

    doi：10.3233/RNN-150591

    authors： Bates KA,Drummond ES,Cozens GS,Harvey AR

    更新日期：2016-01-01 00:00:00

  • Improvement of motor performance in children with cerebral palsy treated with exoskeleton robotic training: A retrospective explorative analysis.

    abstract：BACKGROUND:Robot-assisted gait training (RAGT) is widely used in children with cerebral palsy (CP), but information about optimal intervention frequency and duration is still lacking and the current evidence about effect of RAGT on motor endurance and fitness is very preliminary. OBJECTIVE:To investigate the effect of...

    journal_title：Restorative neurology and neuroscience

    pub_type： 杂志文章

    doi：10.3233/RNN-180897

    authors： Digiacomo F,Tamburin S,Tebaldi S,Pezzani M,Tagliafierro M,Casale R,Bartolo M

    更新日期：2019-01-01 00:00:00

  • Institutional profile: integrated center for research and treatment of vertigo, balance and ocular motor disorders.

    abstract：:In 2009 the German BMBF (German Ministry of Education and Research) established an Integrated Center for Research and Treatment (IFB(LMU)) of Vertigo, Balance and Ocular Motor Disorders in Munich. After the 10-year period of funding by the BMBF, it is envisioned that the (IFB(LMU)) will continue over the long term wit...

    journal_title：Restorative neurology and neuroscience

    pub_type： 社论

    doi：10.3233/RNN-2010-0510

    authors： Brandt T,Zwergal A,Jahn K,Strupp M

    更新日期：2010-01-01 00:00:00

  • Neglect and extinction: within and between sensory modalities.

    abstract：PURPOSE:The interest in human conscious awareness has increasingly propelled the study of neglect, the most striking occurrence of an acquired lack of conscious experience of space. Neglect syndromes commonly arise after unilateral brain damage that spares primary sensory areas nonetheless leading to a lack of consciou...

    journal_title：Restorative neurology and neuroscience

    pub_type： 杂志文章,评审

    doi：

    authors： Brozzoli C,Demattè ML,Pavani F,Frassinetti F,Farnè A

    更新日期：2006-01-01 00:00:00

  • Nerve regeneration is improved by insulin-like growth factor I (IGF-I) and basic flbroblast growth factor (bFGF).

    abstract：:In rat sciatic nerves, IGF-I or bFGF was applied distal to a crush to evaluate their effects upon the restoration of the neuromuscular function. In comparison with the recovery following a simple crush, treatment with growth factors resulted in (i) enhanced elongation of regenerating axons ( + 24%) up to day 3 post le...

    journal_title：Restorative neurology and neuroscience

    pub_type： 杂志文章

    doi：10.3233/RNN-1993-5302

    authors： Vergara J,Medina L,Maulén J,Inestrosa NC,Alvarez J

    更新日期：1993-01-01 00:00:00

  • Non-competitive NMDA antagonists and anti-oxidant drugs reduce striatal atrophy and facilitate recovery of function following lesions of the rat cortex.

    abstract：:Following brain injury there is an excessive release of glutamate, a reduction in levels of cellular Mg+ +, and the generation of oxygen free radicals. These processes may contribute to the severity of the behavioral impairments seen following brain injury by leading to secondary neuronal degeneration. The present exp...

    journal_title：Restorative neurology and neuroscience

    pub_type： 杂志文章

    doi：10.3233/RNN-1997-111208

    authors： Hoane MR,Raad C,Barth TM

    更新日期：1997-01-01 00:00:00

  • Comparison of hemodynamic changes after repetitive transcranial magnetic stimulation over the anatomical hand knob and hand motor hotspot: A functional near-infrared spectroscopy study.

    abstract：BACKGROUND:Low-frequency rTMS can induce upregulation of excitability in the contralateral hemisphere by interhemispheric interaction. OBJECTIVE:The aim of this study was to compare the effects of interhemispheric modulation on hemodynamic changes after applying low-frequency rTMS over the anatomical hand knob (HK) an...

    journal_title：Restorative neurology and neuroscience

    pub_type： 杂志文章

    doi：10.3233/RNN-201032

    authors： Kim J,Kim H,Lee J,Lee HJ,Na Y,Chang WH,Kim YH

    更新日期：2020-01-01 00:00:00

  • Therapeutic effects of oral dimethyl fumarate on stroke induced by middle cerebral artery occlusion: An animal experimental study.

    abstract：BACKGROUND:Dimethyl fumarate (DMF) has immune-modulatory and neuro-protective characteristics that can be used for treatment of acute ischemic stroke. OBJECTIVE:To investigate the therapeutic effects of DMF on histological and functional recovery of rats after transient middle cerebral artery (MCA) occlusion. METHODS...

