Comparison of hemodynamic changes after repetitive transcranial magnetic stimulation over the anatomical hand knob and hand motor hotspot: A functional near-infrared spectroscopy study.

abstract：PURPOSE:The present work compared the behavioral outcomes of ACCS therapy delivered either intravenously (i.v.) or intracerebroventricularly (i.c.v.) after penetrating ballistic-like brain injury (PBBI). Histological markers for neuroinflammation and neurodegeneration were employed to investigate the potential therapeu...

journal_title：Restorative neurology and neuroscience

authors： Deng-Bryant Y,Readnower RD,Leung LY,Cunningham TL,Shear DA,Tortella FC

更新日期：2015-01-01 00:00:00

abstract：:Regenerating nerve fiber sprouts enveloped by olfactory bulb (OB) ensheathing cells (ECs) seem to escape the inhibitory influence of gliotic tissue. Accordingly, these cells may be useful for general repair of injured CNS. Relatively large numbers of ECs could be purified from confluent cultures of adult rat olfactory...

journal_title：Restorative neurology and neuroscience

authors： Gudiño-Cabrera G,Nieto-Sampedro M

更新日期：1996-01-01 00:00:00

abstract：BACKGROUND:Dimethyl fumarate (DMF) has immune-modulatory and neuro-protective characteristics that can be used for treatment of acute ischemic stroke. OBJECTIVE:To investigate the therapeutic effects of DMF on histological and functional recovery of rats after transient middle cerebral artery (MCA) occlusion. METHODS...

journal_title：Restorative neurology and neuroscience

authors： Safari A,Fazeli M,Namavar MR,Tanideh N,Jafari P,Borhani-Haghighi A

更新日期：2017-01-01 00:00:00

abstract：PURPOSE:A realistic body representation needs to be constantly updated. In case of physiological modifications, body representations integrate information coming from different sensory sources, including the sense of touch. Previous studies described transient modifications of these representations following illusory d...

journal_title：Restorative neurology and neuroscience

authors： Cimmino RL,Spitoni G,Serino A,Antonucci G,Catagni M,Camagni M,Haggard P,Pizzamiglio L

更新日期：2013-01-01 00:00:00

abstract：PURPOSE:To assess whether insights from postural control without additional visual feedback (VFB) could be gained to explain the possible VFB effects (or non-effects) on upright stance performance. METHODS:The center-of-pressure (CP) displacements of 39 patients with a recent hemispheric stroke (93 days ± 56; mean ± s...

journal_title：Restorative neurology and neuroscience

authors： Rougier P,Boudrahem S

更新日期：2010-01-01 00:00:00

abstract：:In four patients with left visuo-spatial hemineglect and right brain- damage, the therapeutic effects of Transcutaneous Electrical Nervous Stimulation (TENS) of the left neck muscles, associated with a non-specific treatment, and of a specific rehabilitation paradigm were investigated. The two treatments were given fo...

journal_title：Restorative neurology and neuroscience

authors： Pizzamiglio L,Vallar G,Magnotti L

更新日期：1996-01-01 00:00:00

abstract：BACKGROUND:The current treatment intervention study determined the effect of coupled bilateral training (i.e., bilateral movements and EMG-triggered neuromuscular stimulation) and resistive load (mass) on upper extremity motor recovery in chronic stroke. METHODS:Thirty chronic stroke subjects were randomly assigned to...

journal_title：Restorative neurology and neuroscience

authors： Cauraugh JH,Coombes SA,Lodha N,Naik SK,Summers JJ

更新日期：2009-01-01 00:00:00

abstract：:Traumatic brain and spinal cord injuries are severe burdens for the patients, their relatives, the health care providers and society as a whole. Recent data demonstrate the magnitude of the problem: It is mostly a disease of the young gen-eration (age 20-45 years) with mortality rates for severe traumatic brain injury...

journal_title：Restorative neurology and neuroscience

authors： Neugebauer E,Lefering R,Noth J

更新日期：1999-01-01 00:00:00

abstract：:Vestibular habituation was studied in normal subjects and in patients with cerebellar disease using a stimulation paradigm proposed in this paper. Six caloric stimuli were repeated daily in the same ear during six days and electronystagmographic responses at the beginning and the end of that period were compared. The ...

journal_title：Restorative neurology and neuroscience

authors： Suarez H,Caffa C,Macadar O

更新日期：1992-01-01 00:00:00

abstract：PURPOSE:Glutamate transporters are responsible for removing glutamate from the extracellular space and have the potential to protect neurons from excitotoxicity. In the present study, the effects of ceftriaxone and (2R, 4R)-APDC (APDC) on the protein expression of GLAST and GLT-1, the rate of glutamate uptake, and neur...

