Melatonin: from the hormone to the drug?

abstract：BACKGROUND:The patients with chronic Disorders of Consciousness (DoC) mostly present with extremely challenging differential diagnosis. The advanced analysis of electroencephalographic (EEG) signals induced by brain stimulation paradigms may provide an appropriate approach to differentiate patients with DoC, besides th...

journal_title：Restorative neurology and neuroscience

authors： Naro A,Leo A,Bruno R,Cannavò A,Buda A,Manuli A,Bramanti A,Bramanti P,Calabrò RS

更新日期：2017-01-01 00:00:00

abstract：PURPOSE:Immunomodulatory agents are often combined in organ transplantation to minimize toxicity and enhance therapeutic effect. We hypothesized that combining low-dose FK506 with anti-CD40 Ligand (anti-CD40L mAb) would enhance regeneration through peripheral nerve allografts while preserving immune unresponsiveness. ...

journal_title：Restorative neurology and neuroscience

authors： Brenner MJ,Mackinnon SE,Rickman SR,Jaramillo A,Tung TH,Hunter DA,Mohanakumar T

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Progressive apoptosis in the dopaminergic neurons of substantia nigra lead to Parkinson's disease. Since neurons require substantially higher supply of energy, their mitochondria have a pivotal status in neuronal survival. These organelles have a key role to play in apoptosis and any impairment thereof may l...

journal_title：Restorative neurology and neuroscience

authors： Qadri R,Namdeo M,Behari M,Goyal V,Sharma S,Mukhopadhyay AK

更新日期：2018-01-01 00:00:00

abstract：:The aim of this study was to gauge the possible sprouting of primary afferent fibers following dorsal rhizotomies using Fos-like immunoreactivity (Fos-LI) in order to label neurons activated by formalin injection into the rat forepaw. To assess the functional consequences of possible sprouting of fine diameter primary...

journal_title：Restorative neurology and neuroscience

authors： Abbadie C,Lombard MC,Morain F,Besson JM

更新日期：1994-01-01 00:00:00

abstract：PURPOSE:Previous neuroimaging studies of oddball tasks and other paradigms measuring attention processes support right hemisphere dominance for attentional processes. Using an auditory selective attention task, we studied the functional asymmetry of the human brain in response to attended or unattended deviant tones. S...

journal_title：Restorative neurology and neuroscience

authors： Petit L,Simon G,Joliot M,Andersson F,Bertin T,Zago L,Mellet E,Tzourio-Mazoyer N

更新日期：2007-01-01 00:00:00

abstract：PURPOSE:A realistic body representation needs to be constantly updated. In case of physiological modifications, body representations integrate information coming from different sensory sources, including the sense of touch. Previous studies described transient modifications of these representations following illusory d...

journal_title：Restorative neurology and neuroscience

authors： Cimmino RL,Spitoni G,Serino A,Antonucci G,Catagni M,Camagni M,Haggard P,Pizzamiglio L

更新日期：2013-01-01 00:00:00

abstract：PURPOSE:Contralateral primary sensori-motor cortex (SM1) activation by passive movement was investigated by functional MRI (fMRI) at the early stage of stroke, to determine whether SM1 activation can be used to predict the degree of motor recovery of the hemiplegic hand. METHODS:We studied 17 stroke patients who showe...

journal_title：Restorative neurology and neuroscience

authors： Jang SH,Kim YH,Chang Y,Han BS,Byun WM,Chang CH

更新日期：2004-01-01 00:00:00

abstract：:The lamination of dentate gyrus afferents established during development is maintained following lesion-induced reactive growth in the adult. After partial deafferentation sprouts from undamaged afferents restore most synapses, while respecting the laminae relative boundaries. No evidence of trans-laminar sprouting ha...

journal_title：Restorative neurology and neuroscience

authors： Collazos-Castro JE,Nieto-Sampedro M

更新日期：2001-01-01 00:00:00

abstract：PURPOSE:In brain-computer interfaces (BCIs), electrical brain signals during motor imagery are utilized as commands connecting the brain to a computer. To use BCI in patients with stroke, unique brain signal changes should be characterized during motor imagery process. This study aimed to examine the trial-dependent mo...

journal_title：Restorative neurology and neuroscience

authors： Lee M,Park CH,Im CH,Kim JH,Kwon GH,Kim L,Chang WH,Kim YH

更新日期：2015-08-26 00:00:00

abstract：PURPOSE:To evaluate whether repetitive optokinetic stimulation with active pursuit eye movements leads to substantial and greater recovery from visual neglect as compared to conventional visual scanning training. METHODS:Two groups of five patients with leftsided hemineglect were consecutively collected and matched fo...

