Fetal porcine ventral mesencephalon grafts: dissection procedure and cellular characterization in culture.

abstract：BACKGROUND:Robotic rehabilitation is a highly promising approach to recover lost functions after stroke or other neurological disorders. Unfortunately, robotic rehabilitation currently suffers from "motor slacking", a phenomenon in which the human motor system reduces muscle activation levels and movement excursions, o...

journal_title：Restorative neurology and neuroscience

authors： Washabaugh EP,Treadway E,Gillespie RB,Remy CD,Krishnan C

更新日期：2018-01-01 00:00:00

abstract：:The hypothesis that a destabilization of mitochondrial function during neuronal exposure to excitatory amino acids may be involved in the mechanism of neuronal death was examined. The mitochondrial membrane potential (Delta(psi)m) and the cytoplasmic Ca2+ concentration ([Ca2+]c) were monitored simultaneously in single...

journal_title：Restorative neurology and neuroscience

authors： Kiedrowski L

更新日期：1998-06-01 00:00:00

abstract：:Many of the present limitations of peripheral nerve repair might be overcome by performing nerve repairs at the axon level. One approach to nerve repair at this level would be to implant a neuroprosthesis in the form of a microelectronic switchboard which could route the connections of regenerated axons to their corre...

journal_title：Restorative neurology and neuroscience

authors： Rosen JM,Grosser M,Hentz VR

更新日期：1990-01-01 00:00:00

abstract：PURPOSE:Despite advances towards potential clinically viable therapies there has been only limited success in improving functional recovery following traumatic brain injury (TBI). In rats, exposure to an enriched environment (EE) improves learning and fosters motor skill development. Induced pluripotent stem cells (iPS...

journal_title：Restorative neurology and neuroscience

authors： Dunkerson J,Moritz KE,Young J,Pionk T,Fink K,Rossignol J,Dunbar G,Smith JS

更新日期：2014-01-01 00:00:00

abstract：PURPOSE:Current models of intracerebral hematoma are difficult to use for neurotransplantation studies because of high mortality and important variations of morphology, size and location of blood deposits. We propose a modification of the autologous blood infusion technique in rats to reduce these limitations. METHODS...

journal_title：Restorative neurology and neuroscience

authors： Barth A,Guzman R,Andres RH,Mordasini P,Barth L,Widmer HR

更新日期：2007-01-01 00:00:00

abstract：:Contemporary strategies to promote motor recovery following stroke focus on repetitive voluntary movements. Although successful movement relies on efficient sensorimotor integration, functional outcomes often bias motor therapy toward motor-related impairments such as weakness, spasticity and synergies; sensory therap...

journal_title：Restorative neurology and neuroscience

authors： Bolognini N,Russo C,Edwards DJ

更新日期：2016-04-11 00:00:00

abstract：BACKGROUND:High definition transcranial direct current stimulation (HD-tDCS) has been administered over single brain regions for small numbers of sessions. Safety, feasibility and tolerability of HD-tDCS over multiple brain regions, multiple daily stimulations and long periods are not established. OBJECTIVE:We studied...

journal_title：Restorative neurology and neuroscience

authors： Turski CA,Kessler-Jones A,Chow C,Hermann B,Hsu D,Jones J,Seeger SK,Chappell R,Boly M,Ikonomidou C

更新日期：2017-01-01 00:00:00

abstract：PURPOSE:Repairing the spinal cord with peripheral nerve grafts (PNG) and adjuvant acidic fibroblast growth factor (FGF1) has previously resulted in partial functional recovery. To aid microsurgical placement of PNGs, a graft holder device was previously developed by our group. In hope for a translational development we...

journal_title：Restorative neurology and neuroscience

authors： Nordblom J,Persson JK,Aberg J,Blom H,Engqvist H,Brismar H,Sjödahl J,Josephson A,Frostell A,Thams S,Brundin L,Svensson M,Mattsson P

更新日期：2012-01-01 00:00:00

abstract：:Bridging large defects in mixed nerves is still an unsolved problem in reconstructive microsurgery. Two main aspects may be distinguished: one is to obtain an appropriate substitute for the lost neural tissue, the second to direct fibers toward their previous end-organs with the highest possible specificity. In the pr...

journal_title：Restorative neurology and neuroscience

authors： Papaloïzos MY,Holmquist B,Lundborg G

更新日期：1997-01-01 00:00:00

abstract：:Various basic qualitative and quantitative methods for the evaluation of sensorimotor functions after Traumatic Brain Injury (TBI) are introduced and discussed. Methodological aspects are illustrated by a single case follow-up study of a child after severe TBI (age 11; 7–12;1 yrs; 6, 8 and 12 month post TBI) in compar...

journal_title：Restorative neurology and neuroscience

authors： Jöhnk K,Kuhtz-Buschbeck JP,Stolze H,Serocki G,Kalwa S,Ritz A,Benz B,Illert M