journal_title：Restorative neurology and neuroscience

authors： Beller JA,Gurkoff GG,Berman RF,Lyeth BG

更新日期：2011-01-01 00:00:00

abstract：PURPOSE:Immunomodulatory agents are often combined in organ transplantation to minimize toxicity and enhance therapeutic effect. We hypothesized that combining low-dose FK506 with anti-CD40 Ligand (anti-CD40L mAb) would enhance regeneration through peripheral nerve allografts while preserving immune unresponsiveness. ...

journal_title：Restorative neurology and neuroscience

authors： Brenner MJ,Mackinnon SE,Rickman SR,Jaramillo A,Tung TH,Hunter DA,Mohanakumar T

更新日期：2005-01-01 00:00:00

abstract：:Many of the present limitations of peripheral nerve repair might be overcome by performing nerve repairs at the axon level. One approach to nerve repair at this level would be to implant a neuroprosthesis in the form of a microelectronic switchboard which could route the connections of regenerated axons to their corre...

journal_title：Restorative neurology and neuroscience

authors： Rosen JM,Grosser M,Hentz VR

更新日期：1990-01-01 00:00:00

abstract：BACKGROUND:Hearing loss is becoming a real social and health problem. Its prevalence in the elderly is an epidemic. The risk of developing hearing loss is also growing among younger people. If left untreated, hearing loss can perpetuate development of neurodegenerative diseases, including dementia. Despite recent advan...

journal_title：Restorative neurology and neuroscience

authors： Cieśla K,Wolak T,Lorens A,Heimler B,Skarżyński H,Amedi A

更新日期：2019-01-01 00:00:00

abstract：:The effects of striatal transplantation of PC12 cells on amphetamine-induced rotational behavior and monoamine levels were examined in rats with unilateral 6-hydroxydopamine (6-OHDA) lesions in the nigrostriatal pathway. A total of 9 × 104 or 9 × 105 cells of PC12 was implanted into 3 sites in the striatum and changes...

journal_title：Restorative neurology and neuroscience

authors： Hori Y,Kageyama H,Kihara T,Ikeda M,Nakano A,Kurosawa A

更新日期：1993-01-01 00:00:00

abstract：PURPOSE:Current models of intracerebral hematoma are difficult to use for neurotransplantation studies because of high mortality and important variations of morphology, size and location of blood deposits. We propose a modification of the autologous blood infusion technique in rats to reduce these limitations. METHODS...

journal_title：Restorative neurology and neuroscience

authors： Barth A,Guzman R,Andres RH,Mordasini P,Barth L,Widmer HR

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:After stroke, the learned non-use of a paretic arm is a major obstacle to the improvement of hand function. OBJECTIVE:We examined whether patients with a central paresis could profit from applying the self-regulation strategy of making if-then plans that specify situational triggers to using the paretic arm...

journal_title：Restorative neurology and neuroscience

authors： Marquardt MK,Cohen AL,Gollwitzer PM,Gilbert SJ,Dettmers C

更新日期：2017-01-01 00:00:00

abstract：PURPOSE:Transgenic manipulation of mouse physiology facilitates the preclinical study of genetic risk factors, neural plasticity, and reactive processes accompanying Alzheimer's disease. Alternatively, entorhinal cortex lesions (ECLs) model pathophysiological denervation and axonal sprouting in rat. Given reports of an...

journal_title：Restorative neurology and neuroscience

authors： Feeney EJ,Stephenson D,Kleiman R,Bove S,Cron C,Moody L,Robinson M,Ramirez JJ

更新日期：2013-01-01 00:00:00

abstract：:Over the past few decades astrocytes have emerged from being considered simple packing tissue in the brain to become major players in the development, survival and functioning of central nervous system (CNS) neurons. As the influence that astrocytes (and the various molecules they produce) have on the development of C...

journal_title：Restorative neurology and neuroscience

authors： Gates MA,Dunnett SB

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND:Oxidative stress is an important factor in the pathophysiologic changes after traumatic brain injury (TBI). Connexin43 (Cx43) was reported to contribute to cerebral damage. However, the impacts of Cx40 have not been investigated in detail. OBJECTIVE:In the present study, we hypothesized that Cx40 was involv...

journal_title：Restorative neurology and neuroscience

authors： Chen W,Guo Y,Yang W,Zheng P,Zeng J,Tong W

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Multiple Sclerosis is a heterogeneous disorders involving in early stage gait and balance. Together with immunomodulating therapies, rehabilitation had a crucial role in improving motor tasks and quality of life. Between the emerging techniques, Focal Vibrations (FV) could play a role, but they have been use...

journal_title：Restorative neurology and neuroscience

authors： Spina E,Carotenuto A,Aceto MG,Cerillo I,Silvestre F,Arace F,Paone P,Orefice G,Iodice R

