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Usage of the middle finger shapes reorganization of the primary somatosensory cortex in patients with index finger amputation.

Abstract：

PURPOSE:The primary somatosensory cortex (S1) is somatotopically reorganized after limb amputation. The duration of the amputation, the intensity of phantom limb pain but also a multifactoral model of altered cerebral input have been discussed to be associated with cortical changes. Patients with finger amputation rarely show phantom limb pain, the deafferented cortical area is small but other fingers might well overtake function. METHOD:We selected a group of index finger amputated patients and performed a high resolution (in plane: 1.5 mm2) S1-mapping during tactile stimulation of finger tips. RESULT:We found an interhemispheric imbalance of the distance between the thumb and middle finger only for the patient-group. When patients used their middle finger more they showed less interhemispheric imbalance, increased spatial tactile discrimination and increased fMRI-activation in response to stimulation. Phantom limb pain was not associated with somatotopic representation parameters in S1. CONCLUSIONS:Overall, our fMRI-data point to a usage dependent plasticity of Brodmann's area 3b in man.

journal_name

Restor Neurol Neurosci

journal_title

Restorative neurology and neuroscience

authors

Oelschläger M,Pfannmöller J,Langner I,Lotze M

doi

10.3233/RNN-130380

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

507-15

issue

4

eissn

0922-6028

issn

1878-3627

pii

B825T2P006882174

journal_volume

32

pub_type

杂志文章

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