    journal_title：Restorative neurology and neuroscience

    pub_type： 杂志文章

    doi：10.3233/RNN-160670

    authors： Safari A,Fazeli M,Namavar MR,Tanideh N,Jafari P,Borhani-Haghighi A

    更新日期：2017-01-01 00:00:00

  • Vision restoration therapy (VRT) efficacy as assessed by comparative perimetric analysis and subjective questionnaires.

    abstract：PURPOSE:We wished to evaluate the efficacy of vision restoration therapy (VRT) in patients with post-chiasmatic brain damage using different functional perimetric tests. These were compared with measures of subjective vision and reaction time. METHODS:An open trial was conducted with hemianopia/scotoma (n=16) patients...

    journal_title：Restorative neurology and neuroscience

    pub_type： 临床试验,杂志文章

    doi：

    authors： Sabel BA,Kenkel S,Kasten E

    更新日期：2004-01-01 00:00:00

  • Changes in Glial Fibrillary Acidic Protein Immunoreactivity in Response to Experimental Hepatic Encephalopathy in the Rat Hippocampus.

    abstract：:The response of astroglial cells in the hippocampus to long-term portacaval anastomosis (PCA), an experimental model of hepatic encephalopathy, was studied in adult male rats and compared with controls. Six months after PCA, the rat hippocampi were processed for glial fibrillary acidic protein (GFAP). GFAP-immunoposit...

    journal_title：Restorative neurology and neuroscience

    pub_type： 杂志文章

    doi：

    authors： Suarez I,Bodega G,Fernandez B

    更新日期：1998-01-01 00:00:00

  • The impact of enriched environment and transplantation of murine cortical embryonic stem cells on recovery from controlled cortical contusion injury.

    abstract：PURPOSE:The effectiveness of embryonic stem cell (eSC) therapy has been explored in many models of neurological disease and several research groups have shown that eSC treatment leads to improved outcomes in pre-clinical models of traumatic brain injury (TBI). Though functional recovery occurs, few surviving eSCs appea...

    journal_title：Restorative neurology and neuroscience

    pub_type： 杂志文章

    doi：10.3233/RNN-120299

    authors： Peruzzaro ST,Gallagher J,Dunkerson J,Fluharty S,Mudd D,Hoane MR,Smith JS

    更新日期：2013-01-01 00:00:00

  • The difference between mechanisms of kainate and glutamate excitotoxicity in vitro: osmotic lesion versus mitochondrial depolarization.

    abstract：:The hypothesis that a destabilization of mitochondrial function during neuronal exposure to excitatory amino acids may be involved in the mechanism of neuronal death was examined. The mitochondrial membrane potential (Delta(psi)m) and the cytoplasmic Ca2+ concentration ([Ca2+]c) were monitored simultaneously in single...

    journal_title：Restorative neurology and neuroscience

    pub_type： 杂志文章

    doi：

    authors： Kiedrowski L

    更新日期：1998-06-01 00:00:00

  • Extended Multiple-Field High-Definition transcranial direct current stimulation (HD-tDCS) is well tolerated and safe in healthy adults.

    abstract：BACKGROUND:High definition transcranial direct current stimulation (HD-tDCS) has been administered over single brain regions for small numbers of sessions. Safety, feasibility and tolerability of HD-tDCS over multiple brain regions, multiple daily stimulations and long periods are not established. OBJECTIVE:We studied...

    journal_title：Restorative neurology and neuroscience

    pub_type： 杂志文章

    doi：10.3233/RNN-170757

    authors： Turski CA,Kessler-Jones A,Chow C,Hermann B,Hsu D,Jones J,Seeger SK,Chappell R,Boly M,Ikonomidou C

    更新日期：2017-01-01 00:00:00

  • Fate of afferents to the dentate gyrus following destruction of granule cells with colchicine.

    abstract：:Granule cells of the dentate gyrus can be selectively destroyed by intrahippocampal injections of colchicine. The present study evaluates the consequences of this selective neuronal destruction on the afferent axon terminals which have been deprived of their normal targets. The area of the neuropil in the dentate gyru...

    journal_title：Restorative neurology and neuroscience

    pub_type： 杂志文章

    doi：10.3233/RNN-1992-3605

    authors： Goldschmidt RB,Steward O

    更新日期：1992-01-01 00:00:00

  • Mobile game-based virtual reality rehabilitation program for upper limb dysfunction after ischemic stroke.

    abstract：BACKGROUND:Virtual reality (VR) has the potential to provide intensive, repetitive, and task-oriented training, and game-based therapy can enhance patients' motivation and enjoyment. OBJECTIVE:The objective of the present study was to develop a mobile game-based upper extremity VR program for patients who have experie...