journal_title：Restorative neurology and neuroscience

authors： Kerkhoff G,Keller I,Ritter V,Marquardt C

更新日期：2006-01-01 00:00:00

abstract：:Animals with unilateral neurotoxic lesions in the striatum exhibit a stereotypical biased rotational behavior in response to dopamine agonists. We recently argued that the rotational test may be subject to sensitization effects of the drug. Accordingly, we proposed the drug-free elevated body swing test (EBST) as an a...

journal_title：Restorative neurology and neuroscience

authors： Borlongan CV,Cahill DW,Sanberg PR

更新日期：1995-01-01 00:00:00

abstract：PURPOSE:Repairing the spinal cord with peripheral nerve grafts (PNG) and adjuvant acidic fibroblast growth factor (FGF1) has previously resulted in partial functional recovery. To aid microsurgical placement of PNGs, a graft holder device was previously developed by our group. In hope for a translational development we...

journal_title：Restorative neurology and neuroscience

authors： Nordblom J,Persson JK,Aberg J,Blom H,Engqvist H,Brismar H,Sjödahl J,Josephson A,Frostell A,Thams S,Brundin L,Svensson M,Mattsson P

更新日期：2012-01-01 00:00:00

abstract：:PURPOSE: Nerve allografts are highly antigenic and, thus, require the continuous use of immunosuppressive drugs. FK 506 was found to pre-vent rejection successfully. However, clinically neurotoxic complications have been noted in the central and peripheral nervous system although an increased rate of axonal regenerati...

journal_title：Restorative neurology and neuroscience

authors： Fansa H,Keilhoff G,Horn T,Altmann S,Wolf G,Schneider W

更新日期：2000-01-01 00:00:00

abstract：:Non-invasive brain stimulation techniques, such as repetitive transcranial magnetic stimulation (rTMS), can modify cortical excitability in a lasting fashion. The modification can be bi-directional in nature and holds considerable therapeutic promise for a number of neurological conditions. However, the effectiveness ...

journal_title：Restorative neurology and neuroscience

authors： Todd G,Ridding MC

更新日期：2010-01-01 00:00:00

abstract：PURPOSE:To investigate the effects of the androgen testosterone propionate (TP), on regeneration of the recurrent laryngeal nerve (RLN) after unilateral crush injury using assessment of vocal fold mobility (VFM) as a measure of behavioral recovery. METHODS:48 adult male rats underwent standardized crush injury of left...

journal_title：Restorative neurology and neuroscience

authors： Brown TJ,Pittman AL,Monaco GN,Benscoter BJ,Mantravadi AV,Akst LM,Jones KJ,Foecking EM

更新日期：2013-01-01 00:00:00

abstract：:Psychopathy is a mental disorder marked by deficient emotional responses, lack of empathy, and poor behavioral controls, commonly resulting in persistent antisocial deviance and criminal behavior. Accumulating research suggests that psychopathy follows a developmental trajectory with strong genetic influences, and whi...

journal_title：Restorative neurology and neuroscience

authors： Anderson NE,Kiehl KA

更新日期：2014-01-01 00:00:00

abstract：PURPOSE:The primary somatosensory cortex (S1) is somatotopically reorganized after limb amputation. The duration of the amputation, the intensity of phantom limb pain but also a multifactoral model of altered cerebral input have been discussed to be associated with cortical changes. Patients with finger amputation rare...

journal_title：Restorative neurology and neuroscience

authors： Oelschläger M,Pfannmöller J,Langner I,Lotze M

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Dimethyl fumarate (DMF) has immune-modulatory and neuro-protective characteristics that can be used for treatment of acute ischemic stroke. OBJECTIVE:To investigate the therapeutic effects of DMF on histological and functional recovery of rats after transient middle cerebral artery (MCA) occlusion. METHODS...

journal_title：Restorative neurology and neuroscience

authors： Safari A,Fazeli M,Namavar MR,Tanideh N,Jafari P,Borhani-Haghighi A

更新日期：2017-01-01 00:00:00

abstract：:Many of the present limitations of peripheral nerve repair might be overcome by performing nerve repairs at the axon level. One approach to nerve repair at this level would be to implant a neuroprosthesis in the form of a microelectronic switchboard which could route the connections of regenerated axons to their corre...

journal_title：Restorative neurology and neuroscience

authors： Rosen JM,Grosser M,Hentz VR

更新日期：1990-01-01 00:00:00

abstract：BACKGROUND:Specific investigation of dual task-interference (DTI) may help researchers to develop the optimal training exercise for enhancing the performance of daily activities. OBJECTIVES:To reveal the DTI by comparing the performances between personalized single tasks (cognitive or motor task) and dual task with se...