更新日期：1999-01-01 00:00:00

abstract：PURPOSE:To investigate the effects of the androgen testosterone propionate (TP), on regeneration of the recurrent laryngeal nerve (RLN) after unilateral crush injury using assessment of vocal fold mobility (VFM) as a measure of behavioral recovery. METHODS:48 adult male rats underwent standardized crush injury of left...

journal_title：Restorative neurology and neuroscience

authors： Brown TJ,Pittman AL,Monaco GN,Benscoter BJ,Mantravadi AV,Akst LM,Jones KJ,Foecking EM

更新日期：2013-01-01 00:00:00

abstract：:The application of brain stimulation techniques for modulation of cortical excitability changes underlying spatial neglect following right-brain-damage has been the first application of brain stimulation in the rehabilitation setting. Several factors concur in making neglect a prototype of cognitive disorders that can...

journal_title：Restorative neurology and neuroscience

authors： Oliveri M

更新日期：2011-01-01 00:00:00

abstract：PURPOSE:To demonstrate, in a proof-of-concept study, whether potentiating ipsilesional higher motor areas (premotor cortex and supplementary motor area) augments and accelerates recovery associated with constraint induced movement. METHODS:In a randomized, double-blinded pilot clinical study, 12 patients with chronic ...

journal_title：Restorative neurology and neuroscience

authors： Cunningham DA,Varnerin N,Machado A,Bonnett C,Janini D,Roelle S,Potter-Baker K,Sankarasubramanian V,Wang X,Yue G,Plow EB

更新日期：2015-01-01 00:00:00

abstract：PURPOSE:To investigate the effect and underlying mechanism of Aceglutamide on motor dysfunction in rats after cerebral ischemia-reperfusion. METHODS:Adult male Sprague-Dawley rats were subjected to 2 h transient middle cerebral artery occlusion (MCAO). Aceglutamide or vehicle was intraperitoneally given to rats at 24 ...

journal_title：Restorative neurology and neuroscience

authors： Zhang R,Yang N,Ji C,Zheng J,Liang Z,Hou CY,Liu YY,Zuo PP

更新日期：2015-01-01 00:00:00

abstract：PURPOSE:The primary somatosensory cortex (S1) is somatotopically reorganized after limb amputation. The duration of the amputation, the intensity of phantom limb pain but also a multifactoral model of altered cerebral input have been discussed to be associated with cortical changes. Patients with finger amputation rare...

journal_title：Restorative neurology and neuroscience

authors： Oelschläger M,Pfannmöller J,Langner I,Lotze M

更新日期：2014-01-01 00:00:00

abstract：PURPOSE:Several recent studies have demonstrated that following short-term monocular deprivation in normal adults, the patched eye, rather than the unpatched eye, becomes stronger in subsequent binocular viewing. However, little is known about the site and nature of the underlying processes. In this study, we examine t...

journal_title：Restorative neurology and neuroscience

authors： Zhou J,Baker DH,Simard M,Saint-Amour D,Hess RF

更新日期：2015-01-01 00:00:00

abstract：PURPOSE:Understanding the neural mechanisms of stroke recovery is of paramount importance for neurorehabilitation. METHODS:For this purpose, we analyzed several TMS and EEG variables and their association with motor recovery. Thirty-five subjects with chronic stroke were recruited. The neurophysiological examination i...

journal_title：Restorative neurology and neuroscience

authors： Simis M,Doruk D,Imamura M,Anghinah R,Morales-Quezada L,Fregni F,Battistella LR

更新日期：2016-01-01 00:00:00

abstract：:Many toxic factors are generated during stroke that contribute directly to the death of neurons. Several recent studies suggest that a suicide-like phenomena similar to apoptosis or programmed cell death also contributes to the loss of neurons in stroke. The evidence implicating apoptosis in stroke can be divided into...

journal_title：Restorative neurology and neuroscience

authors： Linnik MD

更新日期：1996-01-01 00:00:00

abstract：BACKGROUND:The patients with chronic Disorders of Consciousness (DoC) mostly present with extremely challenging differential diagnosis. The advanced analysis of electroencephalographic (EEG) signals induced by brain stimulation paradigms may provide an appropriate approach to differentiate patients with DoC, besides th...

journal_title：Restorative neurology and neuroscience

authors： Naro A,Leo A,Bruno R,Cannavò A,Buda A,Manuli A,Bramanti A,Bramanti P,Calabrò RS

更新日期：2017-01-01 00:00:00

abstract：PURPOSE:Exogenously applied BDNF has been shown to rescue rat retinal ganglion cells (RGCs) from axotomy-induced apoptotic death, presumably via activation of its high affinity receptor TrkB. Since both TrkB and BDNF are endogenously expressed in RGCs, auto- or para-crine neurotrophic loops in the retina may be involve...