更新日期：2016-09-21 00:00:00

abstract：BACKGROUND:High definition transcranial direct current stimulation (HD-tDCS) has been administered over single brain regions for small numbers of sessions. Safety, feasibility and tolerability of HD-tDCS over multiple brain regions, multiple daily stimulations and long periods are not established. OBJECTIVE:We studied...

journal_title：Restorative neurology and neuroscience

authors： Turski CA,Kessler-Jones A,Chow C,Hermann B,Hsu D,Jones J,Seeger SK,Chappell R,Boly M,Ikonomidou C

更新日期：2017-01-01 00:00:00

abstract：:Basic science studies demonstrated mechanisms of plasticity and metaplasticity. More recent human studies identified some of these mechanisms as operating in multiple areas of human cognition, such as learning and memory, and in functional recovery from lesions in the CNS, as in stroke. One of the goals of neurorehabi...

journal_title：Restorative neurology and neuroscience

authors： Celnik PA,Cohen LG

更新日期：2004-01-01 00:00:00

abstract：PURPOSE:Repairing the spinal cord with peripheral nerve grafts (PNG) and adjuvant acidic fibroblast growth factor (FGF1) has previously resulted in partial functional recovery. To aid microsurgical placement of PNGs, a graft holder device was previously developed by our group. In hope for a translational development we...

journal_title：Restorative neurology and neuroscience

authors： Nordblom J,Persson JK,Aberg J,Blom H,Engqvist H,Brismar H,Sjödahl J,Josephson A,Frostell A,Thams S,Brundin L,Svensson M,Mattsson P

更新日期：2012-01-01 00:00:00

abstract：:In rat sciatic nerves, IGF-I or bFGF was applied distal to a crush to evaluate their effects upon the restoration of the neuromuscular function. In comparison with the recovery following a simple crush, treatment with growth factors resulted in (i) enhanced elongation of regenerating axons ( + 24%) up to day 3 post le...

journal_title：Restorative neurology and neuroscience

authors： Vergara J,Medina L,Maulén J,Inestrosa NC,Alvarez J

更新日期：1993-01-01 00:00:00

abstract：BACKGROUND:In low vision patients, the assessment of contrast sensitivity is an essential tool to determine the stage of visual impairment. However, traditional contrast sensitivity tests rely on verbal feedback, and the expertise of the examiner. OBJECTIVE:In the current study, a fast, OKN-based virtual diagnosis too...

journal_title：Restorative neurology and neuroscience

authors： Tatiyosyan SA,Rifai K,Wahl S

更新日期：2020-01-01 00:00:00

abstract：PURPOSE:The relationship between auditory temporal-order perception and phoneme discrimination has been discussed for several years, based on findings, showing that patients with cerebral damage in the left hemisphere and aphasia, as well as children with specific language impairments, show deficits in temporal-process...

journal_title：Restorative neurology and neuroscience

authors： Fink M,Churan J,Wittmann M

更新日期：2005-01-01 00:00:00

abstract：:The brain can undergo self-repair and has the ability to compensate for functions lost after a stroke. The plasticity of the ischemic brain is influenced by several factors including aging and pharmacotherapy. Fluoxetine is an antidepressant which enhances serotonergic neurotransmission through selective inhibition of...

journal_title：Restorative neurology and neuroscience

authors： Sun Y,Sun X,Qu H,Zhao S,Xiao T,Zhao C

更新日期：2017-01-01 00:00:00

abstract：:Melatonin (MLT) is a methoxyindole secreted principally by the pineal gland. It is synthesized at night under normal environmental conditions. The endogenous rhythm of secretion is generated by the suprachiasmatic nuclei and entrained by the light/dark cycle. Light is able to both suppress or synchronize melatonin pro...

journal_title：Restorative neurology and neuroscience

authors： Claustrat B,Brun J,Geoffriau M,Chazot G

更新日期：1998-06-01 00:00:00

abstract：:Following brain injury there is an excessive release of glutamate, a reduction in levels of cellular Mg+ +, and the generation of oxygen free radicals. These processes may contribute to the severity of the behavioral impairments seen following brain injury by leading to secondary neuronal degeneration. The present exp...

journal_title：Restorative neurology and neuroscience

authors： Hoane MR,Raad C,Barth TM

更新日期：1997-01-01 00:00:00

abstract：:The outgrowth of neurites in neuronal cell cultures reflects the intrinsic capacity for neurite regeneration and morphological rearrangements after axotomy and in plasticity. The role of fast axonal transport in these neurite outgrowth responses has not been investigated. We have recently shown that sabeluzole (R58735...

journal_title：Restorative neurology and neuroscience

authors： Geerts H,Nuydens R,Nuyens R,Cornelissen F

更新日期：1992-01-01 00:00:00