journal_title：Restorative neurology and neuroscience

authors： Kang EK,Shin D,Yun JY,Park W,Park HW

更新日期：2018-01-01 00:00:00

abstract：PURPOSE:To determine how age at the time of left middle cerebral artery stroke affects language lateralization in a combined sample of subjects with perinatal, childhood, and adult stroke. METHODS:19 participants who had perinatal stroke (<1 month of age), 32 with later stroke, and 51 sex-/age-matched healthy controls...

journal_title：Restorative neurology and neuroscience

authors： Szaflarski JP,Allendorfer JB,Byars AW,Vannest J,Dietz A,Hernando KA,Holland SK

更新日期：2014-01-01 00:00:00

abstract：PURPOSE:There is considerable variability in the extent and nature of the glial response to injury and neurodegeneration. Transplantation of fetal cortical tissue onto the brain of neonatal host rats or mice results in region-specific changes dependent on where the fetal tissue is placed. These changes include chronic ...

journal_title：Restorative neurology and neuroscience

authors： Bates KA,Drummond ES,Cozens GS,Harvey AR

更新日期：2016-01-01 00:00:00

abstract：PURPOSE:Interacting with others by reading their emotional expressions is an essential social skill in humans. How this ability develops during infancy and what brain processes underpin infants' perception of emotion in different modalities are the questions dealt with in this paper. METHODS:Literature review. RESULT...

journal_title：Restorative neurology and neuroscience

authors： Grossmann T

更新日期：2010-01-01 00:00:00

abstract：:The objective of this study was to develop an optimal dissection procedure for fetal porcine ventral mesencephalon (VM) grafts and to characterize the cellular composition of such an explant, in particular with respect to the dopaminergic and GABAergic components. We have used a monolayer cell culture system to study ...

journal_title：Restorative neurology and neuroscience

authors： van Roon WM,Copray JC,Hogenesch RI,Kema I,Meyer EM,Molenaar G,Lugard C,Staal MJ,Go KG

更新日期：1995-01-01 00:00:00

abstract：:Contemporary strategies to promote motor recovery following stroke focus on repetitive voluntary movements. Although successful movement relies on efficient sensorimotor integration, functional outcomes often bias motor therapy toward motor-related impairments such as weakness, spasticity and synergies; sensory therap...

journal_title：Restorative neurology and neuroscience

authors： Bolognini N,Russo C,Edwards DJ

更新日期：2016-04-11 00:00:00

abstract：PURPOSE:Transgenic manipulation of mouse physiology facilitates the preclinical study of genetic risk factors, neural plasticity, and reactive processes accompanying Alzheimer's disease. Alternatively, entorhinal cortex lesions (ECLs) model pathophysiological denervation and axonal sprouting in rat. Given reports of an...

journal_title：Restorative neurology and neuroscience

authors： Feeney EJ,Stephenson D,Kleiman R,Bove S,Cron C,Moody L,Robinson M,Ramirez JJ

更新日期：2013-01-01 00:00:00

abstract：PURPOSE:We examined the feasibility and outcome of electromyographically triggered electrical muscle stimulation (EMG-ES) plus unilateral or bilateral task specific practice on arm function in chronic stroke survivors with moderate-severe hemiplegia. Transcranial magnetic stimulation was used to examine inter-hemispher...

journal_title：Restorative neurology and neuroscience

authors： Singer BJ,Vallence AM,Cleary S,Cooper I,Loftus AM

更新日期：2013-01-01 00:00:00

abstract：:Bridging large defects in mixed nerves is still an unsolved problem in reconstructive microsurgery. Two main aspects may be distinguished: one is to obtain an appropriate substitute for the lost neural tissue, the second to direct fibers toward their previous end-organs with the highest possible specificity. In the pr...

journal_title：Restorative neurology and neuroscience

authors： Papaloïzos MY,Holmquist B,Lundborg G

更新日期：1997-01-01 00:00:00

abstract：:Many ocular diseases (such as glaucoma, diabetic retinopathy, age-related macular degeneration, and traumatic eye injuries) can result in the degeneration of retinal cells and the subsequent loss of vision. Some kinds of treatments, such as drugs, stem cell transplantation and surgery are reported to be effective in c...

journal_title：Restorative neurology and neuroscience

authors： Li HY,Rong SS,Hong X,Guo R,Yang FZ,Liang YY,Li A,So KF

更新日期：2019-01-01 00:00:00

abstract：PURPOSE:Aging is believed to affect epigenetic marking of brain DNA with 5-methylcytosine (5mC) and possibly via the 5mC to 5-hydroxymethylcytosine (5hmC) conversion by TET (ten-eleven translocation) enzymes. We investigated the impact of aging on hippocampal DNA 5-hydroxymethylation including in the sequence of aging-...

journal_title：Restorative neurology and neuroscience

authors： Chen H,Dzitoyeva S,Manev H

更新日期：2012-01-01 00:00:00