journal_title：Restorative neurology and neuroscience

authors： Hirsch S,Labes M,Bähr M

更新日期：2000-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Neuroplastic alterations of cortical excitability and activity represent the likely neurophysiological foundation of learning and memory formation. Beyond their induction, alterations of these processes by subsequent modification of cortical activity, termed metaplasticity, came into the focus of...

journal_title：Restorative neurology and neuroscience

authors： Thirugnanasambandam N,Sparing R,Dafotakis M,Meister IG,Paulus W,Nitsche MA,Fink GR

更新日期：2011-01-01 00:00:00

abstract：PURPOSE:The aim of the present study was to explore the use of two-photon microscopy for investigating the therapeutic time window of methylprednisolone (MP) treatment after spinal cord injury (SCI). METHODS:Twenty-four YFP H-line mice were subjected to hemisection SCI and then divided into four groups. Group 1 receiv...

journal_title：Restorative neurology and neuroscience

authors： Zhang Y,Zhang L,Ji X,Pang M,Ju F,Zhang J,Li W,Zhang S,He Z,Gan WB,Tang P

更新日期：2015-01-01 00:00:00

abstract：PURPOSE:Hemispatial neglect, a failure to orient to the contralateral side of the lesion, is a disabling disorder after stroke. Previously arm activation combined with visual training or visual scanning training were found effective in rehabilitation of hemispatial neglect. The aim of this study was to determine whethe...

journal_title：Restorative neurology and neuroscience

authors： Luukkainen-Markkula R,Tarkka IM,Pitkänen K,Sivenius J,Hämäläinen H

更新日期：2009-01-01 00:00:00

abstract：:In 2009 the German BMBF (German Ministry of Education and Research) established an Integrated Center for Research and Treatment (IFB(LMU)) of Vertigo, Balance and Ocular Motor Disorders in Munich. After the 10-year period of funding by the BMBF, it is envisioned that the (IFB(LMU)) will continue over the long term wit...

journal_title：Restorative neurology and neuroscience

authors： Brandt T,Zwergal A,Jahn K,Strupp M

更新日期：2010-01-01 00:00:00

abstract：:Since various studies, including multi-centre studies, investigating the effect of repetitive transcranial magnetic stimulation (rTMS) in depression have shown different results, it is now important to research, which symptoms of depression are most responsive to this kind of non-invasive brain stimulation. Furthermor...

journal_title：Restorative neurology and neuroscience

authors： Höppner J,Berger C,Walter U,Padberg F,Buchmann J,Herwig U,Domes G

更新日期：2010-01-01 00:00:00

abstract：:In rat sciatic nerves, IGF-I or bFGF was applied distal to a crush to evaluate their effects upon the restoration of the neuromuscular function. In comparison with the recovery following a simple crush, treatment with growth factors resulted in (i) enhanced elongation of regenerating axons ( + 24%) up to day 3 post le...

journal_title：Restorative neurology and neuroscience

authors： Vergara J,Medina L,Maulén J,Inestrosa NC,Alvarez J

更新日期：1993-01-01 00:00:00

abstract：:Injury of the nervous system initiates a cascade of signal transduction including a rise in extracellular glutamate which leads to subsequent secondary neuronal loss. Excitotoxicity is known to play a crucial role in cell death spinal cord trauma. Gangliosides, particularly monosialogangliosides (GM1), are protective ...

journal_title：Restorative neurology and neuroscience

authors： Vorwerk CK,Bonheur J,Kreutz MR,Dreyer EB,Laev H

更新日期：1999-01-01 00:00:00

abstract：PURPOSE:Previous neuroimaging studies of oddball tasks and other paradigms measuring attention processes support right hemisphere dominance for attentional processes. Using an auditory selective attention task, we studied the functional asymmetry of the human brain in response to attended or unattended deviant tones. S...

journal_title：Restorative neurology and neuroscience

authors： Petit L,Simon G,Joliot M,Andersson F,Bertin T,Zago L,Mellet E,Tzourio-Mazoyer N

更新日期：2007-01-01 00:00:00

abstract：:Axonotmesis of the left sciatic nerve was performed on adult male Wistar rats. T1 values of the crushed nerve samples were determined with proton magnetic resonance spectroscopy. Denervation changes of the dependent hind plantar flexor muscles were assessed with proton magnetic resonance imaging of their cross-section...

journal_title：Restorative neurology and neuroscience

authors： Ribarič S,Jarh O,Sepe A,Demsar F

更新日期：1992-01-01 00:00:00

abstract：:The mechanisms underlying recovery of function following damage to the CNS, although suspected, are virtually unknown. After damage to the adult cat spinal cord, recovery of motor behavior depends on which systems have been interrupted and which remain intact. For example, following hemisection, overground (voluntary)...

journal_title：Restorative neurology and neuroscience

authors： Goldberger ME

更新日期：1991-01-01 00:00:00