The response to repetitive stimulation of human motor cortex is influenced by the history of synaptic activity.

Abstract:

:Non-invasive brain stimulation techniques, such as repetitive transcranial magnetic stimulation (rTMS), can modify cortical excitability in a lasting fashion. The modification can be bi-directional in nature and holds considerable therapeutic promise for a number of neurological conditions. However, the effectiveness of these techniques is currently limited by large intra- and inter-subject variability in the response. A number of factors that contribute to response variability have now been identified, with one of the most important being the history of synaptic activity within the cortical region being targeted by stimulation. In this review we discuss what is currently known about the influence of behaviourally, or experimentally, induced changes in synaptic activity in the cortical (or interconnected) region being targeted by stimulation on the response to rTMS techniques. Understanding such influences is a critical step in the development of effective therapeutic paradigms employing such techniques.

journal_name

Restor Neurol Neurosci

authors

Todd G,Ridding MC

doi

10.3233/RNN-2010-0565

subject

Has Abstract

pub_date

2010-01-01 00:00:00

pages

459-67

issue

4

eissn

0922-6028

issn

1878-3627

pii

86T82730G7X376K3

journal_volume

28

pub_type

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