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Nerve regeneration is improved by insulin-like growth factor I (IGF-I) and basic flbroblast growth factor (bFGF).

Abstract：

:In rat sciatic nerves, IGF-I or bFGF was applied distal to a crush to evaluate their effects upon the restoration of the neuromuscular function. In comparison with the recovery following a simple crush, treatment with growth factors resulted in (i) enhanced elongation of regenerating axons ( + 24%) up to day 3 post lesion (PL); (ii) more sprouts at early times; (iii) reduced participation of macrophages in the removal of the degenerating myelin in the first week PL; (iv) restoration of the neuromuscular transmission 2 days earlier; (v) a prolonged relaxation time and a reduced specific tetanic tension at week 3 PL but not at week 7 PL. Other indicators of recovery such as conduction velocity of nerve impulse, muscle weight, specific twitch tension, and time to peak were not affected by bFGF or IGF-I. Results suggest that IGF-I and bFGF affect locally Schwann cells and axons, and also the neuron as a whole, including its trophic function. We conclude that IGF-I and bFGF applied to the nerve, albeit moderately, improve the recovery of the neuromuscular function.

journal_name

Restor Neurol Neurosci

journal_title

Restorative neurology and neuroscience

authors

Vergara J,Medina L,Maulén J,Inestrosa NC,Alvarez J

doi

10.3233/RNN-1993-5302

subject

Has Abstract

pub_date

1993-01-01 00:00:00

pages

181-9

issue

3

eissn

0922-6028

issn

1878-3627

pii

G302R85544027616

journal_volume

5

pub_type

杂志文章

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