    journal_title：Restorative neurology and neuroscience

    pub_type： 杂志文章,随机对照试验

    doi：10.3233/RNN-150626

    authors： Choi YH,Ku J,Lim H,Kim YH,Paik NJ

    更新日期：2016-05-02 00:00:00

  • Suprachiasmatic nucleus lesions abolish and fetal grafts restore circadian gnawing rhythms in hamsters.

    abstract：:It is widely accepted that the suprachiasmatic nuclei (SCN) of the hypothalamus serve as biological pacemakers, organizing daily activities. However some circadian rhythms are controlled by extra-SCN structures. Transplantation of fetal donor SCN in SCN-lesioned rodents induces recovery of rhythmic locomotor and drink...

    journal_title：Restorative neurology and neuroscience

    pub_type： 杂志文章

    doi：10.3233/RNN-1994-6207

    authors： Le Sauter J,Silver R

    更新日期：1994-01-01 00:00:00

  • Psychopathy: developmental perspectives and their implications for treatment.

    abstract：:Psychopathy is a mental disorder marked by deficient emotional responses, lack of empathy, and poor behavioral controls, commonly resulting in persistent antisocial deviance and criminal behavior. Accumulating research suggests that psychopathy follows a developmental trajectory with strong genetic influences, and whi...

    journal_title：Restorative neurology and neuroscience

    pub_type： 杂志文章,评审

    doi：10.3233/RNN-139001

    authors： Anderson NE,Kiehl KA

    更新日期：2014-01-01 00:00:00

  • Developmental and reactive growth of dentate gyrus afferents: cellular and molecular interactions.

    abstract：:The lamination of dentate gyrus afferents established during development is maintained following lesion-induced reactive growth in the adult. After partial deafferentation sprouts from undamaged afferents restore most synapses, while respecting the laminae relative boundaries. No evidence of trans-laminar sprouting ha...

    journal_title：Restorative neurology and neuroscience

    pub_type： 杂志文章,评审

    doi：

    authors： Collazos-Castro JE,Nieto-Sampedro M

    更新日期：2001-01-01 00:00:00

  • The influence of astrocytes on the development, regeneration and reconstruction of the nigrostriatal dopamine system.

    abstract：:Over the past few decades astrocytes have emerged from being considered simple packing tissue in the brain to become major players in the development, survival and functioning of central nervous system (CNS) neurons. As the influence that astrocytes (and the various molecules they produce) have on the development of C...

    journal_title：Restorative neurology and neuroscience

    pub_type： 杂志文章,评审

    doi：

    authors： Gates MA,Dunnett SB

    更新日期：2001-01-01 00:00:00

  • Pharmacological enhancement of glutamate transport reduces excitotoxicity in vitro.

    abstract：PURPOSE:Glutamate transporters are responsible for removing glutamate from the extracellular space and have the potential to protect neurons from excitotoxicity. In the present study, the effects of ceftriaxone and (2R, 4R)-APDC (APDC) on the protein expression of GLAST and GLT-1, the rate of glutamate uptake, and neur...

    journal_title：Restorative neurology and neuroscience

    pub_type： 杂志文章

    doi：10.3233/RNN-2011-603

    authors： Beller JA,Gurkoff GG,Berman RF,Lyeth BG

    更新日期：2011-01-01 00:00:00

  • A low-cost system for coil tracking during transcranial magnetic stimulation.

    abstract：PURPOSE:Accurate coil placement over a target area is critical during transcranial magnetic stimulation (TMS), as small deviations can alter testing outcomes. Accordingly, frameless stereotaxic systems (FSS) are recommended for reliable coil placement during TMS applications. However, FSS is not practical due to the co...

    journal_title：Restorative neurology and neuroscience

    pub_type： 杂志文章

    doi：10.3233/RNN-150609

    authors： Washabaugh EP,Krishnan C

    更新日期：2016-01-01 00:00:00

  • IVth International Symposium on Neural Transplantation.

    abstract：:IVth International Symposium on Neural TransplantationEdited by William J. Freed and Jeffrey M. RosensteinThe George Washington University, Washington, DC, USAJuly 12-16, 1992. ...

    journal_title：Restorative neurology and neuroscience

    pub_type： 杂志文章

    doi：10.3233/RNN-1992-4301

    authors：

    更新日期：1992-01-01 00:00:00

  • Neuroplasticity of sign language: implications from structural and functional brain imaging.

    abstract：PURPOSE:The present study was designed to investigate the neural correlates of German Sign Language (Deutsche Gebärdensprache; DGS) processing. In particular, was expected the impact of the visuo-spatial mode in sign language on underlying neural networks compared to the impact of the interpretation of linguistic infor...

    journal_title：Restorative neurology and neuroscience

    pub_type： 杂志文章

    doi：

    authors： Meyer M,Toepel U,Keller J,Nussbaumer D,Zysset S,Friederici AD

    更新日期：2007-01-01 00:00:00

  • Antioxidant therapy in experimental spinal cord injury.

    abstract：:We have tested the capacity of several compounds with in vitro and/or in vivo antioxidant or antilipolytic activity to ameliorate locomotor function in cats subjected to static loading (i.e. compression) injury of the spinal cord. These include the synthetic glucocorticoid, methylprednisolone sodium succinate (MP), an...

    journal_title：Restorative neurology and neuroscience

    pub_type： 杂志文章

    doi：10.3233/RNN-1991-245603

    authors： Anderson DK

    更新日期：1991-01-01 00:00:00

  • Assessment of auditory temporal-order thresholds - a comparison of different measurement procedures and the influences of age and gender.

    abstract：PURPOSE:The relationship between auditory temporal-order perception and phoneme discrimination has been discussed for several years, based on findings, showing that patients with cerebral damage in the left hemisphere and aphasia, as well as children with specific language impairments, show deficits in temporal-process...

    journal_title：Restorative neurology and neuroscience

    pub_type： 杂志文章

    doi：

    authors： Fink M,Churan J,Wittmann M

    更新日期：2005-01-01 00:00:00

  • Alterations in mitochondrial membrane potential in peripheral blood mononuclear cells in Parkinson's Disease: Potential for a novel biomarker.

    abstract：BACKGROUND:Progressive apoptosis in the dopaminergic neurons of substantia nigra lead to Parkinson's disease. Since neurons require substantially higher supply of energy, their mitochondria have a pivotal status in neuronal survival. These organelles have a key role to play in apoptosis and any impairment thereof may l...

    journal_title：Restorative neurology and neuroscience

    pub_type： 杂志文章

    doi：10.3233/RNN-180852

    authors： Qadri R,Namdeo M,Behari M,Goyal V,Sharma S,Mukhopadhyay AK

    更新日期：2018-01-01 00:00:00

  • Preliminary experiments in nerve regeneration through laser-drilled holes in silicon chips.

    abstract：:Many of the present limitations of peripheral nerve repair might be overcome by performing nerve repairs at the axon level. One approach to nerve repair at this level would be to implant a neuroprosthesis in the form of a microelectronic switchboard which could route the connections of regenerated axons to their corre...

    journal_title：Restorative neurology and neuroscience

    pub_type： 杂志文章

    doi：10.3233/RNN-1990-2205

    authors： Rosen JM,Grosser M,Hentz VR

    更新日期：1990-01-01 00:00:00

  • Usage of the middle finger shapes reorganization of the primary somatosensory cortex in patients with index finger amputation.

    abstract：PURPOSE:The primary somatosensory cortex (S1) is somatotopically reorganized after limb amputation. The duration of the amputation, the intensity of phantom limb pain but also a multifactoral model of altered cerebral input have been discussed to be associated with cortical changes. Patients with finger amputation rare...

    journal_title：Restorative neurology and neuroscience

    pub_type： 杂志文章

    doi：10.3233/RNN-130380

    authors： Oelschläger M,Pfannmöller J,Langner I,Lotze M

    更新日期：2014-01-01 00:00:00

  • Fetal porcine ventral mesencephalon grafts: dissection procedure and cellular characterization in culture.

    abstract：:The objective of this study was to develop an optimal dissection procedure for fetal porcine ventral mesencephalon (VM) grafts and to characterize the cellular composition of such an explant, in particular with respect to the dopaminergic and GABAergic components. We have used a monolayer cell culture system to study ...

    journal_title：Restorative neurology and neuroscience

    pub_type： 杂志文章

    doi：10.3233/RNN-1994-7402

    authors： van Roon WM,Copray JC,Hogenesch RI,Kema I,Meyer EM,Molenaar G,Lugard C,Staal MJ,Go KG

    更新日期：1995-01-01 00:00:00

  • GM1-Ganglioside Suppresses Septodentate Sprouting and Enhances Recovery from Entorhinal Cortex Lesions on DRL Perfomance and Locomotor Behavior in Rats.

    abstract：:Administration of gangliosides accelerates recovery of function after entorhinal cortex lesions on open field activity and learned spatial alternation tasks. In the present study, we examined whether GM1 ganglioside might enhance recovery from bilateral entorhinal cortex lesions on a differential reinforcement of low-...

    journal_title：Restorative neurology and neuroscience

    pub_type： 杂志文章

    doi：

    authors： Ramirez JJ,MacDonald K,Mañibo J,Payne J,Tuite C

    更新日期：1998-01-01 00:00:00